Nucleoporin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleoporin

Gene product:

Nucleoporin NUP53b

Species:

Leishmania major

UniProt:

E9ADT2_LEIMA

TriTrypDb:

LmjF.29.0800 , LMJLV39_290013500 , LMJSD75_290013500

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0032991	protein-containing complex	1	2
GO:0044613	nuclear pore central transport channel	3	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9ADT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.550
CLV_NRD_NRD_1	270	272	PF00675	0.576
CLV_NRD_NRD_1	336	338	PF00675	0.487
CLV_NRD_NRD_1	412	414	PF00675	0.395
CLV_NRD_NRD_1	443	445	PF00675	0.653
CLV_PCSK_KEX2_1	201	203	PF00082	0.410
CLV_PCSK_KEX2_1	270	272	PF00082	0.576
CLV_PCSK_KEX2_1	336	338	PF00082	0.487
CLV_PCSK_KEX2_1	443	445	PF00082	0.595
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.410
CLV_PCSK_PC7_1	197	203	PF00082	0.394
CLV_PCSK_SKI1_1	18	22	PF00082	0.625
CLV_PCSK_SKI1_1	238	242	PF00082	0.575
CLV_PCSK_SKI1_1	413	417	PF00082	0.479
DEG_APCC_DBOX_1	237	245	PF00400	0.578
DEG_APCC_DBOX_1	269	277	PF00400	0.558
DEG_SPOP_SBC_1	232	236	PF00917	0.614
DEG_SPOP_SBC_1	469	473	PF00917	0.666
DEG_SPOP_SBC_1	484	488	PF00917	0.505
DEG_SPOP_SBC_1	54	58	PF00917	0.531
DOC_CDC14_PxL_1	450	458	PF14671	0.677
DOC_CYCLIN_RxL_1	408	417	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	352	355	PF00134	0.641
DOC_MAPK_gen_1	201	207	PF00069	0.573
DOC_PP1_RVXF_1	160	167	PF00149	0.504
DOC_PP2B_LxvP_1	352	355	PF13499	0.641
DOC_PP4_FxxP_1	451	454	PF00568	0.678
DOC_PP4_FxxP_1	520	523	PF00568	0.591
DOC_USP7_MATH_1	101	105	PF00917	0.709
DOC_USP7_MATH_1	224	228	PF00917	0.648
DOC_USP7_MATH_1	230	234	PF00917	0.558
DOC_USP7_MATH_1	317	321	PF00917	0.749
DOC_USP7_MATH_1	326	330	PF00917	0.511
DOC_USP7_MATH_1	362	366	PF00917	0.767
DOC_USP7_MATH_1	445	449	PF00917	0.586
DOC_USP7_MATH_1	584	588	PF00917	0.731
DOC_USP7_MATH_1	633	637	PF00917	0.708
DOC_WW_Pin1_4	25	30	PF00397	0.679
DOC_WW_Pin1_4	322	327	PF00397	0.660
DOC_WW_Pin1_4	443	448	PF00397	0.646
DOC_WW_Pin1_4	582	587	PF00397	0.581
LIG_Actin_WH2_2	345	362	PF00022	0.679
LIG_Actin_WH2_2	381	398	PF00022	0.524
LIG_APCC_ABBAyCdc20_2	190	196	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	103	107	PF00533	0.695
LIG_BRCT_BRCA1_1	447	451	PF00533	0.661
LIG_FHA_1	110	116	PF00498	0.608
LIG_FHA_1	159	165	PF00498	0.517
LIG_FHA_1	168	174	PF00498	0.579
LIG_FHA_1	485	491	PF00498	0.636
LIG_FHA_1	523	529	PF00498	0.567
LIG_FHA_2	344	350	PF00498	0.487
LIG_FHA_2	447	453	PF00498	0.648
LIG_GBD_Chelix_1	330	338	PF00786	0.536
LIG_LIR_Apic_2	448	454	PF02991	0.671
LIG_LIR_Apic_2	517	523	PF02991	0.671
LIG_LIR_Gen_1	163	173	PF02991	0.505
LIG_LIR_Gen_1	325	334	PF02991	0.563
LIG_LIR_Nem_3	163	169	PF02991	0.499
LIG_LIR_Nem_3	2	6	PF02991	0.718
LIG_LIR_Nem_3	234	240	PF02991	0.525
LIG_LIR_Nem_3	325	330	PF02991	0.605
LIG_LIR_Nem_3	448	453	PF02991	0.647
LIG_LYPXL_yS_3	148	151	PF13949	0.584
LIG_MLH1_MIPbox_1	447	451	PF16413	0.661
LIG_NRP_CendR_1	648	650	PF00754	0.730
LIG_PTAP_UEV_1	598	603	PF05743	0.645
LIG_SH2_CRK	237	241	PF00017	0.582
LIG_SH2_GRB2like	206	209	PF00017	0.591
LIG_SH2_STAP1	286	290	PF00017	0.471
LIG_SH2_STAT5	204	207	PF00017	0.582
