Cysteine peptidase C (CPC)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like

Species:

Leishmania major

UniProt:

E9ADT5_LEIMA

TriTrypDb:

LmjF.29.0820 , LMJLV39_290013800 , LMJSD75_290013800

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	2
GO:0005615	extracellular space	2	2
GO:0005764	lysosome	7	2
GO:0005773	vacuole	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008219	cell death	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.444
CLV_NRD_NRD_1	70	72	PF00675	0.554
CLV_PCSK_KEX2_1	148	150	PF00082	0.422
CLV_PCSK_SKI1_1	275	279	PF00082	0.490
CLV_PCSK_SKI1_1	6	10	PF00082	0.666
DOC_CKS1_1	213	218	PF01111	0.346
DOC_MAPK_gen_1	241	250	PF00069	0.491
DOC_MAPK_gen_1	4	11	PF00069	0.609
DOC_MAPK_MEF2A_6	241	250	PF00069	0.413
DOC_PP1_RVXF_1	286	293	PF00149	0.346
DOC_USP7_MATH_1	207	211	PF00917	0.423
DOC_USP7_MATH_1	28	32	PF00917	0.676
DOC_WW_Pin1_4	212	217	PF00397	0.346
LIG_14-3-3_CanoR_1	138	143	PF00244	0.378
LIG_14-3-3_CanoR_1	148	156	PF00244	0.348
LIG_14-3-3_CanoR_1	4	12	PF00244	0.651
LIG_14-3-3_CanoR_1	87	92	PF00244	0.525
LIG_APCC_ABBA_1	260	265	PF00400	0.346
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	156	160	PF00533	0.447
LIG_CtBP_PxDLS_1	255	259	PF00389	0.257
LIG_deltaCOP1_diTrp_1	310	317	PF00928	0.348
LIG_EVH1_2	85	89	PF00568	0.519
LIG_FHA_1	150	156	PF00498	0.455
LIG_FHA_1	257	263	PF00498	0.411
LIG_FHA_1	79	85	PF00498	0.506
LIG_FHA_2	111	117	PF00498	0.367
LIG_FHA_2	209	215	PF00498	0.452
LIG_FHA_2	218	224	PF00498	0.367
LIG_IRF3_LxIS_1	109	115	PF10401	0.257
LIG_LIR_Apic_2	210	216	PF02991	0.383
LIG_LIR_Apic_2	24	30	PF02991	0.706
LIG_LIR_Gen_1	136	146	PF02991	0.365
LIG_LIR_Nem_3	136	142	PF02991	0.410
LIG_LIR_Nem_3	264	269	PF02991	0.358
LIG_LIR_Nem_3	271	277	PF02991	0.386
LIG_LIR_Nem_3	31	36	PF02991	0.533
LIG_LIR_Nem_3	313	319	PF02991	0.377
LIG_SH2_CRK	213	217	PF00017	0.384
LIG_SH2_CRK	27	31	PF00017	0.660
LIG_SH2_NCK_1	27	31	PF00017	0.628
LIG_SH2_STAP1	263	267	PF00017	0.365
LIG_SH2_STAT5	139	142	PF00017	0.389
LIG_SH2_STAT5	316	319	PF00017	0.346
LIG_SH2_STAT5	60	63	PF00017	0.535
LIG_SH3_3	189	195	PF00018	0.450
LIG_SH3_3	203	209	PF00018	0.368
LIG_SUMO_SIM_par_1	245	252	PF11976	0.452
LIG_SUMO_SIM_par_1	254	259	PF11976	0.374
LIG_TRAF2_1	337	340	PF00917	0.553
LIG_TRAF2_1	90	93	PF00917	0.425
LIG_TYR_ITIM	298	303	PF00017	0.323
LIG_WRC_WIRS_1	139	144	PF05994	0.379
LIG_WW_3	84	88	PF00397	0.518
MOD_CDK_SPK_2	212	217	PF00069	0.444
MOD_CK1_1	306	312	PF00069	0.409
MOD_CK2_1	110	116	PF00069	0.400
MOD_CK2_1	217	223	PF00069	0.438
MOD_CK2_1	63	69	PF00069	0.506
MOD_CK2_1	87	93	PF00069	0.438
MOD_CMANNOS	175	178	PF00535	0.419
MOD_GlcNHglycan	23	26	PF01048	0.433
MOD_GlcNHglycan	270	273	PF01048	0.407
MOD_GlcNHglycan	329	332	PF01048	0.323
MOD_GlcNHglycan	54	57	PF01048	0.561
MOD_GlcNHglycan	6	9	PF01048	0.583
MOD_GSK3_1	118	125	PF00069	0.371
