Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 7 protein

Species:

Leishmania major

UniProt:

E9ADS3_LEIMA

TriTrypDb:

LmjF.29.0710 , LMJLV39_290012500 , LMJSD75_290012500

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0030665	clathrin-coated vesicle membrane	6	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0032991	protein-containing complex	1	2
GO:0034464	BBSome	2	2
GO:0035869	ciliary transition zone	2	2
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9ADS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS3

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	2
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006826	iron ion transport	8	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030001	metal ion transport	6	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0033036	macromolecule localization	2	2
GO:0033572	transferrin transport	5	2
GO:0044782	cilium organization	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0060271	cilium assembly	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070925	organelle assembly	5	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.474
CLV_C14_Caspase3-7	620	624	PF00656	0.603
CLV_NRD_NRD_1	108	110	PF00675	0.394
CLV_NRD_NRD_1	13	15	PF00675	0.475
CLV_NRD_NRD_1	148	150	PF00675	0.498
CLV_NRD_NRD_1	403	405	PF00675	0.682
CLV_NRD_NRD_1	688	690	PF00675	0.559
CLV_PCSK_KEX2_1	13	15	PF00082	0.505
CLV_PCSK_KEX2_1	504	506	PF00082	0.487
CLV_PCSK_KEX2_1	57	59	PF00082	0.567
CLV_PCSK_KEX2_1	644	646	PF00082	0.403
CLV_PCSK_KEX2_1	688	690	PF00082	0.559
CLV_PCSK_KEX2_1	738	740	PF00082	0.527
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.487
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.567
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.407
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.527
CLV_PCSK_SKI1_1	112	116	PF00082	0.411
CLV_PCSK_SKI1_1	15	19	PF00082	0.453
CLV_PCSK_SKI1_1	223	227	PF00082	0.478
CLV_PCSK_SKI1_1	602	606	PF00082	0.477
CLV_PCSK_SKI1_1	629	633	PF00082	0.408
CLV_PCSK_SKI1_1	84	88	PF00082	0.485
DEG_APCC_DBOX_1	579	587	PF00400	0.432
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DEG_ODPH_VHL_1	156	168	PF01847	0.488
DOC_ANK_TNKS_1	583	590	PF00023	0.296
DOC_CDC14_PxL_1	397	405	PF14671	0.621
DOC_CDC14_PxL_1	590	598	PF14671	0.413
DOC_CDC14_PxL_1	706	714	PF14671	0.492
DOC_CKS1_1	130	135	PF01111	0.358
DOC_CKS1_1	65	70	PF01111	0.473
DOC_CYCLIN_RxL_1	219	229	PF00134	0.492
DOC_MAPK_DCC_7	2	12	PF00069	0.530
DOC_MAPK_gen_1	35	43	PF00069	0.405
DOC_MAPK_gen_1	504	512	PF00069	0.469
DOC_MAPK_gen_1	57	65	PF00069	0.497
DOC_MAPK_gen_1	644	650	PF00069	0.438
