Putative high mobility group protein homolog tdp-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

High mobility group protein TDP1

Species:

Leishmania major

UniProt:

E9ADT8_LEIMA

TriTrypDb:

LmjF.29.0850 , LMJLV39_290014100 , LMJSD75_290014100

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ADT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT8

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000182	rDNA binding	7	2
GO:0000217	DNA secondary structure binding	5	2
GO:0000400	four-way junction DNA binding	6	2
GO:0000402	crossed form four-way junction DNA binding	7	2
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	12
GO:0008301	DNA binding, bending	5	2
GO:0043565	sequence-specific DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:1990837	sequence-specific double-stranded DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.724
CLV_C14_Caspase3-7	291	295	PF00656	0.728
CLV_NRD_NRD_1	36	38	PF00675	0.579
CLV_NRD_NRD_1	83	85	PF00675	0.617
CLV_PCSK_FUR_1	84	88	PF00082	0.694
CLV_PCSK_KEX2_1	192	194	PF00082	0.594
CLV_PCSK_KEX2_1	208	210	PF00082	0.237
CLV_PCSK_KEX2_1	261	263	PF00082	0.323
CLV_PCSK_KEX2_1	35	37	PF00082	0.552
CLV_PCSK_KEX2_1	83	85	PF00082	0.565
CLV_PCSK_KEX2_1	86	88	PF00082	0.573
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.581
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.237
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.323
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.581
CLV_PCSK_SKI1_1	117	121	PF00082	0.317
CLV_PCSK_SKI1_1	15	19	PF00082	0.603
CLV_PCSK_SKI1_1	196	200	PF00082	0.628
CLV_PCSK_SKI1_1	208	212	PF00082	0.213
CLV_PCSK_SKI1_1	59	63	PF00082	0.567
CLV_PCSK_SKI1_1	83	87	PF00082	0.685
DEG_SPOP_SBC_1	283	287	PF00917	0.755
DEG_SPOP_SBC_1	288	292	PF00917	0.761
DOC_CKS1_1	61	66	PF01111	0.588
DOC_MAPK_MEF2A_6	117	126	PF00069	0.519
DOC_USP7_MATH_1	265	269	PF00917	0.543
DOC_USP7_MATH_1	279	283	PF00917	0.642
DOC_USP7_MATH_1	288	292	PF00917	0.769
DOC_USP7_MATH_1	5	9	PF00917	0.723
DOC_USP7_MATH_1	94	98	PF00917	0.624
DOC_USP7_UBL2_3	107	111	PF12436	0.564
DOC_USP7_UBL2_3	133	137	PF12436	0.540
DOC_USP7_UBL2_3	192	196	PF12436	0.532
DOC_USP7_UBL2_3	95	99	PF12436	0.675
DOC_WW_Pin1_4	118	123	PF00397	0.525
DOC_WW_Pin1_4	44	49	PF00397	0.641
DOC_WW_Pin1_4	60	65	PF00397	0.487
DOC_WW_Pin1_4	87	92	PF00397	0.617
LIG_14-3-3_CanoR_1	209	217	PF00244	0.454
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_FHA_1	142	148	PF00498	0.465
LIG_FHA_1	48	54	PF00498	0.626
LIG_FHA_1	61	67	PF00498	0.520
LIG_FHA_2	60	66	PF00498	0.615
LIG_LIR_Gen_1	121	127	PF02991	0.465
LIG_LIR_Gen_1	163	169	PF02991	0.550
LIG_LIR_Nem_3	121	126	PF02991	0.454
LIG_LIR_Nem_3	163	168	PF02991	0.519
LIG_LIR_Nem_3	212	217	PF02991	0.463
LIG_LIR_Nem_3	45	49	PF02991	0.586
LIG_RPA_C_Fungi	181	193	PF08784	0.549
LIG_SH2_CRK	165	169	PF00017	0.333
LIG_SH2_STAP1	176	180	PF00017	0.415
LIG_SH2_STAP1	252	256	PF00017	0.297
LIG_SH2_STAT5	123	126	PF00017	0.332
LIG_SH2_STAT5	183	186	PF00017	0.553
LIG_SH2_STAT5	214	217	PF00017	0.313
LIG_SH3_2	204	209	PF14604	0.598
LIG_SH3_3	201	207	PF00018	0.594
LIG_SH3_3	271	277	PF00018	0.697
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.581
LIG_TRAF2_1	158	161	PF00917	0.347
LIG_TRAF2_1	245	248	PF00917	0.429
LIG_TRAF2_1	251	254	PF00917	0.438
LIG_UBA3_1	146	155	PF00899	0.333
MOD_CDC14_SPxK_1	90	93	PF00782	0.500
MOD_CDK_SPxK_1	87	93	PF00069	0.494
MOD_CK1_1	27	33	PF00069	0.532
MOD_CK1_1	272	278	PF00069	0.691
MOD_CK1_1	282	288	PF00069	0.756
MOD_CK1_1	290	296	PF00069	0.692
MOD_CK2_1	13	19	PF00069	0.515
MOD_CK2_1	155	161	PF00069	0.433
MOD_CK2_1	242	248	PF00069	0.397
MOD_CK2_1	59	65	PF00069	0.579
MOD_Cter_Amidation	105	108	PF01082	0.585
MOD_Cter_Amidation	194	197	PF01082	0.599
MOD_GlcNHglycan	1	4	PF01048	0.660
MOD_GlcNHglycan	102	105	PF01048	0.756
MOD_GlcNHglycan	244	247	PF01048	0.491
MOD_GlcNHglycan	266	270	PF01048	0.640
MOD_GlcNHglycan	281	284	PF01048	0.820
MOD_GlcNHglycan	286	289	PF01048	0.745
MOD_GlcNHglycan	78	83	PF01048	0.549
MOD_GSK3_1	141	148	PF00069	0.420
MOD_GSK3_1	265	272	PF00069	0.675
MOD_GSK3_1	279	286	PF00069	0.671
MOD_GSK3_1	288	295	PF00069	0.719
MOD_N-GLC_1	5	10	PF02516	0.634
MOD_NEK2_1	13	18	PF00069	0.553
MOD_PIKK_1	272	278	PF00454	0.612
MOD_PKA_1	155	161	PF00069	0.415
MOD_PKA_2	269	275	PF00069	0.640
MOD_PKB_1	87	95	PF00069	0.705
MOD_Plk_1	13	19	PF00069	0.523
MOD_Plk_1	160	166	PF00069	0.415
MOD_Plk_4	13	19	PF00069	0.494
MOD_ProDKin_1	118	124	PF00069	0.397
MOD_ProDKin_1	44	50	PF00069	0.641
MOD_ProDKin_1	60	66	PF00069	0.483
MOD_ProDKin_1	87	93	PF00069	0.621
MOD_SUMO_for_1	198	201	PF00179	0.611
MOD_SUMO_for_1	85	88	PF00179	0.666
MOD_SUMO_rev_2	103	112	PF00179	0.549
MOD_SUMO_rev_2	158	163	PF00179	0.395
MOD_SUMO_rev_2	170	174	PF00179	0.279
MOD_SUMO_rev_2	201	207	PF00179	0.511
MOD_SUMO_rev_2	245	251	PF00179	0.363
TRG_DiLeu_BaEn_1	52	57	PF01217	0.554
TRG_ENDOCYTIC_2	123	126	PF00928	0.313
TRG_ENDOCYTIC_2	165	168	PF00928	0.313
TRG_ENDOCYTIC_2	214	217	PF00928	0.327
TRG_ENDOCYTIC_2	252	255	PF00928	0.313
TRG_ER_diArg_1	34	37	PF00400	0.460
TRG_ER_diArg_1	83	85	PF00400	0.607
TRG_NLS_Bipartite_1	83	99	PF00514	0.642
TRG_NLS_MonoExtC_3	195	200	PF00514	0.630
TRG_NLS_MonoExtC_3	94	99	PF00514	0.723
TRG_NLS_MonoExtN_4	193	200	PF00514	0.645
TRG_NLS_MonoExtN_4	93	99	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C9	Leptomonas seymouri	68%	99%
A0A0S4KNH5	Bodo saltans	38%	77%
A0A1X0NZM0	Trypanosomatidae	44%	100%
A0A3Q8IEB8	Leishmania donovani	96%	99%
A0A3R7KR63	Trypanosoma rangeli	46%	100%
A4HH93	Leishmania braziliensis	87%	100%
A4I4D9	Leishmania infantum	96%	99%
C9ZL24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ALZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P26586	Trypanosoma brucei rhodesiense	42%	100%
V5B1M8	Trypanosoma cruzi	47%	100%