Putative U-box domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain protein, putative

Species:

Leishmania major

UniProt:

E9ADT0_LEIMA

TriTrypDb:

LmjF.29.0780 , LMJLV39_290013300 , LMJSD75_290013300

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADT0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.424
CLV_C14_Caspase3-7	514	518	PF00656	0.628
CLV_NRD_NRD_1	428	430	PF00675	0.545
CLV_NRD_NRD_1	50	52	PF00675	0.449
CLV_NRD_NRD_1	72	74	PF00675	0.482
CLV_PCSK_KEX2_1	428	430	PF00082	0.542
CLV_PCSK_KEX2_1	50	52	PF00082	0.395
CLV_PCSK_KEX2_1	72	74	PF00082	0.482
CLV_PCSK_SKI1_1	107	111	PF00082	0.558
CLV_PCSK_SKI1_1	428	432	PF00082	0.487
CLV_PCSK_SKI1_1	562	566	PF00082	0.376
DOC_CDC14_PxL_1	477	485	PF14671	0.628
DOC_CYCLIN_yClb1_LxF_4	368	374	PF00134	0.462
DOC_MAPK_gen_1	107	117	PF00069	0.534
DOC_MAPK_gen_1	484	493	PF00069	0.567
DOC_MAPK_gen_1	50	57	PF00069	0.482
DOC_MAPK_gen_1	72	81	PF00069	0.349
DOC_MAPK_MEF2A_6	123	132	PF00069	0.357
DOC_MAPK_MEF2A_6	209	218	PF00069	0.337
DOC_PP1_RVXF_1	207	213	PF00149	0.387
DOC_PP1_RVXF_1	89	96	PF00149	0.429
DOC_PP4_FxxP_1	185	188	PF00568	0.339
DOC_USP7_MATH_1	116	120	PF00917	0.593
DOC_USP7_MATH_1	233	237	PF00917	0.548
DOC_USP7_MATH_1	357	361	PF00917	0.510
DOC_USP7_MATH_1	399	403	PF00917	0.383
DOC_USP7_MATH_1	437	441	PF00917	0.535
DOC_USP7_MATH_1	89	93	PF00917	0.535
DOC_USP7_UBL2_3	205	209	PF12436	0.453
DOC_USP7_UBL2_3	260	264	PF12436	0.448
DOC_WW_Pin1_4	532	537	PF00397	0.320
DOC_WW_Pin1_4	567	572	PF00397	0.417
LIG_14-3-3_CanoR_1	123	131	PF00244	0.370
LIG_14-3-3_CanoR_1	336	342	PF00244	0.409
LIG_14-3-3_CanoR_1	401	405	PF00244	0.508
LIG_14-3-3_CanoR_1	428	436	PF00244	0.458
LIG_14-3-3_CanoR_1	475	483	PF00244	0.726
LIG_14-3-3_CanoR_1	562	571	PF00244	0.378
LIG_Actin_WH2_2	125	143	PF00022	0.348
LIG_Actin_WH2_2	385	403	PF00022	0.478
LIG_AP2alpha_1	342	346	PF02296	0.477
LIG_BIR_II_1	1	5	PF00653	0.398
LIG_BIR_III_4	378	382	PF00653	0.405
LIG_BRCT_BRCA1_1	314	318	PF00533	0.379
LIG_BRCT_BRCA1_1	439	443	PF00533	0.458
LIG_BRCT_BRCA1_1	91	95	PF00533	0.543
LIG_deltaCOP1_diTrp_1	421	427	PF00928	0.507
LIG_EH1_1	154	162	PF00400	0.345
LIG_EH1_1	385	393	PF00400	0.641
LIG_eIF4E_1	386	392	PF01652	0.567
LIG_EVH1_2	168	172	PF00568	0.461
LIG_FHA_1	205	211	PF00498	0.373
LIG_FHA_1	275	281	PF00498	0.335
LIG_FHA_1	523	529	PF00498	0.320
LIG_FHA_2	276	282	PF00498	0.332
LIG_GBD_Chelix_1	291	299	PF00786	0.447
LIG_GBD_Chelix_1	306	314	PF00786	0.263
LIG_Integrin_RGD_1	39	41	PF01839	0.359
LIG_LIR_Gen_1	23	31	PF02991	0.449
LIG_LIR_Gen_1	340	350	PF02991	0.476
LIG_LIR_Gen_1	440	451	PF02991	0.356
LIG_LIR_Gen_1	75	84	PF02991	0.418
LIG_LIR_Gen_1	92	101	PF02991	0.461
LIG_LIR_Nem_3	317	323	PF02991	0.392
LIG_LIR_Nem_3	340	345	PF02991	0.436
LIG_LIR_Nem_3	421	427	PF02991	0.562
LIG_LIR_Nem_3	440	446	PF02991	0.237
LIG_LIR_Nem_3	75	80	PF02991	0.391
LIG_LIR_Nem_3	92	98	PF02991	0.303
LIG_MYND_1	481	485	PF01753	0.693
LIG_NRBOX	160	166	PF00104	0.333
LIG_PDZ_Class_2	596	601	PF00595	0.549
LIG_Pex14_1	423	427	PF04695	0.450
LIG_Pex14_2	338	342	PF04695	0.486
LIG_Pex14_2	419	423	PF04695	0.417
LIG_SH2_GRB2like	367	370	PF00017	0.462
LIG_SH2_GRB2like	60	63	PF00017	0.347
LIG_SH2_PTP2	367	370	PF00017	0.391
LIG_SH2_STAP1	170	174	PF00017	0.405
LIG_SH2_STAP1	541	545	PF00017	0.449
LIG_SH2_STAT5	10	13	PF00017	0.531
LIG_SH2_STAT5	287	290	PF00017	0.346
