Putative U3 small nucleolar ribonucleoprotein protein MPP10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar ribonucleoprotein protein MPP10, putative

Species:

Leishmania major

UniProt:

E9ADS7_LEIMA

TriTrypDb:

LmjF.29.0750 , LMJLV39_290013000 , LMJSD75_290013000

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	10
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	10
GO:0034457	Mpp10 complex	3	10
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

E9ADS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006364	rRNA processing	8	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016072	rRNA metabolic process	7	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.405
CLV_NRD_NRD_1	112	114	PF00675	0.376
CLV_NRD_NRD_1	134	136	PF00675	0.446
CLV_NRD_NRD_1	149	151	PF00675	0.432
CLV_NRD_NRD_1	190	192	PF00675	0.413
CLV_NRD_NRD_1	193	195	PF00675	0.344
CLV_NRD_NRD_1	241	243	PF00675	0.443
CLV_NRD_NRD_1	258	260	PF00675	0.354
CLV_NRD_NRD_1	409	411	PF00675	0.362
CLV_NRD_NRD_1	46	48	PF00675	0.621
CLV_NRD_NRD_1	481	483	PF00675	0.389
CLV_NRD_NRD_1	638	640	PF00675	0.354
CLV_NRD_NRD_1	650	652	PF00675	0.369
CLV_NRD_NRD_1	662	664	PF00675	0.579
CLV_NRD_NRD_1	81	83	PF00675	0.629
CLV_PCSK_FUR_1	236	240	PF00082	0.449
CLV_PCSK_KEX2_1	112	114	PF00082	0.376
CLV_PCSK_KEX2_1	149	151	PF00082	0.399
CLV_PCSK_KEX2_1	190	192	PF00082	0.412
CLV_PCSK_KEX2_1	238	240	PF00082	0.444
CLV_PCSK_KEX2_1	241	243	PF00082	0.444
CLV_PCSK_KEX2_1	258	260	PF00082	0.357
CLV_PCSK_KEX2_1	415	417	PF00082	0.392
CLV_PCSK_KEX2_1	432	434	PF00082	0.288
CLV_PCSK_KEX2_1	46	48	PF00082	0.662
CLV_PCSK_KEX2_1	481	483	PF00082	0.434
CLV_PCSK_KEX2_1	638	640	PF00082	0.358
CLV_PCSK_KEX2_1	664	666	PF00082	0.612
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.466
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.418
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.288
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.477
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.612
CLV_PCSK_PC7_1	236	242	PF00082	0.485
CLV_PCSK_PC7_1	634	640	PF00082	0.369
CLV_PCSK_SKI1_1	101	105	PF00082	0.344
CLV_PCSK_SKI1_1	161	165	PF00082	0.401
CLV_PCSK_SKI1_1	195	199	PF00082	0.389
CLV_PCSK_SKI1_1	209	213	PF00082	0.344
CLV_PCSK_SKI1_1	28	32	PF00082	0.653
CLV_PCSK_SKI1_1	415	419	PF00082	0.444
CLV_PCSK_SKI1_1	435	439	PF00082	0.155
CLV_PCSK_SKI1_1	516	520	PF00082	0.444
CLV_PCSK_SKI1_1	634	638	PF00082	0.317
CLV_PCSK_SKI1_1	85	89	PF00082	0.340
DEG_APCC_DBOX_1	100	108	PF00400	0.401
DEG_APCC_DBOX_1	434	442	PF00400	0.444
DEG_APCC_DBOX_1	53	61	PF00400	0.487
DEG_MDM2_SWIB_1	418	425	PF02201	0.485
DOC_ANK_TNKS_1	265	272	PF00023	0.252
DOC_MAPK_gen_1	432	441	PF00069	0.444
DOC_MAPK_gen_1	505	513	PF00069	0.369
