LeishMANIAdb
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ABC transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ABC transporter-like protein
Gene product:
ABC transporter-like protein
Species:
Leishmania major
UniProt:
E9ADV0_LEIMA
TriTrypDb:
LmjF.29.0930 , LMJLV39_290015700 , LMJSD75_290015700
Length:
722

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic ABC transporters.. Expanded on the Trypanosoma rangeli and theileri lineages

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

E9ADV0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0005215 transporter activity 1 6
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0015399 primary active transmembrane transporter activity 4 6
GO:0017076 purine nucleotide binding 4 13
GO:0022804 active transmembrane transporter activity 3 6
GO:0022857 transmembrane transporter activity 2 6
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0042626 ATPase-coupled transmembrane transporter activity 2 6
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:0140657 ATP-dependent activity 1 6
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0140359 ABC-type transporter activity 3 4
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 156 160 PF00656 0.545
CLV_NRD_NRD_1 545 547 PF00675 0.427
CLV_NRD_NRD_1 613 615 PF00675 0.409
CLV_NRD_NRD_1 79 81 PF00675 0.476
CLV_NRD_NRD_1 93 95 PF00675 0.413
CLV_PCSK_KEX2_1 547 549 PF00082 0.430
CLV_PCSK_KEX2_1 613 615 PF00082 0.410
CLV_PCSK_KEX2_1 79 81 PF00082 0.420
CLV_PCSK_KEX2_1 93 95 PF00082 0.317
CLV_PCSK_PC1ET2_1 547 549 PF00082 0.434
CLV_PCSK_SKI1_1 306 310 PF00082 0.545
CLV_PCSK_SKI1_1 363 367 PF00082 0.576
CLV_PCSK_SKI1_1 474 478 PF00082 0.295
CLV_PCSK_SKI1_1 540 544 PF00082 0.330
CLV_PCSK_SKI1_1 563 567 PF00082 0.306
DEG_APCC_DBOX_1 469 477 PF00400 0.568
DEG_APCC_DBOX_1 93 101 PF00400 0.592
DEG_Nend_Nbox_1 1 3 PF02207 0.734
DOC_CDC14_PxL_1 637 645 PF14671 0.439
DOC_CKS1_1 354 359 PF01111 0.747
DOC_CYCLIN_yCln2_LP_2 214 220 PF00134 0.525
DOC_CYCLIN_yCln2_LP_2 574 580 PF00134 0.453
DOC_MAPK_DCC_7 638 646 PF00069 0.424
DOC_MAPK_FxFP_2 221 224 PF00069 0.597
DOC_MAPK_gen_1 203 212 PF00069 0.510
DOC_MAPK_gen_1 546 556 PF00069 0.626
DOC_MAPK_gen_1 613 619 PF00069 0.543
DOC_MAPK_gen_1 93 99 PF00069 0.602
DOC_MAPK_MEF2A_6 203 212 PF00069 0.558
DOC_MAPK_MEF2A_6 514 521 PF00069 0.450
DOC_MAPK_MEF2A_6 52 60 PF00069 0.574
DOC_MAPK_MEF2A_6 536 543 PF00069 0.616
DOC_MAPK_MEF2A_6 568 576 PF00069 0.391
DOC_MAPK_MEF2A_6 584 593 PF00069 0.323
DOC_MAPK_MEF2A_6 638 646 PF00069 0.424
DOC_PP1_RVXF_1 512 519 PF00149 0.304
DOC_PP1_RVXF_1 612 619 PF00149 0.577
DOC_PP1_SILK_1 647 652 PF00149 0.350
DOC_PP2B_LxvP_1 150 153 PF13499 0.596
DOC_PP2B_LxvP_1 294 297 PF13499 0.635
DOC_PP2B_LxvP_1 574 577 PF13499 0.484
DOC_PP4_FxxP_1 221 224 PF00568 0.597
DOC_PP4_FxxP_1 325 328 PF00568 0.733
DOC_SPAK_OSR1_1 464 468 PF12202 0.608
DOC_USP7_MATH_1 107 111 PF00917 0.571
DOC_USP7_MATH_1 261 265 PF00917 0.587
DOC_USP7_MATH_1 332 336 PF00917 0.767
DOC_USP7_MATH_1 389 393 PF00917 0.687
DOC_USP7_MATH_1 499 503 PF00917 0.549
DOC_USP7_MATH_1 531 535 PF00917 0.497
DOC_WW_Pin1_4 213 218 PF00397 0.551
DOC_WW_Pin1_4 3 8 PF00397 0.666
DOC_WW_Pin1_4 333 338 PF00397 0.779
DOC_WW_Pin1_4 353 358 PF00397 0.710
DOC_WW_Pin1_4 370 375 PF00397 0.749
DOC_WW_Pin1_4 447 452 PF00397 0.688
LIG_14-3-3_CanoR_1 349 354 PF00244 0.752
LIG_14-3-3_CanoR_1 359 367 PF00244 0.724
LIG_14-3-3_CanoR_1 386 395 PF00244 0.651
LIG_14-3-3_CanoR_1 470 474 PF00244 0.622
LIG_14-3-3_CanoR_1 584 590 PF00244 0.366
LIG_Actin_WH2_2 455 472 PF00022 0.627
LIG_Actin_WH2_2 525 542 PF00022 0.500
LIG_Actin_WH2_2 569 586 PF00022 0.485
LIG_Actin_WH2_2 705 722 PF00022 0.450
LIG_BIR_III_4 226 230 PF00653 0.552
LIG_BRCT_BRCA1_1 200 204 PF00533 0.553
LIG_BRCT_BRCA1_1 221 225 PF00533 0.581
LIG_BRCT_BRCA1_1 334 338 PF00533 0.809
LIG_BRCT_BRCA1_1 361 365 PF00533 0.765
LIG_BRCT_BRCA1_1 552 556 PF00533 0.549
LIG_BRCT_BRCA1_1 626 630 PF00533 0.489
LIG_BRCT_BRCA1_1 88 92 PF00533 0.576
LIG_CtBP_PxDLS_1 188 193 PF00389 0.458
LIG_EH1_1 510 518 PF00400 0.358
LIG_eIF4E_1 511 517 PF01652 0.362
LIG_eIF4E_1 587 593 PF01652 0.396
LIG_FHA_1 174 180 PF00498 0.616
LIG_FHA_1 235 241 PF00498 0.564
LIG_FHA_1 248 254 PF00498 0.463
LIG_FHA_1 266 272 PF00498 0.414
LIG_FHA_1 389 395 PF00498 0.688
LIG_FHA_1 4 10 PF00498 0.656
LIG_FHA_1 495 501 PF00498 0.386
LIG_FHA_2 397 403 PF00498 0.602
LIG_FHA_2 678 684 PF00498 0.370
LIG_Integrin_isoDGR_2 77 79 PF01839 0.433
LIG_LIR_Apic_2 324 328 PF02991 0.769
LIG_LIR_Gen_1 222 231 PF02991 0.595
LIG_LIR_Gen_1 289 297 PF02991 0.620
LIG_LIR_Gen_1 348 358 PF02991 0.772
LIG_LIR_Gen_1 569 579 PF02991 0.398
LIG_LIR_Gen_1 620 629 PF02991 0.412
LIG_LIR_Gen_1 682 690 PF02991 0.338
LIG_LIR_Nem_3 148 154 PF02991 0.568
LIG_LIR_Nem_3 159 165 PF02991 0.518
LIG_LIR_Nem_3 289 294 PF02991 0.586
LIG_LIR_Nem_3 348 354 PF02991 0.759
LIG_LIR_Nem_3 569 574 PF02991 0.388
LIG_LIR_Nem_3 620 626 PF02991 0.388
LIG_LIR_Nem_3 627 633 PF02991 0.380
LIG_LIR_Nem_3 682 687 PF02991 0.324
LIG_MYND_1 328 332 PF01753 0.724
LIG_Pex14_1 70 74 PF04695 0.659
LIG_Pex14_2 221 225 PF04695 0.581
LIG_SH2_CRK 351 355 PF00017 0.775
LIG_SH2_CRK 47 51 PF00017 0.617
LIG_SH2_CRK 551 555 PF00017 0.573
LIG_SH2_CRK 626 630 PF00017 0.370
LIG_SH2_CRK 654 658 PF00017 0.365
LIG_SH2_GRB2like 290 293 PF00017 0.591
LIG_SH2_NCK_1 626 630 PF00017 0.418
LIG_SH2_SRC 605 608 PF00017 0.238
LIG_SH2_STAP1 34 38 PF00017 0.521
LIG_SH2_STAP1 420 424 PF00017 0.548
LIG_SH2_STAP1 425 429 PF00017 0.557
LIG_SH2_STAP1 587 591 PF00017 0.396
LIG_SH2_STAP1 626 630 PF00017 0.424
LIG_SH2_STAT5 144 147 PF00017 0.605
LIG_SH2_STAT5 290 293 PF00017 0.550
