Putative flagellar radial spoke protein-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar radial spoke protein-like, putative

Species:

Leishmania major

UniProt:

E9ADR8_LEIMA

TriTrypDb:

LmjF.29.0660 , LMJLV39_290012000 , LMJSD75_290012000

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	12
GO:0005929	cilium	4	12
GO:0005930	axoneme	2	2
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

E9ADR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0001578	microtubule bundle formation	4	2
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0035082	axoneme assembly	5	2
GO:0060294	cilium movement involved in cell motility	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0030030	cell projection organization	4	10
GO:0030031	cell projection assembly	5	10
GO:0044782	cilium organization	5	10
GO:0060271	cilium assembly	6	10
GO:0070925	organelle assembly	5	10
GO:0120031	plasma membrane bounded cell projection assembly	6	10
GO:0120036	plasma membrane bounded cell projection organization	5	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	291	297	PF00089	0.196
CLV_NRD_NRD_1	101	103	PF00675	0.218
CLV_NRD_NRD_1	242	244	PF00675	0.276
CLV_NRD_NRD_1	482	484	PF00675	0.204
CLV_NRD_NRD_1	98	100	PF00675	0.217
CLV_PCSK_FUR_1	99	103	PF00082	0.269
CLV_PCSK_KEX2_1	101	103	PF00082	0.218
CLV_PCSK_KEX2_1	242	244	PF00082	0.277
CLV_PCSK_KEX2_1	98	100	PF00082	0.217
DEG_COP1_1	335	345	PF00400	0.446
DOC_ANK_TNKS_1	576	583	PF00023	0.536
DOC_CDC14_PxL_1	364	372	PF14671	0.415
DOC_CYCLIN_yCln2_LP_2	463	469	PF00134	0.446
DOC_PP1_RVXF_1	497	504	PF00149	0.509
DOC_PP2B_LxvP_1	149	152	PF13499	0.509
DOC_PP2B_LxvP_1	299	302	PF13499	0.493
DOC_PP2B_LxvP_1	463	466	PF13499	0.446
DOC_PP2B_LxvP_1	542	545	PF13499	0.509
DOC_PP2B_LxvP_1	91	94	PF13499	0.404
DOC_USP7_MATH_1	171	175	PF00917	0.456
DOC_USP7_MATH_1	245	249	PF00917	0.500
DOC_USP7_MATH_1	440	444	PF00917	0.446
DOC_USP7_MATH_1	470	474	PF00917	0.452
DOC_USP7_MATH_1	517	521	PF00917	0.471
DOC_USP7_MATH_1	74	78	PF00917	0.502
DOC_USP7_UBL2_3	392	396	PF12436	0.413
DOC_WW_Pin1_4	278	283	PF00397	0.428
DOC_WW_Pin1_4	443	448	PF00397	0.413
LIG_14-3-3_CanoR_1	14	22	PF00244	0.446
LIG_14-3-3_CanoR_1	323	332	PF00244	0.404
LIG_14-3-3_CanoR_1	417	422	PF00244	0.457
LIG_14-3-3_CanoR_1	516	522	PF00244	0.448
LIG_APCC_ABBAyCdc20_2	58	64	PF00400	0.502
LIG_BIR_III_4	39	43	PF00653	0.413
LIG_BRCT_BRCA1_1	173	177	PF00533	0.439
LIG_eIF4E_1	394	400	PF01652	0.404
LIG_FHA_1	21	27	PF00498	0.471
LIG_FHA_1	418	424	PF00498	0.532
LIG_FHA_1	506	512	PF00498	0.425
LIG_FHA_2	265	271	PF00498	0.490
LIG_FHA_2	393	399	PF00498	0.413
LIG_FHA_2	562	568	PF00498	0.414
LIG_LIR_Apic_2	568	574	PF02991	0.475
LIG_LIR_Gen_1	272	282	PF02991	0.415
LIG_LIR_Gen_1	520	526	PF02991	0.424
LIG_LIR_Nem_3	155	160	PF02991	0.437
LIG_LIR_Nem_3	174	180	PF02991	0.509
LIG_LIR_Nem_3	272	277	PF02991	0.446
LIG_MYND_1	368	372	PF01753	0.415
LIG_MYND_1	540	544	PF01753	0.388
LIG_PDZ_Class_3	585	590	PF00595	0.665
LIG_Pex14_1	390	394	PF04695	0.404
LIG_PTAP_UEV_1	246	251	PF05743	0.413
LIG_RPA_C_Fungi	318	330	PF08784	0.384
LIG_RPA_C_Fungi	42	54	PF08784	0.179
LIG_SH2_CRK	157	161	PF00017	0.384
LIG_SH2_CRK	364	368	PF00017	0.252
LIG_SH2_CRK	538	542	PF00017	0.413
LIG_SH2_CRK	571	575	PF00017	0.483
LIG_SH2_GRB2like	143	146	PF00017	0.296
