FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADT6_LEIMA

TriTrypDb:

LmjF.29.0830 , LMJLV39_290013900 , LMJSD75_290013900

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	7
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ADT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.562
CLV_NRD_NRD_1	245	247	PF00675	0.641
CLV_NRD_NRD_1	361	363	PF00675	0.735
CLV_NRD_NRD_1	474	476	PF00675	0.510
CLV_PCSK_KEX2_1	245	247	PF00082	0.641
CLV_PCSK_KEX2_1	361	363	PF00082	0.762
CLV_PCSK_KEX2_1	474	476	PF00082	0.453
CLV_PCSK_SKI1_1	208	212	PF00082	0.584
CLV_PCSK_SKI1_1	228	232	PF00082	0.549
CLV_PCSK_SKI1_1	237	241	PF00082	0.581
CLV_PCSK_SKI1_1	26	30	PF00082	0.749
DEG_Nend_UBRbox_2	1	3	PF02207	0.566
DOC_CDC14_PxL_1	272	280	PF14671	0.408
DOC_CDC14_PxL_1	342	350	PF14671	0.540
DOC_MAPK_gen_1	215	223	PF00069	0.377
DOC_MAPK_HePTP_8	450	462	PF00069	0.318
DOC_MAPK_MEF2A_6	453	462	PF00069	0.377
DOC_USP7_MATH_1	138	142	PF00917	0.548
DOC_USP7_MATH_1	235	239	PF00917	0.421
DOC_USP7_MATH_1	259	263	PF00917	0.439
DOC_USP7_MATH_1	356	360	PF00917	0.538
DOC_USP7_MATH_1	6	10	PF00917	0.570
DOC_USP7_UBL2_3	179	183	PF12436	0.483
DOC_WW_Pin1_4	346	351	PF00397	0.564
DOC_WW_Pin1_4	37	42	PF00397	0.566
DOC_WW_Pin1_4	426	431	PF00397	0.596
DOC_WW_Pin1_4	445	450	PF00397	0.529
LIG_14-3-3_CanoR_1	169	174	PF00244	0.381
LIG_14-3-3_CanoR_1	453	458	PF00244	0.377
LIG_14-3-3_CanoR_1	474	481	PF00244	0.591
LIG_14-3-3_CanoR_1	5	11	PF00244	0.434
LIG_Actin_WH2_2	264	281	PF00022	0.351
LIG_BRCT_BRCA1_1	455	459	PF00533	0.282
LIG_deltaCOP1_diTrp_1	298	308	PF00928	0.437
LIG_FHA_1	107	113	PF00498	0.444
LIG_FHA_2	258	264	PF00498	0.461
LIG_FHA_2	82	88	PF00498	0.552
LIG_Integrin_RGD_1	327	329	PF01839	0.686
LIG_LIR_Apic_2	399	405	PF02991	0.486
LIG_LIR_Gen_1	214	223	PF02991	0.336
LIG_LIR_Gen_1	456	467	PF02991	0.282
LIG_LIR_Nem_3	214	219	PF02991	0.342
LIG_LIR_Nem_3	269	275	PF02991	0.467
LIG_LIR_Nem_3	319	325	PF02991	0.459
LIG_LIR_Nem_3	451	455	PF02991	0.391
LIG_LIR_Nem_3	456	462	PF02991	0.396
LIG_MYND_1	346	350	PF01753	0.544
LIG_NRBOX	457	463	PF00104	0.397
LIG_PDZ_Class_1	479	484	PF00595	0.590
LIG_SH2_CRK	452	456	PF00017	0.318
LIG_SH2_PTP2	402	405	PF00017	0.529
LIG_SH2_SRC	173	176	PF00017	0.449
LIG_SH2_STAT5	16	19	PF00017	0.446
LIG_SH2_STAT5	173	176	PF00017	0.394
LIG_SH2_STAT5	282	285	PF00017	0.393
LIG_SH2_STAT5	331	334	PF00017	0.537