LIG_SH2_STAT5 380 383 PF00017 0.747
LIG_SH2_STAT5 471 474 PF00017 0.607
LIG_SH2_STAT5 571 574 PF00017 0.370
LIG_SH2_STAT5 605 608 PF00017 0.409
LIG_SH2_STAT5 623 626 PF00017 0.163
LIG_SH2_STAT5 659 662 PF00017 0.415
LIG_SH2_STAT5 677 680 PF00017 0.339
LIG_SH2_STAT5 684 687 PF00017 0.297
LIG_SH3_2 451 456 PF14604 0.625
LIG_SH3_3 325 331 PF00018 0.773
LIG_SH3_3 371 377 PF00018 0.748
LIG_SH3_3 448 454 PF00018 0.774
LIG_SH3_3 6 12 PF00018 0.759
LIG_SH3_3 63 69 PF00018 0.644
LIG_SH3_CIN85_PxpxPR_1 451 456 PF14604 0.569
LIG_Sin3_3 480 487 PF02671 0.494
LIG_SUMO_SIM_anti_2 588 593 PF11976 0.357
LIG_SUMO_SIM_par_1 153 159 PF11976 0.612
LIG_SUMO_SIM_par_1 249 255 PF11976 0.521
LIG_SUMO_SIM_par_1 390 400 PF11976 0.694
LIG_SUMO_SIM_par_1 492 497 PF11976 0.425
LIG_SUMO_SIM_par_1 521 527 PF11976 0.391
LIG_SUMO_SIM_par_1 563 569 PF11976 0.472
LIG_SUMO_SIM_par_1 700 705 PF11976 0.345
LIG_TRAF2_1 317 320 PF00917 0.783
LIG_TYR_ITIM 657 662 PF00017 0.509
LIG_UBA3_1 150 158 PF00899 0.510
LIG_WRC_WIRS_1 322 327 PF05994 0.740
LIG_WW_1 377 380 PF00397 0.738
LIG_WW_3 356 360 PF00397 0.703
LIG_WW_3 453 457 PF00397 0.594
MOD_CDK_SPxK_1 353 359 PF00069 0.711
MOD_CK1_1 110 116 PF00069 0.509
MOD_CK1_1 16 22 PF00069 0.648
MOD_CK1_1 254 260 PF00069 0.450
MOD_CK1_1 333 339 PF00069 0.706
MOD_CK1_1 388 394 PF00069 0.623
MOD_CK1_1 444 450 PF00069 0.733
MOD_CK1_1 585 591 PF00069 0.400
MOD_CK1_1 694 700 PF00069 0.462
MOD_CK1_1 705 711 PF00069 0.366
MOD_CK2_1 196 202 PF00069 0.427
MOD_CK2_1 499 505 PF00069 0.560
MOD_CMANNOS 615 618 PF00535 0.472
MOD_Cter_Amidation 191 194 PF01082 0.429
MOD_Cter_Amidation 77 80 PF01082 0.552
MOD_GlcNHglycan 122 125 PF01048 0.454
MOD_GlcNHglycan 18 21 PF01048 0.708
MOD_GlcNHglycan 263 266 PF01048 0.519
MOD_GlcNHglycan 280 283 PF01048 0.239
MOD_GlcNHglycan 387 390 PF01048 0.715
MOD_GlcNHglycan 391 394 PF01048 0.683
MOD_GlcNHglycan 399 402 PF01048 0.541
MOD_GlcNHglycan 443 446 PF01048 0.576
MOD_GlcNHglycan 630 633 PF01048 0.391
MOD_GlcNHglycan 697 700 PF01048 0.469
MOD_GlcNHglycan 704 707 PF01048 0.422
MOD_GlcNHglycan 88 91 PF01048 0.455
MOD_GSK3_1 234 241 PF00069 0.464
MOD_GSK3_1 247 254 PF00069 0.283
MOD_GSK3_1 261 268 PF00069 0.346
MOD_GSK3_1 286 293 PF00069 0.450
MOD_GSK3_1 326 333 PF00069 0.684
MOD_GSK3_1 345 352 PF00069 0.721
MOD_GSK3_1 385 392 PF00069 0.649
MOD_GSK3_1 410 417 PF00069 0.490
MOD_GSK3_1 441 448 PF00069 0.648
MOD_GSK3_1 46 53 PF00069 0.461
MOD_GSK3_1 605 612 PF00069 0.451
MOD_GSK3_1 624 631 PF00069 0.350
MOD_GSK3_1 673 680 PF00069 0.494
MOD_GSK3_1 691 698 PF00069 0.431
MOD_N-GLC_1 370 375 PF02516 0.695
MOD_N-GLC_1 673 678 PF02516 0.493
MOD_N-GLC_1 691 696 PF02516 0.460
MOD_N-GLC_2 234 236 PF02516 0.525
MOD_NEK2_1 219 224 PF00069 0.463
MOD_NEK2_1 469 474 PF00069 0.500
MOD_NEK2_1 550 555 PF00069 0.435
MOD_NEK2_1 566 571 PF00069 0.286