DOC_MAPK_MEF2A_6	66	74	PF00069	0.642
DOC_USP7_MATH_1	131	135	PF00917	0.252
DOC_USP7_MATH_1	2	6	PF00917	0.736
DOC_USP7_MATH_1	503	507	PF00917	0.406
DOC_USP7_UBL2_3	186	190	PF12436	0.423
DOC_USP7_UBL2_3	195	199	PF12436	0.204
DOC_USP7_UBL2_3	411	415	PF12436	0.485
DOC_USP7_UBL2_3	642	646	PF12436	0.384
DOC_WW_Pin1_4	567	572	PF00397	0.344
DOC_WW_Pin1_4	627	632	PF00397	0.444
DOC_WW_Pin1_4	66	71	PF00397	0.583
DOC_WW_Pin1_4	7	12	PF00397	0.749
LIG_14-3-3_CanoR_1	33	43	PF00244	0.658
LIG_14-3-3_CanoR_1	416	425	PF00244	0.401
LIG_14-3-3_CanoR_1	482	487	PF00244	0.322
LIG_14-3-3_CanoR_1	615	624	PF00244	0.474
LIG_14-3-3_CanoR_1	85	93	PF00244	0.345
LIG_Actin_WH2_2	536	551	PF00022	0.321
LIG_Actin_WH2_2	60	75	PF00022	0.615
LIG_BIR_III_4	322	326	PF00653	0.369
LIG_BRCT_BRCA1_1	617	621	PF00533	0.416
LIG_Clathr_ClatBox_1	438	442	PF01394	0.444
LIG_deltaCOP1_diTrp_1	205	212	PF00928	0.348
LIG_FHA_1	166	172	PF00498	0.369
LIG_FHA_1	459	465	PF00498	0.359
LIG_FHA_1	624	630	PF00498	0.429
LIG_FHA_1	87	93	PF00498	0.384
LIG_FHA_2	486	492	PF00498	0.345
LIG_FHA_2	539	545	PF00498	0.344
LIG_FHA_2	600	606	PF00498	0.369
LIG_FHA_2	628	634	PF00498	0.444
LIG_FHA_2	79	85	PF00498	0.633
LIG_LIR_Gen_1	420	430	PF02991	0.480
LIG_LIR_Gen_1	618	629	PF02991	0.369
LIG_LIR_Nem_3	420	425	PF02991	0.480
LIG_LIR_Nem_3	474	480	PF02991	0.344
LIG_LIR_Nem_3	618	624	PF02991	0.369
LIG_LIR_Nem_3	90	96	PF02991	0.372
LIG_PCNA_yPIPBox_3	177	191	PF02747	0.406
LIG_Pex14_1	208	212	PF04695	0.344
LIG_Pex14_2	418	422	PF04695	0.401
LIG_PTB_Apo_2	440	447	PF02174	0.485
LIG_PTB_Apo_2	563	570	PF02174	0.344
LIG_PTB_Phospho_1	563	569	PF10480	0.401
LIG_SH2_NCK_1	61	65	PF00017	0.561
LIG_SH2_SRC	477	480	PF00017	0.401
LIG_SH2_STAP1	497	501	PF00017	0.444
LIG_SH2_STAP1	514	518	PF00017	0.344
LIG_SH2_STAT3	328	331	PF00017	0.429
LIG_SH2_STAT5	335	338	PF00017	0.369
LIG_SH2_STAT5	569	572	PF00017	0.401
LIG_SH3_3	12	18	PF00018	0.725
LIG_SH3_3	529	535	PF00018	0.429
LIG_SH3_4	572	579	PF00018	0.401
LIG_SUMO_SIM_par_1	436	442	PF11976	0.403
LIG_TRAF2_1	217	220	PF00917	0.444
LIG_TRAF2_1	245	248	PF00917	0.408
LIG_TRAF2_1	277	280	PF00917	0.346
LIG_UBA3_1	510	516	PF00899	0.344
MOD_CDC14_SPxK_1	10	13	PF00782	0.779
MOD_CDK_SPK_2	567	572	PF00069	0.344
MOD_CDK_SPK_2	627	632	PF00069	0.444
MOD_CDK_SPxK_1	7	13	PF00069	0.786
MOD_CDK_SPxxK_3	627	634	PF00069	0.444
MOD_CDK_SPxxK_3	66	73	PF00069	0.640
MOD_CK1_1	165	171	PF00069	0.345
MOD_CK1_1	3	9	PF00069	0.689
MOD_CK1_1	45	51	PF00069	0.571
MOD_CK1_1	506	512	PF00069	0.373
MOD_CK1_1	62	68	PF00069	0.466
MOD_CK2_1	190	196	PF00069	0.291
MOD_CK2_1	274	280	PF00069	0.432
MOD_CK2_1	391	397	PF00069	0.415
MOD_CK2_1	538	544	PF00069	0.344
MOD_CK2_1	599	605	PF00069	0.369
MOD_CK2_1	627	633	PF00069	0.436