MOD_GSK3_1	150	157	PF00069	0.416
MOD_GSK3_1	208	215	PF00069	0.445
MOD_GSK3_1	218	225	PF00069	0.375
MOD_GSK3_1	232	239	PF00069	0.291
MOD_GSK3_1	74	81	PF00069	0.500
MOD_N-GLC_1	218	223	PF02516	0.346
MOD_N-GLC_1	87	92	PF02516	0.573
MOD_N-GLC_2	324	326	PF02516	0.353
MOD_NEK2_1	110	115	PF00069	0.494
MOD_NEK2_1	150	155	PF00069	0.375
MOD_NEK2_1	18	23	PF00069	0.647
MOD_NEK2_1	256	261	PF00069	0.411
MOD_NEK2_1	36	41	PF00069	0.494
MOD_PIKK_1	291	297	PF00454	0.374
MOD_PK_1	87	93	PF00069	0.509
MOD_PKA_1	148	154	PF00069	0.444
MOD_PKA_2	148	154	PF00069	0.389
MOD_Plk_1	256	262	PF00069	0.404
MOD_Plk_1	87	93	PF00069	0.563
MOD_Plk_4	208	214	PF00069	0.458
MOD_Plk_4	36	42	PF00069	0.558
MOD_ProDKin_1	212	218	PF00069	0.346
MOD_SUMO_for_1	240	243	PF00179	0.424
TRG_DiLeu_BaEn_1	69	74	PF01217	0.502
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.649
TRG_ENDOCYTIC_2	139	142	PF00928	0.419
TRG_ENDOCYTIC_2	263	266	PF00928	0.319
TRG_ENDOCYTIC_2	274	277	PF00928	0.330
TRG_ENDOCYTIC_2	300	303	PF00928	0.346
TRG_ENDOCYTIC_2	316	319	PF00928	0.346
TRG_ER_diArg_1	148	150	PF00400	0.444
TRG_ER_FFAT_1	97	106	PF00635	0.374
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	31%	97%
A0A0N0P293	Leptomonas seymouri	27%	92%
A0A0N0P8D1	Leptomonas seymouri	62%	100%
A0A0N1PA65	Leptomonas seymouri	28%	73%
A0A0S4IN52	Bodo saltans	51%	100%
A0A0S4J328	Bodo saltans	26%	100%
A0A0S4J7T4	Bodo saltans	28%	67%
A0A0S4J918	Bodo saltans	27%	100%
A0A0S4JIQ4	Bodo saltans	23%	100%
A0A0S4JPQ2	Bodo saltans	27%	92%
A0A0S4JSZ3	Bodo saltans	24%	92%
A0A0S4JV57	Bodo saltans	31%	92%
A0A0S4JXJ3	Bodo saltans	24%	89%
A0A0S4KGP4	Bodo saltans	29%	100%
A0A0S4KI32	Bodo saltans	28%	100%
A0A0S4KJA5	Bodo saltans	25%	73%
A0A1X0NTV4	Trypanosomatidae	55%	100%
A0A1X0NXC8	Trypanosomatidae	24%	90%
A0A3R7N5T7	Trypanosoma rangeli	52%	100%
A0A3S5H682	Leishmania donovani	30%	86%
A0A3S5H683	Leishmania donovani	30%	77%
A0A3S5H684	Leishmania donovani	31%	77%
A0A3S5H685	Leishmania donovani	31%	77%
A0A3S7WQD0	Leishmania donovani	31%	77%
A0A422NMB7	Trypanosoma rangeli	31%	100%
A0A6L0WJ22	Leishmania infantum	31%	77%
A1E295	Sus scrofa	44%	100%
A1KXI0	Blomia tropicalis	28%	100%
A2XQE8	Oryza sativa subsp. indica	26%	100%
A4H5E4	Leishmania braziliensis	29%	77%
A4H5E5	Leishmania braziliensis	29%	77%
A4H5E6	Leishmania braziliensis	29%	77%
A4HA92	Leishmania braziliensis	29%	71%
A4HH90	Leishmania braziliensis	69%	100%
A4HTP0	Leishmania infantum	30%	89%
A4I4D6	Leishmania infantum	91%	100%
A5HII1	Actinidia deliciosa	29%	89%
B2LSD2	Mucuna pruriens	26%	79%
C9ZQ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3ZZ07	Rattus norvegicus	26%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	68%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	93%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	77%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
