Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triple RNA binding domain protein 3

Species:

Leishmania major

UniProt:

E9ADS0_LEIMA

TriTrypDb:

LmjF.29.0680 , LMJLV39_290012200 , LMJSD75_290012200

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ADS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADS0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	444	448	PF00656	0.513
CLV_C14_Caspase3-7	719	723	PF00656	0.752
CLV_MEL_PAP_1	452	458	PF00089	0.387
CLV_NRD_NRD_1	132	134	PF00675	0.762
CLV_NRD_NRD_1	151	153	PF00675	0.667
CLV_NRD_NRD_1	228	230	PF00675	0.698
CLV_NRD_NRD_1	261	263	PF00675	0.685
CLV_NRD_NRD_1	349	351	PF00675	0.504
CLV_NRD_NRD_1	426	428	PF00675	0.555
CLV_NRD_NRD_1	454	456	PF00675	0.522
CLV_NRD_NRD_1	527	529	PF00675	0.796
CLV_NRD_NRD_1	587	589	PF00675	0.346
CLV_NRD_NRD_1	62	64	PF00675	0.616
CLV_NRD_NRD_1	671	673	PF00675	0.703
CLV_NRD_NRD_1	82	84	PF00675	0.505
CLV_PCSK_FUR_1	89	93	PF00082	0.698
CLV_PCSK_KEX2_1	132	134	PF00082	0.745
CLV_PCSK_KEX2_1	151	153	PF00082	0.667
CLV_PCSK_KEX2_1	228	230	PF00082	0.698
CLV_PCSK_KEX2_1	454	456	PF00082	0.522
CLV_PCSK_KEX2_1	527	529	PF00082	0.796
CLV_PCSK_KEX2_1	62	64	PF00082	0.616
CLV_PCSK_KEX2_1	671	673	PF00082	0.703
CLV_PCSK_KEX2_1	717	719	PF00082	0.726
CLV_PCSK_KEX2_1	735	737	PF00082	0.504
CLV_PCSK_KEX2_1	787	789	PF00082	0.725
CLV_PCSK_KEX2_1	91	93	PF00082	0.706
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.703
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.726
CLV_PCSK_PC1ET2_1	735	737	PF00082	0.504
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.725
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.706
CLV_PCSK_SKI1_1	320	324	PF00082	0.468
CLV_PCSK_SKI1_1	350	354	PF00082	0.544
CLV_PCSK_SKI1_1	386	390	PF00082	0.482
CLV_PCSK_SKI1_1	403	407	PF00082	0.516
CLV_PCSK_SKI1_1	427	431	PF00082	0.510
CLV_PCSK_SKI1_1	673	677	PF00082	0.622
CLV_PCSK_SKI1_1	806	810	PF00082	0.821
CLV_Separin_Metazoa	404	408	PF03568	0.515
DEG_APCC_DBOX_1	402	410	PF00400	0.511
DEG_Nend_UBRbox_1	1	4	PF02207	0.470
DEG_SCF_FBW7_1	439	444	PF00400	0.524
DEG_SPOP_SBC_1	108	112	PF00917	0.617
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.526
DOC_MAPK_gen_1	278	286	PF00069	0.519
DOC_MAPK_gen_1	427	433	PF00069	0.502
DOC_MAPK_gen_1	588	594	PF00069	0.546
DOC_MAPK_gen_1	626	634	PF00069	0.546
DOC_MAPK_RevD_3	441	455	PF00069	0.511
DOC_PP4_FxxP_1	165	168	PF00568	0.725
DOC_PP4_FxxP_1	609	612	PF00568	0.546
DOC_USP7_MATH_1	107	111	PF00917	0.680
DOC_USP7_MATH_1	205	209	PF00917	0.723
DOC_USP7_MATH_1	212	216	PF00917	0.712
DOC_USP7_MATH_1	484	488	PF00917	0.760
DOC_USP7_MATH_1	493	497	PF00917	0.644
DOC_USP7_MATH_1	535	539	PF00917	0.801
DOC_USP7_MATH_1	755	759	PF00917	0.771
DOC_USP7_MATH_1	778	782	PF00917	0.711
DOC_USP7_MATH_1	99	103	PF00917	0.628
DOC_USP7_UBL2_3	279	283	PF12436	0.594
DOC_USP7_UBL2_3	365	369	PF12436	0.613
DOC_USP7_UBL2_3	377	381	PF12436	0.663
DOC_USP7_UBL2_3	669	673	PF12436	0.611
DOC_USP7_UBL2_3	713	717	PF12436	0.711
