Phytanoyl-CoA dioxygenase (PhyH)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytanoyl-CoA dioxygenase (PhyH), putative

Species:

Leishmania major

UniProt:

E9ADU5_LEIMA

TriTrypDb:

LmjF.29.0885 , LMJLV39_290015100 , LMJSD75_290015100

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.351
CLV_NRD_NRD_1	312	314	PF00675	0.529
CLV_PCSK_KEX2_1	256	258	PF00082	0.407
CLV_PCSK_KEX2_1	312	314	PF00082	0.540
CLV_PCSK_KEX2_1	316	318	PF00082	0.433
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.514
CLV_PCSK_PC7_1	312	318	PF00082	0.463
CLV_PCSK_SKI1_1	117	121	PF00082	0.356
CLV_PCSK_SKI1_1	284	288	PF00082	0.455
CLV_PCSK_SKI1_1	331	335	PF00082	0.656
DEG_Nend_UBRbox_1	1	4	PF02207	0.463
DOC_CYCLIN_RxL_1	117	127	PF00134	0.383
DOC_MAPK_gen_1	312	320	PF00069	0.416
DOC_MAPK_MEF2A_6	259	268	PF00069	0.265
DOC_PP2B_PxIxI_1	233	239	PF00149	0.326
DOC_SPAK_OSR1_1	153	157	PF12202	0.409
DOC_USP7_MATH_1	135	139	PF00917	0.394
DOC_USP7_MATH_1	267	271	PF00917	0.269
DOC_USP7_MATH_1	333	337	PF00917	0.508
DOC_USP7_UBL2_3	120	124	PF12436	0.201
DOC_WW_Pin1_4	260	265	PF00397	0.403
LIG_14-3-3_CanoR_1	2	6	PF00244	0.676
LIG_14-3-3_CanoR_1	257	263	PF00244	0.395
LIG_14-3-3_CanoR_1	284	290	PF00244	0.361
LIG_Actin_WH2_2	271	286	PF00022	0.409
LIG_BRCT_BRCA1_1	196	200	PF00533	0.428
LIG_Clathr_ClatBox_1	235	239	PF01394	0.298
LIG_FHA_1	103	109	PF00498	0.292
LIG_FHA_1	160	166	PF00498	0.410
LIG_FHA_1	206	212	PF00498	0.201
LIG_FHA_1	42	48	PF00498	0.401
LIG_FHA_2	321	327	PF00498	0.526
LIG_FHA_2	95	101	PF00498	0.470
LIG_LIR_Gen_1	140	151	PF02991	0.283
LIG_LIR_Gen_1	197	204	PF02991	0.409
LIG_LIR_Gen_1	87	95	PF02991	0.326
LIG_LIR_Nem_3	140	146	PF02991	0.279
LIG_LIR_Nem_3	197	203	PF02991	0.322
LIG_LIR_Nem_3	275	279	PF02991	0.288
LIG_LIR_Nem_3	87	92	PF02991	0.326
LIG_MYND_3	136	140	PF01753	0.322
LIG_NRBOX	178	184	PF00104	0.279
LIG_PCNA_yPIPBox_3	112	124	PF02747	0.303
LIG_Pex14_2	298	302	PF04695	0.355
LIG_SH2_CRK	276	280	PF00017	0.281
LIG_SH2_GRB2like	143	146	PF00017	0.357
LIG_SH2_STAP1	126	130	PF00017	0.248
LIG_SH2_STAP1	227	231	PF00017	0.279
LIG_SH2_STAP1	73	77	PF00017	0.395
LIG_SH2_STAP1	80	84	PF00017	0.402
LIG_SH2_STAT3	126	129	PF00017	0.357
LIG_SH2_STAT5	118	121	PF00017	0.297
LIG_SH2_STAT5	295	298	PF00017	0.386
LIG_SH3_3	228	234	PF00018	0.279
LIG_SH3_3	259	265	PF00018	0.285
LIG_SUMO_SIM_par_1	234	240	PF11976	0.357
LIG_SUMO_SIM_par_1	263	270	PF11976	0.269