F4HVZ1	Arabidopsis thaliana	36%	90%
G5EGP8	Caenorhabditis elegans	25%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	25%	100%
O35186	Rattus norvegicus	29%	100%
O45734	Caenorhabditis elegans	28%	100%
O46427	Sus scrofa	29%	100%
O60911	Homo sapiens	29%	100%
O65039	Ricinus communis	31%	94%
O65493	Arabidopsis thaliana	27%	96%
O70370	Mus musculus	29%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	30%	100%
O97397	Phaedon cochleariae	29%	100%
O97578	Canis lupus familiaris	29%	78%
P00784	Carica papaya	27%	99%
P00785	Actinidia chinensis var. chinensis	28%	89%
P00786	Rattus norvegicus	29%	100%
P00787	Rattus norvegicus	45%	100%
P04988	Dictyostelium discoideum	23%	99%
P05167	Hordeum vulgare	31%	94%
P06797	Mus musculus	26%	100%
P07154	Rattus norvegicus	26%	100%
P07688	Bos taurus	44%	100%
P07711	Homo sapiens	28%	100%
P07858	Homo sapiens	44%	100%
P09668	Homo sapiens	27%	100%
P10056	Carica papaya	26%	98%
P10605	Mus musculus	46%	100%
P13277	Homarus americanus	26%	100%
P14080	Carica papaya	29%	97%
P15242	Rattus norvegicus	27%	100%
P16311	Dermatophagoides farinae	25%	100%
P19092	Haemonchus contortus	43%	99%
P22497	Theileria parva	29%	77%
P25249	Hordeum vulgare	26%	92%
P25250	Hordeum vulgare	26%	91%
P25326	Bos taurus	29%	100%
P25774	Homo sapiens	27%	100%
P25776	Oryza sativa subsp. japonica	29%	74%
P25777	Oryza sativa subsp. japonica	28%	73%
P25778	Oryza sativa subsp. japonica	31%	94%
P25779	Trypanosoma cruzi	31%	73%
P25782	Homarus americanus	30%	100%
P25784	Homarus americanus	29%	100%
P25792	Schistosoma mansoni	43%	100%
P25793	Haemonchus contortus	43%	99%
P25802	Ostertagia ostertagi	41%	100%
P25803	Phaseolus vulgaris	29%	94%
P25804	Pisum sativum	25%	94%
P25807	Caenorhabditis elegans	42%	100%
P25975	Bos taurus	28%	100%
P36184	Entamoeba histolytica	26%	100%
P36185	Entamoeba histolytica	28%	100%
P36400	Leishmania mexicana	30%	77%
P43157	Schistosoma japonicum	42%	99%
P43233	Gallus gallus	42%	100%
P43234	Homo sapiens	27%	100%
P43236	Oryctolagus cuniculus	28%	100%
P43295	Arabidopsis thaliana	24%	94%
P43296	Arabidopsis thaliana	25%	92%
P43297	Arabidopsis thaliana	27%	74%
P43507	Caenorhabditis elegans	44%	92%
P43508	Caenorhabditis elegans	41%	100%
P43509	Caenorhabditis elegans	44%	99%
P43510	Caenorhabditis elegans	46%	90%
P49935	Mus musculus	29%	100%
P53634	Homo sapiens	30%	73%
P54640	Dictyostelium discoideum	26%	99%
P55097	Mus musculus	28%	100%
P56202	Homo sapiens	29%	90%
P56203	Mus musculus	28%	92%
P80067	Rattus norvegicus	29%	74%
P83205	Ovis aries	45%	100%
P90850	Caenorhabditis elegans	33%	75%
P92131	Giardia intestinalis	36%	100%
P92132	Giardia intestinalis	37%	100%
P92133	Giardia intestinalis	38%	100%
P97821	Mus musculus	29%	74%
Q01957	Entamoeba histolytica	28%	100%
Q01958	Entamoeba histolytica	27%	100%
Q02765	Rattus norvegicus	30%	100%
Q05094	Leishmania pifanoi	30%	77%
