LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ADT7_LEIMA
TriTrypDb:
LmjF.29.0840 , LMJLV39_290014000 , LMJSD75_290014000
Length:
391

Annotations

LeishMANIAdb annotations

This protein is only found among Kinetoplastds. However, its function is unclear, could be a transporter or channel protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005635 nuclear envelope 4 2
GO:0005737 cytoplasm 2 2
GO:0005819 spindle 5 2
GO:0016020 membrane 2 9
GO:0031967 organelle envelope 3 2
GO:0031975 envelope 2 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9ADT7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.378
CLV_NRD_NRD_1 183 185 PF00675 0.404
CLV_PCSK_KEX2_1 122 124 PF00082 0.378
CLV_PCSK_KEX2_1 183 185 PF00082 0.404
CLV_PCSK_SKI1_1 178 182 PF00082 0.483
CLV_PCSK_SKI1_1 183 187 PF00082 0.333
DOC_CKS1_1 369 374 PF01111 0.306
DOC_MAPK_gen_1 122 130 PF00069 0.485
DOC_MAPK_MEF2A_6 123 132 PF00069 0.474
DOC_MAPK_MEF2A_6 208 216 PF00069 0.545
DOC_MAPK_RevD_3 170 184 PF00069 0.407
DOC_PP2B_PxIxI_1 106 112 PF00149 0.410
DOC_PP4_FxxP_1 104 107 PF00568 0.314
DOC_PP4_FxxP_1 11 14 PF00568 0.654
DOC_PP4_FxxP_1 118 121 PF00568 0.533
DOC_PP4_FxxP_1 338 341 PF00568 0.696
DOC_PP4_FxxP_1 51 54 PF00568 0.317
DOC_USP7_MATH_1 139 143 PF00917 0.292
DOC_USP7_MATH_1 259 263 PF00917 0.397
DOC_USP7_MATH_1 311 315 PF00917 0.385
DOC_WW_Pin1_4 10 15 PF00397 0.662
DOC_WW_Pin1_4 27 32 PF00397 0.513
DOC_WW_Pin1_4 368 373 PF00397 0.262
LIG_14-3-3_CanoR_1 122 128 PF00244 0.571
LIG_14-3-3_CanoR_1 45 51 PF00244 0.475
LIG_APCC_ABBA_1 65 70 PF00400 0.499
LIG_BIR_II_1 1 5 PF00653 0.699
LIG_BRCT_BRCA1_1 268 272 PF00533 0.452
LIG_BRCT_BRCA1_1 29 33 PF00533 0.544
LIG_CaM_NSCaTE_8 347 354 PF13499 0.355
LIG_CSL_BTD_1 209 212 PF09270 0.644
LIG_DLG_GKlike_1 123 130 PF00625 0.496
LIG_FHA_1 159 165 PF00498 0.477
LIG_FHA_1 216 222 PF00498 0.279
LIG_FHA_1 369 375 PF00498 0.313
LIG_FHA_1 47 53 PF00498 0.342
LIG_FHA_1 96 102 PF00498 0.275
LIG_LIR_Apic_2 10 14 PF02991 0.656
LIG_LIR_Apic_2 49 54 PF02991 0.322
LIG_LIR_Gen_1 129 140 PF02991 0.313
LIG_LIR_Nem_3 129 135 PF02991 0.364
LIG_LIR_Nem_3 166 170 PF02991 0.373
LIG_LIR_Nem_3 203 209 PF02991 0.668
LIG_LIR_Nem_3 277 282 PF02991 0.347
LIG_LIR_Nem_3 30 36 PF02991 0.539
LIG_LIR_Nem_3 330 336 PF02991 0.638
LIG_LIR_Nem_3 56 61 PF02991 0.344
LIG_PDZ_Class_2 386 391 PF00595 0.410
LIG_Pex14_1 201 205 PF04695 0.615
LIG_Pex14_2 114 118 PF04695 0.535
LIG_Pex14_2 333 337 PF04695 0.610
LIG_Pex14_2 46 50 PF04695 0.472
LIG_Pex14_2 51 55 PF04695 0.434
LIG_PTB_Apo_2 384 391 PF02174 0.306