LIG_SH2_STAT5	402	405	PF00017	0.529
LIG_SH3_2	335	340	PF14604	0.531
LIG_SH3_3	220	226	PF00018	0.380
LIG_SH3_3	270	276	PF00018	0.396
LIG_SH3_3	332	338	PF00018	0.501
LIG_SH3_3	347	353	PF00018	0.508
LIG_SH3_3	38	44	PF00018	0.508
LIG_SH3_3	424	430	PF00018	0.521
LIG_SUMO_SIM_par_1	147	154	PF11976	0.462
LIG_SUMO_SIM_par_1	9	15	PF11976	0.536
LIG_TRAF2_1	119	122	PF00917	0.515
LIG_TRAF2_1	124	127	PF00917	0.570
LIG_TRAF2_2	353	358	PF00917	0.591
LIG_TYR_ITIM	450	455	PF00017	0.476
MOD_CDK_SPxK_1	346	352	PF00069	0.544
MOD_CK1_1	141	147	PF00069	0.540
MOD_CK1_1	40	46	PF00069	0.558
MOD_CK1_1	406	412	PF00069	0.600
MOD_CK1_1	415	421	PF00069	0.559
MOD_CK1_1	9	15	PF00069	0.582
MOD_GlcNHglycan	139	143	PF01048	0.743
MOD_GlcNHglycan	162	165	PF01048	0.631
MOD_GlcNHglycan	408	411	PF01048	0.734
MOD_GlcNHglycan	420	423	PF01048	0.701
MOD_GlcNHglycan	469	472	PF01048	0.257
MOD_GSK3_1	138	145	PF00069	0.576
MOD_GSK3_1	300	307	PF00069	0.434
MOD_GSK3_1	311	318	PF00069	0.457
MOD_GSK3_1	33	40	PF00069	0.600
MOD_GSK3_1	56	63	PF00069	0.551
MOD_N-GLC_1	329	334	PF02516	0.774
MOD_NEK2_1	151	156	PF00069	0.436
MOD_NEK2_1	203	208	PF00069	0.373
MOD_NEK2_1	467	472	PF00069	0.377
MOD_NEK2_1	60	65	PF00069	0.521
MOD_NEK2_2	235	240	PF00069	0.409
MOD_PIKK_1	300	306	PF00454	0.428
MOD_PIKK_1	403	409	PF00454	0.559
MOD_PK_1	453	459	PF00069	0.377
MOD_PKA_1	474	480	PF00069	0.622
MOD_PKA_2	309	315	PF00069	0.423
MOD_PKA_2	375	381	PF00069	0.503
MOD_PKA_2	383	389	PF00069	0.502
MOD_PKA_2	418	424	PF00069	0.541
MOD_PKA_2	474	480	PF00069	0.658
MOD_Plk_1	56	62	PF00069	0.593
MOD_Plk_2-3	106	112	PF00069	0.506
MOD_Plk_2-3	56	62	PF00069	0.560
MOD_Plk_4	169	175	PF00069	0.432
MOD_Plk_4	193	199	PF00069	0.416
MOD_Plk_4	453	459	PF00069	0.397
MOD_Plk_4	6	12	PF00069	0.461
MOD_ProDKin_1	346	352	PF00069	0.563
MOD_ProDKin_1	37	43	PF00069	0.566
MOD_ProDKin_1	426	432	PF00069	0.596
MOD_ProDKin_1	445	451	PF00069	0.522
MOD_SUMO_for_1	296	299	PF00179	0.418
TRG_ENDOCYTIC_2	452	455	PF00928	0.413
TRG_ER_diArg_1	361	364	PF00400	0.535
TRG_ER_diArg_1	379	382	PF00400	0.459
TRG_ER_diArg_1	473	475	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q7	Leptomonas seymouri	58%	96%
A0A3S7X2C7	Leishmania donovani	91%	100%
A4HH91	Leishmania braziliensis	70%	100%
A4I4D7	Leishmania infantum	92%	100%
C9ZL27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9ALZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%