DOC_USP7_UBL2_3	802	806	PF12436	0.800
DOC_WW_Pin1_4	132	137	PF00397	0.687
DOC_WW_Pin1_4	223	228	PF00397	0.799
DOC_WW_Pin1_4	333	338	PF00397	0.523
DOC_WW_Pin1_4	437	442	PF00397	0.520
DOC_WW_Pin1_4	489	494	PF00397	0.725
LIG_14-3-3_CanoR_1	116	121	PF00244	0.730
LIG_14-3-3_CanoR_1	132	136	PF00244	0.564
LIG_14-3-3_CanoR_1	22	28	PF00244	0.523
LIG_14-3-3_CanoR_1	486	493	PF00244	0.605
LIG_14-3-3_CanoR_1	736	743	PF00244	0.685
LIG_14-3-3_CanoR_1	745	750	PF00244	0.548
LIG_14-3-3_CanoR_1	83	87	PF00244	0.724
LIG_14-3-3_CanoR_1	89	95	PF00244	0.683
LIG_AP2alpha_1	445	449	PF02296	0.500
LIG_APCC_ABBA_1	592	597	PF00400	0.546
LIG_BIR_III_2	142	146	PF00653	0.704
LIG_BRCT_BRCA1_1	11	15	PF00533	0.483
LIG_BRCT_BRCA1_1	161	165	PF00533	0.764
LIG_FHA_1	35	41	PF00498	0.524
LIG_FHA_1	354	360	PF00498	0.641
LIG_FHA_1	383	389	PF00498	0.467
LIG_FHA_1	438	444	PF00498	0.520
LIG_FHA_1	770	776	PF00498	0.693
LIG_FHA_2	133	139	PF00498	0.767
LIG_FHA_2	299	305	PF00498	0.566
LIG_FHA_2	433	439	PF00498	0.544
LIG_FHA_2	442	448	PF00498	0.452
LIG_Integrin_isoDGR_2	348	350	PF01839	0.532
LIG_Integrin_RGD_1	188	190	PF01839	0.702
LIG_LIR_Apic_2	162	168	PF02991	0.754
LIG_LIR_Apic_2	608	612	PF02991	0.546
LIG_LIR_Gen_1	447	456	PF02991	0.513
LIG_LIR_Gen_1	550	560	PF02991	0.588
LIG_LIR_Nem_3	447	452	PF02991	0.502
LIG_LIR_Nem_3	550	556	PF02991	0.594
LIG_NRP_CendR_1	809	811	PF00754	0.781
LIG_Pex14_2	309	313	PF04695	0.529
LIG_Pex14_2	445	449	PF04695	0.500
LIG_RPA_C_Fungi	450	462	PF08784	0.521
LIG_SH2_STAP1	291	295	PF00017	0.637
LIG_SH2_STAP1	614	618	PF00017	0.411
LIG_SH2_STAP1	657	661	PF00017	0.627
LIG_SH2_STAT5	291	294	PF00017	0.609
LIG_SH2_STAT5	564	567	PF00017	0.411
LIG_SH2_STAT5	674	677	PF00017	0.719
LIG_SH3_3	294	300	PF00018	0.632
LIG_SH3_3	312	318	PF00018	0.541
LIG_SH3_3	356	362	PF00018	0.536
LIG_SH3_3	393	399	PF00018	0.509
LIG_SH3_3	93	99	PF00018	0.691
LIG_SUMO_SIM_anti_2	504	513	PF11976	0.699
LIG_SUMO_SIM_par_1	144	149	PF11976	0.699
LIG_TRAF2_1	157	160	PF00917	0.720
LIG_TRAF2_1	246	249	PF00917	0.840
LIG_TRAF2_1	301	304	PF00917	0.661
LIG_TRAF2_1	649	652	PF00917	0.693
LIG_UBA3_1	389	395	PF00899	0.498
LIG_WRC_WIRS_1	430	435	PF05994	0.500
MOD_CDC14_SPxK_1	226	229	PF00782	0.759
MOD_CDK_SPK_2	223	228	PF00069	0.667
MOD_CDK_SPxK_1	223	229	PF00069	0.760
MOD_CK1_1	110	116	PF00069	0.597
MOD_CK1_1	206	212	PF00069	0.820
MOD_CK1_1	223	229	PF00069	0.523
MOD_CK1_1	234	240	PF00069	0.632
MOD_CK1_1	336	342	PF00069	0.519
MOD_CK1_1	538	544	PF00069	0.690
MOD_CK1_1	58	64	PF00069	0.839
MOD_CK1_1	782	788	PF00069	0.807
MOD_CK2_1	243	249	PF00069	0.785
MOD_CK2_1	269	275	PF00069	0.619
MOD_CK2_1	298	304	PF00069	0.685
MOD_CK2_1	432	438	PF00069	0.506
MOD_CK2_1	694	700	PF00069	0.805
MOD_Cter_Amidation	130	133	PF01082	0.751
MOD_Cter_Amidation	348	351	PF01082	0.540
MOD_Cter_Amidation	452	455	PF01082	0.537
MOD_Cter_Amidation	715	718	PF01082	0.829
MOD_Cter_Amidation	785	788	PF01082	0.749
MOD_GlcNHglycan	113	116	PF01048	0.738
