Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate transporter, putative

Species:

Leishmania major

UniProt:

E9ADR7_LEIMA

TriTrypDb:

LmjF.29.0650 , LMJLV39_290011900 , LMJSD75_290011900

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ADR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0006811	monoatomic ion transport	4	8
GO:0006817	phosphate ion transport	7	8
GO:0006820	monoatomic anion transport	5	8
GO:0009987	cellular process	1	2
GO:0015698	inorganic anion transport	6	8
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0035435	phosphate ion transmembrane transport	6	2
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0055085	transmembrane transport	2	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098661	inorganic anion transmembrane transport	5	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0005315	inorganic phosphate transmembrane transporter activity	4	8
GO:0015291	secondary active transmembrane transporter activity	4	8
GO:0015293	symporter activity	5	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022804	active transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.500
CLV_NRD_NRD_1	175	177	PF00675	0.244
CLV_NRD_NRD_1	358	360	PF00675	0.246
CLV_NRD_NRD_1	408	410	PF00675	0.226
CLV_PCSK_KEX2_1	175	177	PF00082	0.270
CLV_PCSK_KEX2_1	358	360	PF00082	0.246
CLV_PCSK_SKI1_1	176	180	PF00082	0.242
CLV_PCSK_SKI1_1	190	194	PF00082	0.193
CLV_PCSK_SKI1_1	485	489	PF00082	0.326
CLV_PCSK_SKI1_1	680	684	PF00082	0.258
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.323
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.466
DOC_MAPK_DCC_7	79	88	PF00069	0.277
DOC_MAPK_gen_1	409	416	PF00069	0.495
DOC_MAPK_gen_1	492	500	PF00069	0.446
DOC_MAPK_MEF2A_6	145	154	PF00069	0.238
DOC_MAPK_MEF2A_6	92	99	PF00069	0.241
DOC_PP1_RVXF_1	284	291	PF00149	0.464
DOC_PP2B_LxvP_1	157	160	PF13499	0.323
DOC_PP2B_LxvP_1	336	339	PF13499	0.500
DOC_PP4_FxxP_1	116	119	PF00568	0.435
DOC_USP7_MATH_1	214	218	PF00917	0.285
DOC_USP7_MATH_1	255	259	PF00917	0.464
DOC_USP7_MATH_1	378	382	PF00917	0.500
DOC_WW_Pin1_4	380	385	PF00397	0.549
DOC_WW_Pin1_4	402	407	PF00397	0.429
DOC_WW_Pin1_4	422	427	PF00397	0.407
DOC_WW_Pin1_4	500	505	PF00397	0.474
DOC_WW_Pin1_4	622	627	PF00397	0.442
LIG_14-3-3_CanoR_1	182	187	PF00244	0.416
LIG_APCC_ABBA_1	428	433	PF00400	0.393
LIG_BRCT_BRCA1_1	112	116	PF00533	0.270
LIG_BRCT_BRCA1_1	37	41	PF00533	0.435
LIG_CaM_NSCaTE_8	630	637	PF13499	0.311
LIG_CtBP_PxDLS_1	649	653	PF00389	0.235
LIG_FHA_1	12	18	PF00498	0.235
LIG_FHA_1	121	127	PF00498	0.329
LIG_FHA_1	136	142	PF00498	0.270
LIG_FHA_1	165	171	PF00498	0.275
LIG_FHA_1	269	275	PF00498	0.482
LIG_FHA_1	298	304	PF00498	0.498
LIG_FHA_1	323	329	PF00498	0.490
LIG_FHA_1	4	10	PF00498	0.333
LIG_FHA_1	638	644	PF00498	0.270
