zf-C2HE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scavenger mRNA decapping enzyme C-term binding, putative

Species:

Leishmania major

UniProt:

E9ADR6_LEIMA

TriTrypDb:

LmjF.29.0640 , LMJLV39_290011800 , LMJSD75_290011800

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR6

Function

Biological processes
Term	Name	Level	Count
GO:0000012	single strand break repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003684	damaged DNA binding	5	2
GO:0003690	double-stranded DNA binding	5	2
GO:0003697	single-stranded DNA binding	5	2
GO:0003723	RNA binding	4	2
GO:0003725	double-stranded RNA binding	5	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004529	DNA exonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0005488	binding	1	2
GO:0008409	5'-3' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0030983	mismatched DNA binding	6	2
GO:0033699	DNA 5'-adenosine monophosphate hydrolase activity	8	2
GO:0035312	5'-3' DNA exonuclease activity	7	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:1990165	single-strand break-containing DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.400
CLV_C14_Caspase3-7	323	327	PF00656	0.400
CLV_NRD_NRD_1	158	160	PF00675	0.481
CLV_NRD_NRD_1	301	303	PF00675	0.199
CLV_NRD_NRD_1	31	33	PF00675	0.421
CLV_NRD_NRD_1	79	81	PF00675	0.518
CLV_PCSK_FUR_1	29	33	PF00082	0.418
CLV_PCSK_KEX2_1	158	160	PF00082	0.481
CLV_PCSK_KEX2_1	301	303	PF00082	0.199
CLV_PCSK_KEX2_1	31	33	PF00082	0.421
CLV_PCSK_KEX2_1	79	81	PF00082	0.518
CLV_PCSK_SKI1_1	159	163	PF00082	0.468
CLV_PCSK_SKI1_1	17	21	PF00082	0.413
CLV_PCSK_SKI1_1	277	281	PF00082	0.199
CLV_PCSK_SKI1_1	288	292	PF00082	0.199
DEG_APCC_DBOX_1	169	177	PF00400	0.318
DEG_Nend_Nbox_1	1	3	PF02207	0.443
DEG_SCF_FBW7_1	191	198	PF00400	0.460
DEG_SPOP_SBC_1	111	115	PF00917	0.484
DOC_CDC14_PxL_1	213	221	PF14671	0.304
DOC_CDC14_PxL_1	307	315	PF14671	0.400
DOC_CKS1_1	121	126	PF01111	0.484
DOC_CKS1_1	88	93	PF01111	0.481
DOC_CYCLIN_RxL_1	14	24	PF00134	0.410
DOC_CYCLIN_yClb5_NLxxxL_5	17	23	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.400
DOC_MAPK_MEF2A_6	235	242	PF00069	0.400
DOC_PP2B_LxvP_1	254	257	PF13499	0.400
DOC_USP7_MATH_1	161	165	PF00917	0.448
DOC_USP7_MATH_1	183	187	PF00917	0.305
DOC_USP7_MATH_1	196	200	PF00917	0.468
DOC_USP7_MATH_1	227	231	PF00917	0.302
DOC_USP7_MATH_1	309	313	PF00917	0.400
DOC_USP7_MATH_1	385	389	PF00917	0.199
DOC_USP7_MATH_1	391	395	PF00917	0.199
DOC_USP7_MATH_1	47	51	PF00917	0.433
DOC_USP7_MATH_1	83	87	PF00917	0.509
DOC_USP7_UBL2_3	181	185	PF12436	0.305
DOC_USP7_UBL2_3	403	407	PF12436	0.321
DOC_WW_Pin1_4	120	125	PF00397	0.488
DOC_WW_Pin1_4	127	132	PF00397	0.468
DOC_WW_Pin1_4	146	151	PF00397	0.489
DOC_WW_Pin1_4	191	196	PF00397	0.458
DOC_WW_Pin1_4	217	222	PF00397	0.326
DOC_WW_Pin1_4	324	329	PF00397	0.400
DOC_WW_Pin1_4	43	48	PF00397	0.430
DOC_WW_Pin1_4	87	92	PF00397	0.483
LIG_14-3-3_CanoR_1	117	122	PF00244	0.503
LIG_14-3-3_CanoR_1	158	165	PF00244	0.460
LIG_14-3-3_CanoR_1	261	266	PF00244	0.400
LIG_14-3-3_CanoR_1	288	298	PF00244	0.400
LIG_14-3-3_CanoR_1	359	363	PF00244	0.199
LIG_14-3-3_CanoR_1	79	88	PF00244	0.507
LIG_Actin_WH2_2	275	293	PF00022	0.400
LIG_BIR_III_2	244	248	PF00653	0.400
LIG_CtBP_PxDLS_1	257	261	PF00389	0.400
LIG_DLG_GKlike_1	261	268	PF00625	0.400
LIG_FHA_1	160	166	PF00498	0.441
LIG_FHA_1	192	198	PF00498	0.465
LIG_FHA_2	267	273	PF00498	0.400
LIG_FHA_2	321	327	PF00498	0.400
LIG_LIR_Gen_1	338	345	PF02991	0.199
LIG_LIR_Nem_3	10	16	PF02991	0.411
LIG_LIR_Nem_3	132	138	PF02991	0.486
LIG_LIR_Nem_3	284	289	PF02991	0.400
LIG_LIR_Nem_3	338	342	PF02991	0.240
LIG_LYPXL_yS_3	216	219	PF13949	0.286
LIG_MYND_1	217	221	PF01753	0.318
LIG_Pex14_2	303	307	PF04695	0.400
LIG_Pex14_2	339	343	PF04695	0.199
LIG_PTB_Apo_2	240	247	PF02174	0.400
LIG_SH2_STAT5	286	289	PF00017	0.400
LIG_SH2_STAT5	298	301	PF00017	0.400
LIG_SH3_2	88	93	PF14604	0.481
LIG_SH3_3	134	140	PF00018	0.494
LIG_SH3_3	308	314	PF00018	0.400
LIG_SH3_3	384	390	PF00018	0.199
LIG_SH3_3	85	91	PF00018	0.490
LIG_SUMO_SIM_anti_2	35	44	PF11976	0.434
LIG_WRC_WIRS_1	336	341	PF05994	0.220
LIG_WRPW_2	213	216	PF00400	0.286
MOD_CDK_SPxK_1	87	93	PF00069	0.483
MOD_CDK_SPxxK_3	324	331	PF00069	0.400
MOD_CK1_1	120	126	PF00069	0.485
MOD_CK1_1	164	170	PF00069	0.366
MOD_CK1_1	186	192	PF00069	0.353
MOD_CK1_1	198	204	PF00069	0.451
MOD_CK1_1	338	344	PF00069	0.199
MOD_CK1_1	46	52	PF00069	0.433
MOD_CK1_1	82	88	PF00069	0.502
MOD_CK2_1	199	205	PF00069	0.433
MOD_CK2_1	217	223	PF00069	0.323
MOD_GlcNHglycan	185	188	PF01048	0.319
MOD_GlcNHglycan	81	84	PF01048	0.509
MOD_GSK3_1	123	130	PF00069	0.474
MOD_GSK3_1	157	164	PF00069	0.462
MOD_GSK3_1	186	193	PF00069	0.364
MOD_GSK3_1	195	202	PF00069	0.464
MOD_GSK3_1	320	327	PF00069	0.400
MOD_GSK3_1	381	388	PF00069	0.199
MOD_GSK3_1	43	50	PF00069	0.432
MOD_GSK3_1	79	86	PF00069	0.513
MOD_NEK2_1	1	6	PF00069	0.439
MOD_NEK2_1	125	130	PF00069	0.473
MOD_NEK2_1	34	39	PF00069	0.429
MOD_OFUCOSY	33	39	PF10250	0.427
MOD_OFUCOSY	44	51	PF10250	0.434
MOD_PKA_1	79	85	PF00069	0.514
MOD_PKA_2	157	163	PF00069	0.471
MOD_PKA_2	358	364	PF00069	0.199
MOD_PKA_2	67	73	PF00069	0.475
MOD_PKA_2	79	85	PF00069	0.514
MOD_Plk_1	364	370	PF00069	0.199
MOD_Plk_4	186	192	PF00069	0.353
MOD_Plk_4	228	234	PF00069	0.199
MOD_Plk_4	246	252	PF00069	0.400
MOD_Plk_4	338	344	PF00069	0.199
MOD_ProDKin_1	120	126	PF00069	0.485
MOD_ProDKin_1	127	133	PF00069	0.467
MOD_ProDKin_1	146	152	PF00069	0.491
MOD_ProDKin_1	191	197	PF00069	0.460
MOD_ProDKin_1	217	223	PF00069	0.323
MOD_ProDKin_1	324	330	PF00069	0.400
MOD_ProDKin_1	43	49	PF00069	0.432
MOD_ProDKin_1	87	93	PF00069	0.483
MOD_SUMO_rev_2	220	227	PF00179	0.332
MOD_SUMO_rev_2	373	380	PF00179	0.199
TRG_DiLeu_BaEn_2	20	26	PF01217	0.409
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.496
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.297
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.400
TRG_ENDOCYTIC_2	216	219	PF00928	0.286
TRG_ENDOCYTIC_2	336	339	PF00928	0.213
TRG_ER_diArg_1	157	159	PF00400	0.483
TRG_ER_diArg_1	29	32	PF00400	0.419
TRG_ER_diArg_1	301	303	PF00400	0.400
TRG_NES_CRM1_1	10	24	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O74859	SCHPO	29%	100%
P61797	CANLF	38%	100%
P61798	CHICK	33%	100%
P61799	DANRE	38%	100%
P61800	TAKRU	38%	100%
P61801	XENTR	35%	100%
P61802	CIOIN	33%	100%
Q08702	YEAST	28%	100%
Q558W0	DICDI	38%	100%
Q7T287	XENLA	36%	100%
Q7TQC5	MOUSE	38%	100%
Q7YRZ1	PIG	39%	100%
Q7YRZ2	BOVIN	39%	100%
Q7Z2E3	HUMAN	38%	100%
Q8K4H4	RAT	38%	100%
Q8MSG8	DROME	27%	62%
Q9BGQ0	MACFA	38%	100%
Q9M041	ARATH	33%	45%