MOD_GlcNHglycan	148	151	PF01048	0.833
MOD_GlcNHglycan	205	208	PF01048	0.819
MOD_GlcNHglycan	210	213	PF01048	0.744
MOD_GlcNHglycan	233	237	PF01048	0.773
MOD_GlcNHglycan	271	274	PF01048	0.613
MOD_GlcNHglycan	31	34	PF01048	0.524
MOD_GlcNHglycan	310	313	PF01048	0.633
MOD_GlcNHglycan	42	45	PF01048	0.536
MOD_GlcNHglycan	456	459	PF01048	0.502
MOD_GlcNHglycan	495	498	PF01048	0.725
MOD_GlcNHglycan	522	525	PF01048	0.692
MOD_GlcNHglycan	535	538	PF01048	0.789
MOD_GlcNHglycan	540	543	PF01048	0.694
MOD_GlcNHglycan	640	643	PF01048	0.729
MOD_GlcNHglycan	784	787	PF01048	0.681
MOD_GlcNHglycan	799	802	PF01048	0.561
MOD_GlcNHglycan	84	87	PF01048	0.733
MOD_GSK3_1	107	114	PF00069	0.643
MOD_GSK3_1	116	123	PF00069	0.627
MOD_GSK3_1	208	215	PF00069	0.678
MOD_GSK3_1	25	32	PF00069	0.527
MOD_GSK3_1	265	272	PF00069	0.654
MOD_GSK3_1	34	41	PF00069	0.496
MOD_GSK3_1	437	444	PF00069	0.526
MOD_GSK3_1	463	470	PF00069	0.645
MOD_GSK3_1	485	492	PF00069	0.751
MOD_GSK3_1	533	540	PF00069	0.802
MOD_GSK3_1	595	602	PF00069	0.402
MOD_GSK3_1	741	748	PF00069	0.585
MOD_GSK3_1	778	785	PF00069	0.816
MOD_LATS_1	36	42	PF00433	0.538
MOD_N-GLC_1	533	538	PF02516	0.754
MOD_N-GLC_1	544	549	PF02516	0.587
MOD_N-GLC_1	708	713	PF02516	0.820
MOD_N-GLC_1	755	760	PF02516	0.769
MOD_NEK2_1	120	125	PF00069	0.646
MOD_NEK2_1	25	30	PF00069	0.526
MOD_NEK2_1	353	358	PF00069	0.619
MOD_NEK2_1	40	45	PF00069	0.517
MOD_NEK2_1	675	680	PF00069	0.632
MOD_PIKK_1	120	126	PF00454	0.608
MOD_PIKK_1	421	427	PF00454	0.571
MOD_PK_1	676	682	PF00069	0.619
MOD_PKA_1	454	460	PF00069	0.521
MOD_PKA_2	131	137	PF00069	0.736
MOD_PKA_2	454	460	PF00069	0.521
MOD_PKA_2	474	480	PF00069	0.502
MOD_PKA_2	485	491	PF00069	0.595
MOD_PKA_2	55	61	PF00069	0.835
MOD_PKA_2	82	88	PF00069	0.682
MOD_PKB_1	218	226	PF00069	0.598
MOD_Plk_1	507	513	PF00069	0.672
MOD_Plk_2-3	243	249	PF00069	0.728
MOD_Plk_2-3	694	700	PF00069	0.739
MOD_Plk_4	220	226	PF00069	0.620
MOD_Plk_4	507	513	PF00069	0.672
MOD_ProDKin_1	132	138	PF00069	0.686
MOD_ProDKin_1	223	229	PF00069	0.802
MOD_ProDKin_1	333	339	PF00069	0.517
MOD_ProDKin_1	437	443	PF00069	0.520
MOD_ProDKin_1	489	495	PF00069	0.725
MOD_SUMO_rev_2	360	364	PF00179	0.574
MOD_SUMO_rev_2	408	417	PF00179	0.530
MOD_SUMO_rev_2	719	726	PF00179	0.755
TRG_DiLeu_BaEn_1	551	556	PF01217	0.597
TRG_DiLeu_BaEn_3	160	166	PF01217	0.763
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.529
TRG_ENDOCYTIC_2	553	556	PF00928	0.590
TRG_ER_diArg_1	227	229	PF00400	0.685
TRG_ER_diArg_1	454	456	PF00400	0.522
TRG_ER_diArg_1	526	528	PF00400	0.595
TRG_ER_diLys_1	807	811	PF00400	0.824
TRG_NES_CRM1_1	275	287	PF08389	0.584
TRG_NLS_Bipartite_1	717	739	PF00514	0.830
TRG_NLS_MonoExtC_3	734	740	PF00514	0.754
TRG_NLS_MonoExtC_3	805	810	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C3	Leptomonas seymouri	62%	100%
A0A3S7X2A3	Leishmania donovani	85%	100%
A4HH75	Leishmania braziliensis	83%	100%
A4I4C1	Leishmania infantum	85%	100%
E9AM10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%