LIG_FHA_1	681	687	PF00498	0.278
LIG_FHA_1	693	699	PF00498	0.292
LIG_FHA_2	578	584	PF00498	0.285
LIG_FHA_2	58	64	PF00498	0.270
LIG_GBD_Chelix_1	686	694	PF00786	0.302
LIG_Integrin_RGD_1	294	296	PF01839	0.264
LIG_IRF3_LxIS_1	686	692	PF10401	0.269
LIG_LIR_Apic_2	113	119	PF02991	0.435
LIG_LIR_Apic_2	142	146	PF02991	0.249
LIG_LIR_Apic_2	372	378	PF02991	0.446
LIG_LIR_Gen_1	106	116	PF02991	0.272
LIG_LIR_Gen_1	204	215	PF02991	0.280
LIG_LIR_Gen_1	38	45	PF02991	0.498
LIG_LIR_Gen_1	569	579	PF02991	0.242
LIG_LIR_Gen_1	590	600	PF02991	0.266
LIG_LIR_Gen_1	60	70	PF02991	0.282
LIG_LIR_Nem_3	106	112	PF02991	0.272
LIG_LIR_Nem_3	204	210	PF02991	0.280
LIG_LIR_Nem_3	38	44	PF02991	0.498
LIG_LIR_Nem_3	542	548	PF02991	0.442
LIG_LIR_Nem_3	569	575	PF02991	0.242
LIG_LIR_Nem_3	590	596	PF02991	0.266
LIG_LIR_Nem_3	60	65	PF02991	0.284
LIG_LIR_Nem_3	674	678	PF02991	0.492
LIG_MYND_1	426	430	PF01753	0.393
LIG_NRBOX	197	203	PF00104	0.361
LIG_REV1ctd_RIR_1	288	298	PF16727	0.485
LIG_SH2_CRK	230	234	PF00017	0.265
LIG_SH2_CRK	375	379	PF00017	0.446
LIG_SH2_CRK	58	62	PF00017	0.309
LIG_SH2_PTP2	143	146	PF00017	0.246
LIG_SH2_STAP1	230	234	PF00017	0.236
LIG_SH2_STAT5	111	114	PF00017	0.309
LIG_SH2_STAT5	143	146	PF00017	0.235
LIG_SH2_STAT5	172	175	PF00017	0.272
LIG_SH2_STAT5	543	546	PF00017	0.485
LIG_SH2_STAT5	58	61	PF00017	0.297
LIG_SH3_2	523	528	PF14604	0.427
LIG_SH3_3	306	312	PF00018	0.466
LIG_SH3_3	325	331	PF00018	0.476
LIG_SH3_3	336	342	PF00018	0.425
LIG_SH3_3	495	501	PF00018	0.443
LIG_SH3_3	520	526	PF00018	0.442
LIG_SH3_3	533	539	PF00018	0.442
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.335
LIG_SUMO_SIM_par_1	118	123	PF11976	0.435
LIG_SUMO_SIM_par_1	620	625	PF11976	0.442
LIG_SUMO_SIM_par_1	648	653	PF11976	0.235
LIG_SUMO_SIM_par_1	687	692	PF11976	0.270
LIG_TYR_ITIM	228	233	PF00017	0.259
LIG_TYR_ITIM	56	61	PF00017	0.270
LIG_WRC_WIRS_1	23	28	PF05994	0.270
LIG_WRC_WIRS_1	555	560	PF05994	0.280
LIG_WW_3	308	312	PF00397	0.464
MOD_CDK_SPxK_1	622	628	PF00069	0.442
MOD_CDK_SPxxK_3	402	409	PF00069	0.393
MOD_CK1_1	103	109	PF00069	0.210
MOD_CK1_1	258	264	PF00069	0.464
MOD_CK1_1	368	374	PF00069	0.525
MOD_CK1_1	398	404	PF00069	0.536
MOD_CK1_1	434	440	PF00069	0.519
MOD_CK1_1	480	486	PF00069	0.467
MOD_CK1_1	554	560	PF00069	0.280
MOD_CK1_1	591	597	PF00069	0.285
MOD_CK1_1	692	698	PF00069	0.270
MOD_CK2_1	457	463	PF00069	0.558
MOD_CK2_1	506	512	PF00069	0.493
MOD_CK2_1	57	63	PF00069	0.309
MOD_CK2_1	577	583	PF00069	0.285
MOD_DYRK1A_RPxSP_1	382	386	PF00069	0.411
MOD_GlcNHglycan	105	108	PF01048	0.321
MOD_GlcNHglycan	112	115	PF01048	0.286
MOD_GlcNHglycan	146	149	PF01048	0.452
MOD_GlcNHglycan	257	260	PF01048	0.264
MOD_GlcNHglycan	296	300	PF01048	0.285
MOD_GlcNHglycan	303	306	PF01048	0.306
MOD_GlcNHglycan	36	40	PF01048	0.254
MOD_GlcNHglycan	400	403	PF01048	0.354
MOD_GlcNHglycan	46	49	PF01048	0.279
MOD_GlcNHglycan	471	474	PF01048	0.326
MOD_GlcNHglycan	569	572	PF01048	0.500
MOD_GlcNHglycan	691	694	PF01048	0.270
MOD_GlcNHglycan	79	82	PF01048	0.502
MOD_GSK3_1	118	125	PF00069	0.435
MOD_GSK3_1	135	142	PF00069	0.270
MOD_GSK3_1	268	275	PF00069	0.394
MOD_GSK3_1	286	293	PF00069	0.476
MOD_GSK3_1	297	304	PF00069	0.470
MOD_GSK3_1	365	372	PF00069	0.478
MOD_GSK3_1	376	383	PF00069	0.440
MOD_GSK3_1	391	398	PF00069	0.449
MOD_GSK3_1	418	425	PF00069	0.463
MOD_GSK3_1	469	476	PF00069	0.508
MOD_GSK3_1	587	594	PF00069	0.316
MOD_GSK3_1	609	616	PF00069	0.340
MOD_GSK3_1	637	644	PF00069	0.280
MOD_GSK3_1	685	692	PF00069	0.274
MOD_GSK3_1	702	709	PF00069	0.302
MOD_N-GLC_1	11	16	PF02516	0.477
MOD_N-GLC_1	391	396	PF02516	0.330
MOD_N-GLC_1	566	571	PF02516	0.442
MOD_NEK2_1	110	115	PF00069	0.292
MOD_NEK2_1	135	140	PF00069	0.364
MOD_NEK2_1	197	202	PF00069	0.283
MOD_NEK2_1	216	221	PF00069	0.333
MOD_NEK2_1	290	295	PF00069	0.465
MOD_NEK2_1	395	400	PF00069	0.548
MOD_NEK2_1	609	614	PF00069	0.371
MOD_NEK2_1	641	646	PF00069	0.258
MOD_NEK2_1	689	694	PF00069	0.286
MOD_NEK2_2	487	492	PF00069	0.437
MOD_NMyristoyl	1	7	PF02799	0.367
MOD_PIKK_1	214	220	PF00454	0.285
MOD_PIKK_1	588	594	PF00454	0.285
MOD_PIKK_1	650	656	PF00454	0.270
MOD_PIKK_1	86	92	PF00454	0.246
MOD_Plk_1	11	17	PF00069	0.277
MOD_Plk_1	286	292	PF00069	0.464
MOD_Plk_1	369	375	PF00069	0.484
MOD_Plk_1	391	397	PF00069	0.469
MOD_Plk_2-3	272	278	PF00069	0.418
MOD_Plk_2-3	352	358	PF00069	0.583
MOD_Plk_4	122	128	PF00069	0.324
MOD_Plk_4	139	145	PF00069	0.235
MOD_Plk_4	19	25	PF00069	0.281
MOD_Plk_4	197	203	PF00069	0.360
MOD_Plk_4	286	292	PF00069	0.468
MOD_Plk_4	391	397	PF00069	0.454
MOD_Plk_4	554	560	PF00069	0.280
MOD_Plk_4	57	63	PF00069	0.270
MOD_Plk_4	609	615	PF00069	0.367
MOD_Plk_4	634	640	PF00069	0.280
MOD_Plk_4	685	691	PF00069	0.277
MOD_Plk_4	696	702	PF00069	0.326
MOD_ProDKin_1	380	386	PF00069	0.549
MOD_ProDKin_1	402	408	PF00069	0.429
MOD_ProDKin_1	422	428	PF00069	0.407
MOD_ProDKin_1	500	506	PF00069	0.474
MOD_ProDKin_1	622	628	PF00069	0.442
MOD_SUMO_rev_2	278	288	PF00179	0.446
MOD_SUMO_rev_2	480	486	PF00179	0.524
TRG_ENDOCYTIC_2	230	233	PF00928	0.274
TRG_ENDOCYTIC_2	576	579	PF00928	0.242
TRG_ENDOCYTIC_2	58	61	PF00928	0.309
TRG_ER_diArg_1	174	176	PF00400	0.453
TRG_ER_diArg_1	181	184	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.193

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C5	Leptomonas seymouri	65%	100%
A0A1X0P0T2	Trypanosomatidae	53%	100%
A0A3S7X2A5	Leishmania donovani	94%	100%
A4HH72	Leishmania braziliensis	76%	99%
A4I4B8	Leishmania infantum	94%	100%
E9AM13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q63488	Rattus norvegicus	23%	100%
Q80UP8	Mus musculus	23%	100%
Q95L97	Felis catus	24%	100%