LIG_SH2_STAT5	450	453	PF00017	0.632
LIG_SH3_2	355	360	PF14604	0.563
LIG_SH3_3	135	141	PF00018	0.666
LIG_SH3_3	287	293	PF00018	0.476
LIG_SH3_3	352	358	PF00018	0.541
LIG_SH3_3	451	457	PF00018	0.676
LIG_SH3_3	596	602	PF00018	0.778
LIG_SH3_3	603	609	PF00018	0.646
LIG_UBA3_1	240	248	PF00899	0.573
LIG_WRC_WIRS_1	189	194	PF05994	0.572
LIG_WW_2	454	457	PF00397	0.674
MOD_CK1_1	109	115	PF00069	0.601
MOD_CK1_1	167	173	PF00069	0.586
MOD_CK1_1	210	216	PF00069	0.501
MOD_CK1_1	222	228	PF00069	0.594
MOD_CK1_1	233	239	PF00069	0.533
MOD_CK1_1	343	349	PF00069	0.551
MOD_CK1_1	446	452	PF00069	0.630
MOD_CK1_1	600	606	PF00069	0.688
MOD_CK2_1	326	332	PF00069	0.658
MOD_CK2_1	343	349	PF00069	0.405
MOD_GlcNHglycan	104	107	PF01048	0.724
MOD_GlcNHglycan	112	115	PF01048	0.572
MOD_GlcNHglycan	134	137	PF01048	0.662
MOD_GlcNHglycan	222	225	PF01048	0.686
MOD_GlcNHglycan	227	230	PF01048	0.740
MOD_GlcNHglycan	305	308	PF01048	0.582
MOD_GlcNHglycan	342	345	PF01048	0.485
MOD_GlcNHglycan	364	367	PF01048	0.760
MOD_GlcNHglycan	373	376	PF01048	0.579
MOD_GlcNHglycan	41	44	PF01048	0.729
MOD_GlcNHglycan	473	476	PF01048	0.684
MOD_GlcNHglycan	487	490	PF01048	0.541
MOD_GlcNHglycan	497	500	PF01048	0.637
MOD_GlcNHglycan	549	552	PF01048	0.637
MOD_GlcNHglycan	586	589	PF01048	0.660
MOD_GlcNHglycan	599	602	PF01048	0.658
MOD_GlcNHglycan	635	638	PF01048	0.766
MOD_GSK3_1	106	113	PF00069	0.697
MOD_GSK3_1	128	135	PF00069	0.688
MOD_GSK3_1	220	227	PF00069	0.672
MOD_GSK3_1	228	235	PF00069	0.569
MOD_GSK3_1	28	35	PF00069	0.710
MOD_GSK3_1	299	306	PF00069	0.612
MOD_GSK3_1	322	329	PF00069	0.669
MOD_GSK3_1	339	346	PF00069	0.390
MOD_GSK3_1	49	56	PF00069	0.604
MOD_GSK3_1	504	511	PF00069	0.633
MOD_GSK3_1	547	554	PF00069	0.576
MOD_GSK3_1	582	589	PF00069	0.655
MOD_GSK3_1	97	104	PF00069	0.724
MOD_N-GLC_1	155	160	PF02516	0.576
MOD_N-GLC_1	207	212	PF02516	0.603
MOD_N-GLC_1	371	376	PF02516	0.591
MOD_NEK2_1	107	112	PF00069	0.661
MOD_NEK2_1	123	128	PF00069	0.629
MOD_NEK2_1	129	134	PF00069	0.721
MOD_NEK2_1	303	308	PF00069	0.759
MOD_NEK2_1	348	353	PF00069	0.654
MOD_NEK2_1	395	400	PF00069	0.605
MOD_NEK2_1	494	499	PF00069	0.686
MOD_PIKK_1	164	170	PF00454	0.570
MOD_PIKK_1	643	649	PF00454	0.679
MOD_PKA_2	395	401	PF00069	0.457
MOD_PKA_2	643	649	PF00069	0.727
MOD_Plk_1	155	161	PF00069	0.574
MOD_Plk_1	164	170	PF00069	0.450
MOD_Plk_1	348	354	PF00069	0.607
MOD_Plk_1	396	402	PF00069	0.572
MOD_Plk_4	326	332	PF00069	0.560
MOD_Plk_4	348	354	PF00069	0.662
MOD_Plk_4	446	452	PF00069	0.668
MOD_ProDKin_1	25	31	PF00069	0.681
MOD_ProDKin_1	322	328	PF00069	0.653
MOD_ProDKin_1	443	449	PF00069	0.649
MOD_ProDKin_1	582	588	PF00069	0.581
TRG_DiLeu_BaEn_2	187	193	PF01217	0.473
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.566
TRG_ENDOCYTIC_2	148	151	PF00928	0.561
TRG_ENDOCYTIC_2	204	207	PF00928	0.582
TRG_ENDOCYTIC_2	237	240	PF00928	0.513
TRG_ENDOCYTIC_2	450	453	PF00928	0.799
TRG_ER_diArg_1	336	338	PF00400	0.487
TRG_ER_diArg_1	442	444	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7L5N2	Trypanosoma rangeli	32%	100%
A0A3S7X2B5	Leishmania donovani	88%	99%
A4HH87	Leishmania braziliensis	82%	100%
A4I4D3	Leishmania infantum	81%	93%
E9ALZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%