RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

E9ADU0_LEIMA

TriTrypDb:

LmjF.29.0865 , LMJLV39_290014500 , LMJSD75_290014500

Length:

114

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0032991	protein-containing complex	1	4
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

E9ADU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADU0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.254
CLV_NRD_NRD_1	65	67	PF00675	0.215
CLV_NRD_NRD_1	76	78	PF00675	0.231
CLV_NRD_NRD_1	97	99	PF00675	0.455
CLV_PCSK_FUR_1	95	99	PF00082	0.451
CLV_PCSK_KEX2_1	105	107	PF00082	0.291
CLV_PCSK_KEX2_1	23	25	PF00082	0.254
CLV_PCSK_KEX2_1	65	67	PF00082	0.215
CLV_PCSK_KEX2_1	76	78	PF00082	0.231
CLV_PCSK_KEX2_1	95	97	PF00082	0.455
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.453
CLV_PCSK_SKI1_1	23	27	PF00082	0.254
CLV_PCSK_SKI1_1	37	41	PF00082	0.215
CLV_PCSK_SKI1_1	85	89	PF00082	0.549
DEG_Nend_UBRbox_2	1	3	PF02207	0.569
DOC_CYCLIN_RxL_1	21	31	PF00134	0.273
DOC_USP7_MATH_1	14	18	PF00917	0.461
DOC_USP7_MATH_1	64	68	PF00917	0.518
LIG_14-3-3_CanoR_1	65	69	PF00244	0.507
LIG_APCC_ABBA_1	52	57	PF00400	0.415
LIG_BRCT_BRCA1_1	43	47	PF00533	0.507
LIG_FHA_1	5	11	PF00498	0.371
LIG_LIR_Nem_3	31	36	PF02991	0.428
LIG_SH2_STAT3	29	32	PF00017	0.415
LIG_SH2_STAT5	27	30	PF00017	0.415
LIG_SH2_STAT5	9	12	PF00017	0.359
MOD_CK2_1	15	21	PF00069	0.395
MOD_Cter_Amidation	74	77	PF01082	0.241
MOD_GlcNHglycan	17	20	PF01048	0.397
MOD_GSK3_1	53	60	PF00069	0.428
MOD_NEK2_1	28	33	PF00069	0.428
MOD_NEK2_2	4	9	PF00069	0.363
MOD_NEK2_2	64	69	PF00069	0.489
MOD_PIKK_1	28	34	PF00454	0.428
MOD_PKA_2	64	70	PF00069	0.507
MOD_Plk_4	4	10	PF00069	0.341
MOD_SUMO_rev_2	2	7	PF00179	0.456
MOD_SUMO_rev_2	99	107	PF00179	0.527
TRG_ER_diArg_1	22	24	PF00400	0.340
TRG_ER_diArg_1	76	78	PF00400	0.531
TRG_ER_diArg_1	95	98	PF00400	0.453
TRG_NLS_Bipartite_1	95	109	PF00514	0.611
TRG_NLS_MonoExtN_4	102	109	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM99	Leptomonas seymouri	85%	100%
A0A0S4J2L5	Bodo saltans	50%	79%
A0A1X0NZM5	Trypanosomatidae	72%	100%
A0A3S7X280	Leishmania donovani	99%	100%
A0A422NRL3	Trypanosoma rangeli	70%	100%
A4HH94	Leishmania braziliensis	96%	100%
A4I4E0	Leishmania infantum	99%	100%
C9ZL22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	97%
E9ALZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q7LL14	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%