DOC_MAPK_HePTP_8	402	414	PF00069	0.588
DOC_MAPK_MEF2A_6	160	168	PF00069	0.432
DOC_MAPK_MEF2A_6	405	414	PF00069	0.566
DOC_MAPK_MEF2A_6	501	510	PF00069	0.503
DOC_MAPK_MEF2A_6	57	65	PF00069	0.535
DOC_PP1_RVXF_1	148	155	PF00149	0.478
DOC_PP1_RVXF_1	221	227	PF00149	0.493
DOC_PP4_FxxP_1	155	158	PF00568	0.512
DOC_PP4_FxxP_1	65	68	PF00568	0.443
DOC_USP7_MATH_1	439	443	PF00917	0.485
DOC_USP7_MATH_1	633	637	PF00917	0.367
DOC_USP7_MATH_1	678	682	PF00917	0.522
DOC_USP7_MATH_1	800	804	PF00917	0.624
DOC_USP7_MATH_1	806	810	PF00917	0.561
DOC_USP7_MATH_1	838	842	PF00917	0.646
DOC_WW_Pin1_4	129	134	PF00397	0.368
DOC_WW_Pin1_4	422	427	PF00397	0.440
DOC_WW_Pin1_4	473	478	PF00397	0.722
DOC_WW_Pin1_4	486	491	PF00397	0.536
DOC_WW_Pin1_4	494	499	PF00397	0.352
DOC_WW_Pin1_4	64	69	PF00397	0.456
DOC_WW_Pin1_4	847	852	PF00397	0.590
LIG_14-3-3_CanoR_1	124	129	PF00244	0.457
LIG_14-3-3_CanoR_1	257	265	PF00244	0.465
LIG_14-3-3_CanoR_1	317	322	PF00244	0.460
LIG_14-3-3_CanoR_1	521	525	PF00244	0.533
LIG_14-3-3_CanoR_1	602	610	PF00244	0.468
LIG_Actin_WH2_2	181	198	PF00022	0.450
LIG_BRCT_BRCA1_1	261	265	PF00533	0.534
LIG_BRCT_BRCA1_1	414	418	PF00533	0.440
LIG_BRCT_MDC1_1	851	855	PF00533	0.482
LIG_EH1_1	218	226	PF00400	0.384
LIG_FHA_1	120	126	PF00498	0.382
LIG_FHA_1	130	136	PF00498	0.330
LIG_FHA_1	212	218	PF00498	0.404
LIG_FHA_1	282	288	PF00498	0.406
LIG_FHA_1	309	315	PF00498	0.420
LIG_FHA_1	392	398	PF00498	0.458
LIG_FHA_1	464	470	PF00498	0.559
LIG_FHA_1	482	488	PF00498	0.566
LIG_FHA_1	530	536	PF00498	0.445
LIG_FHA_1	552	558	PF00498	0.560
LIG_FHA_1	613	619	PF00498	0.456
LIG_FHA_1	802	808	PF00498	0.659
LIG_FHA_2	14	20	PF00498	0.443
LIG_FHA_2	143	149	PF00498	0.475
LIG_FHA_2	297	303	PF00498	0.486
LIG_FHA_2	377	383	PF00498	0.580
LIG_FHA_2	423	429	PF00498	0.489
LIG_FHA_2	702	708	PF00498	0.610
LIG_FHA_2	788	794	PF00498	0.618
LIG_LIR_Gen_1	131	142	PF02991	0.403
LIG_LIR_Gen_1	262	270	PF02991	0.536
LIG_LIR_Gen_1	747	756	PF02991	0.487
LIG_LIR_LC3C_4	434	437	PF02991	0.505
LIG_LIR_Nem_3	131	137	PF02991	0.433
LIG_LIR_Nem_3	262	268	PF02991	0.529
LIG_LIR_Nem_3	47	53	PF02991	0.434
LIG_LIR_Nem_3	747	751	PF02991	0.441
LIG_LYPXL_S_1	676	680	PF13949	0.505
LIG_LYPXL_yS_3	677	680	PF13949	0.510
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.463
LIG_Pex14_2	605	609	PF04695	0.441
LIG_SH2_CRK	218	222	PF00017	0.458
LIG_SH2_NCK_1	546	550	PF00017	0.388
LIG_SH2_PTP2	167	170	PF00017	0.450
LIG_SH2_PTP2	537	540	PF00017	0.497
LIG_SH2_PTP2	815	818	PF00017	0.635
LIG_SH2_SRC	280	283	PF00017	0.422
LIG_SH2_STAP1	525	529	PF00017	0.569
LIG_SH2_STAT3	227	230	PF00017	0.447
LIG_SH2_STAT3	525	528	PF00017	0.531
LIG_SH2_STAT5	167	170	PF00017	0.480
