Guanine deaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Guanine deaminase

Gene product:

guanine deaminase, putative

Species:

Leishmania major

UniProt:

E9ADU1_LEIMA

TriTrypDb:

LmjF.29.0867 , LMJLV39_290014600 , LMJSD75_290014600

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006144	purine nucleobase metabolic process	5	11
GO:0006145	purine nucleobase catabolic process	6	11
GO:0006147	guanine catabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009112	nucleobase metabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019439	aromatic compound catabolic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044270	cellular nitrogen compound catabolic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046098	guanine metabolic process	6	11
GO:0046113	nucleobase catabolic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0046700	heterocycle catabolic process	4	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072523	purine-containing compound catabolic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901361	organic cyclic compound catabolic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0008892	guanine deaminase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	11
GO:0019239	deaminase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.462
CLV_NRD_NRD_1	271	273	PF00675	0.261
CLV_PCSK_KEX2_1	271	273	PF00082	0.261
CLV_PCSK_KEX2_1	92	94	PF00082	0.200
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.200
CLV_PCSK_SKI1_1	196	200	PF00082	0.316
CLV_PCSK_SKI1_1	23	27	PF00082	0.358
CLV_PCSK_SKI1_1	272	276	PF00082	0.261
CLV_PCSK_SKI1_1	314	318	PF00082	0.269
CLV_PCSK_SKI1_1	342	346	PF00082	0.329
DEG_APCC_DBOX_1	15	23	PF00400	0.360
DEG_ODPH_VHL_1	396	407	PF01847	0.542
DOC_CKS1_1	11	16	PF01111	0.402
DOC_MAPK_gen_1	254	263	PF00069	0.536
DOC_MAPK_gen_1	314	321	PF00069	0.494
DOC_MAPK_MEF2A_6	314	323	PF00069	0.545
DOC_PP1_RVXF_1	108	115	PF00149	0.461
DOC_PP2B_LxvP_1	205	208	PF13499	0.461
DOC_PP4_FxxP_1	11	14	PF00568	0.331
DOC_USP7_MATH_1	115	119	PF00917	0.503
DOC_USP7_MATH_1	181	185	PF00917	0.461
DOC_USP7_MATH_1	216	220	PF00917	0.445
DOC_USP7_MATH_1	333	337	PF00917	0.548
DOC_USP7_MATH_1	350	354	PF00917	0.516
DOC_USP7_MATH_1	370	374	PF00917	0.568
DOC_USP7_MATH_1	412	416	PF00917	0.492
DOC_WW_Pin1_4	10	15	PF00397	0.397
DOC_WW_Pin1_4	177	182	PF00397	0.528
LIG_14-3-3_CanoR_1	16	20	PF00244	0.481
LIG_14-3-3_CanoR_1	271	275	PF00244	0.470
LIG_14-3-3_CanoR_1	371	376	PF00244	0.496
LIG_APCC_ABBAyCdc20_2	110	116	PF00400	0.400
LIG_BIR_III_2	178	182	PF00653	0.503
LIG_BRCT_BRCA1_1	187	191	PF00533	0.461
LIG_Clathr_ClatBox_1	416	420	PF01394	0.542
LIG_deltaCOP1_diTrp_1	95	103	PF00928	0.461
LIG_eIF4E_1	400	406	PF01652	0.461
LIG_eIF4E_1	445	451	PF01652	0.503
LIG_eIF4E_1	68	74	PF01652	0.461
LIG_FHA_1	129	135	PF00498	0.467
LIG_FHA_1	16	22	PF00498	0.532
LIG_FHA_1	200	206	PF00498	0.597
LIG_FHA_2	422	428	PF00498	0.494
LIG_FHA_2	7	13	PF00498	0.397
LIG_Integrin_isoDGR_2	447	449	PF01839	0.342
LIG_LIR_Apic_2	9	14	PF02991	0.334
LIG_LIR_Gen_1	116	127	PF02991	0.469
LIG_LIR_Gen_1	426	437	PF02991	0.448
LIG_LIR_Gen_1	46	54	PF02991	0.355
LIG_LIR_Nem_3	106	112	PF02991	0.471
LIG_LIR_Nem_3	116	122	PF02991	0.498
LIG_LIR_Nem_3	264	269	PF02991	0.478
LIG_LIR_Nem_3	426	432	PF02991	0.448
LIG_LIR_Nem_3	46	50	PF02991	0.354
LIG_MYND_1	208	212	PF01753	0.400
LIG_Pex14_1	7	11	PF04695	0.256
LIG_Pex14_1	97	101	PF04695	0.503
LIG_PTB_Apo_2	300	307	PF02174	0.447
LIG_SH2_CRK	101	105	PF00017	0.503
LIG_SH2_CRK	119	123	PF00017	0.361
LIG_SH2_CRK	47	51	PF00017	0.391
LIG_SH2_GRB2like	445	448	PF00017	0.542
LIG_SH2_NCK_1	343	347	PF00017	0.528
LIG_SH2_NCK_1	434	438	PF00017	0.494
LIG_SH2_SRC	445	448	PF00017	0.542
LIG_SH2_SRC	68	71	PF00017	0.503
LIG_SH2_STAP1	119	123	PF00017	0.478
LIG_SH2_STAP1	343	347	PF00017	0.547
LIG_SH2_STAP1	47	51	PF00017	0.429
LIG_SH2_STAT5	136	139	PF00017	0.495
LIG_SH2_STAT5	280	283	PF00017	0.524
LIG_SH2_STAT5	305	308	PF00017	0.480
LIG_SH2_STAT5	445	448	PF00017	0.495
LIG_SH2_STAT5	68	71	PF00017	0.461
LIG_SH3_3	34	40	PF00018	0.421
LIG_SH3_3	75	81	PF00018	0.449
LIG_SxIP_EBH_1	204	213	PF03271	0.470
