Cytochrome b5 heme-binding domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ADU2_LEIMA

TriTrypDb:

LmjF.29.0868 , LMJLV39_290014700 , LMJSD75_290014700

Length:

168

Annotations

LeishMANIAdb annotations

This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9ADU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0020037	heme binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.657
CLV_NRD_NRD_1	29	31	PF00675	0.321
CLV_NRD_NRD_1	59	61	PF00675	0.368
CLV_NRD_NRD_1	79	81	PF00675	0.504
CLV_PCSK_KEX2_1	13	15	PF00082	0.561
CLV_PCSK_KEX2_1	156	158	PF00082	0.657
CLV_PCSK_KEX2_1	29	31	PF00082	0.229
CLV_PCSK_KEX2_1	59	61	PF00082	0.378
CLV_PCSK_KEX2_1	79	81	PF00082	0.498
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.537

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH0	Leptomonas seymouri	64%	98%
A0A3S7X2B2	Leishmania donovani	96%	100%
A0A3S7X2E8	Leishmania donovani	43%	97%
A4HH96	Leishmania braziliensis	84%	100%
A4I4E2	Leishmania infantum	96%	100%
E9ALY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%

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