LIG_SH2_STAT5	184	187	PF00017	0.357
LIG_SH2_STAT5	537	540	PF00017	0.497
LIG_SH2_STAT5	736	739	PF00017	0.377
LIG_SH2_STAT5	750	753	PF00017	0.391
LIG_SH2_STAT5	815	818	PF00017	0.635
LIG_SH2_STAT5	98	101	PF00017	0.455
LIG_SH3_3	250	256	PF00018	0.571
LIG_SH3_3	484	490	PF00018	0.617
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.498
LIG_SUMO_SIM_par_1	410	415	PF11976	0.491
LIG_SUMO_SIM_par_1	611	617	PF11976	0.480
LIG_SUMO_SIM_par_1	636	642	PF11976	0.336
LIG_TRAF2_1	719	722	PF00917	0.518
LIG_TRAF2_1	731	734	PF00917	0.512
LIG_TRAF2_1	790	793	PF00917	0.639
LIG_TRFH_1	154	158	PF08558	0.491
LIG_TYR_ITIM	216	221	PF00017	0.450
LIG_TYR_ITIM	535	540	PF00017	0.502
LIG_WRC_WIRS_1	337	342	PF05994	0.366
LIG_WRC_WIRS_1	745	750	PF05994	0.496
MOD_CDK_SPxxK_3	494	501	PF00069	0.525
MOD_CK1_1	34	40	PF00069	0.527
MOD_CK1_1	479	485	PF00069	0.703
MOD_CK1_1	551	557	PF00069	0.532
MOD_CK1_1	612	618	PF00069	0.466
MOD_CK1_1	636	642	PF00069	0.358
MOD_CK1_1	681	687	PF00069	0.525
MOD_CK1_1	849	855	PF00069	0.718
MOD_CK2_1	13	19	PF00069	0.330
MOD_CK2_1	142	148	PF00069	0.464
MOD_CK2_1	376	382	PF00069	0.570
MOD_CK2_1	422	428	PF00069	0.508
MOD_CK2_1	716	722	PF00069	0.475
MOD_CK2_1	787	793	PF00069	0.624
MOD_Cter_Amidation	55	58	PF01082	0.530
MOD_GlcNHglycan	170	173	PF01048	0.431
MOD_GlcNHglycan	2	5	PF01048	0.722
MOD_GlcNHglycan	21	24	PF01048	0.312
MOD_GlcNHglycan	230	233	PF01048	0.386
MOD_GlcNHglycan	340	343	PF01048	0.357
MOD_GlcNHglycan	414	417	PF01048	0.535
MOD_GlcNHglycan	437	440	PF01048	0.506
MOD_GlcNHglycan	481	484	PF01048	0.697
MOD_GlcNHglycan	525	528	PF01048	0.524
MOD_GlcNHglycan	557	560	PF01048	0.555
MOD_GlcNHglycan	718	721	PF01048	0.539
MOD_GlcNHglycan	828	831	PF01048	0.518
MOD_GSK3_1	13	20	PF00069	0.418
MOD_GSK3_1	226	233	PF00069	0.382
MOD_GSK3_1	290	297	PF00069	0.502
MOD_GSK3_1	304	311	PF00069	0.294
MOD_GSK3_1	391	398	PF00069	0.565
MOD_GSK3_1	418	425	PF00069	0.430
MOD_GSK3_1	431	438	PF00069	0.389
MOD_GSK3_1	452	459	PF00069	0.470
MOD_GSK3_1	472	479	PF00069	0.426
MOD_GSK3_1	488	495	PF00069	0.386
MOD_GSK3_1	516	523	PF00069	0.467
MOD_GSK3_1	548	555	PF00069	0.514
MOD_GSK3_1	67	74	PF00069	0.555
MOD_GSK3_1	678	685	PF00069	0.511
MOD_GSK3_1	767	774	PF00069	0.469
MOD_GSK3_1	838	845	PF00069	0.714
MOD_GSK3_1	847	854	PF00069	0.644
MOD_N-GLC_1	119	124	PF02516	0.404
MOD_NEK2_1	141	146	PF00069	0.372
MOD_NEK2_1	226	231	PF00069	0.481
MOD_NEK2_1	292	297	PF00069	0.523
MOD_NEK2_1	308	313	PF00069	0.238
MOD_NEK2_1	336	341	PF00069	0.347
MOD_NEK2_1	412	417	PF00069	0.485
MOD_NEK2_1	418	423	PF00069	0.407
MOD_NEK2_1	516	521	PF00069	0.450
MOD_NEK2_1	603	608	PF00069	0.451
MOD_NEK2_1	609	614	PF00069	0.410