LIG_SH2_CRK 279 283 PF00017 0.319
LIG_SH2_NCK_1 196 200 PF00017 0.306
LIG_SH2_STAP1 196 200 PF00017 0.391
LIG_SH2_STAT5 19 22 PF00017 0.561
LIG_SH2_STAT5 196 199 PF00017 0.376
LIG_SH2_STAT5 309 312 PF00017 0.338
LIG_SH2_STAT5 36 39 PF00017 0.497
LIG_SH2_STAT5 370 373 PF00017 0.403
LIG_SH2_STAT5 47 50 PF00017 0.279
LIG_SH3_3 206 212 PF00018 0.592
LIG_SH3_3 214 220 PF00018 0.300
LIG_SH3_3 338 344 PF00018 0.566
LIG_SH3_3 366 372 PF00018 0.296
LIG_SH3_3 85 91 PF00018 0.419
LIG_SUMO_SIM_anti_2 98 104 PF11976 0.357
LIG_TYR_ITIM 60 65 PF00017 0.325
LIG_UBA3_1 57 66 PF00899 0.306
LIG_WRC_WIRS_1 140 145 PF05994 0.311
LIG_WW_2 212 215 PF00397 0.628
MOD_CDK_SPK_2 27 32 PF00069 0.617
MOD_CDK_SPxxK_3 27 34 PF00069 0.624
MOD_CK1_1 126 132 PF00069 0.417
MOD_CK1_1 304 310 PF00069 0.344
MOD_CK1_1 79 85 PF00069 0.456
MOD_GlcNHglycan 225 228 PF01048 0.402
MOD_GlcNHglycan 257 260 PF01048 0.603
MOD_GlcNHglycan 83 86 PF01048 0.628
MOD_GSK3_1 255 262 PF00069 0.401
MOD_GSK3_1 266 273 PF00069 0.337
MOD_GSK3_1 300 307 PF00069 0.357
MOD_GSK3_1 347 354 PF00069 0.318
MOD_GSK3_1 76 83 PF00069 0.484
MOD_NEK2_1 153 158 PF00069 0.421
MOD_NEK2_1 163 168 PF00069 0.403
MOD_NEK2_1 200 205 PF00069 0.611
MOD_NEK2_1 255 260 PF00069 0.407
MOD_NEK2_1 270 275 PF00069 0.384
MOD_NEK2_1 351 356 PF00069 0.362
MOD_NEK2_1 46 51 PF00069 0.319
MOD_NEK2_1 76 81 PF00069 0.415
MOD_Plk_4 123 129 PF00069 0.551
MOD_Plk_4 131 137 PF00069 0.309
MOD_Plk_4 246 252 PF00069 0.373
MOD_Plk_4 285 291 PF00069 0.377
MOD_Plk_4 304 310 PF00069 0.315
MOD_Plk_4 32 38 PF00069 0.603
MOD_Plk_4 342 348 PF00069 0.474
MOD_Plk_4 357 363 PF00069 0.242
MOD_Plk_4 46 52 PF00069 0.244
MOD_Plk_4 95 101 PF00069 0.325
MOD_ProDKin_1 10 16 PF00069 0.655
MOD_ProDKin_1 27 33 PF00069 0.513
MOD_ProDKin_1 368 374 PF00069 0.262
MOD_SUMO_rev_2 2 11 PF00179 0.660
TRG_ENDOCYTIC_2 150 153 PF00928 0.431
TRG_ENDOCYTIC_2 279 282 PF00928 0.318
TRG_ENDOCYTIC_2 62 65 PF00928 0.279
TRG_ER_diArg_1 121 123 PF00400 0.546
TRG_ER_diArg_1 182 184 PF00400 0.404
TRG_ER_diArg_1 201 204 PF00400 0.437
TRG_Pf-PMV_PEXEL_1 184 189 PF00026 0.297

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEY8 Leptomonas seymouri 60% 100%
A0A1X0P088 Trypanosomatidae 34% 100%
A0A3Q8IH62 Leishmania donovani 96% 100%
A0A3R7MU19 Trypanosoma rangeli 37% 92%
A4HH92 Leishmania braziliensis 84% 100%
A4I4D8 Leishmania infantum 96% 100%
C9ZL26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9ALZ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BH42 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS