Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADS2_LEIMA

TriTrypDb:

LmjF.29.0700 , LMJLV39_290012400 , LMJSD75_290012400

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.577
CLV_C14_Caspase3-7	339	343	PF00656	0.593
CLV_NRD_NRD_1	146	148	PF00675	0.755
CLV_NRD_NRD_1	278	280	PF00675	0.547
CLV_NRD_NRD_1	399	401	PF00675	0.540
CLV_NRD_NRD_1	534	536	PF00675	0.555
CLV_NRD_NRD_1	709	711	PF00675	0.697
CLV_NRD_NRD_1	97	99	PF00675	0.804
CLV_PCSK_FUR_1	95	99	PF00082	0.794
CLV_PCSK_KEX2_1	146	148	PF00082	0.680
CLV_PCSK_KEX2_1	463	465	PF00082	0.576
CLV_PCSK_KEX2_1	534	536	PF00082	0.573
CLV_PCSK_KEX2_1	95	97	PF00082	0.773
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.542
CLV_PCSK_SKI1_1	435	439	PF00082	0.559
CLV_PCSK_SKI1_1	440	444	PF00082	0.509
CLV_PCSK_SKI1_1	567	571	PF00082	0.527
CLV_PCSK_SKI1_1	73	77	PF00082	0.595
DEG_APCC_KENBOX_2	169	173	PF00400	0.576
DEG_SPOP_SBC_1	46	50	PF00917	0.575
DOC_CKS1_1	481	486	PF01111	0.537
DOC_CYCLIN_RxL_1	541	551	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.741
DOC_MAPK_DCC_7	204	214	PF00069	0.567
DOC_MAPK_gen_1	463	470	PF00069	0.536
DOC_MAPK_gen_1	593	602	PF00069	0.540
DOC_MAPK_MEF2A_6	378	386	PF00069	0.538
DOC_MAPK_MEF2A_6	675	683	PF00069	0.440
DOC_PP1_RVXF_1	202	209	PF00149	0.549
DOC_PP1_RVXF_1	542	549	PF00149	0.625
DOC_PP2B_LxvP_1	469	472	PF13499	0.574
DOC_PP4_FxxP_1	443	446	PF00568	0.521
DOC_USP7_MATH_1	160	164	PF00917	0.791
DOC_USP7_MATH_1	165	169	PF00917	0.751
DOC_USP7_MATH_1	18	22	PF00917	0.547
DOC_USP7_MATH_1	26	30	PF00917	0.478
DOC_USP7_MATH_1	414	418	PF00917	0.456
DOC_USP7_MATH_1	51	55	PF00917	0.663
DOC_USP7_MATH_1	6	10	PF00917	0.593
DOC_USP7_MATH_1	633	637	PF00917	0.697
DOC_USP7_MATH_1	645	649	PF00917	0.604
DOC_USP7_MATH_1	662	666	PF00917	0.646
DOC_USP7_MATH_1	698	702	PF00917	0.752
DOC_USP7_UBL2_3	213	217	PF12436	0.462
DOC_WW_Pin1_4	13	18	PF00397	0.647
DOC_WW_Pin1_4	174	179	PF00397	0.618
DOC_WW_Pin1_4	480	485	PF00397	0.683
LIG_14-3-3_CanoR_1	138	145	PF00244	0.785
LIG_14-3-3_CanoR_1	146	151	PF00244	0.649
LIG_14-3-3_CanoR_1	252	256	PF00244	0.642
LIG_14-3-3_CanoR_1	263	267	PF00244	0.730
LIG_14-3-3_CanoR_1	279	286	PF00244	0.449
LIG_14-3-3_CanoR_1	294	302	PF00244	0.397
LIG_14-3-3_CanoR_1	32	41	PF00244	0.552
LIG_14-3-3_CanoR_1	352	360	PF00244	0.469
LIG_14-3-3_CanoR_1	400	408	PF00244	0.463
LIG_14-3-3_CanoR_1	440	446	PF00244	0.578
LIG_14-3-3_CanoR_1	457	466	PF00244	0.467
LIG_14-3-3_CanoR_1	634	640	PF00244	0.721
LIG_Actin_WH2_2	281	296	PF00022	0.700
LIG_Actin_WH2_2	426	442	PF00022	0.607
LIG_APCC_ABBAyCdc20_2	496	502	PF00400	0.631
LIG_BIR_III_4	342	346	PF00653	0.653
LIG_Clathr_ClatBox_1	327	331	PF01394	0.475
LIG_deltaCOP1_diTrp_1	300	308	PF00928	0.397
LIG_FHA_1	101	107	PF00498	0.745
LIG_FHA_1	175	181	PF00498	0.793
LIG_FHA_1	272	278	PF00498	0.721
