Putative signal peptide peptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal peptide peptidase, putative

Species:

Leishmania major

UniProt:

E9ADU8_LEIMA

TriTrypDb:

LmjF.29.0910 , LMJLV39_290015500 , LMJSD75_290015500

Length:

309

Annotations

LeishMANIAdb annotations

Orthologous to animal ER-localized signal peptide peptidases, including minor histocompatibility antigen H13.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ADU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU8

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	2
GO:0006508	proteolysis	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016485	protein processing	5	2
GO:0019538	protein metabolic process	3	2
GO:0033619	membrane protein proteolysis	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004190	aspartic-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0016787	hydrolase activity	2	11
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	6	2
GO:0070001	aspartic-type peptidase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.259
CLV_PCSK_KEX2_1	188	190	PF00082	0.270
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.230
CLV_PCSK_SKI1_1	147	151	PF00082	0.438
CLV_PCSK_SKI1_1	161	165	PF00082	0.305
DEG_APCC_DBOX_1	188	196	PF00400	0.470
DOC_CDC14_PxL_1	223	231	PF14671	0.268
DOC_CYCLIN_yClb1_LxF_4	145	150	PF00134	0.281
DOC_MAPK_gen_1	160	166	PF00069	0.318
DOC_MAPK_gen_1	188	194	PF00069	0.481
DOC_MAPK_gen_1	3	10	PF00069	0.611
DOC_MAPK_MEF2A_6	38	47	PF00069	0.304
DOC_PP1_RVXF_1	145	151	PF00149	0.257
DOC_PP2B_LxvP_1	16	19	PF13499	0.346
DOC_PP4_FxxP_1	224	227	PF00568	0.287
DOC_USP7_MATH_1	295	299	PF00917	0.629
DOC_USP7_UBL2_3	184	188	PF12436	0.495
DOC_USP7_UBL2_3	62	66	PF12436	0.597
LIG_AP2alpha_1	123	127	PF02296	0.287
LIG_BRCT_BRCA1_1	190	194	PF00533	0.504
LIG_BRCT_BRCA1_1	31	35	PF00533	0.378
LIG_deltaCOP1_diTrp_1	125	130	PF00928	0.268
LIG_EH1_1	192	200	PF00400	0.495
LIG_FHA_1	111	117	PF00498	0.481
LIG_FHA_1	194	200	PF00498	0.453
LIG_FHA_1	206	212	PF00498	0.231
LIG_FHA_1	69	75	PF00498	0.417
LIG_FHA_2	138	144	PF00498	0.272
LIG_FHA_2	99	105	PF00498	0.395
LIG_LIR_Gen_1	112	123	PF02991	0.444
LIG_LIR_Gen_1	232	239	PF02991	0.402
LIG_LIR_Gen_1	248	257	PF02991	0.566
LIG_LIR_Gen_1	28	37	PF02991	0.298
LIG_LIR_Gen_1	39	49	PF02991	0.208
LIG_LIR_Nem_3	112	118	PF02991	0.432
LIG_LIR_Nem_3	125	130	PF02991	0.272
LIG_LIR_Nem_3	232	236	PF02991	0.402
LIG_LIR_Nem_3	248	252	PF02991	0.516
LIG_LIR_Nem_3	28	33	PF02991	0.298
LIG_LIR_Nem_3	39	44	PF02991	0.269
LIG_LIR_Nem_3	46	51	PF02991	0.175
LIG_MLH1_MIPbox_1	190	194	PF16413	0.504
LIG_Pex14_2	111	115	PF04695	0.439
LIG_Pex14_2	123	127	PF04695	0.287
LIG_Pex14_2	224	228	PF04695	0.310
LIG_Pex14_2	84	88	PF04695	0.347
LIG_SH2_GRB2like	40	43	PF00017	0.292
LIG_SH2_PTP2	30	33	PF00017	0.268
LIG_SH2_PTP2	64	67	PF00017	0.593
LIG_SH2_STAP1	124	128	PF00017	0.268
LIG_SH2_STAP1	201	205	PF00017	0.312
LIG_SH2_STAT5	186	189	PF00017	0.439
LIG_SH2_STAT5	193	196	PF00017	0.425
LIG_SH2_STAT5	201	204	PF00017	0.268