MOD_CK2_1	637	643	PF00069	0.501
MOD_CK2_1	78	84	PF00069	0.660
MOD_Cter_Amidation	147	150	PF01082	0.372
MOD_Cter_Amidation	644	647	PF01082	0.444
MOD_GlcNHglycan	120	123	PF01048	0.400
MOD_GlcNHglycan	125	128	PF01048	0.394
MOD_GlcNHglycan	140	143	PF01048	0.210
MOD_GlcNHglycan	2	5	PF01048	0.741
MOD_GlcNHglycan	47	50	PF01048	0.544
MOD_GlcNHglycan	6	9	PF01048	0.740
MOD_GSK3_1	118	125	PF00069	0.382
MOD_GSK3_1	162	169	PF00069	0.370
MOD_GSK3_1	2	9	PF00069	0.695
MOD_GSK3_1	41	48	PF00069	0.598
MOD_GSK3_1	454	461	PF00069	0.339
MOD_GSK3_1	481	488	PF00069	0.330
MOD_GSK3_1	62	69	PF00069	0.501
MOD_GSK3_1	623	630	PF00069	0.429
MOD_GSK3_1	667	674	PF00069	0.693
MOD_NEK2_1	24	29	PF00069	0.593
MOD_NEK2_1	34	39	PF00069	0.584
MOD_NEK2_1	42	47	PF00069	0.505
MOD_NEK2_1	53	58	PF00069	0.344
MOD_NEK2_1	637	642	PF00069	0.485
MOD_PKA_1	190	196	PF00069	0.291
MOD_PKA_1	481	487	PF00069	0.384
MOD_PKA_2	166	172	PF00069	0.444
MOD_PKA_2	190	196	PF00069	0.291
MOD_PKA_2	24	30	PF00069	0.610
MOD_PKA_2	32	38	PF00069	0.601
MOD_PKA_2	45	51	PF00069	0.631
MOD_PKA_2	481	487	PF00069	0.326
MOD_PKA_2	53	59	PF00069	0.583
MOD_PKA_2	614	620	PF00069	0.385
MOD_PKA_2	637	643	PF00069	0.450
MOD_Plk_1	420	426	PF00069	0.399
MOD_Plk_2-3	391	397	PF00069	0.485
MOD_Plk_2-3	538	544	PF00069	0.344
MOD_Plk_2-3	623	629	PF00069	0.429
MOD_Plk_4	331	337	PF00069	0.369
MOD_Plk_4	48	54	PF00069	0.429
MOD_Plk_4	506	512	PF00069	0.344
MOD_ProDKin_1	567	573	PF00069	0.344
MOD_ProDKin_1	627	633	PF00069	0.444
MOD_ProDKin_1	66	72	PF00069	0.588
MOD_ProDKin_1	7	13	PF00069	0.749
MOD_SUMO_for_1	462	465	PF00179	0.369
MOD_SUMO_for_1	535	538	PF00179	0.408
MOD_SUMO_rev_2	648	654	PF00179	0.354
TRG_DiLeu_BaEn_1	179	184	PF01217	0.369
TRG_DiLeu_BaEn_4	279	285	PF01217	0.331
TRG_DiLeu_BaEn_4	311	317	PF01217	0.485
TRG_ENDOCYTIC_2	477	480	PF00928	0.401
TRG_ER_diArg_1	111	113	PF00400	0.428
TRG_ER_diArg_1	149	152	PF00400	0.461
TRG_ER_diArg_1	236	239	PF00400	0.449
TRG_ER_diArg_1	240	242	PF00400	0.438
TRG_ER_diArg_1	258	261	PF00400	0.324
TRG_ER_diArg_1	521	524	PF00400	0.429
TRG_ER_diArg_1	637	639	PF00400	0.344
TRG_ER_diArg_1	662	665	PF00400	0.589
TRG_NLS_Bipartite_1	646	668	PF00514	0.663
TRG_NLS_MonoCore_2	662	667	PF00514	0.676
TRG_NLS_MonoExtC_3	189	194	PF00514	0.459
TRG_NLS_MonoExtN_4	190	195	PF00514	0.389
TRG_NLS_MonoExtN_4	663	668	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q4	Leptomonas seymouri	70%	99%
A0A0S4JKJ8	Bodo saltans	46%	100%
A0A3S7X283	Leishmania donovani	93%	100%
A0A422NRR1	Trypanosoma rangeli	48%	100%
A4HH82	Leishmania braziliensis	82%	99%
A4I4C8	Leishmania infantum	93%	100%
C9ZL36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AM03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%