MOD_NEK2_1 583 588 PF00069 0.362
MOD_NEK2_1 617 622 PF00069 0.426
MOD_NEK2_1 624 629 PF00069 0.462
MOD_NEK2_1 702 707 PF00069 0.438
MOD_NEK2_1 715 720 PF00069 0.460
MOD_NEK2_2 146 151 PF00069 0.572
MOD_NEK2_2 153 158 PF00069 0.471
MOD_NEK2_2 290 295 PF00069 0.533
MOD_NEK2_2 46 51 PF00069 0.495
MOD_NEK2_2 531 536 PF00069 0.518
MOD_PIKK_1 117 123 PF00454 0.558
MOD_PIKK_1 196 202 PF00454 0.535
MOD_PIKK_1 234 240 PF00454 0.508
MOD_PIKK_1 336 342 PF00454 0.762
MOD_PIKK_1 412 418 PF00454 0.553
MOD_PIKK_1 499 505 PF00454 0.510
MOD_PK_1 349 355 PF00069 0.675
MOD_PKA_2 117 123 PF00069 0.573
MOD_PKA_2 358 364 PF00069 0.681
MOD_PKA_2 385 391 PF00069 0.613
MOD_PKA_2 469 475 PF00069 0.466
MOD_PKA_2 583 589 PF00069 0.558
MOD_Plk_1 129 135 PF00069 0.577
MOD_Plk_1 234 240 PF00069 0.446
MOD_Plk_1 673 679 PF00069 0.496
MOD_Plk_1 691 697 PF00069 0.493
MOD_Plk_4 107 113 PF00069 0.421
MOD_Plk_4 146 152 PF00069 0.508
MOD_Plk_4 247 253 PF00069 0.400
MOD_Plk_4 265 271 PF00069 0.272
MOD_Plk_4 349 355 PF00069 0.733
MOD_Plk_4 414 420 PF00069 0.478
MOD_Plk_4 46 52 PF00069 0.494
MOD_Plk_4 552 558 PF00069 0.421
MOD_Plk_4 624 630 PF00069 0.408
MOD_Plk_4 645 651 PF00069 0.391
MOD_Plk_4 657 663 PF00069 0.325
MOD_Plk_4 705 711 PF00069 0.395
MOD_ProDKin_1 213 219 PF00069 0.431
MOD_ProDKin_1 3 9 PF00069 0.589
MOD_ProDKin_1 333 339 PF00069 0.755
MOD_ProDKin_1 353 359 PF00069 0.657
MOD_ProDKin_1 370 376 PF00069 0.713
MOD_ProDKin_1 447 453 PF00069 0.618
TRG_DiLeu_BaEn_1 235 240 PF01217 0.430
TRG_DiLeu_BaLyEn_6 137 142 PF01217 0.536
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.272
TRG_DiLeu_BaLyEn_6 639 644 PF01217 0.545
TRG_ENDOCYTIC_2 351 354 PF00928 0.721
TRG_ENDOCYTIC_2 47 50 PF00928 0.536
TRG_ENDOCYTIC_2 551 554 PF00928 0.487
TRG_ENDOCYTIC_2 571 574 PF00928 0.141
TRG_ENDOCYTIC_2 621 624 PF00928 0.370
TRG_ENDOCYTIC_2 626 629 PF00928 0.331
TRG_ENDOCYTIC_2 654 657 PF00928 0.454
TRG_ENDOCYTIC_2 659 662 PF00928 0.486
TRG_ENDOCYTIC_2 684 687 PF00928 0.395
TRG_ER_diArg_1 138 141 PF00400 0.543
TRG_ER_diArg_1 613 615 PF00400 0.495
TRG_ER_diArg_1 79 82 PF00400 0.631
TRG_ER_diArg_1 92 94 PF00400 0.543
TRG_NES_CRM1_1 54 68 PF08389 0.461
TRG_NLS_MonoCore_2 545 550 PF00514 0.544
TRG_NLS_MonoExtN_4 546 551 PF00514 0.544
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.652

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I174 Leptomonas seymouri 52% 100%
A0A0S4JPC7 Bodo saltans 29% 85%
A0A1X0NXY3 Trypanosomatidae 22% 100%
A0A1X0NZQ7 Trypanosomatidae 33% 100%
A0A3R7KD05 Trypanosoma rangeli 34% 100%
A0A3S5H7K9 Leishmania donovani 94% 100%
A4HHA4 Leishmania braziliensis 81% 100%
A4I4F0 Leishmania infantum 95% 100%
E9ALY0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BIB9 Trypanosoma cruzi 21% 100%
V5BLN9 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS