Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADT3_LEIMA

TriTrypDb:

LmjF.29.0805 , LMJLV39_290013600 , LMJSD75_290013600

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.831
CLV_C14_Caspase3-7	277	281	PF00656	0.762
CLV_C14_Caspase3-7	348	352	PF00656	0.653
CLV_NRD_NRD_1	15	17	PF00675	0.634
CLV_NRD_NRD_1	272	274	PF00675	0.701
CLV_NRD_NRD_1	344	346	PF00675	0.825
CLV_NRD_NRD_1	427	429	PF00675	0.831
CLV_NRD_NRD_1	491	493	PF00675	0.577
CLV_NRD_NRD_1	574	576	PF00675	0.713
CLV_PCSK_KEX2_1	137	139	PF00082	0.792
CLV_PCSK_KEX2_1	15	17	PF00082	0.634
CLV_PCSK_KEX2_1	272	274	PF00082	0.701
CLV_PCSK_KEX2_1	316	318	PF00082	0.593
CLV_PCSK_KEX2_1	427	429	PF00082	0.670
CLV_PCSK_KEX2_1	491	493	PF00082	0.577
CLV_PCSK_KEX2_1	574	576	PF00082	0.713
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.719
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.593
CLV_PCSK_SKI1_1	102	106	PF00082	0.834
CLV_PCSK_SKI1_1	28	32	PF00082	0.400
CLV_PCSK_SKI1_1	448	452	PF00082	0.732
CLV_PCSK_SKI1_1	588	592	PF00082	0.600
DEG_APCC_DBOX_1	27	35	PF00400	0.649
DEG_Nend_Nbox_1	1	3	PF02207	0.765
DEG_SCF_FBW7_1	103	110	PF00400	0.713
DEG_SCF_FBW7_1	171	177	PF00400	0.713
DEG_SPOP_SBC_1	163	167	PF00917	0.785
DEG_SPOP_SBC_1	54	58	PF00917	0.766
DEG_SPOP_SBC_1	61	65	PF00917	0.744
DEG_SPOP_SBC_1	83	87	PF00917	0.758
DOC_CKS1_1	104	109	PF01111	0.709
DOC_CKS1_1	124	129	PF01111	0.618
DOC_CKS1_1	171	176	PF01111	0.713
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	332	335	PF00134	0.577
DOC_MAPK_gen_1	432	439	PF00069	0.728
DOC_MAPK_gen_1	474	483	PF00069	0.722
DOC_MAPK_gen_1	553	561	PF00069	0.667
DOC_PP2B_LxvP_1	332	335	PF13499	0.577
DOC_USP7_MATH_1	107	111	PF00917	0.710
DOC_USP7_MATH_1	128	132	PF00917	0.803
DOC_USP7_MATH_1	164	168	PF00917	0.794
DOC_USP7_MATH_1	206	210	PF00917	0.661
DOC_USP7_MATH_1	230	234	PF00917	0.695
DOC_USP7_MATH_1	236	240	PF00917	0.632
DOC_USP7_MATH_1	274	278	PF00917	0.670
DOC_USP7_MATH_1	301	305	PF00917	0.646
DOC_USP7_MATH_1	341	345	PF00917	0.597
DOC_USP7_MATH_1	360	364	PF00917	0.631
DOC_USP7_MATH_1	417	421	PF00917	0.797
DOC_USP7_MATH_1	579	583	PF00917	0.605
DOC_USP7_MATH_1	83	87	PF00917	0.758
DOC_WW_Pin1_4	103	108	PF00397	0.508
DOC_WW_Pin1_4	111	116	PF00397	0.749
DOC_WW_Pin1_4	123	128	PF00397	0.549
DOC_WW_Pin1_4	148	153	PF00397	0.711
DOC_WW_Pin1_4	170	175	PF00397	0.721
DOC_WW_Pin1_4	226	231	PF00397	0.731
DOC_WW_Pin1_4	280	285	PF00397	0.714
DOC_WW_Pin1_4	291	296	PF00397	0.752
DOC_WW_Pin1_4	421	426	PF00397	0.738
DOC_WW_Pin1_4	84	89	PF00397	0.824
LIG_14-3-3_CanoR_1	102	107	PF00244	0.712
LIG_14-3-3_CanoR_1	138	146	PF00244	0.669
LIG_14-3-3_CanoR_1	251	255	PF00244	0.653
LIG_14-3-3_CanoR_1	405	415	PF00244	0.812
LIG_14-3-3_CanoR_1	416	426	PF00244	0.621
LIG_14-3-3_CanoR_1	477	483	PF00244	0.802
LIG_14-3-3_CanoR_1	545	551	PF00244	0.770
LIG_BRCT_BRCA1_1	434	438	PF00533	0.805
