Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADS9_LEIMA

TriTrypDb:

LmjF.29.0770 , LMJLV39_290013200 , LMJSD75_290013200

Length:

195

Annotations

LeishMANIAdb annotations

Seems to form a single continuous helix according to predictions. Kinetoplastid-only protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ADS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.697
CLV_NRD_NRD_1	108	110	PF00675	0.350
CLV_NRD_NRD_1	53	55	PF00675	0.419
CLV_NRD_NRD_1	70	72	PF00675	0.427
CLV_PCSK_FUR_1	94	98	PF00082	0.452
CLV_PCSK_KEX2_1	191	193	PF00082	0.682
CLV_PCSK_KEX2_1	53	55	PF00082	0.372
CLV_PCSK_KEX2_1	96	98	PF00082	0.460
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.682
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.450
DEG_APCC_DBOX_1	101	109	PF00400	0.631
DOC_MAPK_gen_1	109	117	PF00069	0.456
DOC_MAPK_MEF2A_6	109	117	PF00069	0.456
DOC_PP2B_LxvP_1	44	47	PF13499	0.662
DOC_USP7_MATH_1	152	156	PF00917	0.430
DOC_USP7_MATH_1	18	22	PF00917	0.625
DOC_USP7_UBL2_3	72	76	PF12436	0.684
LIG_14-3-3_CanoR_1	102	108	PF00244	0.655
LIG_14-3-3_CanoR_1	151	157	PF00244	0.424
LIG_14-3-3_CanoR_1	23	32	PF00244	0.599
LIG_14-3-3_CanoR_1	4	10	PF00244	0.645
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	6	10	PF00533	0.674
LIG_BRCT_BRCA1_1	69	73	PF00533	0.692
LIG_FHA_1	168	174	PF00498	0.407
LIG_FHA_1	24	30	PF00498	0.608
LIG_LIR_Apic_2	129	133	PF02991	0.291
LIG_SH2_NCK_1	149	153	PF00017	0.426
LIG_SH2_STAT5	130	133	PF00017	0.500
LIG_SH2_STAT5	135	138	PF00017	0.410
LIG_SH3_3	169	175	PF00018	0.439
MOD_CK1_1	11	17	PF00069	0.672
MOD_CK1_1	3	9	PF00069	0.680
MOD_CK1_1	66	72	PF00069	0.700
MOD_GlcNHglycan	13	16	PF01048	0.449
MOD_GlcNHglycan	20	23	PF01048	0.430
MOD_GlcNHglycan	6	9	PF01048	0.598
MOD_GlcNHglycan	77	80	PF01048	0.415
MOD_GSK3_1	18	25	PF00069	0.643
MOD_GSK3_1	4	11	PF00069	0.809
MOD_GSK3_1	63	70	PF00069	0.700
MOD_N-GLC_1	103	108	PF02516	0.436
MOD_NEK2_1	10	15	PF00069	0.782
MOD_NEK2_1	126	131	PF00069	0.413
MOD_PKA_2	22	28	PF00069	0.653
MOD_PKA_2	3	9	PF00069	0.643
MOD_Plk_1	103	109	PF00069	0.624
MOD_Plk_4	103	109	PF00069	0.614
MOD_Plk_4	126	132	PF00069	0.366
MOD_SUMO_rev_2	68	78	PF00179	0.646
TRG_ENDOCYTIC_2	135	138	PF00928	0.369
TRG_ER_diArg_1	53	56	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C6	Leptomonas seymouri	64%	100%
A0A1X0NZL1	Trypanosomatidae	46%	100%
A0A3S7X2B4	Leishmania donovani	88%	100%
A4HH84	Leishmania braziliensis	71%	97%
A4I4D0	Leishmania infantum	88%	100%
C9ZL34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AM01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%