LIG_FHA_1	317	323	PF00498	0.497
LIG_FHA_1	352	358	PF00498	0.488
LIG_FHA_1	368	374	PF00498	0.608
LIG_FHA_1	381	387	PF00498	0.458
LIG_FHA_1	454	460	PF00498	0.509
LIG_FHA_1	671	677	PF00498	0.621
LIG_FHA_1	74	80	PF00498	0.565
LIG_FHA_2	105	111	PF00498	0.727
LIG_FHA_2	273	279	PF00498	0.781
LIG_FHA_2	287	293	PF00498	0.469
LIG_FHA_2	295	301	PF00498	0.483
LIG_FHA_2	442	448	PF00498	0.517
LIG_FHA_2	617	623	PF00498	0.747
LIG_FHA_2	69	75	PF00498	0.597
LIG_LIR_Apic_2	21	26	PF02991	0.466
LIG_LIR_Apic_2	512	517	PF02991	0.612
LIG_LIR_Apic_2	549	555	PF02991	0.511
LIG_LIR_Nem_3	19	25	PF02991	0.460
LIG_LIR_Nem_3	253	258	PF02991	0.642
LIG_LYPXL_yS_3	255	258	PF13949	0.744
LIG_NRBOX	323	329	PF00104	0.447
LIG_NRP_CendR_1	710	712	PF00754	0.665
LIG_PCNA_yPIPBox_3	294	302	PF02747	0.533
LIG_PCNA_yPIPBox_3	567	578	PF02747	0.378
LIG_Pex14_2	548	552	PF04695	0.480
LIG_SH2_CRK	23	27	PF00017	0.459
LIG_SH2_CRK	379	383	PF00017	0.622
LIG_SH2_NCK_1	23	27	PF00017	0.552
LIG_SH2_SRC	379	382	PF00017	0.542
LIG_SH2_SRC	514	517	PF00017	0.713
LIG_SH2_STAT5	27	30	PF00017	0.499
LIG_SH2_STAT5	454	457	PF00017	0.519
LIG_SH2_STAT5	514	517	PF00017	0.694
LIG_SH3_3	261	267	PF00018	0.725
LIG_SH3_3	383	389	PF00018	0.478
LIG_SH3_3	476	482	PF00018	0.756
LIG_SH3_3	663	669	PF00018	0.654
LIG_Sin3_3	8	15	PF02671	0.536
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.469
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.461
LIG_SUMO_SIM_par_1	101	107	PF11976	0.717
LIG_SUMO_SIM_par_1	325	331	PF11976	0.422
LIG_TRAF2_1	560	563	PF00917	0.515
LIG_TRAF2_2	242	247	PF00917	0.583
MOD_CK1_1	115	121	PF00069	0.665
MOD_CK1_1	133	139	PF00069	0.777
MOD_CK1_1	21	27	PF00069	0.475
MOD_CK1_1	251	257	PF00069	0.604
MOD_CK1_1	271	277	PF00069	0.455
MOD_CK1_1	4	10	PF00069	0.584
MOD_CK1_1	45	51	PF00069	0.597
MOD_CK1_1	458	464	PF00069	0.609
MOD_CK1_1	648	654	PF00069	0.727
MOD_CK1_1	701	707	PF00069	0.777
MOD_CK2_1	104	110	PF00069	0.720
MOD_CK2_1	146	152	PF00069	0.712
MOD_CK2_1	160	166	PF00069	0.555
MOD_CK2_1	272	278	PF00069	0.771
MOD_CK2_1	294	300	PF00069	0.523
MOD_CK2_1	441	447	PF00069	0.475
MOD_CK2_1	616	622	PF00069	0.725
MOD_CK2_1	68	74	PF00069	0.595
MOD_Cter_Amidation	93	96	PF01082	0.683
MOD_GlcNHglycan	100	103	PF01048	0.798
MOD_GlcNHglycan	114	117	PF01048	0.577
MOD_GlcNHglycan	140	143	PF01048	0.767
MOD_GlcNHglycan	157	160	PF01048	0.584
MOD_GlcNHglycan	166	170	PF01048	0.705
MOD_GlcNHglycan	191	195	PF01048	0.500
MOD_GlcNHglycan	227	233	PF01048	0.696
MOD_GlcNHglycan	235	238	PF01048	0.651
MOD_GlcNHglycan	28	31	PF01048	0.412
MOD_GlcNHglycan	280	283	PF01048	0.659
MOD_GlcNHglycan	36	39	PF01048	0.555
MOD_GlcNHglycan	700	703	PF01048	0.803
MOD_GlcNHglycan	8	11	PF01048	0.505
MOD_GSK3_1	100	107	PF00069	0.729
MOD_GSK3_1	126	133	PF00069	0.752
MOD_GSK3_1	134	141	PF00069	0.779
MOD_GSK3_1	258	265	PF00069	0.701
