Solute carrier family 35 member F6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF914), putative

Species:

Leishmania major

UniProt:

E9ADU6_LEIMA

TriTrypDb:

LmjF.29.0890 , LMJLV39_290015300 , LMJSD75_290015300

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ADU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.527
CLV_C14_Caspase3-7	424	428	PF00656	0.595
CLV_PCSK_KEX2_1	17	19	PF00082	0.236
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.272
CLV_PCSK_PC7_1	13	19	PF00082	0.220
CLV_PCSK_SKI1_1	13	17	PF00082	0.222
CLV_PCSK_SKI1_1	138	142	PF00082	0.178
CLV_PCSK_SKI1_1	18	22	PF00082	0.259
CLV_PCSK_SKI1_1	203	207	PF00082	0.689
CLV_PCSK_SKI1_1	285	289	PF00082	0.309
CLV_PCSK_SKI1_1	353	357	PF00082	0.385
DEG_APCC_DBOX_1	12	20	PF00400	0.466
DEG_APCC_KENBOX_2	391	395	PF00400	0.439
DEG_MDM2_SWIB_1	84	92	PF02201	0.404
DOC_CYCLIN_yClb1_LxF_4	351	356	PF00134	0.509
DOC_MAPK_gen_1	86	95	PF00069	0.428
DOC_MAPK_MEF2A_6	253	260	PF00069	0.401
DOC_PP1_RVXF_1	351	357	PF00149	0.509
DOC_PP4_FxxP_1	122	125	PF00568	0.254
DOC_PP4_FxxP_1	198	201	PF00568	0.229
DOC_PP4_FxxP_1	61	64	PF00568	0.310
DOC_USP7_MATH_1	226	230	PF00917	0.518
DOC_USP7_MATH_1	265	269	PF00917	0.385
DOC_USP7_MATH_1	289	293	PF00917	0.488
DOC_WW_Pin1_4	221	226	PF00397	0.481
DOC_WW_Pin1_4	417	422	PF00397	0.445
LIG_14-3-3_CanoR_1	291	295	PF00244	0.509
LIG_AP2alpha_2	389	391	PF02296	0.465
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_4	161	165	PF00653	0.205
LIG_BRCT_BRCA1_1	323	327	PF00533	0.241
LIG_BRCT_BRCA1_1	5	9	PF00533	0.581
LIG_Clathr_ClatBox_1	157	161	PF01394	0.239
LIG_deltaCOP1_diTrp_1	283	287	PF00928	0.416
LIG_deltaCOP1_diTrp_1	298	305	PF00928	0.416
LIG_EH1_1	304	312	PF00400	0.304
LIG_eIF4E_1	62	68	PF01652	0.269
LIG_FHA_1	109	115	PF00498	0.213
LIG_FHA_1	140	146	PF00498	0.287
LIG_FHA_1	188	194	PF00498	0.254
LIG_FHA_1	222	228	PF00498	0.465
LIG_FHA_1	306	312	PF00498	0.304
LIG_FHA_1	332	338	PF00498	0.333
LIG_FHA_1	34	40	PF00498	0.239
LIG_FHA_1	370	376	PF00498	0.513
LIG_FHA_1	436	442	PF00498	0.535
LIG_FHA_2	293	299	PF00498	0.431
LIG_FHA_2	396	402	PF00498	0.559
LIG_LIR_Apic_2	120	125	PF02991	0.287
LIG_LIR_Apic_2	195	201	PF02991	0.234
LIG_LIR_Gen_1	268	277	PF02991	0.321
LIG_LIR_Gen_1	298	309	PF02991	0.445
LIG_LIR_Gen_1	324	335	PF02991	0.216
LIG_LIR_Gen_1	358	367	PF02991	0.273
LIG_LIR_Gen_1	53	63	PF02991	0.245
LIG_LIR_Gen_1	99	110	PF02991	0.297
LIG_LIR_Nem_3	131	135	PF02991	0.261
LIG_LIR_Nem_3	268	273	PF02991	0.283
LIG_LIR_Nem_3	276	282	PF02991	0.219
LIG_LIR_Nem_3	283	287	PF02991	0.345
LIG_LIR_Nem_3	298	304	PF02991	0.405
LIG_LIR_Nem_3	324	330	PF02991	0.205
LIG_LIR_Nem_3	345	350	PF02991	0.280
LIG_LIR_Nem_3	358	362	PF02991	0.236
LIG_LIR_Nem_3	45	49	PF02991	0.210
LIG_LIR_Nem_3	53	58	PF02991	0.242
LIG_LIR_Nem_3	6	12	PF02991	0.563
LIG_LIR_Nem_3	79	84	PF02991	0.426
LIG_LIR_Nem_3	99	105	PF02991	0.188
LIG_LYPXL_yS_3	46	49	PF13949	0.229
LIG_PCNA_yPIPBox_3	343	353	PF02747	0.173
LIG_Pex14_2	270	274	PF04695	0.287
LIG_Pex14_2	280	284	PF04695	0.194
LIG_Pex14_2	301	305	PF04695	0.333
LIG_Pex14_2	379	383	PF04695	0.428
LIG_Pex14_2	57	61	PF04695	0.331
LIG_Pex14_2	83	87	PF04695	0.431
LIG_PTB_Apo_2	77	84	PF02174	0.447
LIG_REV1ctd_RIR_1	130	140	PF16727	0.299
LIG_REV1ctd_RIR_1	81	90	PF16727	0.444
LIG_SH2_CRK	55	59	PF00017	0.262
LIG_SH2_CRK	90	94	PF00017	0.273
LIG_SH2_GRB2like	110	113	PF00017	0.309
LIG_SH2_PTP2	102	105	PF00017	0.333
