LeishMANIAdb
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Putative high mobility group protein homolog tdp-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative high mobility group protein homolog tdp-1
Gene product:
High mobility group protein TDP1
Species:
Leishmania major
UniProt:
E9ADT8_LEIMA
TriTrypDb:
LmjF.29.0850 , LMJLV39_290014100 , LMJSD75_290014100
Length:
299

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005730 nucleolus 5 2
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

E9ADT8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT8

Function

Biological processes
Term Name Level Count
GO:0010468 regulation of gene expression 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0019222 regulation of metabolic process 3 2
GO:0050789 regulation of biological process 2 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
Molecular functions
Term Name Level Count
GO:0000182 rDNA binding 7 2
GO:0000217 DNA secondary structure binding 5 2
GO:0000400 four-way junction DNA binding 6 2
GO:0000402 crossed form four-way junction DNA binding 7 2
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003690 double-stranded DNA binding 5 2
GO:0005488 binding 1 12
GO:0008301 DNA binding, bending 5 2
GO:0043565 sequence-specific DNA binding 5 2
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:1990837 sequence-specific double-stranded DNA binding 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 286 290 PF00656 0.724
CLV_C14_Caspase3-7 291 295 PF00656 0.728
CLV_NRD_NRD_1 36 38 PF00675 0.579
CLV_NRD_NRD_1 83 85 PF00675 0.617
CLV_PCSK_FUR_1 84 88 PF00082 0.694
CLV_PCSK_KEX2_1 192 194 PF00082 0.594
CLV_PCSK_KEX2_1 208 210 PF00082 0.237
CLV_PCSK_KEX2_1 261 263 PF00082 0.323
CLV_PCSK_KEX2_1 35 37 PF00082 0.552
CLV_PCSK_KEX2_1 83 85 PF00082 0.565
CLV_PCSK_KEX2_1 86 88 PF00082 0.573
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.581
CLV_PCSK_PC1ET2_1 208 210 PF00082 0.237
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.323
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.581
CLV_PCSK_SKI1_1 117 121 PF00082 0.317
CLV_PCSK_SKI1_1 15 19 PF00082 0.603
CLV_PCSK_SKI1_1 196 200 PF00082 0.628
CLV_PCSK_SKI1_1 208 212 PF00082 0.213
CLV_PCSK_SKI1_1 59 63 PF00082 0.567
CLV_PCSK_SKI1_1 83 87 PF00082 0.685
DEG_SPOP_SBC_1 283 287 PF00917 0.755
DEG_SPOP_SBC_1 288 292 PF00917 0.761
DOC_CKS1_1 61 66 PF01111 0.588
DOC_MAPK_MEF2A_6 117 126 PF00069 0.519
DOC_USP7_MATH_1 265 269 PF00917 0.543
DOC_USP7_MATH_1 279 283 PF00917 0.642
DOC_USP7_MATH_1 288 292 PF00917 0.769
DOC_USP7_MATH_1 5 9 PF00917 0.723
DOC_USP7_MATH_1 94 98 PF00917 0.624
DOC_USP7_UBL2_3 107 111 PF12436 0.564
DOC_USP7_UBL2_3 133 137 PF12436 0.540
DOC_USP7_UBL2_3 192 196 PF12436 0.532
DOC_USP7_UBL2_3 95 99 PF12436 0.675
DOC_WW_Pin1_4 118 123 PF00397 0.525
DOC_WW_Pin1_4 44 49 PF00397 0.641
DOC_WW_Pin1_4 60 65 PF00397 0.487
DOC_WW_Pin1_4 87 92 PF00397 0.617
LIG_14-3-3_CanoR_1 209 217 PF00244 0.454
LIG_BIR_II_1 1 5 PF00653 0.592
LIG_FHA_1 142 148 PF00498 0.465
LIG_FHA_1 48 54 PF00498 0.626
LIG_FHA_1 61 67 PF00498 0.520
LIG_FHA_2 60 66 PF00498 0.615
LIG_LIR_Gen_1 121 127 PF02991 0.465
LIG_LIR_Gen_1 163 169 PF02991 0.550
LIG_LIR_Nem_3 121 126 PF02991 0.454
LIG_LIR_Nem_3 163 168 PF02991 0.519
LIG_LIR_Nem_3 212 217 PF02991 0.463
LIG_LIR_Nem_3 45 49 PF02991 0.586
LIG_RPA_C_Fungi 181 193 PF08784 0.549
LIG_SH2_CRK 165 169 PF00017 0.333
LIG_SH2_STAP1 176 180 PF00017 0.415
LIG_SH2_STAP1 252 256 PF00017 0.297
LIG_SH2_STAT5 123 126 PF00017 0.332
LIG_SH2_STAT5 183 186 PF00017 0.553
LIG_SH2_STAT5 214 217 PF00017 0.313
LIG_SH3_2 204 209 PF14604 0.598
LIG_SH3_3 201 207 PF00018 0.594
LIG_SH3_3 271 277 PF00018 0.697
LIG_SUMO_SIM_anti_2 16 23 PF11976 0.581
LIG_TRAF2_1 158 161 PF00917 0.347
LIG_TRAF2_1 245 248 PF00917 0.429
LIG_TRAF2_1 251 254 PF00917 0.438
LIG_UBA3_1 146 155 PF00899 0.333
MOD_CDC14_SPxK_1 90 93 PF00782 0.500
MOD_CDK_SPxK_1 87 93 PF00069 0.494
MOD_CK1_1 27 33 PF00069 0.532
MOD_CK1_1 272 278 PF00069 0.691
MOD_CK1_1 282 288 PF00069 0.756
MOD_CK1_1 290 296 PF00069 0.692
MOD_CK2_1 13 19 PF00069 0.515
MOD_CK2_1 155 161 PF00069 0.433
MOD_CK2_1 242 248 PF00069 0.397
MOD_CK2_1 59 65 PF00069 0.579
MOD_Cter_Amidation 105 108 PF01082 0.585
MOD_Cter_Amidation 194 197 PF01082 0.599
MOD_GlcNHglycan 1 4 PF01048 0.660
MOD_GlcNHglycan 102 105 PF01048 0.756
MOD_GlcNHglycan 244 247 PF01048 0.491
MOD_GlcNHglycan 266 270 PF01048 0.640
MOD_GlcNHglycan 281 284 PF01048 0.820
MOD_GlcNHglycan 286 289 PF01048 0.745
MOD_GlcNHglycan 78 83 PF01048 0.549
MOD_GSK3_1 141 148 PF00069 0.420
MOD_GSK3_1 265 272 PF00069 0.675
MOD_GSK3_1 279 286 PF00069 0.671
MOD_GSK3_1 288 295 PF00069 0.719
MOD_N-GLC_1 5 10 PF02516 0.634
MOD_NEK2_1 13 18 PF00069 0.553
MOD_PIKK_1 272 278 PF00454 0.612
MOD_PKA_1 155 161 PF00069 0.415
MOD_PKA_2 269 275 PF00069 0.640
MOD_PKB_1 87 95 PF00069 0.705
MOD_Plk_1 13 19 PF00069 0.523
MOD_Plk_1 160 166 PF00069 0.415
MOD_Plk_4 13 19 PF00069 0.494
MOD_ProDKin_1 118 124 PF00069 0.397
MOD_ProDKin_1 44 50 PF00069 0.641
MOD_ProDKin_1 60 66 PF00069 0.483
MOD_ProDKin_1 87 93 PF00069 0.621
MOD_SUMO_for_1 198 201 PF00179 0.611
MOD_SUMO_for_1 85 88 PF00179 0.666
MOD_SUMO_rev_2 103 112 PF00179 0.549
MOD_SUMO_rev_2 158 163 PF00179 0.395
MOD_SUMO_rev_2 170 174 PF00179 0.279
MOD_SUMO_rev_2 201 207 PF00179 0.511
MOD_SUMO_rev_2 245 251 PF00179 0.363
TRG_DiLeu_BaEn_1 52 57 PF01217 0.554
TRG_ENDOCYTIC_2 123 126 PF00928 0.313
TRG_ENDOCYTIC_2 165 168 PF00928 0.313
TRG_ENDOCYTIC_2 214 217 PF00928 0.327
TRG_ENDOCYTIC_2 252 255 PF00928 0.313
TRG_ER_diArg_1 34 37 PF00400 0.460
TRG_ER_diArg_1 83 85 PF00400 0.607
TRG_NLS_Bipartite_1 83 99 PF00514 0.642
TRG_NLS_MonoExtC_3 195 200 PF00514 0.630
TRG_NLS_MonoExtC_3 94 99 PF00514 0.723
TRG_NLS_MonoExtN_4 193 200 PF00514 0.645
TRG_NLS_MonoExtN_4 93 99 PF00514 0.577
TRG_Pf-PMV_PEXEL_1 83 88 PF00026 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8C9 Leptomonas seymouri 68% 99%
A0A0S4KNH5 Bodo saltans 38% 77%
A0A1X0NZM0 Trypanosomatidae 44% 100%
A0A3Q8IEB8 Leishmania donovani 96% 99%
A0A3R7KR63 Trypanosoma rangeli 46% 100%
A4HH93 Leishmania braziliensis 87% 100%
A4I4D9 Leishmania infantum 96% 99%
C9ZL24 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ALZ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P26586 Trypanosoma brucei rhodesiense 42% 100%
V5B1M8 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS