Letm1 RBD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LETM1 and EF-hand domain-containing protein 1, putative

Species:

Leishmania major

UniProt:

E9ADU9_LEIMA

TriTrypDb:

LmjF.29.0920 , LMJLV39_290015600 , LMJSD75_290015600

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005739	mitochondrion	5	3
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ADU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006812	monoatomic cation transport	5	3
GO:0006816	calcium ion transport	7	3
GO:0006851	mitochondrial calcium ion transmembrane transport	4	3
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006875	obsolete intracellular metal ion homeostasis	6	2
GO:0009987	cellular process	1	3
GO:0019725	cellular homeostasis	2	2
GO:0030001	metal ion transport	6	3
GO:0030003	intracellular monoatomic cation homeostasis	5	2
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0042592	homeostatic process	3	2
GO:0048878	chemical homeostasis	4	2
GO:0050801	monoatomic ion homeostasis	5	2
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055065	obsolete metal ion homeostasis	7	2
GO:0055080	monoatomic cation homeostasis	6	2
GO:0055082	intracellular chemical homeostasis	3	2
GO:0055085	transmembrane transport	2	3
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0070588	calcium ion transmembrane transport	6	3
GO:0098655	monoatomic cation transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098662	inorganic cation transmembrane transport	5	3
GO:0098771	inorganic ion homeostasis	6	2
GO:1990542	mitochondrial transmembrane transport	3	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0005432	calcium:sodium antiporter activity	7	3
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015081	sodium ion transmembrane transporter activity	6	3
GO:0015085	calcium ion transmembrane transporter activity	6	3
GO:0015291	secondary active transmembrane transporter activity	4	3
GO:0015297	antiporter activity	5	3
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0015368	calcium:monoatomic cation antiporter activity	7	3
GO:0022804	active transmembrane transporter activity	3	3
GO:0022853	active monoatomic ion transmembrane transporter activity	4	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0044877	protein-containing complex binding	2	12
GO:0046872	metal ion binding	4	3
GO:0046873	metal ion transmembrane transporter activity	5	3
GO:0140828	metal cation:monoatomic cation antiporter activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.381
CLV_C14_Caspase3-7	377	381	PF00656	0.567
CLV_NRD_NRD_1	171	173	PF00675	0.519
CLV_NRD_NRD_1	234	236	PF00675	0.487
CLV_NRD_NRD_1	239	241	PF00675	0.487
CLV_NRD_NRD_1	313	315	PF00675	0.646
CLV_NRD_NRD_1	325	327	PF00675	0.546
CLV_NRD_NRD_1	466	468	PF00675	0.681
CLV_NRD_NRD_1	79	81	PF00675	0.287
CLV_NRD_NRD_1	8	10	PF00675	0.501
CLV_PCSK_KEX2_1	171	173	PF00082	0.519
CLV_PCSK_KEX2_1	234	236	PF00082	0.482
CLV_PCSK_KEX2_1	239	241	PF00082	0.477
CLV_PCSK_KEX2_1	31	33	PF00082	0.467
CLV_PCSK_KEX2_1	325	327	PF00082	0.595
CLV_PCSK_KEX2_1	402	404	PF00082	0.626
CLV_PCSK_KEX2_1	79	81	PF00082	0.292
CLV_PCSK_KEX2_1	8	10	PF00082	0.486
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.467
