Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADT9_LEIMA

TriTrypDb:

LmjF.29.0860 , LMJLV39_290014400 , LMJSD75_290014400

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.675
CLV_NRD_NRD_1	348	350	PF00675	0.685
CLV_NRD_NRD_1	499	501	PF00675	0.599
CLV_PCSK_KEX2_1	204	206	PF00082	0.635
CLV_PCSK_PC7_1	200	206	PF00082	0.691
CLV_PCSK_SKI1_1	236	240	PF00082	0.710
CLV_PCSK_SKI1_1	359	363	PF00082	0.698
CLV_PCSK_SKI1_1	366	370	PF00082	0.693
CLV_PCSK_SKI1_1	418	422	PF00082	0.670
CLV_PCSK_SKI1_1	468	472	PF00082	0.540
DEG_APCC_DBOX_1	467	475	PF00400	0.515
DEG_Nend_UBRbox_3	1	3	PF02207	0.713
DEG_SPOP_SBC_1	24	28	PF00917	0.809
DOC_CKS1_1	404	409	PF01111	0.799
DOC_CYCLIN_RxL_1	353	365	PF00134	0.726
DOC_MAPK_MEF2A_6	88	97	PF00069	0.499
DOC_PP1_RVXF_1	364	371	PF00149	0.789
DOC_PP2B_LxvP_1	361	364	PF13499	0.780
DOC_PP2B_LxvP_1	412	415	PF13499	0.648
DOC_SPAK_OSR1_1	290	294	PF12202	0.537
DOC_USP7_MATH_1	186	190	PF00917	0.619
DOC_USP7_MATH_1	209	213	PF00917	0.709
DOC_USP7_MATH_1	23	27	PF00917	0.815
DOC_USP7_MATH_1	389	393	PF00917	0.747
DOC_USP7_MATH_1	427	431	PF00917	0.581
DOC_USP7_MATH_1	476	480	PF00917	0.678
DOC_USP7_MATH_1	51	55	PF00917	0.678
DOC_USP7_UBL2_3	482	486	PF12436	0.621
DOC_WW_Pin1_4	203	208	PF00397	0.745
DOC_WW_Pin1_4	224	229	PF00397	0.730
DOC_WW_Pin1_4	231	236	PF00397	0.678
DOC_WW_Pin1_4	25	30	PF00397	0.798
DOC_WW_Pin1_4	295	300	PF00397	0.637
DOC_WW_Pin1_4	317	322	PF00397	0.683
DOC_WW_Pin1_4	336	341	PF00397	0.569
DOC_WW_Pin1_4	397	402	PF00397	0.744
DOC_WW_Pin1_4	403	408	PF00397	0.711
DOC_WW_Pin1_4	429	434	PF00397	0.546
DOC_WW_Pin1_4	71	76	PF00397	0.819
LIG_14-3-3_CanoR_1	236	242	PF00244	0.665
LIG_14-3-3_CanoR_1	305	312	PF00244	0.536
LIG_14-3-3_CanoR_1	366	371	PF00244	0.731
LIG_14-3-3_CanoR_1	446	451	PF00244	0.487
LIG_14-3-3_CanoR_1	46	51	PF00244	0.642
LIG_Actin_WH2_2	2	20	PF00022	0.718
LIG_Actin_WH2_2	90	105	PF00022	0.325
LIG_BRCT_BRCA1_1	272	276	PF00533	0.542
LIG_BRCT_BRCA1_1	62	66	PF00533	0.812
LIG_FHA_1	158	164	PF00498	0.575
LIG_FHA_1	280	286	PF00498	0.504
LIG_FHA_1	298	304	PF00498	0.495
LIG_FHA_1	36	42	PF00498	0.780
LIG_FHA_1	432	438	PF00498	0.591
LIG_FHA_1	445	451	PF00498	0.630
LIG_FHA_1	59	65	PF00498	0.723
LIG_FHA_1	92	98	PF00498	0.440
LIG_FHA_2	321	327	PF00498	0.663
LIG_FHA_2	367	373	PF00498	0.796
LIG_FHA_2	47	53	PF00498	0.636
LIG_FHA_2	76	82	PF00498	0.798
LIG_LIR_Gen_1	282	291	PF02991	0.522
LIG_LIR_Nem_3	273	279	PF02991	0.570
LIG_LIR_Nem_3	282	286	PF02991	0.473
LIG_RPA_C_Fungi	285	297	PF08784	0.562
LIG_SH2_NCK_1	48	52	PF00017	0.654
LIG_SH2_STAP1	256	260	PF00017	0.488
LIG_SH2_STAP1	279	283	PF00017	0.554
LIG_SH2_STAT5	48	51	PF00017	0.630
LIG_SH3_3	298	304	PF00018	0.682
LIG_SH3_3	313	319	PF00018	0.700
LIG_SH3_3	398	404	PF00018	0.734
LIG_SH3_4	482	489	PF00018	0.547
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.663
LIG_SUMO_SIM_par_1	109	116	PF11976	0.387
LIG_SUMO_SIM_par_1	320	326	PF11976	0.663
LIG_SUMO_SIM_par_1	436	442	PF11976	0.449
LIG_TRAF2_1	179	182	PF00917	0.601
MOD_CDK_SPK_2	231	236	PF00069	0.746
MOD_CK1_1	111	117	PF00069	0.550
MOD_CK1_1	159	165	PF00069	0.582