LIG_SH2_STAT5	30	33	PF00017	0.268
LIG_SH2_STAT5	40	43	PF00017	0.278
LIG_SH2_STAT5	48	51	PF00017	0.268
LIG_SH2_STAT5	64	67	PF00017	0.503
LIG_SH3_3	261	267	PF00018	0.690
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.441
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.119
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.325
LIG_SUMO_SIM_par_1	132	141	PF11976	0.239
LIG_SUMO_SIM_par_1	250	256	PF11976	0.506
LIG_TRAF2_1	258	261	PF00917	0.649
LIG_TRAF2_1	269	272	PF00917	0.657
LIG_WRC_WIRS_1	230	235	PF05994	0.315
LIG_WRC_WIRS_1	275	280	PF05994	0.484
LIG_WRC_WIRS_1	44	49	PF05994	0.333
MOD_CK1_1	159	165	PF00069	0.304
MOD_CK1_1	253	259	PF00069	0.590
MOD_CK1_1	274	280	PF00069	0.516
MOD_CK1_1	50	56	PF00069	0.344
MOD_CK2_1	255	261	PF00069	0.597
MOD_CK2_1	291	297	PF00069	0.602
MOD_CK2_1	98	104	PF00069	0.395
MOD_GlcNHglycan	233	236	PF01048	0.387
MOD_GlcNHglycan	260	264	PF01048	0.413
MOD_GlcNHglycan	292	296	PF01048	0.492
MOD_GSK3_1	176	183	PF00069	0.302
MOD_GSK3_1	201	208	PF00069	0.268
MOD_GSK3_1	25	32	PF00069	0.427
MOD_GSK3_1	255	262	PF00069	0.539
MOD_GSK3_1	291	298	PF00069	0.728
MOD_GSK3_1	43	50	PF00069	0.143
MOD_GSK3_1	75	82	PF00069	0.361
MOD_GSK3_1	94	101	PF00069	0.146
MOD_N-GLC_1	20	25	PF02516	0.359
MOD_NEK2_1	111	116	PF00069	0.368
MOD_NEK2_1	194	199	PF00069	0.469
MOD_NEK2_1	20	25	PF00069	0.287
MOD_NEK2_1	205	210	PF00069	0.252
MOD_NEK2_1	229	234	PF00069	0.273
MOD_NEK2_1	47	52	PF00069	0.196
MOD_NEK2_1	94	99	PF00069	0.318
MOD_NEK2_2	79	84	PF00069	0.378
MOD_PKA_1	188	194	PF00069	0.440
MOD_PKA_2	188	194	PF00069	0.465
MOD_Plk_1	271	277	PF00069	0.618
MOD_Plk_4	111	117	PF00069	0.444
MOD_Plk_4	150	156	PF00069	0.253
MOD_Plk_4	159	165	PF00069	0.196
MOD_Plk_4	176	182	PF00069	0.296
MOD_Plk_4	188	194	PF00069	0.434
MOD_Plk_4	20	26	PF00069	0.287
MOD_Plk_4	201	207	PF00069	0.247
MOD_Plk_4	250	256	PF00069	0.519
MOD_Plk_4	274	280	PF00069	0.559
MOD_Plk_4	47	53	PF00069	0.277
MOD_Plk_4	79	85	PF00069	0.460
MOD_SUMO_rev_2	292	301	PF00179	0.673
MOD_SUMO_rev_2	302	309	PF00179	0.649
TRG_ENDOCYTIC_2	124	127	PF00928	0.279
TRG_ENDOCYTIC_2	30	33	PF00928	0.268
TRG_ENDOCYTIC_2	40	43	PF00928	0.278
TRG_ENDOCYTIC_2	48	51	PF00928	0.268
TRG_ER_diLys_1	304	309	PF00400	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y2	Leptomonas seymouri	66%	91%
A0A0S4JJ36	Bodo saltans	46%	82%
A0A1X0P170	Trypanosomatidae	58%	87%
A0A3Q8IDL5	Leishmania donovani	93%	100%
A0A3R7NBZ0	Trypanosoma rangeli	58%	100%
A4HHA2	Leishmania braziliensis	85%	100%
A4I4E8	Leishmania infantum	93%	100%
B9FJ61	Oryza sativa subsp. japonica	39%	90%
C9ZLJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	88%
E9ALY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O81062	Arabidopsis thaliana	36%	90%
P49049	Caenorhabditis elegans	40%	66%
Q6ZGL9	Oryza sativa subsp. japonica	39%	90%
Q8TCT6	Homo sapiens	30%	80%
Q8TCT9	Homo sapiens	31%	82%
Q9CUS9	Mus musculus	30%	80%
Q9D8V0	Mus musculus	33%	82%
Q9UTA3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%