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.626
CLV_PCSK_PC7_1	235	241	PF00082	0.562
CLV_PCSK_SKI1_1	28	32	PF00082	0.470
CLV_PCSK_SKI1_1	326	330	PF00082	0.599
CLV_PCSK_SKI1_1	402	406	PF00082	0.582
CLV_PCSK_SKI1_1	452	456	PF00082	0.601
CLV_PCSK_SKI1_1	457	461	PF00082	0.592
CLV_PCSK_SKI1_1	55	59	PF00082	0.373
CLV_PCSK_SKI1_1	69	73	PF00082	0.341
CLV_PCSK_SKI1_1	82	86	PF00082	0.267
CLV_PCSK_SKI1_1	90	94	PF00082	0.287
DEG_APCC_DBOX_1	324	332	PF00400	0.393
DEG_APCC_DBOX_1	338	346	PF00400	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DEG_SPOP_SBC_1	483	487	PF00917	0.616
DOC_AGCK_PIF_2	442	447	PF00069	0.467
DOC_CYCLIN_RxL_1	79	89	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.344
DOC_MAPK_gen_1	31	42	PF00069	0.648
DOC_MAPK_gen_1	314	322	PF00069	0.435
DOC_MAPK_gen_1	325	331	PF00069	0.350
DOC_MAPK_gen_1	69	77	PF00069	0.569
DOC_MAPK_gen_1	79	85	PF00069	0.487
DOC_MAPK_MEF2A_6	201	210	PF00069	0.322
DOC_PP1_RVXF_1	53	59	PF00149	0.554
DOC_PP1_RVXF_1	60	66	PF00149	0.527
DOC_PP2B_LxvP_1	109	112	PF13499	0.344
DOC_PP2B_LxvP_1	186	189	PF13499	0.308
DOC_PP4_FxxP_1	200	203	PF00568	0.381
DOC_USP7_MATH_1	19	23	PF00917	0.712
DOC_USP7_MATH_1	376	380	PF00917	0.515
DOC_USP7_MATH_1	414	418	PF00917	0.431
DOC_USP7_UBL2_3	16	20	PF12436	0.711
DOC_USP7_UBL2_3	31	35	PF12436	0.668
DOC_USP7_UBL2_3	364	368	PF12436	0.510
DOC_USP7_UBL2_3	407	411	PF12436	0.474
DOC_WW_Pin1_4	227	232	PF00397	0.381
LIG_14-3-3_CanoR_1	274	282	PF00244	0.287
LIG_14-3-3_CanoR_1	3	7	PF00244	0.676
LIG_14-3-3_CanoR_1	314	318	PF00244	0.402
LIG_14-3-3_CanoR_1	339	343	PF00244	0.497
LIG_Actin_WH2_2	33	50	PF00022	0.661
LIG_Actin_WH2_2	56	74	PF00022	0.562
LIG_APCC_ABBA_1	103	108	PF00400	0.344
LIG_APCC_ABBAyCdc20_2	133	139	PF00400	0.362
LIG_BRCT_BRCA1_1	438	442	PF00533	0.358
LIG_Clathr_ClatBox_1	250	254	PF01394	0.301
LIG_eIF4E_1	51	57	PF01652	0.542
LIG_FHA_1	16	22	PF00498	0.720
LIG_FHA_1	211	217	PF00498	0.255
LIG_FHA_1	224	230	PF00498	0.343
LIG_FHA_1	24	30	PF00498	0.750
LIG_FHA_1	277	283	PF00498	0.288
LIG_FHA_1	87	93	PF00498	0.487
LIG_FHA_2	158	164	PF00498	0.214
LIG_FHA_2	342	348	PF00498	0.433
LIG_FHA_2	438	444	PF00498	0.378
LIG_FHA_2	484	490	PF00498	0.579
LIG_FHA_2	76	82	PF00498	0.487
LIG_LIR_Apic_2	198	203	PF02991	0.337
LIG_LIR_Apic_2	302	308	PF02991	0.276
LIG_LIR_Gen_1	194	203	PF02991	0.353
LIG_LIR_Gen_1	287	293	PF02991	0.278
LIG_LIR_Gen_1	297	308	PF02991	0.286
LIG_LIR_Gen_1	439	449	PF02991	0.381
LIG_LIR_Gen_1	99	109	PF02991	0.344
LIG_LIR_Nem_3	194	200	PF02991	0.302
LIG_LIR_Nem_3	287	292	PF02991	0.281
LIG_LIR_Nem_3	297	303	PF02991	0.286
LIG_LIR_Nem_3	382	388	PF02991	0.480
LIG_LIR_Nem_3	439	445	PF02991	0.370
LIG_LIR_Nem_3	99	104	PF02991	0.328
LIG_MYND_1	119	123	PF01753	0.276
LIG_NRP_CendR_1	500	501	PF00754	0.808
LIG_PCNA_PIPBox_1	389	398	PF02747	0.389
LIG_PCNA_yPIPBox_3	389	403	PF02747	0.392
LIG_Pex14_2	54	58	PF04695	0.554
LIG_SH2_CRK	220	224	PF00017	0.318
LIG_SH2_CRK	39	43	PF00017	0.606
LIG_SH2_STAP1	67	71	PF00017	0.534
LIG_SH2_STAT3	67	70	PF00017	0.539
LIG_SH2_STAT5	153	156	PF00017	0.301
LIG_SH2_STAT5	190	193	PF00017	0.362
LIG_SH2_STAT5	395	398	PF00017	0.372
LIG_SH3_3	225	231	PF00018	0.362
LIG_SH3_3	467	473	PF00018	0.505
LIG_Sin3_3	107	114	PF02671	0.363
