tRNA dimethylallyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IPP transferase, putative

Species:

Leishmania major

UniProt:

E9ADU7_LEIMA

TriTrypDb:

LmjF.29.0900 , LMJLV39_290015400 , LMJSD75_290015400

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	2
GO:0052381	tRNA dimethylallyltransferase activity	4	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140101	catalytic activity, acting on a tRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.496
CLV_C14_Caspase3-7	4	8	PF00656	0.219
CLV_NRD_NRD_1	12	14	PF00675	0.341
CLV_NRD_NRD_1	190	192	PF00675	0.478
CLV_NRD_NRD_1	210	212	PF00675	0.499
CLV_NRD_NRD_1	80	82	PF00675	0.305
CLV_PCSK_KEX2_1	12	14	PF00082	0.332
CLV_PCSK_KEX2_1	183	185	PF00082	0.276
CLV_PCSK_KEX2_1	190	192	PF00082	0.496
CLV_PCSK_KEX2_1	210	212	PF00082	0.499
CLV_PCSK_KEX2_1	80	82	PF00082	0.305
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.270
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.573
CLV_PCSK_PC7_1	186	192	PF00082	0.438
CLV_PCSK_SKI1_1	191	195	PF00082	0.477
CLV_PCSK_SKI1_1	20	24	PF00082	0.209
CLV_PCSK_SKI1_1	3	7	PF00082	0.457
DEG_APCC_DBOX_1	185	193	PF00400	0.431
DEG_APCC_DBOX_1	19	27	PF00400	0.293
DEG_Nend_UBRbox_2	1	3	PF02207	0.287
DOC_CYCLIN_RxL_1	88	101	PF00134	0.480
DOC_MAPK_gen_1	12	18	PF00069	0.371
DOC_MAPK_MEF2A_6	173	180	PF00069	0.457
DOC_PP2B_LxvP_1	206	209	PF13499	0.496
DOC_USP7_MATH_1	121	125	PF00917	0.455
DOC_USP7_MATH_1	38	42	PF00917	0.305
DOC_USP7_UBL2_3	32	36	PF12436	0.457
LIG_14-3-3_CanoR_1	39	43	PF00244	0.495
LIG_Actin_WH2_2	19	34	PF00022	0.344
LIG_BRCT_BRCA1_1	51	55	PF00533	0.371
LIG_FHA_1	106	112	PF00498	0.459
LIG_FHA_2	133	139	PF00498	0.432
LIG_FHA_2	62	68	PF00498	0.351
LIG_LIR_Gen_1	108	115	PF02991	0.470
LIG_LIR_Gen_1	50	55	PF02991	0.371
LIG_LIR_Nem_3	108	113	PF02991	0.464
LIG_LIR_Nem_3	50	54	PF02991	0.305
LIG_MLH1_MIPbox_1	51	55	PF16413	0.371
LIG_PCNA_PIPBox_1	126	135	PF02747	0.484
LIG_PCNA_TLS_4	3	10	PF02747	0.331
LIG_Pex14_2	110	114	PF04695	0.517
LIG_Pex14_2	132	136	PF04695	0.404
LIG_Pex14_2	51	55	PF04695	0.305
LIG_Rb_LxCxE_1	41	64	PF01857	0.305
LIG_SH2_STAT3	82	85	PF00017	0.305
LIG_SH3_3	134	140	PF00018	0.517
LIG_TRAF2_1	159	162	PF00917	0.461
LIG_UBA3_1	145	149	PF00899	0.539
LIG_WRC_WIRS_1	129	134	PF05994	0.486
LIG_WRC_WIRS_1	6	11	PF05994	0.263
MOD_CK1_1	61	67	PF00069	0.287
MOD_CK2_1	132	138	PF00069	0.424
MOD_CK2_1	156	162	PF00069	0.460
MOD_CK2_1	38	44	PF00069	0.271
MOD_CK2_1	63	69	PF00069	0.342
MOD_CK2_1	99	105	PF00069	0.470
MOD_GSK3_1	121	128	PF00069	0.497
MOD_GSK3_1	49	56	PF00069	0.371
MOD_GSK3_1	58	65	PF00069	0.286
MOD_NEK2_1	132	137	PF00069	0.495
MOD_NEK2_1	141	146	PF00069	0.513
MOD_NEK2_1	97	102	PF00069	0.453
MOD_PIKK_1	156	162	PF00454	0.568
MOD_PIKK_1	49	55	PF00454	0.356
MOD_PKA_2	185	191	PF00069	0.520
MOD_PKA_2	38	44	PF00069	0.317
MOD_Plk_1	49	55	PF00069	0.371
MOD_Plk_4	128	134	PF00069	0.479
MOD_Plk_4	141	147	PF00069	0.490
MOD_Plk_4	5	11	PF00069	0.339
MOD_Plk_4	58	64	PF00069	0.331
MOD_SUMO_rev_2	156	165	PF00179	0.450
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.310
TRG_ER_diArg_1	12	14	PF00400	0.335
TRG_ER_diArg_1	189	191	PF00400	0.456
TRG_ER_diArg_1	80	82	PF00400	0.305
TRG_ER_diLys_1	210	215	PF00400	0.661
TRG_NES_CRM1_1	4	19	PF08389	0.331
TRG_NLS_MonoCore_2	209	214	PF00514	0.576
TRG_NLS_MonoExtC_3	210	215	PF00514	0.513
TRG_NLS_MonoExtN_4	181	187	PF00514	0.470
TRG_NLS_MonoExtN_4	207	214	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI4	Leptomonas seymouri	57%	100%
A0A3Q8IIN6	Leishmania donovani	94%	100%
A4HHA1	Leishmania braziliensis	82%	100%
A4I4E7	Leishmania infantum	94%	100%
E9ALY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%