LIG_TRAF2_1	180	183	PF00917	0.476
LIG_TYR_ITAM	106	122	PF00017	0.503
LIG_UBA3_1	147	155	PF00899	0.542
MOD_CDK_SPxK_1	10	16	PF00069	0.400
MOD_CK1_1	118	124	PF00069	0.503
MOD_CK1_1	365	371	PF00069	0.513
MOD_CK2_1	177	183	PF00069	0.503
MOD_CK2_1	241	247	PF00069	0.467
MOD_CK2_1	357	363	PF00069	0.545
MOD_CK2_1	370	376	PF00069	0.527
MOD_CK2_1	46	52	PF00069	0.502
MOD_CK2_1	6	12	PF00069	0.371
MOD_GlcNHglycan	123	126	PF01048	0.342
MOD_GlcNHglycan	306	309	PF01048	0.303
MOD_GlcNHglycan	328	332	PF01048	0.293
MOD_GlcNHglycan	333	336	PF01048	0.292
MOD_GlcNHglycan	352	355	PF01048	0.311
MOD_GlcNHglycan	359	362	PF01048	0.305
MOD_GlcNHglycan	367	370	PF01048	0.354
MOD_GlcNHglycan	54	57	PF01048	0.523
MOD_GSK3_1	117	124	PF00069	0.452
MOD_GSK3_1	177	184	PF00069	0.464
MOD_GSK3_1	327	334	PF00069	0.451
MOD_GSK3_1	39	46	PF00069	0.596
MOD_GSK3_1	407	414	PF00069	0.542
MOD_GSK3_1	6	13	PF00069	0.405
MOD_N-GLC_1	128	133	PF02516	0.261
MOD_N-GLC_1	30	35	PF02516	0.355
MOD_N-GLC_1	412	417	PF02516	0.328
MOD_NEK2_1	142	147	PF00069	0.528
MOD_NEK2_1	304	309	PF00069	0.461
MOD_NEK2_1	379	384	PF00069	0.463
MOD_NEK2_1	6	11	PF00069	0.320
MOD_NEK2_2	136	141	PF00069	0.447
MOD_NEK2_2	333	338	PF00069	0.542
MOD_PIKK_1	362	368	PF00454	0.555
MOD_PK_1	371	377	PF00069	0.496
MOD_PKA_2	15	21	PF00069	0.426
MOD_PKA_2	270	276	PF00069	0.447
MOD_PKA_2	370	376	PF00069	0.519
MOD_Plk_1	115	121	PF00069	0.542
MOD_Plk_1	142	148	PF00069	0.447
MOD_Plk_1	181	187	PF00069	0.505
MOD_Plk_1	407	413	PF00069	0.480
MOD_Plk_4	118	124	PF00069	0.447
MOD_Plk_4	142	148	PF00069	0.503
MOD_Plk_4	206	212	PF00069	0.507
MOD_Plk_4	333	339	PF00069	0.461
MOD_Plk_4	412	418	PF00069	0.522
MOD_Plk_4	441	447	PF00069	0.436
MOD_Plk_4	46	52	PF00069	0.521
MOD_Plk_4	6	12	PF00069	0.407
MOD_Plk_4	93	99	PF00069	0.533
MOD_ProDKin_1	10	16	PF00069	0.400
MOD_ProDKin_1	177	183	PF00069	0.528
MOD_SUMO_rev_2	388	393	PF00179	0.482
TRG_DiLeu_BaEn_1	143	148	PF01217	0.542
TRG_DiLeu_BaEn_1	284	289	PF01217	0.461
TRG_ENDOCYTIC_2	109	112	PF00928	0.447
TRG_ENDOCYTIC_2	119	122	PF00928	0.447
TRG_ENDOCYTIC_2	47	50	PF00928	0.396
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG27	Leptomonas seymouri	79%	100%
A0A1X0NZN2	Trypanosomatidae	62%	100%
A0A3Q8IBE4	Leishmania donovani	96%	100%
A0A422NRP3	Trypanosoma rangeli	62%	100%
A0B7V2	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	26%	100%
A0LMI3	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	27%	100%
A0RCM7	Bacillus thuringiensis (strain Al Hakam)	22%	100%
A1VD37	Desulfovibrio vulgaris subsp. vulgaris (strain DP4)	28%	100%
A3DEQ2	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)	24%	100%
A4FW32	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	25%	100%
A4HH95	Leishmania braziliensis	87%	100%
A4I4E1	Leishmania infantum	96%	100%
A4J675	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	24%	100%
A4XJI3	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)	25%	100%
A5D1G6	Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)	24%	100%
A5UMN6	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	25%	100%
A6UQD4	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6UUG9	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	27%	100%
A6VH76	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	26%	100%
A7GNR9	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	24%	100%
A7I6C5	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	27%	100%
A9A9H3	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	25%	100%
B0K2W0	Thermoanaerobacter sp. (strain X514)	25%	100%
B0K8R8	Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)	25%	100%
B5YDN9	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	24%	100%
B5YLB7	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	25%	100%
B6YUF8	Thermococcus onnurineus (strain NA1)	30%	100%
B7HIQ2	Bacillus cereus (strain B4264)	22%	100%
B7HMN9	Bacillus cereus (strain AH187)	23%	100%
B7IS56	Bacillus cereus (strain G9842)	23%	100%
B7JJI0	Bacillus cereus (strain AH820)	23%	100%
B8CX03	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	25%	100%