LIG_BRCT_BRCA1_1	51	55	PF00533	0.629
LIG_EH_1	399	403	PF12763	0.709
LIG_FHA_1	120	126	PF00498	0.702
LIG_FHA_1	166	172	PF00498	0.727
LIG_FHA_1	284	290	PF00498	0.837
LIG_FHA_1	434	440	PF00498	0.743
LIG_FHA_1	449	455	PF00498	0.616
LIG_FHA_1	547	553	PF00498	0.709
LIG_FHA_1	554	560	PF00498	0.581
LIG_FHA_1	8	14	PF00498	0.697
LIG_FHA_2	1	7	PF00498	0.738
LIG_FHA_2	104	110	PF00498	0.744
LIG_FHA_2	229	235	PF00498	0.683
LIG_FHA_2	245	251	PF00498	0.480
LIG_FHA_2	292	298	PF00498	0.744
LIG_FHA_2	310	316	PF00498	0.703
LIG_FHA_2	369	375	PF00498	0.737
LIG_FHA_2	386	392	PF00498	0.528
LIG_LIR_Apic_2	48	54	PF02991	0.770
LIG_LIR_Gen_1	260	269	PF02991	0.724
LIG_LIR_Gen_1	293	303	PF02991	0.807
LIG_LIR_Gen_1	586	595	PF02991	0.639
LIG_LIR_Gen_1	97	108	PF02991	0.645
LIG_LIR_Nem_3	260	264	PF02991	0.695
LIG_LIR_Nem_3	293	299	PF02991	0.810
LIG_LIR_Nem_3	372	378	PF02991	0.714
LIG_LIR_Nem_3	586	592	PF02991	0.637
LIG_LIR_Nem_3	6	12	PF02991	0.704
LIG_LIR_Nem_3	97	103	PF02991	0.651
LIG_Pex14_1	257	261	PF04695	0.669
LIG_Pex14_1	585	589	PF04695	0.714
LIG_PTAP_UEV_1	87	92	PF05743	0.818
LIG_REV1ctd_RIR_1	188	198	PF16727	0.568
LIG_SH2_CRK	261	265	PF00017	0.702
LIG_SH2_CRK	51	55	PF00017	0.789
LIG_SH2_CRK	589	593	PF00017	0.640
LIG_SH2_NCK_1	51	55	PF00017	0.789
LIG_SH2_STAP1	9	13	PF00017	0.691
LIG_SH2_STAT3	565	568	PF00017	0.694
LIG_SH2_STAT5	378	381	PF00017	0.771
LIG_SH2_STAT5	9	12	PF00017	0.692
LIG_SH3_3	101	107	PF00018	0.565
LIG_SH3_3	124	130	PF00018	0.821
LIG_SH3_3	285	291	PF00018	0.681
LIG_SH3_3	419	425	PF00018	0.735
LIG_SH3_3	434	440	PF00018	0.746
LIG_SH3_3	69	75	PF00018	0.750
LIG_SH3_3	85	91	PF00018	0.821
LIG_TRAF2_1	389	392	PF00917	0.592
LIG_TRAF2_1	4	7	PF00917	0.718
LIG_TRAF2_1	570	573	PF00917	0.575
MOD_CDC14_SPxK_1	424	427	PF00782	0.744
MOD_CDK_SPxK_1	170	176	PF00069	0.714
MOD_CDK_SPxK_1	421	427	PF00069	0.741
MOD_CDK_SPxxK_3	421	428	PF00069	0.743
MOD_CK1_1	119	125	PF00069	0.659
MOD_CK1_1	136	142	PF00069	0.596
MOD_CK1_1	151	157	PF00069	0.659
MOD_CK1_1	165	171	PF00069	0.651
MOD_CK1_1	172	178	PF00069	0.606
MOD_CK1_1	201	207	PF00069	0.814
MOD_CK1_1	225	231	PF00069	0.826
MOD_CK1_1	283	289	PF00069	0.838
MOD_CK1_1	363	369	PF00069	0.659
MOD_CK1_1	49	55	PF00069	0.702
MOD_CK1_1	56	62	PF00069	0.709
MOD_CK1_1	63	69	PF00069	0.632
MOD_CK1_1	76	82	PF00069	0.818
MOD_CK1_1	86	92	PF00069	0.666
MOD_CK2_1	1	7	PF00069	0.738
MOD_CK2_1	103	109	PF00069	0.789
MOD_CK2_1	201	207	PF00069	0.698
MOD_CK2_1	228	234	PF00069	0.829
MOD_CK2_1	236	242	PF00069	0.746
MOD_CK2_1	244	250	PF00069	0.418
MOD_CK2_1	368	374	PF00069	0.743
MOD_CK2_1	385	391	PF00069	0.524
MOD_GlcNHglycan	109	112	PF01048	0.723
MOD_GlcNHglycan	118	121	PF01048	0.654
MOD_GlcNHglycan	195	198	PF01048	0.653
MOD_GlcNHglycan	224	227	PF01048	0.776
MOD_GlcNHglycan	238	241	PF01048	0.653
MOD_GlcNHglycan	267	270	PF01048	0.626
MOD_GlcNHglycan	3	6	PF01048	0.612
MOD_GlcNHglycan	303	306	PF01048	0.793
MOD_GlcNHglycan	318	321	PF01048	0.580
MOD_GlcNHglycan	365	368	PF01048	0.620
MOD_GlcNHglycan	408	411	PF01048	0.721
MOD_GlcNHglycan	419	422	PF01048	0.611
MOD_GlcNHglycan	47	51	PF01048	0.604
MOD_GlcNHglycan	519	522	PF01048	0.791
MOD_GlcNHglycan	542	545	PF01048	0.780
MOD_GlcNHglycan	576	579	PF01048	0.725
MOD_GlcNHglycan	581	584	PF01048	0.632
MOD_GlcNHglycan	59	62	PF01048	0.678
MOD_GlcNHglycan	78	81	PF01048	0.820
MOD_GlcNHglycan	88	91	PF01048	0.656
MOD_GSK3_1	103	110	PF00069	0.816
MOD_GSK3_1	116	123	PF00069	0.629
MOD_GSK3_1	133	140	PF00069	0.583
MOD_GSK3_1	147	154	PF00069	0.710
MOD_GSK3_1	163	170	PF00069	0.561
MOD_GSK3_1	201	208	PF00069	0.795
MOD_GSK3_1	222	229	PF00069	0.767
MOD_GSK3_1	279	286	PF00069	0.671
MOD_GSK3_1	354	361	PF00069	0.723
MOD_GSK3_1	417	424	PF00069	0.795
MOD_GSK3_1	45	52	PF00069	0.612
MOD_GSK3_1	490	497	PF00069	0.622
MOD_GSK3_1	53	60	PF00069	0.611
MOD_GSK3_1	61	68	PF00069	0.496
MOD_GSK3_1	79	86	PF00069	0.702
MOD_N-GLC_1	363	368	PF02516	0.752
MOD_NEK2_1	264	269	PF00069	0.708
MOD_NEK2_1	45	50	PF00069	0.593
MOD_NEK2_1	55	60	PF00069	0.579
MOD_NEK2_1	94	99	PF00069	0.780
MOD_NEK2_2	433	438	PF00069	0.727
MOD_PIKK_1	120	126	PF00454	0.759
MOD_PKA_1	137	143	PF00069	0.673
MOD_PKA_1	272	278	PF00069	0.674
MOD_PKA_1	316	322	PF00069	0.600
MOD_PKA_1	574	580	PF00069	0.723
MOD_PKA_1	73	79	PF00069	0.747
MOD_PKA_2	137	143	PF00069	0.673
MOD_PKA_2	193	199	PF00069	0.653
MOD_PKA_2	250	256	PF00069	0.653
MOD_PKA_2	272	278	PF00069	0.791
MOD_PKA_2	316	322	PF00069	0.600
MOD_PKA_2	341	347	PF00069	0.619
MOD_PKA_2	476	482	PF00069	0.641
MOD_PKA_2	490	496	PF00069	0.627
MOD_PKA_2	573	579	PF00069	0.724
MOD_PKA_2	76	82	PF00069	0.829
MOD_Plk_1	206	212	PF00069	0.814
MOD_Plk_1	22	28	PF00069	0.488
MOD_Plk_1	249	255	PF00069	0.582
MOD_Plk_1	37	43	PF00069	0.581
MOD_Plk_1	46	52	PF00069	0.519
MOD_Plk_4	128	134	PF00069	0.842
MOD_Plk_4	22	28	PF00069	0.429
MOD_Plk_4	433	439	PF00069	0.725
MOD_ProDKin_1	103	109	PF00069	0.510
MOD_ProDKin_1	111	117	PF00069	0.750
MOD_ProDKin_1	123	129	PF00069	0.549
MOD_ProDKin_1	148	154	PF00069	0.713
MOD_ProDKin_1	170	176	PF00069	0.722
MOD_ProDKin_1	226	232	PF00069	0.731
MOD_ProDKin_1	280	286	PF00069	0.715
MOD_ProDKin_1	291	297	PF00069	0.750
MOD_ProDKin_1	421	427	PF00069	0.741
MOD_ProDKin_1	84	90	PF00069	0.823
MOD_SUMO_rev_2	131	139	PF00179	0.736
TRG_DiLeu_BaEn_1	260	265	PF01217	0.699
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.722
TRG_ENDOCYTIC_2	261	264	PF00928	0.699
TRG_ENDOCYTIC_2	589	592	PF00928	0.718
TRG_ER_diArg_1	15	17	PF00400	0.634
TRG_ER_diArg_1	271	273	PF00400	0.701
TRG_ER_diArg_1	426	428	PF00400	0.752
TRG_ER_diArg_1	558	561	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIM2	Leishmania donovani	90%	100%
A4HH88	Leishmania braziliensis	70%	100%
A4I4D4	Leishmania infantum	90%	100%
E9ALZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%