LIG_TRAF2_1	478	481	PF00917	0.623
LIG_TRAF2_1	487	490	PF00917	0.588
LIG_TYR_ITIM	298	303	PF00017	0.276
LIG_TYR_ITIM	42	47	PF00017	0.642
LIG_UBA3_1	404	412	PF00899	0.388
LIG_WRC_WIRS_1	159	164	PF05994	0.287
MOD_CDK_SPxxK_3	227	234	PF00069	0.381
MOD_CK1_1	22	28	PF00069	0.704
MOD_CK1_1	341	347	PF00069	0.496
MOD_CK1_1	353	359	PF00069	0.544
MOD_CK1_1	485	491	PF00069	0.559
MOD_CK2_1	121	127	PF00069	0.276
MOD_CK2_1	341	347	PF00069	0.440
MOD_CK2_1	371	377	PF00069	0.499
MOD_CK2_1	483	489	PF00069	0.590
MOD_CK2_1	75	81	PF00069	0.487
MOD_Cter_Amidation	498	501	PF01082	0.799
MOD_DYRK1A_RPxSP_1	227	231	PF00069	0.381
MOD_GlcNHglycan	154	157	PF01048	0.531
MOD_GlcNHglycan	22	25	PF01048	0.545
MOD_GlcNHglycan	360	363	PF01048	0.724
MOD_GlcNHglycan	374	377	PF01048	0.642
MOD_GSK3_1	121	128	PF00069	0.270
MOD_GSK3_1	15	22	PF00069	0.705
MOD_GSK3_1	154	161	PF00069	0.300
MOD_GSK3_1	219	226	PF00069	0.368
MOD_GSK3_1	309	316	PF00069	0.380
MOD_GSK3_1	334	341	PF00069	0.470
MOD_GSK3_1	372	379	PF00069	0.495
MOD_GSK3_1	414	421	PF00069	0.402
MOD_GSK3_1	428	435	PF00069	0.381
MOD_GSK3_1	448	455	PF00069	0.261
MOD_GSK3_1	485	492	PF00069	0.557
MOD_N-GLC_1	267	272	PF02516	0.545
MOD_N-GLC_1	432	437	PF02516	0.648
MOD_NEK2_1	154	159	PF00069	0.290
MOD_NEK2_1	175	180	PF00069	0.330
MOD_NEK2_1	2	7	PF00069	0.628
MOD_NEK2_1	210	215	PF00069	0.281
MOD_NEK2_1	233	238	PF00069	0.351
MOD_NEK2_1	58	63	PF00069	0.558
MOD_NEK2_1	84	89	PF00069	0.487
MOD_NEK2_2	140	145	PF00069	0.301
MOD_NEK2_2	278	283	PF00069	0.340
MOD_PIKK_1	127	133	PF00454	0.277
MOD_PIKK_1	23	29	PF00454	0.734
MOD_PKA_2	2	8	PF00069	0.628
MOD_PKA_2	233	239	PF00069	0.374
MOD_PKA_2	273	279	PF00069	0.287
MOD_PKA_2	309	315	PF00069	0.383
MOD_PKA_2	338	344	PF00069	0.473
MOD_Plk_1	294	300	PF00069	0.325
MOD_Plk_1	414	420	PF00069	0.411
MOD_Plk_1	432	438	PF00069	0.336
MOD_Plk_1	489	495	PF00069	0.555
MOD_Plk_2-3	489	495	PF00069	0.608
MOD_Plk_4	2	8	PF00069	0.678
MOD_Plk_4	219	225	PF00069	0.311
MOD_Plk_4	299	305	PF00069	0.276
MOD_Plk_4	414	420	PF00069	0.473
MOD_Plk_4	437	443	PF00069	0.377
MOD_ProDKin_1	227	233	PF00069	0.381
MOD_SUMO_rev_2	485	493	PF00179	0.591
TRG_DiLeu_BaEn_1	246	251	PF01217	0.301
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.501
TRG_DiLeu_LyEn_5	246	251	PF01217	0.301
TRG_ENDOCYTIC_2	220	223	PF00928	0.283
TRG_ENDOCYTIC_2	300	303	PF00928	0.276
TRG_ENDOCYTIC_2	39	42	PF00928	0.588
TRG_ENDOCYTIC_2	44	47	PF00928	0.547
TRG_ENDOCYTIC_2	51	54	PF00928	0.438
TRG_ER_diArg_1	133	136	PF00400	0.315
TRG_ER_diArg_1	144	147	PF00400	0.235
TRG_ER_diArg_1	170	172	PF00400	0.319
TRG_ER_diArg_1	233	235	PF00400	0.287
TRG_ER_diArg_1	238	240	PF00400	0.287
TRG_ER_diArg_1	7	9	PF00400	0.702
TRG_NLS_MonoExtC_3	409	414	PF00514	0.523
TRG_NLS_MonoExtN_4	407	414	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD73	Leptomonas seymouri	85%	99%
A0A0S4JFV9	Bodo saltans	52%	100%
A0A1X0NZY3	Trypanosomatidae	62%	100%
A0A3S5IR30	Trypanosoma rangeli	65%	100%
A0A3S7X2D5	Leishmania donovani	99%	100%
A4HHA3	Leishmania braziliensis	94%	99%
A4I4E9	Leishmania infantum	99%	100%
C9ZLK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ALY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5DI32	Trypanosoma cruzi	64%	100%