SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADS5_LEIMA

TriTrypDb:

LmjF.29.0730 , LMJLV39_290012700 , LMJSD75_290012700

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.719
CLV_C14_Caspase3-7	130	134	PF00656	0.574
CLV_C14_Caspase3-7	168	172	PF00656	0.633
CLV_NRD_NRD_1	16	18	PF00675	0.689
CLV_NRD_NRD_1	36	38	PF00675	0.609
CLV_NRD_NRD_1	48	50	PF00675	0.593
CLV_PCSK_KEX2_1	16	18	PF00082	0.689
CLV_PCSK_KEX2_1	36	38	PF00082	0.587
CLV_PCSK_KEX2_1	48	50	PF00082	0.593
CLV_PCSK_PC7_1	12	18	PF00082	0.624
CLV_PCSK_SKI1_1	211	215	PF00082	0.572
CLV_PCSK_SKI1_1	41	45	PF00082	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.746
DEG_SPOP_SBC_1	3	7	PF00917	0.577
DOC_MAPK_RevD_3	23	37	PF00069	0.517
DOC_USP7_MATH_1	124	128	PF00917	0.695
DOC_USP7_MATH_1	178	182	PF00917	0.652
DOC_USP7_MATH_1	191	195	PF00917	0.445
DOC_USP7_MATH_1	3	7	PF00917	0.804
DOC_WW_Pin1_4	156	161	PF00397	0.719
DOC_WW_Pin1_4	4	9	PF00397	0.695
LIG_14-3-3_CanoR_1	4	8	PF00244	0.665
LIG_14-3-3_CanoR_1	67	71	PF00244	0.614
LIG_14-3-3_CterR_2	223	226	PF00244	0.655
LIG_APCC_ABBA_1	118	123	PF00400	0.709
LIG_FHA_1	168	174	PF00498	0.743
LIG_FHA_1	38	44	PF00498	0.530
LIG_FHA_2	104	110	PF00498	0.706
LIG_FHA_2	55	61	PF00498	0.586
LIG_LIR_Gen_1	133	143	PF02991	0.615
LIG_LIR_Gen_1	192	203	PF02991	0.600
LIG_LIR_Nem_3	133	138	PF02991	0.626
LIG_LIR_Nem_3	192	198	PF02991	0.595
LIG_LIR_Nem_3	201	207	PF02991	0.601
LIG_SH2_CRK	135	139	PF00017	0.619
LIG_SH2_CRK	68	72	PF00017	0.667
LIG_SH2_NCK_1	68	72	PF00017	0.667
LIG_SH2_STAP1	142	146	PF00017	0.559
LIG_SH2_STAP1	182	186	PF00017	0.598
LIG_SH2_STAT5	68	71	PF00017	0.614
LIG_SH3_3	111	117	PF00018	0.680
LIG_SH3_3	157	163	PF00018	0.592
LIG_SH3_3	171	177	PF00018	0.649
LIG_SH3_3	200	206	PF00018	0.656
LIG_SH3_3	22	28	PF00018	0.667
LIG_TRAF2_1	181	184	PF00917	0.538
MOD_CK1_1	112	118	PF00069	0.671
MOD_CK1_1	127	133	PF00069	0.593
MOD_CK1_1	156	162	PF00069	0.721
MOD_CK2_1	159	165	PF00069	0.825
MOD_CK2_1	178	184	PF00069	0.600
MOD_GlcNHglycan	111	114	PF01048	0.624
MOD_GlcNHglycan	186	189	PF01048	0.692
MOD_GlcNHglycan	88	91	PF01048	0.804
MOD_GSK3_1	124	131	PF00069	0.657
MOD_GSK3_1	149	156	PF00069	0.586
MOD_GSK3_1	189	196	PF00069	0.688
MOD_GSK3_1	66	73	PF00069	0.665
MOD_GSK3_1	82	89	PF00069	0.661
MOD_GSK3_1	90	97	PF00069	0.693
MOD_GSK3_1	99	106	PF00069	0.640
MOD_N-GLC_1	153	158	PF02516	0.672
MOD_N-GLC_1	29	34	PF02516	0.576
MOD_NEK2_1	2	7	PF00069	0.735
MOD_NEK2_1	29	34	PF00069	0.698
MOD_NEK2_1	43	48	PF00069	0.524
MOD_NEK2_1	54	59	PF00069	0.614
MOD_PIKK_1	43	49	PF00454	0.578
MOD_PK_1	169	175	PF00069	0.739
MOD_PKA_1	149	155	PF00069	0.577
MOD_PKA_2	131	137	PF00069	0.678
MOD_PKA_2	3	9	PF00069	0.688
MOD_PKA_2	66	72	PF00069	0.615
MOD_Plk_1	153	159	PF00069	0.663
MOD_Plk_1	29	35	PF00069	0.519
MOD_Plk_4	71	77	PF00069	0.766
MOD_ProDKin_1	156	162	PF00069	0.720
MOD_ProDKin_1	4	10	PF00069	0.697
TRG_DiLeu_BaEn_1	210	215	PF01217	0.570
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.588
TRG_ENDOCYTIC_2	135	138	PF00928	0.622
TRG_ENDOCYTIC_2	204	207	PF00928	0.593
TRG_ER_diArg_1	36	38	PF00400	0.711
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I154	Leptomonas seymouri	40%	99%
A0A3Q8IF96	Leishmania donovani	86%	100%
A4HH80	Leishmania braziliensis	61%	100%
A4I4C6	Leishmania infantum	86%	100%
E9AM05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%