LIG_SH2_STAT5	367	370	PF00017	0.347
LIG_SH2_STAT5	60	63	PF00017	0.362
LIG_SH3_2	482	487	PF14604	0.586
LIG_SH3_3	381	387	PF00018	0.546
LIG_SH3_3	461	467	PF00018	0.574
LIG_SH3_3	479	485	PF00018	0.714
LIG_SH3_3	530	536	PF00018	0.305
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.330
LIG_SxIP_EBH_1	473	484	PF03271	0.599
LIG_TRAF2_1	331	334	PF00917	0.456
LIG_TYR_ITIM	365	370	PF00017	0.399
LIG_UBA3_1	132	141	PF00899	0.452
LIG_UBA3_1	159	166	PF00899	0.333
LIG_UBA3_1	255	260	PF00899	0.499
LIG_WRC_WIRS_1	338	343	PF05994	0.482
MOD_CK1_1	236	242	PF00069	0.495
MOD_CK1_1	263	269	PF00069	0.421
MOD_CK1_1	29	35	PF00069	0.479
MOD_CK1_1	290	296	PF00069	0.401
MOD_CK1_1	455	461	PF00069	0.535
MOD_CK1_1	570	576	PF00069	0.496
MOD_CK2_1	100	106	PF00069	0.448
MOD_CK2_1	259	265	PF00069	0.580
MOD_CK2_1	399	405	PF00069	0.552
MOD_GlcNHglycan	12	15	PF01048	0.556
MOD_GlcNHglycan	179	182	PF01048	0.424
MOD_GlcNHglycan	359	362	PF01048	0.430
MOD_GlcNHglycan	396	399	PF01048	0.465
MOD_GlcNHglycan	506	509	PF01048	0.635
MOD_GSK3_1	259	266	PF00069	0.391
MOD_GSK3_1	310	317	PF00069	0.411
MOD_GSK3_1	570	577	PF00069	0.483
MOD_N-GLC_1	248	253	PF02516	0.536
MOD_N-GLC_1	552	557	PF02516	0.340
MOD_N-GLC_1	82	87	PF02516	0.509
MOD_NEK2_1	105	110	PF00069	0.405
MOD_NEK2_1	183	188	PF00069	0.373
MOD_NEK2_1	259	264	PF00069	0.384
MOD_NEK2_1	274	279	PF00069	0.325
MOD_NEK2_1	280	285	PF00069	0.358
MOD_NEK2_1	295	300	PF00069	0.378
MOD_NEK2_1	310	315	PF00069	0.341
MOD_NEK2_1	346	351	PF00069	0.380
MOD_NEK2_2	445	450	PF00069	0.379
MOD_PIKK_1	150	156	PF00454	0.408
MOD_PIKK_1	183	189	PF00454	0.345
MOD_PIKK_1	264	270	PF00454	0.373
MOD_PIKK_1	329	335	PF00454	0.459
MOD_PIKK_1	452	458	PF00454	0.585
MOD_PK_1	509	515	PF00069	0.664
MOD_PKA_1	428	434	PF00069	0.545
MOD_PKA_1	50	56	PF00069	0.420
MOD_PKA_1	72	78	PF00069	0.431
MOD_PKA_2	122	128	PF00069	0.346
MOD_PKA_2	357	363	PF00069	0.529
MOD_PKA_2	400	406	PF00069	0.454
MOD_PKA_2	428	434	PF00069	0.467
MOD_PKA_2	50	56	PF00069	0.429
MOD_PKA_2	72	78	PF00069	0.431
MOD_Plk_1	248	254	PF00069	0.485
MOD_Plk_1	264	270	PF00069	0.445
MOD_Plk_1	438	444	PF00069	0.516
MOD_Plk_1	82	88	PF00069	0.508
MOD_Plk_1	99	105	PF00069	0.305
MOD_Plk_2-3	100	106	PF00069	0.552
MOD_Plk_4	100	106	PF00069	0.512
MOD_Plk_4	251	257	PF00069	0.426
MOD_Plk_4	275	281	PF00069	0.340
MOD_Plk_4	314	320	PF00069	0.465
MOD_Plk_4	337	343	PF00069	0.461
MOD_Plk_4	431	437	PF00069	0.411
MOD_ProDKin_1	532	538	PF00069	0.320
MOD_ProDKin_1	567	573	PF00069	0.417
MOD_SUMO_for_1	109	112	PF00179	0.467
MOD_SUMO_for_1	408	411	PF00179	0.461
MOD_SUMO_rev_2	13	22	PF00179	0.534
TRG_DiLeu_BaEn_2	207	213	PF01217	0.412
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.668
TRG_ENDOCYTIC_2	367	370	PF00928	0.333
TRG_ENDOCYTIC_2	424	427	PF00928	0.506
TRG_ER_diArg_1	427	429	PF00400	0.523
TRG_ER_diArg_1	49	51	PF00400	0.493
TRG_ER_diArg_1	71	73	PF00400	0.489
TRG_NLS_MonoExtN_4	70	77	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG8	Leptomonas seymouri	73%	100%
A0A0S4IVT7	Bodo saltans	48%	98%
A0A1X0NZM7	Trypanosomatidae	45%	96%
A0A3R7MLP4	Trypanosoma rangeli	45%	99%
A0A3S7X270	Leishmania donovani	97%	100%
A4HH85	Leishmania braziliensis	88%	100%
A4I4D1	Leishmania infantum	97%	100%
C9ZL32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9AM00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DLG6	Trypanosoma cruzi	45%	99%