Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania major

UniProt:

E9ADS1_LEIMA

TriTrypDb:

LmjF.29.0690 , LMJLV39_290012300 , LMJSD75_290012300

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005747	mitochondrial respiratory chain complex I	4	2
GO:0020023	kinetoplast	2	2
GO:0030964	NADH dehydrogenase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0045271	respiratory chain complex I	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2

Expansion

Sequence features

E9ADS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	230	232	PF00675	0.462
CLV_PCSK_KEX2_1	230	232	PF00082	0.430
CLV_PCSK_SKI1_1	149	153	PF00082	0.564
CLV_PCSK_SKI1_1	191	195	PF00082	0.545
CLV_PCSK_SKI1_1	242	246	PF00082	0.422
DEG_MDM2_SWIB_1	38	46	PF02201	0.681
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DOC_CKS1_1	157	162	PF01111	0.541
DOC_MAPK_gen_1	230	237	PF00069	0.421
DOC_USP7_MATH_1	5	9	PF00917	0.716
DOC_USP7_MATH_1	75	79	PF00917	0.661
DOC_WW_Pin1_4	156	161	PF00397	0.543
DOC_WW_Pin1_4	257	262	PF00397	0.543
DOC_WW_Pin1_4	97	102	PF00397	0.668
LIG_14-3-3_CanoR_1	4	11	PF00244	0.706
LIG_BIR_III_2	220	224	PF00653	0.514
LIG_BRCT_BRCA1_1	189	193	PF00533	0.577
LIG_BRCT_BRCA1_1	90	94	PF00533	0.635
LIG_deltaCOP1_diTrp_1	143	154	PF00928	0.546
LIG_FHA_1	257	263	PF00498	0.519
LIG_FHA_1	88	94	PF00498	0.654
LIG_FHA_2	224	230	PF00498	0.583
LIG_FHA_2	245	251	PF00498	0.460
LIG_LIR_Gen_1	144	155	PF02991	0.537
LIG_LIR_Gen_1	167	176	PF02991	0.447
LIG_LIR_Gen_1	217	227	PF02991	0.496
LIG_LIR_Nem_3	105	110	PF02991	0.575
LIG_LIR_Nem_3	144	150	PF02991	0.443
LIG_LIR_Nem_3	167	172	PF02991	0.507
LIG_LIR_Nem_3	217	222	PF02991	0.476
LIG_LIR_Nem_3	97	102	PF02991	0.587
LIG_Pex14_1	169	173	PF04695	0.508
LIG_Pex14_2	165	169	PF04695	0.424
LIG_Pex14_2	38	42	PF04695	0.670
LIG_PTB_Apo_2	61	68	PF02174	0.759
LIG_PTB_Phospho_1	61	67	PF10480	0.722
LIG_SH2_CRK	107	111	PF00017	0.626
LIG_SH2_NCK_1	173	177	PF00017	0.545
LIG_SH2_STAP1	205	209	PF00017	0.528
LIG_SH2_STAT5	173	176	PF00017	0.428
LIG_SH2_STAT5	202	205	PF00017	0.506
LIG_SUMO_SIM_anti_2	128	133	PF11976	0.486
LIG_TRAF2_1	254	257	PF00917	0.677
LIG_TYR_ITIM	203	208	PF00017	0.533
MOD_CDK_SPxxK_3	97	104	PF00069	0.668
MOD_CK1_1	156	162	PF00069	0.604
MOD_CK1_1	17	23	PF00069	0.637
MOD_CK1_1	44	50	PF00069	0.612
MOD_CK1_1	6	12	PF00069	0.672
MOD_CK2_1	164	170	PF00069	0.521
MOD_CK2_1	223	229	PF00069	0.590
MOD_CK2_1	97	103	PF00069	0.581
MOD_GlcNHglycan	166	169	PF01048	0.508
MOD_GlcNHglycan	175	179	PF01048	0.457
MOD_GlcNHglycan	19	22	PF01048	0.584
MOD_GlcNHglycan	28	31	PF01048	0.608
MOD_GlcNHglycan	43	46	PF01048	0.658
MOD_GlcNHglycan	5	8	PF01048	0.674
MOD_GlcNHglycan	73	76	PF01048	0.624
MOD_GSK3_1	106	113	PF00069	0.756
MOD_GSK3_1	17	24	PF00069	0.658
MOD_GSK3_1	26	33	PF00069	0.580
MOD_GSK3_1	3	10	PF00069	0.681
MOD_GSK3_1	71	78	PF00069	0.615
MOD_N-GLC_1	134	139	PF02516	0.462
MOD_N-GLC_1	81	86	PF02516	0.725
MOD_NEK2_1	110	115	PF00069	0.713
MOD_NEK2_1	193	198	PF00069	0.518
MOD_NEK2_1	244	249	PF00069	0.500
MOD_NEK2_1	26	31	PF00069	0.638
MOD_NEK2_1	3	8	PF00069	0.715
MOD_NEK2_2	223	228	PF00069	0.524
MOD_NEK2_2	7	12	PF00069	0.741
MOD_PIKK_1	193	199	PF00454	0.502
MOD_PIKK_1	47	53	PF00454	0.619
MOD_PKA_2	110	116	PF00069	0.707
MOD_PKA_2	238	244	PF00069	0.403
MOD_PKA_2	3	9	PF00069	0.715
MOD_PKB_1	12	20	PF00069	0.706
MOD_Plk_1	81	87	PF00069	0.731
MOD_Plk_1	88	94	PF00069	0.664
MOD_Plk_4	223	229	PF00069	0.599
MOD_Plk_4	89	95	PF00069	0.538
MOD_ProDKin_1	156	162	PF00069	0.543
MOD_ProDKin_1	257	263	PF00069	0.548
MOD_ProDKin_1	97	103	PF00069	0.668
TRG_ENDOCYTIC_2	107	110	PF00928	0.637
TRG_ENDOCYTIC_2	205	208	PF00928	0.498
TRG_ER_diArg_1	11	14	PF00400	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P4	Leptomonas seymouri	66%	100%
A0A0S4JHC6	Bodo saltans	39%	100%
A0A1X0P070	Trypanosomatidae	55%	100%
A0A3S7X260	Leishmania donovani	93%	100%
A4HH76	Leishmania braziliensis	83%	100%
A4I4C2	Leishmania infantum	93%	100%
C9ZL46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AM09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BQ11	Trypanosoma cruzi	55%	100%