B8DKS6	Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F)	25%	100%
B8E183	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	25%	100%
B8FRL9	Desulfitobacterium hafniense (strain DSM 10664 / DCB-2)	26%	100%
B8J2Q8	Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB)	22%	100%
C1EPN0	Bacillus cereus (strain 03BB102)	22%	100%
C3L6N3	Bacillus anthracis (strain CDC 684 / NRRL 3495)	23%	100%
C3P768	Bacillus anthracis (strain A0248)	23%	100%
C5BSJ0	Teredinibacter turnerae (strain ATCC 39867 / T7901)	28%	100%
C6A048	Thermococcus sibiricus (strain DSM 12597 / MM 739)	28%	100%
C9ZPZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	88%
E9ALY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O14057	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	86%
O27549	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%
O29265	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O29701	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	25%	100%
O31352	Bacillus cereus (strain ATCC 10987 / NRS 248)	23%	100%
O59184	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O66851	Aquifex aeolicus (strain VF5)	25%	100%
P0CI72	Unknown prokaryotic organism	23%	94%
P72156	Pseudomonas sp. (strain ADP)	25%	96%
P76641	Escherichia coli (strain K12)	28%	100%
Q07729	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	93%
Q0AYV2	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	25%	100%
Q12WS1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	25%	100%
Q18EV7	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	23%	100%
Q1MR44	Lawsonia intracellularis (strain PHE/MN1-00)	24%	100%
Q21IS0	Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)	26%	100%
Q24UA2	Desulfitobacterium hafniense (strain Y51)	26%	100%
Q2FRU6	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	27%	100%
Q2LTB7	Syntrophus aciditrophicus (strain SB)	27%	100%
Q2LUH4	Syntrophus aciditrophicus (strain SB)	25%	100%
Q2NHL6	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	23%	100%
Q2RJW1	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	27%	100%
Q3AC64	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	26%	100%
Q3ITF7	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	26%	100%
Q466Q9	Methanosarcina barkeri (strain Fusaro / DSM 804)	25%	100%
Q58936	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	100%
Q5JER0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	28%	100%
Q5RAV9	Pongo abelii	35%	100%
Q5UYR3	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	27%	100%
Q5WGA8	Alkalihalobacillus clausii (strain KSM-K16)	25%	100%
Q63CU1	Bacillus cereus (strain ZK / E33L)	23%	100%
Q67NQ5	Symbiobacterium thermophilum (strain T / IAM 14863)	26%	100%
Q6HK87	Bacillus thuringiensis subsp. konkukian (strain 97-27)	23%	100%
Q6LX61	Methanococcus maripaludis (strain S2 / LL)	25%	100%
Q72B14	Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)	27%	100%
Q81F14	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	23%	100%
Q81S14	Bacillus anthracis	23%	100%
Q86AW9	Dictyostelium discoideum	33%	100%
Q891Y7	Clostridium tetani (strain Massachusetts / E88)	25%	100%
Q8PUQ3	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	27%	100%
Q8R9L4	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	27%	100%
Q8TRA4	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	27%	100%
Q8TYD4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	29%	100%
Q8U0P7	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q92342	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	98%
Q9EYU0	Acidovorax citrulli	24%	96%
Q9HN51	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	28%	100%
Q9I6Z0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
Q9KC82	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	24%	100%
Q9R111	Mus musculus	36%	100%
Q9RYX4	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	28%	100%
Q9V0Y5	Pyrococcus abyssi (strain GE5 / Orsay)	33%	100%
Q9VMY9	Drosophila melanogaster	35%	100%
Q9WTT6	Rattus norvegicus	37%	100%
Q9X034	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	23%	100%
Q9Y2T3	Homo sapiens	35%	100%
V5BLN7	Trypanosoma cruzi	61%	100%