MOD_GSK3_1	268	275	PF00069	0.705
MOD_GSK3_1	312	319	PF00069	0.561
MOD_GSK3_1	365	372	PF00069	0.638
MOD_GSK3_1	42	49	PF00069	0.579
MOD_GSK3_1	516	523	PF00069	0.659
MOD_GSK3_1	542	549	PF00069	0.431
MOD_GSK3_1	6	13	PF00069	0.542
MOD_GSK3_1	645	652	PF00069	0.733
MOD_GSK3_1	697	704	PF00069	0.706
MOD_GSK3_1	73	80	PF00069	0.559
MOD_N-GLC_1	233	238	PF02516	0.590
MOD_N-GLC_1	294	299	PF02516	0.412
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	104	109	PF00069	0.747
MOD_NEK2_1	125	130	PF00069	0.785
MOD_NEK2_1	250	255	PF00069	0.623
MOD_NEK2_1	258	263	PF00069	0.739
MOD_NEK2_1	293	298	PF00069	0.572
MOD_NEK2_1	323	328	PF00069	0.531
MOD_NEK2_1	367	372	PF00069	0.651
MOD_NEK2_2	18	23	PF00069	0.572
MOD_NEK2_2	51	56	PF00069	0.668
MOD_NEK2_2	670	675	PF00069	0.567
MOD_PIKK_1	240	246	PF00454	0.666
MOD_PIKK_1	258	264	PF00454	0.481
MOD_PIKK_1	316	322	PF00454	0.498
MOD_PIKK_1	401	407	PF00454	0.590
MOD_PIKK_1	419	425	PF00454	0.386
MOD_PIKK_1	701	707	PF00454	0.804
MOD_PK_1	146	152	PF00069	0.674
MOD_PKA_1	146	152	PF00069	0.689
MOD_PKA_1	400	406	PF00069	0.541
MOD_PKA_2	126	132	PF00069	0.734
MOD_PKA_2	133	139	PF00069	0.763
MOD_PKA_2	146	152	PF00069	0.734
MOD_PKA_2	251	257	PF00069	0.619
MOD_PKA_2	262	268	PF00069	0.643
MOD_PKA_2	278	284	PF00069	0.709
MOD_PKA_2	293	299	PF00069	0.524
MOD_PKA_2	351	357	PF00069	0.464
MOD_PKA_2	399	405	PF00069	0.539
MOD_PKA_2	633	639	PF00069	0.691
MOD_PKB_1	66	74	PF00069	0.518
MOD_PKB_1	96	104	PF00069	0.683
MOD_Plk_1	18	24	PF00069	0.566
MOD_Plk_1	190	196	PF00069	0.491
MOD_Plk_1	294	300	PF00069	0.410
MOD_Plk_1	435	441	PF00069	0.616
MOD_Plk_1	542	548	PF00069	0.555
MOD_Plk_1	670	676	PF00069	0.628
MOD_Plk_4	18	24	PF00069	0.490
MOD_Plk_4	294	300	PF00069	0.554
MOD_Plk_4	323	329	PF00069	0.510
MOD_Plk_4	42	48	PF00069	0.605
MOD_Plk_4	509	515	PF00069	0.625
MOD_Plk_4	51	57	PF00069	0.537
MOD_Plk_4	516	522	PF00069	0.586
MOD_Plk_4	662	668	PF00069	0.704
MOD_ProDKin_1	13	19	PF00069	0.648
MOD_ProDKin_1	174	180	PF00069	0.617
MOD_ProDKin_1	480	486	PF00069	0.681
MOD_SUMO_rev_2	272	282	PF00179	0.546
MOD_SUMO_rev_2	538	542	PF00179	0.534
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.528
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.567
TRG_ENDOCYTIC_2	255	258	PF00928	0.715
TRG_ENDOCYTIC_2	311	314	PF00928	0.511
TRG_ENDOCYTIC_2	379	382	PF00928	0.620
TRG_ER_diArg_1	145	147	PF00400	0.676
TRG_ER_diArg_1	534	536	PF00400	0.605
TRG_ER_diArg_1	65	68	PF00400	0.527
TRG_ER_diArg_1	95	98	PF00400	0.808
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE66	Leptomonas seymouri	41%	100%
A0A1X0NZK2	Trypanosomatidae	25%	100%
A0A3Q8IEA8	Leishmania donovani	89%	100%
A0A3R7NL89	Trypanosoma rangeli	27%	100%
A4HH77	Leishmania braziliensis	68%	100%
A4I4C3	Leishmania infantum	89%	100%
E9AM08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%