Mitochondrial F1F0 ATP synthase associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADU3_LEIMA

TriTrypDb:

LmjF.29.0870 , LMJLV39_290014900 , LMJSD75_290014900

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.514
CLV_NRD_NRD_1	30	32	PF00675	0.464
CLV_NRD_NRD_1	38	40	PF00675	0.558
CLV_PCSK_KEX2_1	213	215	PF00082	0.422
CLV_PCSK_KEX2_1	30	32	PF00082	0.405
CLV_PCSK_KEX2_1	398	400	PF00082	0.551
CLV_PCSK_KEX2_1	97	99	PF00082	0.343
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.402
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.343
CLV_PCSK_SKI1_1	16	20	PF00082	0.477
CLV_PCSK_SKI1_1	249	253	PF00082	0.512
CLV_PCSK_SKI1_1	409	413	PF00082	0.373
CLV_PCSK_SKI1_1	450	454	PF00082	0.318
CLV_PCSK_SKI1_1	470	474	PF00082	0.249
DEG_APCC_DBOX_1	66	74	PF00400	0.405
DEG_APCC_DBOX_1	8	16	PF00400	0.606
DEG_Nend_Nbox_1	1	3	PF02207	0.600
DEG_SCF_FBW7_1	363	369	PF00400	0.524
DEG_SPOP_SBC_1	366	370	PF00917	0.612
DOC_CKS1_1	282	287	PF01111	0.457
DOC_CKS1_1	35	40	PF01111	0.377
DOC_CKS1_1	363	368	PF01111	0.565
DOC_CYCLIN_RxL_1	405	415	PF00134	0.379
DOC_CYCLIN_RxL_1	447	456	PF00134	0.345
DOC_CYCLIN_RxL_1	457	466	PF00134	0.376
DOC_MAPK_gen_1	213	221	PF00069	0.381
DOC_MAPK_gen_1	455	464	PF00069	0.432
DOC_MAPK_gen_1	97	105	PF00069	0.317
DOC_MAPK_MEF2A_6	213	221	PF00069	0.381
DOC_MAPK_MEF2A_6	97	105	PF00069	0.317
DOC_PP2B_LxvP_1	8	11	PF13499	0.526
DOC_SPAK_OSR1_1	98	102	PF12202	0.447
DOC_USP7_MATH_1	128	132	PF00917	0.447
DOC_USP7_MATH_1	295	299	PF00917	0.556
DOC_USP7_MATH_1	361	365	PF00917	0.586
DOC_USP7_MATH_1	366	370	PF00917	0.531
DOC_USP7_MATH_1	377	381	PF00917	0.320
DOC_USP7_MATH_1	384	388	PF00917	0.468
DOC_USP7_MATH_1	45	49	PF00917	0.401
DOC_USP7_UBL2_3	343	347	PF12436	0.589
DOC_USP7_UBL2_3	401	405	PF12436	0.483
DOC_WW_Pin1_4	145	150	PF00397	0.388
DOC_WW_Pin1_4	281	286	PF00397	0.458
DOC_WW_Pin1_4	305	310	PF00397	0.556
DOC_WW_Pin1_4	34	39	PF00397	0.365
DOC_WW_Pin1_4	362	367	PF00397	0.643
DOC_WW_Pin1_4	434	439	PF00397	0.479
DOC_WW_Pin1_4	483	488	PF00397	0.629
LIG_14-3-3_CanoR_1	104	112	PF00244	0.464
LIG_14-3-3_CanoR_1	321	327	PF00244	0.579
LIG_14-3-3_CanoR_1	477	483	PF00244	0.517
LIG_Actin_WH2_2	1	18	PF00022	0.543
LIG_AP2alpha_1	277	281	PF02296	0.409
LIG_CaM_IQ_9	242	257	PF13499	0.412
LIG_CaM_NSCaTE_8	152	159	PF13499	0.446
LIG_eIF4E_1	447	453	PF01652	0.385
LIG_eIF4E_1	459	465	PF01652	0.479
LIG_FHA_1	23	29	PF00498	0.417
LIG_FHA_1	435	441	PF00498	0.473
LIG_FHA_1	59	65	PF00498	0.459
LIG_FHA_1	76	82	PF00498	0.479
LIG_FHA_2	124	130	PF00498	0.402
LIG_FHA_2	174	180	PF00498	0.362
LIG_FHA_2	255	261	PF00498	0.406
LIG_FHA_2	265	271	PF00498	0.340
LIG_FHA_2	281	287	PF00498	0.589
LIG_FHA_2	464	470	PF00498	0.496
LIG_FHA_2	484	490	PF00498	0.417
LIG_FHA_2	51	57	PF00498	0.538
LIG_GBD_Chelix_1	403	411	PF00786	0.470
LIG_LIR_Gen_1	169	178	PF02991	0.382
LIG_LIR_Gen_1	202	212	PF02991	0.431
LIG_LIR_Gen_1	444	453	PF02991	0.309
LIG_LIR_Nem_3	140	144	PF02991	0.353
LIG_LIR_Nem_3	160	164	PF02991	0.195
LIG_LIR_Nem_3	169	175	PF02991	0.347
LIG_LIR_Nem_3	202	208	PF02991	0.428
LIG_LIR_Nem_3	456	462	PF02991	0.402
LIG_LRP6_Inhibitor_1	24	30	PF00058	0.491
LIG_NRBOX	337	343	PF00104	0.507
LIG_PCNA_yPIPBox_3	26	40	PF02747	0.537
LIG_Pex14_2	277	281	PF04695	0.409
LIG_PTB_Apo_2	325	332	PF02174	0.586
LIG_SH2_CRK	459	463	PF00017	0.494
LIG_SH2_STAT3	413	416	PF00017	0.396
