Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADT4_LEIMA

TriTrypDb:

LmjF.29.0810 , LMJLV39_290013700 , LMJSD75_290013700

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ADT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.671
CLV_C14_Caspase3-7	244	248	PF00656	0.602
CLV_C14_Caspase3-7	254	258	PF00656	0.617
CLV_C14_Caspase3-7	305	309	PF00656	0.651
CLV_C14_Caspase3-7	355	359	PF00656	0.683
CLV_NRD_NRD_1	290	292	PF00675	0.374
CLV_NRD_NRD_1	347	349	PF00675	0.450
CLV_NRD_NRD_1	468	470	PF00675	0.434
CLV_NRD_NRD_1	471	473	PF00675	0.434
CLV_NRD_NRD_1	531	533	PF00675	0.437
CLV_NRD_NRD_1	568	570	PF00675	0.414
CLV_NRD_NRD_1	85	87	PF00675	0.661
CLV_PCSK_FUR_1	288	292	PF00082	0.365
CLV_PCSK_FUR_1	469	473	PF00082	0.491
CLV_PCSK_FUR_1	532	536	PF00082	0.423
CLV_PCSK_KEX2_1	290	292	PF00082	0.374
CLV_PCSK_KEX2_1	347	349	PF00082	0.450
CLV_PCSK_KEX2_1	468	470	PF00082	0.434
CLV_PCSK_KEX2_1	471	473	PF00082	0.434
CLV_PCSK_KEX2_1	531	533	PF00082	0.436
CLV_PCSK_KEX2_1	534	536	PF00082	0.389
CLV_PCSK_KEX2_1	85	87	PF00082	0.661
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.412
CLV_PCSK_PC7_1	464	470	PF00082	0.488
CLV_PCSK_SKI1_1	168	172	PF00082	0.453
CLV_PCSK_SKI1_1	191	195	PF00082	0.326
CLV_PCSK_SKI1_1	539	543	PF00082	0.401
DEG_Kelch_Keap1_1	313	318	PF01344	0.636
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DOC_ANK_TNKS_1	399	406	PF00023	0.735
DOC_CYCLIN_RxL_1	188	197	PF00134	0.587
DOC_CYCLIN_RxL_1	534	543	PF00134	0.598
DOC_MAPK_gen_1	181	189	PF00069	0.625
DOC_USP7_MATH_1	129	133	PF00917	0.581
DOC_USP7_MATH_1	148	152	PF00917	0.585
DOC_USP7_MATH_1	303	307	PF00917	0.647
DOC_USP7_MATH_1	329	333	PF00917	0.598
DOC_WW_Pin1_4	299	304	PF00397	0.633
DOC_WW_Pin1_4	4	9	PF00397	0.639
DOC_WW_Pin1_4	73	78	PF00397	0.457
LIG_14-3-3_CanoR_1	162	171	PF00244	0.634
LIG_14-3-3_CanoR_1	23	31	PF00244	0.804
LIG_14-3-3_CanoR_1	372	377	PF00244	0.696
LIG_14-3-3_CanoR_1	390	398	PF00244	0.701
LIG_14-3-3_CanoR_1	68	77	PF00244	0.417
LIG_APCC_ABBA_1	292	297	PF00400	0.588
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.585
LIG_deltaCOP1_diTrp_1	606	614	PF00928	0.734
LIG_FHA_1	175	181	PF00498	0.590
LIG_FHA_1	26	32	PF00498	0.756
LIG_FHA_1	45	51	PF00498	0.335
LIG_FHA_2	208	214	PF00498	0.659
LIG_FHA_2	223	229	PF00498	0.606
LIG_FHA_2	507	513	PF00498	0.743
LIG_LIR_Gen_1	184	194	PF02991	0.675
LIG_LIR_Gen_1	274	283	PF02991	0.529
LIG_LIR_Gen_1	540	549	PF02991	0.596
LIG_LIR_Gen_1	57	66	PF02991	0.621
LIG_LIR_Gen_1	78	87	PF02991	0.484
LIG_LIR_Nem_3	184	189	PF02991	0.685
LIG_LIR_Nem_3	240	245	PF02991	0.664
LIG_LIR_Nem_3	540	545	PF02991	0.535
LIG_LIR_Nem_3	57	63	PF02991	0.388
LIG_LIR_Nem_3	78	83	PF02991	0.477
LIG_PDZ_Class_3	612	617	PF00595	0.684
LIG_SH2_CRK	422	426	PF00017	0.636
LIG_SH2_CRK	60	64	PF00017	0.522
LIG_SH2_PTP2	186	189	PF00017	0.589
LIG_SH2_STAP1	18	22	PF00017	0.726
LIG_SH2_STAP1	422	426	PF00017	0.645
LIG_SH2_STAT3	451	454	PF00017	0.650
LIG_SH2_STAT5	186	189	PF00017	0.589
LIG_SH2_STAT5	277	280	PF00017	0.528
LIG_SH2_STAT5	362	365	PF00017	0.603
LIG_SH2_STAT5	451	454	PF00017	0.636
LIG_SH3_1	409	415	PF00018	0.711
LIG_SH3_3	323	329	PF00018	0.684
LIG_SH3_3	380	386	PF00018	0.697
LIG_SH3_3	409	415	PF00018	0.711
LIG_SH3_3	5	11	PF00018	0.693
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.426
LIG_TRAF2_1	463	466	PF00917	0.696
LIG_TRAF2_1	517	520	PF00917	0.701
LIG_TRAF2_1	564	567	PF00917	0.554
LIG_TYR_ITIM	58	63	PF00017	0.619
LIG_UBA3_1	541	550	PF00899	0.584
MOD_CK1_1	132	138	PF00069	0.298
MOD_CK1_1	208	214	PF00069	0.686
MOD_CK1_1	26	32	PF00069	0.747
MOD_CK1_1	3	9	PF00069	0.670
MOD_CK1_1	78	84	PF00069	0.489
MOD_CK2_1	222	228	PF00069	0.564
MOD_CK2_1	361	367	PF00069	0.671
MOD_CK2_1	378	384	PF00069	0.606
MOD_CK2_1	460	466	PF00069	0.646
MOD_CK2_1	492	498	PF00069	0.752
MOD_CK2_1	506	512	PF00069	0.625
MOD_CK2_1	561	567	PF00069	0.553
MOD_CK2_1	88	94	PF00069	0.423
MOD_GlcNHglycan	134	137	PF01048	0.452
MOD_GlcNHglycan	150	153	PF01048	0.456
MOD_GlcNHglycan	159	162	PF01048	0.464
MOD_GlcNHglycan	2	5	PF01048	0.554
MOD_GlcNHglycan	239	242	PF01048	0.441
MOD_GlcNHglycan	28	31	PF01048	0.512
MOD_GlcNHglycan	315	318	PF01048	0.459
MOD_GlcNHglycan	363	366	PF01048	0.534
MOD_GlcNHglycan	456	459	PF01048	0.395
MOD_GlcNHglycan	50	53	PF01048	0.458
MOD_GlcNHglycan	583	587	PF01048	0.513
MOD_GSK3_1	205	212	PF00069	0.699
MOD_GSK3_1	22	29	PF00069	0.733
MOD_GSK3_1	299	306	PF00069	0.642
MOD_GSK3_1	44	51	PF00069	0.436
MOD_GSK3_1	548	555	PF00069	0.567
MOD_GSK3_1	68	75	PF00069	0.515
MOD_NEK2_1	157	162	PF00069	0.667
MOD_NEK2_1	2	7	PF00069	0.680
MOD_NEK2_1	237	242	PF00069	0.589
MOD_NEK2_1	266	271	PF00069	0.540
MOD_NEK2_1	48	53	PF00069	0.388
MOD_NEK2_1	54	59	PF00069	0.345
MOD_NEK2_1	548	553	PF00069	0.566
MOD_NEK2_2	251	256	PF00069	0.605
MOD_PKA_2	22	28	PF00069	0.810
MOD_PKA_2	313	319	PF00069	0.639
MOD_PKA_2	378	384	PF00069	0.701
MOD_PKB_1	86	94	PF00069	0.495
MOD_Plk_1	215	221	PF00069	0.584
MOD_Plk_1	393	399	PF00069	0.676
MOD_Plk_2-3	492	498	PF00069	0.752
MOD_Plk_4	169	175	PF00069	0.632
MOD_Plk_4	266	272	PF00069	0.540
MOD_Plk_4	372	378	PF00069	0.690
MOD_Plk_4	393	399	PF00069	0.676
MOD_Plk_4	54	60	PF00069	0.430
MOD_Plk_4	75	81	PF00069	0.440
MOD_ProDKin_1	299	305	PF00069	0.632
MOD_ProDKin_1	4	10	PF00069	0.640
MOD_ProDKin_1	73	79	PF00069	0.454
MOD_SUMO_rev_2	107	115	PF00179	0.417
MOD_SUMO_rev_2	160	170	PF00179	0.652
MOD_SUMO_rev_2	510	517	PF00179	0.652
TRG_DiLeu_BaEn_1	444	449	PF01217	0.692
TRG_ENDOCYTIC_2	186	189	PF00928	0.671
TRG_ENDOCYTIC_2	242	245	PF00928	0.606
TRG_ENDOCYTIC_2	277	280	PF00928	0.528
TRG_ENDOCYTIC_2	422	425	PF00928	0.647
TRG_ENDOCYTIC_2	60	63	PF00928	0.619
TRG_ER_diArg_1	118	121	PF00400	0.394
TRG_ER_diArg_1	287	290	PF00400	0.560
TRG_ER_diArg_1	467	469	PF00400	0.682
TRG_ER_diArg_1	85	88	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7X5	Leptomonas seymouri	46%	100%
A0A3S7X291	Leishmania donovani	91%	100%
A4HH89	Leishmania braziliensis	72%	100%
A4I4D5	Leishmania infantum	91%	100%
E9ALZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%