MOD_NEK2_1	665	670	PF00069	0.418
MOD_NEK2_1	679	684	PF00069	0.432
MOD_NEK2_1	744	749	PF00069	0.369
MOD_NEK2_1	818	823	PF00069	0.650
MOD_NEK2_1	837	842	PF00069	0.621
MOD_NEK2_2	8	13	PF00069	0.550
MOD_NEK2_2	806	811	PF00069	0.575
MOD_PIKK_1	226	232	PF00454	0.424
MOD_PIKK_1	355	361	PF00454	0.602
MOD_PIKK_1	376	382	PF00454	0.570
MOD_PIKK_1	477	483	PF00454	0.676
MOD_PIKK_1	683	689	PF00454	0.534
MOD_PIKK_1	838	844	PF00454	0.495
MOD_PK_1	294	300	PF00069	0.510
MOD_PK_1	317	323	PF00069	0.478
MOD_PK_1	51	57	PF00069	0.484
MOD_PK_1	548	554	PF00069	0.495
MOD_PKA_1	13	19	PF00069	0.330
MOD_PKA_2	13	19	PF00069	0.330
MOD_PKA_2	256	262	PF00069	0.562
MOD_PKA_2	500	506	PF00069	0.509
MOD_PKA_2	520	526	PF00069	0.526
MOD_PKB_1	393	401	PF00069	0.619
MOD_Plk_1	439	445	PF00069	0.434
MOD_Plk_1	552	558	PF00069	0.630
MOD_Plk_1	787	793	PF00069	0.580
MOD_Plk_4	304	310	PF00069	0.383
MOD_Plk_4	431	437	PF00069	0.464
MOD_Plk_4	452	458	PF00069	0.478
MOD_Plk_4	488	494	PF00069	0.545
MOD_Plk_4	520	526	PF00069	0.439
MOD_Plk_4	552	558	PF00069	0.643
MOD_Plk_4	609	615	PF00069	0.386
MOD_Plk_4	633	639	PF00069	0.387
MOD_Plk_4	87	93	PF00069	0.351
MOD_Plk_4	99	105	PF00069	0.316
MOD_ProDKin_1	129	135	PF00069	0.364
MOD_ProDKin_1	422	428	PF00069	0.446
MOD_ProDKin_1	473	479	PF00069	0.723
MOD_ProDKin_1	486	492	PF00069	0.519
MOD_ProDKin_1	494	500	PF00069	0.360
MOD_ProDKin_1	64	70	PF00069	0.468
MOD_ProDKin_1	847	853	PF00069	0.592
MOD_SUMO_rev_2	147	152	PF00179	0.556
MOD_SUMO_rev_2	76	86	PF00179	0.652
TRG_DiLeu_BaEn_2	150	156	PF01217	0.541
TRG_DiLeu_BaEn_3	598	604	PF01217	0.502
TRG_DiLeu_BaEn_4	407	413	PF01217	0.553
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.479
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.509
TRG_ENDOCYTIC_2	218	221	PF00928	0.484
TRG_ENDOCYTIC_2	537	540	PF00928	0.424
TRG_ENDOCYTIC_2	546	549	PF00928	0.321
TRG_ENDOCYTIC_2	677	680	PF00928	0.510
TRG_ENDOCYTIC_2	745	748	PF00928	0.374
TRG_ENDOCYTIC_2	815	818	PF00928	0.635
TRG_ER_diArg_1	12	14	PF00400	0.463
TRG_ER_diArg_1	464	467	PF00400	0.365
TRG_ER_diArg_1	688	690	PF00400	0.559
TRG_NLS_MonoExtC_3	108	113	PF00514	0.433
TRG_NLS_MonoExtN_4	32	39	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W9	Leptomonas seymouri	62%	100%
A0A1X0NZL6	Trypanosomatidae	35%	100%
A0A3Q8IR58	Leishmania donovani	94%	100%
A0A422NRV6	Trypanosoma rangeli	35%	100%
A4HH78	Leishmania braziliensis	81%	100%
A4I4C4	Leishmania infantum	94%	100%
C9ZL44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AM07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q8IWZ6	Homo sapiens	23%	100%
Q8K2G4	Mus musculus	24%	100%
V5BKF4	Trypanosoma cruzi	34%	100%