Q06964	Entamoeba histolytica	26%	100%
Q10716	Zea mays	25%	92%
Q10717	Zea mays	31%	94%
Q1EIQ3	Psoroptes ovis	23%	100%
Q23894	Dictyostelium discoideum	26%	100%
Q24940	Fasciola hepatica	28%	100%
Q26534	Schistosoma mansoni	27%	100%
Q26563	Schistosoma mansoni	34%	75%
Q26636	Sarcophaga peregrina	29%	100%
Q28944	Sus scrofa	28%	100%
Q3SZI1	Bos taurus	33%	71%
Q3T0I2	Bos taurus	29%	100%
Q3ZCJ8	Bos taurus	32%	73%
Q3ZKN1	Canis lupus familiaris	27%	100%
Q40143	Solanum lycopersicum	30%	96%
Q4QI61	Leishmania major	31%	77%
Q4QI62	Leishmania major	31%	98%
Q4QI64	Leishmania major	31%	98%
Q4QI65	Leishmania major	31%	98%
Q4QI66	Leishmania major	31%	77%
Q4QI67	Leishmania major	31%	98%
Q4QI68	Leishmania major	31%	98%
Q4R5M2	Macaca fascicularis	45%	100%
Q54QD9	Dictyostelium discoideum	40%	100%
Q5E998	Bos taurus	27%	100%
Q5R6D1	Pongo abelii	45%	100%
Q5RB02	Pongo abelii	30%	73%
Q60HG6	Macaca fascicularis	31%	73%
Q63088	Rattus norvegicus	28%	100%
Q6PN98	Onchocerca volvulus	27%	100%
Q6YD92	Petrosia ficiformis	27%	100%
Q7F3A8	Oryza sativa subsp. japonica	28%	92%
Q7GDU7	Oryza sativa subsp. japonica	29%	90%
Q7XWK5	Oryza sativa subsp. japonica	26%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	27%	100%
Q80UB0	Mus musculus	29%	100%
Q86GF7	Pandalus borealis	27%	100%
Q8BM88	Mus musculus	28%	100%
Q8H166	Arabidopsis thaliana	33%	95%
Q8HY81	Canis lupus familiaris	28%	100%
Q8HY82	Saimiri boliviensis boliviensis	27%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	28%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	29%	93%
Q90686	Gallus gallus	28%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	29%	100%
Q91FU7	Invertebrate iridescent virus 6	26%	76%
Q91ZF2	Mus musculus	25%	100%
Q93VC9	Arabidopsis thaliana	40%	94%
Q94B08	Arabidopsis thaliana	29%	90%
Q94K85	Arabidopsis thaliana	40%	95%
Q95029	Drosophila melanogaster	29%	92%
Q99JR5	Mus musculus	31%	73%
Q9BIE1	Leishmania donovani	29%	96%
Q9EQT5	Rattus norvegicus	32%	73%
Q9FMH8	Arabidopsis thaliana	29%	73%
Q9GKL8	Chlorocebus aethiops	28%	100%
Q9GL24	Canis lupus familiaris	27%	100%
Q9GLE3	Sus scrofa	28%	100%
Q9GQM5	Leishmania donovani	91%	100%
Q9GZM7	Homo sapiens	31%	73%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	27%	100%
Q9JI81	Mus musculus	28%	100%
Q9JIA9	Mus musculus	27%	100%
Q9JL96	Mus musculus	27%	100%
Q9LT77	Arabidopsis thaliana	30%	94%
Q9LT78	Arabidopsis thaliana	26%	75%
Q9LXW3	Arabidopsis thaliana	28%	90%
Q9PYY5	Xestia c-nigrum granulosis virus	32%	98%
Q9QZE3	Rattus norvegicus	29%	99%
Q9R013	Mus musculus	23%	74%
Q9R014	Mus musculus	28%	100%
Q9STL4	Arabidopsis thaliana	29%	94%
Q9SUL1	Arabidopsis thaliana	24%	91%
Q9UJW2	Homo sapiens	31%	71%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	26%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	26%	96%
V5B261	Trypanosoma cruzi	26%	87%
V5LU01	Ambrosia artemisiifolia	27%	88%