LIG_SH2_PTP2	359	362	PF00017	0.220
LIG_SH2_SRC	359	362	PF00017	0.262
LIG_SH2_SRC	62	65	PF00017	0.366
LIG_SH2_STAP1	110	114	PF00017	0.118
LIG_SH2_STAP1	55	59	PF00017	0.273
LIG_SH2_STAP1	90	94	PF00017	0.333
LIG_SH2_STAT3	73	76	PF00017	0.389
LIG_SH2_STAT5	102	105	PF00017	0.269
LIG_SH2_STAT5	110	113	PF00017	0.196
LIG_SH2_STAT5	239	242	PF00017	0.354
LIG_SH2_STAT5	313	316	PF00017	0.239
LIG_SH2_STAT5	359	362	PF00017	0.220
LIG_SH2_STAT5	62	65	PF00017	0.275
LIG_SH3_3	198	204	PF00018	0.321
LIG_SH3_3	222	228	PF00018	0.450
LIG_SH3_3	249	255	PF00018	0.361
LIG_SH3_3	372	378	PF00018	0.373
LIG_SUMO_SIM_par_1	156	161	PF11976	0.242
LIG_SUMO_SIM_par_1	308	314	PF11976	0.333
LIG_SUMO_SIM_par_1	91	97	PF11976	0.333
LIG_TYR_ITIM	357	362	PF00017	0.299
LIG_TYR_ITSM	51	58	PF00017	0.239
LIG_UBA3_1	67	72	PF00899	0.385
LIG_WRC_WIRS_1	129	134	PF05994	0.273
LIG_WRC_WIRS_1	267	272	PF05994	0.394
MOD_CK1_1	120	126	PF00069	0.173
MOD_CK1_1	292	298	PF00069	0.496
MOD_CK1_1	3	9	PF00069	0.494
MOD_CK1_1	331	337	PF00069	0.266
MOD_CK1_1	42	48	PF00069	0.220
MOD_CK1_1	422	428	PF00069	0.552
MOD_CK2_1	163	169	PF00069	0.299
MOD_GlcNHglycan	211	214	PF01048	0.629
MOD_GlcNHglycan	323	326	PF01048	0.405
MOD_GlcNHglycan	424	427	PF01048	0.793
MOD_GSK3_1	108	115	PF00069	0.205
MOD_GSK3_1	165	172	PF00069	0.262
MOD_GSK3_1	183	190	PF00069	0.264
MOD_GSK3_1	29	36	PF00069	0.244
MOD_GSK3_1	431	438	PF00069	0.441
MOD_N-GLC_1	328	333	PF02516	0.239
MOD_N-GLC_1	342	347	PF02516	0.239
MOD_N-GLC_1	369	374	PF02516	0.505
MOD_N-GLC_1	42	47	PF02516	0.416
MOD_N-GLC_1	422	427	PF02516	0.730
MOD_N-GLC_2	209	211	PF02516	0.595
MOD_NEK2_1	128	133	PF00069	0.246
MOD_NEK2_1	139	144	PF00069	0.416
MOD_NEK2_1	182	187	PF00069	0.228
MOD_NEK2_1	266	271	PF00069	0.337
MOD_NEK2_1	27	32	PF00069	0.267
MOD_NEK2_1	272	277	PF00069	0.303
MOD_NEK2_1	305	310	PF00069	0.239
MOD_NEK2_1	311	316	PF00069	0.239
MOD_NEK2_1	320	325	PF00069	0.239
MOD_NEK2_1	355	360	PF00069	0.260
MOD_NEK2_1	39	44	PF00069	0.205
MOD_NEK2_2	342	347	PF00069	0.254
MOD_PIKK_1	169	175	PF00454	0.306
MOD_PIKK_1	440	446	PF00454	0.461
MOD_PKA_2	169	175	PF00069	0.304
MOD_PKA_2	290	296	PF00069	0.472
MOD_PKA_2	76	82	PF00069	0.420
MOD_Plk_1	328	334	PF00069	0.239
MOD_Plk_1	342	348	PF00069	0.239
MOD_Plk_1	42	48	PF00069	0.205
MOD_Plk_4	128	134	PF00069	0.239
MOD_Plk_4	183	189	PF00069	0.289
MOD_Plk_4	234	240	PF00069	0.393
MOD_Plk_4	305	311	PF00069	0.246
MOD_Plk_4	342	348	PF00069	0.302
MOD_Plk_4	355	361	PF00069	0.338
MOD_ProDKin_1	221	227	PF00069	0.481
MOD_ProDKin_1	417	423	PF00069	0.444
MOD_SUMO_for_1	219	222	PF00179	0.418
TRG_ENDOCYTIC_2	102	105	PF00928	0.239
TRG_ENDOCYTIC_2	110	113	PF00928	0.118
TRG_ENDOCYTIC_2	313	316	PF00928	0.282
TRG_ENDOCYTIC_2	338	341	PF00928	0.239
TRG_ENDOCYTIC_2	359	362	PF00928	0.239
TRG_ENDOCYTIC_2	46	49	PF00928	0.209
TRG_ENDOCYTIC_2	55	58	PF00928	0.230
TRG_ENDOCYTIC_2	90	93	PF00928	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D2	Leptomonas seymouri	65%	100%
A0A0S4ISV7	Bodo saltans	41%	100%
A0A1X0PAA4	Trypanosomatidae	53%	100%
A0A3S7X2D4	Leishmania donovani	92%	100%
A0A422NJ67	Trypanosoma rangeli	52%	100%
A4HHA0	Leishmania braziliensis	78%	100%
A4I4E6	Leishmania infantum	92%	100%
C9ZLM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ALY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O59785	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	90%
Q8BGK5	Mus musculus	27%	100%
V5BCU4	Trypanosoma cruzi	47%	100%