Putative Qc-SNARE protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania major

UniProt:

E9ADR5_LEIMA

TriTrypDb:

LmjF.29.0630 , LMJLV39_290011700 , LMJSD75_290011700

Length:

139

Annotations

LeishMANIAdb annotations

A SNARE-like tail-anchored coil-coil protein required for ER-to-Golgi transport. Probably not GPI anchored due to reverse topology. Localization: Golgi (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.429
CLV_NRD_NRD_1	11	13	PF00675	0.545
CLV_NRD_NRD_1	66	68	PF00675	0.420
CLV_PCSK_KEX2_1	10	12	PF00082	0.550
CLV_PCSK_KEX2_1	66	68	PF00082	0.413
CLV_PCSK_SKI1_1	66	70	PF00082	0.432
DEG_MDM2_SWIB_1	115	123	PF02201	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.777
DOC_MAPK_MEF2A_6	116	125	PF00069	0.487
DOC_PP1_RVXF_1	107	113	PF00149	0.703
DOC_USP7_MATH_1	40	44	PF00917	0.745
DOC_USP7_MATH_1	68	72	PF00917	0.726
DOC_USP7_MATH_1	96	100	PF00917	0.635
DOC_USP7_UBL2_3	70	74	PF12436	0.703
DOC_WW_Pin1_4	21	26	PF00397	0.737
LIG_14-3-3_CanoR_1	101	105	PF00244	0.543
LIG_14-3-3_CanoR_1	67	73	PF00244	0.673
LIG_14-3-3_CanoR_1	88	94	PF00244	0.628
LIG_BRCT_BRCA1_1	5	9	PF00533	0.662
LIG_FHA_1	44	50	PF00498	0.672
LIG_FHA_1	89	95	PF00498	0.635
LIG_LIR_Gen_1	71	79	PF02991	0.741
LIG_Pex14_2	115	119	PF04695	0.520
LIG_Pex14_2	124	128	PF04695	0.318
LIG_SH2_STAT5	133	136	PF00017	0.378
LIG_TRAF2_1	48	51	PF00917	0.647
LIG_TYR_ITIM	131	136	PF00017	0.355
LIG_UBA3_1	61	70	PF00899	0.688
MOD_CK1_1	24	30	PF00069	0.735
MOD_CK1_1	43	49	PF00069	0.523
MOD_GlcNHglycan	26	29	PF01048	0.482
MOD_GSK3_1	31	38	PF00069	0.716
MOD_GSK3_1	96	103	PF00069	0.631
MOD_NEK2_1	100	105	PF00069	0.578
MOD_NEK2_1	89	94	PF00069	0.597
MOD_NEK2_2	111	116	PF00069	0.587
MOD_NEK2_2	4	9	PF00069	0.662
MOD_NEK2_2	40	45	PF00069	0.687
MOD_NEK2_2	96	101	PF00069	0.630
MOD_PKA_2	100	106	PF00069	0.613
MOD_PKA_2	89	95	PF00069	0.658
MOD_Plk_4	4	10	PF00069	0.664
MOD_Plk_4	89	95	PF00069	0.622
MOD_ProDKin_1	21	27	PF00069	0.738
TRG_DiLeu_BaEn_1	53	58	PF01217	0.635
TRG_ENDOCYTIC_2	133	136	PF00928	0.355
TRG_ER_diArg_1	65	67	PF00400	0.624
TRG_ER_diArg_1	9	12	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG6	Leptomonas seymouri	65%	100%
A0A0S4JHY8	Bodo saltans	32%	100%
A0A1X0NZJ5	Trypanosomatidae	42%	100%
A0A3Q8IIL2	Leishmania donovani	94%	100%
A0A422NUM6	Trypanosoma rangeli	38%	100%
A4HH70	Leishmania braziliensis	83%	100%
A4I4B6	Leishmania infantum	95%	100%
C9ZL52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AM15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%