MOD_CK1_1	212	218	PF00069	0.698
MOD_CK1_1	224	230	PF00069	0.589
MOD_CK1_1	295	301	PF00069	0.644
MOD_CK1_1	306	312	PF00069	0.713
MOD_CK1_1	320	326	PF00069	0.669
MOD_CK1_1	36	42	PF00069	0.794
MOD_CK1_1	56	62	PF00069	0.466
MOD_CK2_1	366	372	PF00069	0.794
MOD_CK2_1	46	52	PF00069	0.634
MOD_CK2_1	491	497	PF00069	0.545
MOD_CK2_1	73	79	PF00069	0.812
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.663
MOD_GlcNHglycan	201	204	PF01048	0.591
MOD_GlcNHglycan	216	220	PF01048	0.719
MOD_GlcNHglycan	223	226	PF01048	0.618
MOD_GlcNHglycan	239	242	PF01048	0.768
MOD_GlcNHglycan	255	259	PF01048	0.595
MOD_GlcNHglycan	294	297	PF01048	0.610
MOD_GlcNHglycan	460	463	PF01048	0.553
MOD_GlcNHglycan	473	477	PF01048	0.484
MOD_GlcNHglycan	478	481	PF01048	0.479
MOD_GSK3_1	107	114	PF00069	0.541
MOD_GSK3_1	195	202	PF00069	0.588
MOD_GSK3_1	208	215	PF00069	0.527
MOD_GSK3_1	295	302	PF00069	0.739
MOD_GSK3_1	306	313	PF00069	0.670
MOD_GSK3_1	33	40	PF00069	0.793
MOD_GSK3_1	362	369	PF00069	0.703
MOD_GSK3_1	380	387	PF00069	0.660
MOD_GSK3_1	425	432	PF00069	0.596
MOD_GSK3_1	458	465	PF00069	0.584
MOD_GSK3_1	46	53	PF00069	0.569
MOD_GSK3_1	472	479	PF00069	0.643
MOD_GSK3_1	56	63	PF00069	0.592
MOD_GSK3_1	66	73	PF00069	0.632
MOD_GSK3_1	75	82	PF00069	0.646
MOD_N-GLC_1	231	236	PF02516	0.714
MOD_N-GLC_1	476	481	PF02516	0.533
MOD_N-GLC_2	246	248	PF02516	0.616
MOD_NEK2_1	108	113	PF00069	0.468
MOD_NEK2_1	230	235	PF00069	0.759
MOD_NEK2_1	292	297	PF00069	0.525
MOD_NEK2_1	425	430	PF00069	0.621
MOD_NEK2_1	57	62	PF00069	0.609
MOD_NEK2_1	66	71	PF00069	0.673
MOD_NEK2_1	97	102	PF00069	0.517
MOD_PIKK_1	113	119	PF00454	0.520
MOD_PIKK_1	270	276	PF00454	0.537
MOD_PIKK_1	306	312	PF00454	0.735
MOD_PIKK_1	344	350	PF00454	0.639
MOD_PIKK_1	58	64	PF00454	0.720
MOD_PKA_2	199	205	PF00069	0.557
MOD_PKB_1	152	160	PF00069	0.469
MOD_PKB_1	44	52	PF00069	0.649
MOD_Plk_1	108	114	PF00069	0.557
MOD_Plk_1	167	173	PF00069	0.476
MOD_Plk_1	215	221	PF00069	0.646
MOD_Plk_1	359	365	PF00069	0.510
MOD_Plk_1	36	42	PF00069	0.749
MOD_Plk_1	476	482	PF00069	0.552
MOD_Plk_1	5	11	PF00069	0.736
MOD_Plk_1	51	57	PF00069	0.718
MOD_Plk_1	91	97	PF00069	0.492
MOD_Plk_2-3	491	497	PF00069	0.545
MOD_Plk_2-3	79	85	PF00069	0.751
MOD_Plk_4	108	114	PF00069	0.541
MOD_Plk_4	167	173	PF00069	0.624
MOD_Plk_4	320	326	PF00069	0.727
MOD_Plk_4	366	372	PF00069	0.794
MOD_Plk_4	97	103	PF00069	0.517
MOD_ProDKin_1	203	209	PF00069	0.737
MOD_ProDKin_1	224	230	PF00069	0.730
MOD_ProDKin_1	231	237	PF00069	0.676
MOD_ProDKin_1	25	31	PF00069	0.798
MOD_ProDKin_1	295	301	PF00069	0.644
MOD_ProDKin_1	317	323	PF00069	0.684
MOD_ProDKin_1	336	342	PF00069	0.566
MOD_ProDKin_1	397	403	PF00069	0.741
MOD_ProDKin_1	429	435	PF00069	0.547
MOD_ProDKin_1	71	77	PF00069	0.819
TRG_DiLeu_BaEn_2	286	292	PF01217	0.343
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.708
TRG_ER_diArg_1	41	44	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I162	Leptomonas seymouri	43%	82%
A0A3Q8IR74	Leishmania donovani	89%	100%
E9AHI3	Leishmania infantum	89%	100%
E9AIT6	Leishmania braziliensis	68%	100%
E9ALZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%