LIG_SH2_STAT5	164	167	PF00017	0.459
LIG_SH2_STAT5	185	188	PF00017	0.412
LIG_SH2_STAT5	445	448	PF00017	0.328
LIG_SH2_STAT5	71	74	PF00017	0.393
LIG_SH3_3	279	285	PF00018	0.425
LIG_SH3_3	32	38	PF00018	0.623
LIG_SH3_3	360	366	PF00018	0.568
LIG_TRAF2_1	167	170	PF00917	0.490
LIG_TRAF2_1	257	260	PF00917	0.411
LIG_TRAF2_1	267	270	PF00917	0.343
LIG_UBA3_1	111	115	PF00899	0.393
MOD_CDK_SPK_2	34	39	PF00069	0.365
MOD_CDK_SPxK_1	34	40	PF00069	0.370
MOD_CDK_SPxxK_3	483	490	PF00069	0.640
MOD_CK1_1	162	168	PF00069	0.466
MOD_CK1_1	22	28	PF00069	0.365
MOD_CK1_1	350	356	PF00069	0.495
MOD_CK1_1	387	393	PF00069	0.433
MOD_CK2_1	104	110	PF00069	0.456
MOD_CK2_1	123	129	PF00069	0.309
MOD_CK2_1	173	179	PF00069	0.480
MOD_CK2_1	254	260	PF00069	0.398
MOD_CK2_1	264	270	PF00069	0.342
MOD_CK2_1	351	357	PF00069	0.581
MOD_CK2_1	45	51	PF00069	0.473
MOD_CK2_1	478	484	PF00069	0.602
MOD_GlcNHglycan	121	124	PF01048	0.524
MOD_GlcNHglycan	224	227	PF01048	0.505
MOD_GlcNHglycan	297	300	PF01048	0.539
MOD_GlcNHglycan	343	346	PF01048	0.544
MOD_GlcNHglycan	43	46	PF01048	0.522
MOD_GSK3_1	119	126	PF00069	0.539
MOD_GSK3_1	128	135	PF00069	0.428
MOD_GSK3_1	195	202	PF00069	0.466
MOD_GSK3_1	347	354	PF00069	0.536
MOD_GSK3_1	361	368	PF00069	0.496
MOD_GSK3_1	41	48	PF00069	0.501
MOD_GSK3_1	71	78	PF00069	0.482
MOD_N-GLC_1	41	46	PF02516	0.530
MOD_NEK2_1	119	124	PF00069	0.503
MOD_NEK2_1	144	149	PF00069	0.463
MOD_NEK2_1	19	24	PF00069	0.382
MOD_NEK2_1	264	269	PF00069	0.529
MOD_NEK2_1	341	346	PF00069	0.465
MOD_NEK2_1	412	417	PF00069	0.316
MOD_NEK2_1	453	458	PF00069	0.453
MOD_NEK2_1	478	483	PF00069	0.542
MOD_NEK2_1	58	63	PF00069	0.421
MOD_NEK2_2	11	16	PF00069	0.585
MOD_NEK2_2	159	164	PF00069	0.433
MOD_NEK2_2	377	382	PF00069	0.644
MOD_PIKK_1	22	28	PF00454	0.483
MOD_PIKK_1	412	418	PF00454	0.371
MOD_PK_1	347	353	PF00069	0.544
MOD_PKA_2	322	328	PF00069	0.578
MOD_PKA_2	355	361	PF00069	0.487
MOD_Plk_1	159	165	PF00069	0.460
MOD_Plk_1	203	209	PF00069	0.432
MOD_Plk_1	347	353	PF00069	0.544
MOD_Plk_1	41	47	PF00069	0.531
MOD_Plk_4	159	165	PF00069	0.463
MOD_Plk_4	347	353	PF00069	0.658
MOD_ProDKin_1	145	151	PF00069	0.383
MOD_ProDKin_1	281	287	PF00069	0.465
MOD_ProDKin_1	305	311	PF00069	0.560
MOD_ProDKin_1	34	40	PF00069	0.370
MOD_ProDKin_1	362	368	PF00069	0.635
MOD_ProDKin_1	434	440	PF00069	0.475
MOD_ProDKin_1	483	489	PF00069	0.635
MOD_SUMO_for_1	219	222	PF00179	0.508
MOD_SUMO_for_1	314	317	PF00179	0.615
MOD_SUMO_rev_2	107	117	PF00179	0.405
MOD_SUMO_rev_2	135	144	PF00179	0.413
MOD_SUMO_rev_2	177	182	PF00179	0.423
MOD_SUMO_rev_2	333	338	PF00179	0.506
MOD_SUMO_rev_2	469	475	PF00179	0.433
TRG_DiLeu_BaEn_4	259	265	PF01217	0.500
TRG_ENDOCYTIC_2	141	144	PF00928	0.339
TRG_ENDOCYTIC_2	172	175	PF00928	0.337
TRG_ENDOCYTIC_2	445	448	PF00928	0.328
TRG_ENDOCYTIC_2	459	462	PF00928	0.386
TRG_ER_diArg_1	103	106	PF00400	0.329
TRG_ER_diArg_1	212	214	PF00400	0.521
TRG_ER_diArg_1	29	31	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E1	Leptomonas seymouri	79%	100%
A0A0S4IX38	Bodo saltans	31%	95%
A0A1X0P156	Trypanosomatidae	45%	100%
A0A3S7X2A6	Leishmania donovani	98%	100%
A0A422NRS1	Trypanosoma rangeli	43%	100%
A4HH97	Leishmania braziliensis	87%	100%
A4I4E3	Leishmania infantum	98%	100%
C9ZL20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ALY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BR79	Trypanosoma cruzi	45%	100%