LIG_SH2_NCK_1	233	237	PF00017	0.179
LIG_SH2_NCK_1	571	575	PF00017	0.483
LIG_SH2_SRC	538	541	PF00017	0.384
LIG_SH2_SRC	550	553	PF00017	0.384
LIG_SH2_SRC	571	574	PF00017	0.500
LIG_SH2_SRC	62	65	PF00017	0.271
LIG_SH2_STAT5	143	146	PF00017	0.296
LIG_SH2_STAT5	189	192	PF00017	0.288
LIG_SH2_STAT5	233	236	PF00017	0.179
LIG_SH2_STAT5	316	319	PF00017	0.238
LIG_SH2_STAT5	394	397	PF00017	0.249
LIG_SH2_STAT5	496	499	PF00017	0.238
LIG_SH2_STAT5	550	553	PF00017	0.296
LIG_SH3_1	537	543	PF00018	0.384
LIG_SH3_1	570	576	PF00018	0.617
LIG_SH3_2	93	98	PF14604	0.238
LIG_SH3_3	244	250	PF00018	0.296
LIG_SH3_3	363	369	PF00018	0.245
LIG_SH3_3	442	448	PF00018	0.395
LIG_SH3_3	537	543	PF00018	0.239
LIG_SH3_3	548	554	PF00018	0.242
LIG_SH3_3	570	576	PF00018	0.473
LIG_SH3_3	90	96	PF00018	0.242
LIG_TRAF2_1	250	253	PF00917	0.384
LIG_TRAF2_1	376	379	PF00917	0.251
LIG_TRAF2_1	422	425	PF00917	0.334
LIG_WRC_WIRS_1	333	338	PF05994	0.296
LIG_WRC_WIRS_1	75	80	PF05994	0.296
LIG_WW_2	540	543	PF00397	0.384
LIG_WW_3	574	578	PF00397	0.640
LIG_WW_3	92	96	PF00397	0.337
MOD_CK1_1	443	449	PF00069	0.449
MOD_CK1_1	459	465	PF00069	0.192
MOD_CK2_1	392	398	PF00069	0.296
MOD_CK2_1	561	567	PF00069	0.377
MOD_GlcNHglycan	110	116	PF01048	0.268
MOD_GlcNHglycan	15	18	PF01048	0.296
MOD_GlcNHglycan	183	186	PF01048	0.226
MOD_GlcNHglycan	247	250	PF01048	0.292
MOD_GlcNHglycan	295	298	PF01048	0.359
MOD_GlcNHglycan	325	328	PF01048	0.296
MOD_GlcNHglycan	349	355	PF01048	0.249
MOD_GlcNHglycan	49	52	PF01048	0.358
MOD_GSK3_1	132	139	PF00069	0.378
MOD_GSK3_1	265	272	PF00069	0.234
MOD_GSK3_1	505	512	PF00069	0.342
MOD_GSK3_1	74	81	PF00069	0.347
MOD_N-GLC_1	440	445	PF02516	0.249
MOD_NEK2_1	49	54	PF00069	0.342
MOD_NEK2_1	78	83	PF00069	0.296
MOD_NEK2_2	171	176	PF00069	0.348
MOD_NEK2_2	478	483	PF00069	0.221
MOD_PIKK_1	20	26	PF00454	0.397
MOD_PIKK_1	223	229	PF00454	0.362
MOD_PKA_2	13	19	PF00069	0.296
MOD_PKA_2	245	251	PF00069	0.384
MOD_PKA_2	293	299	PF00069	0.384
MOD_PKA_2	322	328	PF00069	0.252
MOD_PKA_2	416	422	PF00069	0.331
MOD_PKA_2	65	71	PF00069	0.357
MOD_Plk_1	459	465	PF00069	0.296
MOD_Plk_1	561	567	PF00069	0.331
MOD_Plk_4	408	414	PF00069	0.242
MOD_ProDKin_1	278	284	PF00069	0.271
MOD_ProDKin_1	443	449	PF00069	0.249
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.348
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.331
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.179
TRG_ENDOCYTIC_2	143	146	PF00928	0.439
TRG_ENDOCYTIC_2	157	160	PF00928	0.287
TRG_ENDOCYTIC_2	364	367	PF00928	0.238
TRG_ENDOCYTIC_2	521	524	PF00928	0.278
TRG_ER_diArg_1	100	102	PF00400	0.258
TRG_ER_diArg_1	242	244	PF00400	0.334
TRG_ER_diArg_1	291	294	PF00400	0.271
TRG_ER_diArg_1	97	99	PF00400	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q1	Leptomonas seymouri	70%	100%
A0A0S4JES8	Bodo saltans	40%	100%
A0A1X0P128	Trypanosomatidae	49%	100%
A0A3Q8IE67	Leishmania donovani	95%	83%
A0A3R7KK84	Trypanosoma rangeli	47%	100%
A4HH73	Leishmania braziliensis	84%	100%
A4I4B9	Leishmania infantum	95%	84%
C9ZL49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AM12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q01656	Chlamydomonas reinhardtii	24%	100%
Q8BYM7	Mus musculus	25%	82%
Q8CDR2	Mus musculus	28%	83%
Q9H0K4	Homo sapiens	28%	82%
V5B4W9	Trypanosoma cruzi	47%	100%