Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADR9_LEIMA

TriTrypDb:

LmjF.29.0670 , LMJLV39_290012100 , LMJSD75_290012100

Length:

138

Annotations

LeishMANIAdb annotations

1TM protein with a basic N-terminus that might be a mitochondrial transit signal.. Though conservative, not found outside Kinetoplastida

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	9
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ADR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.417
CLV_NRD_NRD_1	14	16	PF00675	0.409
CLV_NRD_NRD_1	20	22	PF00675	0.390
CLV_PCSK_KEX2_1	20	22	PF00082	0.400
CLV_PCSK_KEX2_1	9	11	PF00082	0.410
CLV_Separin_Metazoa	12	16	PF03568	0.605
DOC_CYCLIN_yClb5_NLxxxL_5	117	123	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.397
DOC_MAPK_gen_1	23	33	PF00069	0.571
DOC_MAPK_gen_1	37	45	PF00069	0.564
DOC_MAPK_MEF2A_6	26	33	PF00069	0.579
DOC_PP4_FxxP_1	49	52	PF00568	0.355
DOC_USP7_MATH_1	62	66	PF00917	0.356
DOC_WW_Pin1_4	111	116	PF00397	0.402
LIG_14-3-3_CanoR_1	20	26	PF00244	0.590
LIG_BRCT_BRCA1_1	99	103	PF00533	0.469
LIG_FHA_1	61	67	PF00498	0.283
LIG_LIR_Apic_2	109	115	PF02991	0.387
LIG_LIR_Gen_1	100	111	PF02991	0.454
LIG_LIR_Gen_1	128	135	PF02991	0.426
LIG_LIR_Nem_3	100	106	PF02991	0.457
LIG_LIR_Nem_3	128	132	PF02991	0.455
LIG_LIR_Nem_3	2	7	PF02991	0.633
LIG_LIR_Nem_3	22	28	PF02991	0.497
LIG_SH2_STAP1	82	86	PF00017	0.367
LIG_SH2_STAP1	88	92	PF00017	0.380
LIG_SH2_STAT5	68	71	PF00017	0.404
LIG_SH3_1	11	17	PF00018	0.606
LIG_SH3_2	122	127	PF14604	0.416
LIG_SH3_3	11	17	PF00018	0.606
LIG_SH3_3	119	125	PF00018	0.419
MOD_CDC14_SPxK_1	114	117	PF00782	0.393
MOD_CDK_SPxK_1	111	117	PF00069	0.396
MOD_CK1_1	5	11	PF00069	0.688
MOD_GSK3_1	71	78	PF00069	0.458
MOD_GSK3_1	93	100	PF00069	0.483
MOD_N-GLC_1	33	38	PF02516	0.380
MOD_NEK2_1	33	38	PF00069	0.597
MOD_NEK2_1	60	65	PF00069	0.277
MOD_NEK2_1	75	80	PF00069	0.315
MOD_NEK2_2	62	67	PF00069	0.361
MOD_PIKK_1	97	103	PF00454	0.475
MOD_PKA_2	19	25	PF00069	0.593
MOD_Plk_4	2	8	PF00069	0.698
MOD_Plk_4	62	68	PF00069	0.306
MOD_Plk_4	71	77	PF00069	0.336
MOD_Plk_4	99	105	PF00069	0.365
MOD_ProDKin_1	111	117	PF00069	0.405
MOD_SUMO_rev_2	128	138	PF00179	0.428
TRG_ENDOCYTIC_2	4	7	PF00928	0.633
TRG_ENDOCYTIC_2	67	70	PF00928	0.399
TRG_ER_diArg_1	19	21	PF00400	0.592
TRG_ER_diArg_1	9	11	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9D3	Leptomonas seymouri	75%	100%
A0A0S4JF31	Bodo saltans	58%	84%
A0A1X0NZT9	Trypanosomatidae	73%	100%
A0A3Q8IH51	Leishmania donovani	97%	100%
A0A3S5IRQ2	Trypanosoma rangeli	64%	100%
A4HH74	Leishmania braziliensis	90%	100%
A4I4C0	Leishmania infantum	97%	100%
C9ZL48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AM11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%