LIG_TRAF2_1	327	330	PF00917	0.591
LIG_WRC_WIRS_1	295	300	PF05994	0.339
MOD_CK1_1	138	144	PF00069	0.284
MOD_CK1_1	237	243	PF00069	0.451
MOD_CK1_1	343	349	PF00069	0.573
MOD_CK2_1	1	7	PF00069	0.688
MOD_CK2_1	320	326	PF00069	0.581
MOD_CK2_1	94	100	PF00069	0.298
MOD_Cter_Amidation	13	16	PF01082	0.335
MOD_Cter_Amidation	190	193	PF01082	0.419
MOD_GlcNHglycan	107	111	PF01048	0.201
MOD_GlcNHglycan	140	143	PF01048	0.319
MOD_GlcNHglycan	196	199	PF01048	0.368
MOD_GlcNHglycan	343	346	PF01048	0.566
MOD_GSK3_1	102	109	PF00069	0.292
MOD_GSK3_1	171	178	PF00069	0.437
MOD_GSK3_1	199	206	PF00069	0.273
MOD_GSK3_1	237	244	PF00069	0.427
MOD_GSK3_1	294	301	PF00069	0.314
MOD_GSK3_1	303	310	PF00069	0.388
MOD_GSK3_1	320	327	PF00069	0.412
MOD_GSK3_1	67	74	PF00069	0.566
MOD_N-GLC_1	241	246	PF02516	0.266
MOD_N-GLC_1	307	312	PF02516	0.421
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	160	165	PF00069	0.442
MOD_NEK2_1	298	303	PF00069	0.367
MOD_NEK2_1	41	46	PF00069	0.362
MOD_NEK2_1	94	99	PF00069	0.409
MOD_PIKK_1	102	108	PF00454	0.269
MOD_PIKK_1	205	211	PF00454	0.371
MOD_PIKK_1	343	349	PF00454	0.573
MOD_PKA_1	71	77	PF00069	0.431
MOD_PKA_2	1	7	PF00069	0.488
MOD_PKA_2	258	264	PF00069	0.339
MOD_Plk_1	106	112	PF00069	0.326
MOD_Plk_2-3	96	102	PF00069	0.292
MOD_Plk_4	1	7	PF00069	0.463
MOD_Plk_4	199	205	PF00069	0.415
MOD_Plk_4	267	273	PF00069	0.269
MOD_Plk_4	320	326	PF00069	0.428
MOD_ProDKin_1	260	266	PF00069	0.403
MOD_SUMO_for_1	286	289	PF00179	0.269
MOD_SUMO_rev_2	43	53	PF00179	0.535
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.326
TRG_ENDOCYTIC_2	143	146	PF00928	0.326
TRG_ENDOCYTIC_2	276	279	PF00928	0.321
TRG_ENDOCYTIC_2	295	298	PF00928	0.399
TRG_ER_diArg_1	146	149	PF00400	0.357
TRG_ER_diArg_1	256	259	PF00400	0.234
TRG_ER_diArg_1	312	314	PF00400	0.626
TRG_NLS_Bipartite_1	316	338	PF00514	0.565
TRG_NLS_MonoExtC_3	333	339	PF00514	0.503
TRG_NLS_MonoExtN_4	331	338	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R0	Leptomonas seymouri	59%	100%
A0A0S4IX88	Bodo saltans	34%	70%
A0A1X0NZP8	Trypanosomatidae	45%	100%
A0A3S7X2B0	Leishmania donovani	95%	100%
A0A422NRL2	Trypanosoma rangeli	45%	100%
A4HH99	Leishmania braziliensis	80%	100%
A4I4E5	Leishmania infantum	95%	100%
C9ZL18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ALY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BH47	Trypanosoma cruzi	44%	100%