C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADR3_LEIMA

TriTrypDb:

LmjF.29.0610 , LMJLV39_290011500 , LMJSD75_290011500

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR3

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	2
GO:0000492	box C/D snoRNP assembly	8	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.594
CLV_NRD_NRD_1	154	156	PF00675	0.495
CLV_NRD_NRD_1	187	189	PF00675	0.462
CLV_NRD_NRD_1	190	192	PF00675	0.505
CLV_NRD_NRD_1	220	222	PF00675	0.429
CLV_NRD_NRD_1	230	232	PF00675	0.543
CLV_NRD_NRD_1	268	270	PF00675	0.656
CLV_NRD_NRD_1	280	282	PF00675	0.693
CLV_NRD_NRD_1	586	588	PF00675	0.630
CLV_NRD_NRD_1	591	593	PF00675	0.592
CLV_PCSK_FUR_1	188	192	PF00082	0.609
CLV_PCSK_FUR_1	278	282	PF00082	0.654
CLV_PCSK_KEX2_1	189	191	PF00082	0.564
CLV_PCSK_KEX2_1	219	221	PF00082	0.430
CLV_PCSK_KEX2_1	232	234	PF00082	0.513
CLV_PCSK_KEX2_1	268	270	PF00082	0.656
CLV_PCSK_KEX2_1	280	282	PF00082	0.693
CLV_PCSK_KEX2_1	586	588	PF00082	0.630
CLV_PCSK_KEX2_1	591	593	PF00082	0.592
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.530
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.513
CLV_PCSK_PC7_1	587	593	PF00082	0.591
CLV_PCSK_SKI1_1	567	571	PF00082	0.659
CLV_PCSK_SKI1_1	625	629	PF00082	0.544
CLV_PCSK_SKI1_1	72	76	PF00082	0.565
DEG_ODPH_VHL_1	49	61	PF01847	0.507
DOC_CKS1_1	55	60	PF01111	0.507
DOC_CYCLIN_RxL_1	69	78	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.604
DOC_MAPK_gen_1	158	168	PF00069	0.503
DOC_MAPK_gen_1	231	242	PF00069	0.634
DOC_PP1_RVXF_1	436	443	PF00149	0.539
DOC_PP2B_LxvP_1	291	294	PF13499	0.553
DOC_PP2B_LxvP_1	74	77	PF13499	0.635
DOC_PP4_FxxP_1	309	312	PF00568	0.661
DOC_SPAK_OSR1_1	620	624	PF12202	0.491
DOC_USP7_MATH_1	106	110	PF00917	0.694
DOC_USP7_MATH_1	247	251	PF00917	0.683
DOC_USP7_MATH_1	255	259	PF00917	0.742
DOC_USP7_MATH_1	261	265	PF00917	0.803
DOC_USP7_MATH_1	358	362	PF00917	0.688
DOC_USP7_MATH_1	365	369	PF00917	0.725
DOC_USP7_MATH_1	487	491	PF00917	0.685
DOC_USP7_MATH_1	508	512	PF00917	0.669
DOC_USP7_MATH_1	541	545	PF00917	0.583
DOC_USP7_MATH_1	8	12	PF00917	0.604
DOC_USP7_MATH_2	521	527	PF00917	0.638
DOC_WW_Pin1_4	249	254	PF00397	0.665
DOC_WW_Pin1_4	279	284	PF00397	0.698
DOC_WW_Pin1_4	294	299	PF00397	0.678
DOC_WW_Pin1_4	335	340	PF00397	0.655
DOC_WW_Pin1_4	359	364	PF00397	0.663
DOC_WW_Pin1_4	387	392	PF00397	0.533
DOC_WW_Pin1_4	527	532	PF00397	0.698
DOC_WW_Pin1_4	54	59	PF00397	0.639
LIG_14-3-3_CanoR_1	104	112	PF00244	0.574
LIG_14-3-3_CanoR_1	151	159	PF00244	0.481
LIG_14-3-3_CanoR_1	233	242	PF00244	0.581
LIG_14-3-3_CanoR_1	602	609	PF00244	0.480
LIG_14-3-3_CanoR_1	72	77	PF00244	0.641
LIG_14-3-3_CterR_2	631	634	PF00244	0.465
LIG_BIR_III_4	301	305	PF00653	0.623
LIG_BIR_III_4	346	350	PF00653	0.628
LIG_BIR_III_4	87	91	PF00653	0.543
LIG_FHA_1	343	349	PF00498	0.675
LIG_FHA_1	376	382	PF00498	0.568
LIG_FHA_1	504	510	PF00498	0.749
LIG_FHA_2	29	35	PF00498	0.581
LIG_FHA_2	40	46	PF00498	0.522
LIG_FHA_2	428	434	PF00498	0.536
LIG_FHA_2	596	602	PF00498	0.505
LIG_LIR_Gen_1	141	152	PF02991	0.392
LIG_LIR_Gen_1	45	54	PF02991	0.541
LIG_LIR_Gen_1	598	607	PF02991	0.492
LIG_LIR_Nem_3	141	147	PF02991	0.443
LIG_LIR_Nem_3	45	49	PF02991	0.519
LIG_LIR_Nem_3	598	603	PF02991	0.504
LIG_Pex14_1	36	40	PF04695	0.552
LIG_REV1ctd_RIR_1	619	629	PF16727	0.444
LIG_SH2_CRK	144	148	PF00017	0.471
LIG_SH2_CRK	22	26	PF00017	0.551
LIG_SH2_CRK	40	44	PF00017	0.550
LIG_SH2_SRC	318	321	PF00017	0.640
LIG_SH2_STAP1	135	139	PF00017	0.399
LIG_SH2_STAP1	22	26	PF00017	0.623
LIG_SH2_STAP1	436	440	PF00017	0.597
LIG_SH2_STAT3	184	187	PF00017	0.453
LIG_SH2_STAT5	121	124	PF00017	0.482
LIG_SH2_STAT5	144	147	PF00017	0.450
LIG_SH2_STAT5	184	187	PF00017	0.489
LIG_SH2_STAT5	412	415	PF00017	0.300
LIG_SH3_1	379	385	PF00018	0.516
LIG_SH3_1	591	597	PF00018	0.547
LIG_SH3_3	170	176	PF00018	0.458
LIG_SH3_3	210	216	PF00018	0.426
LIG_SH3_3	284	290	PF00018	0.721
LIG_SH3_3	310	316	PF00018	0.671
LIG_SH3_3	379	385	PF00018	0.502
LIG_SH3_3	4	10	PF00018	0.676
LIG_SH3_3	502	508	PF00018	0.740
LIG_SH3_3	515	521	PF00018	0.725
LIG_SH3_3	550	556	PF00018	0.651
LIG_SH3_3	590	596	PF00018	0.560
LIG_SH3_3	74	80	PF00018	0.572
LIG_TRAF2_1	130	133	PF00917	0.499
LIG_TRAF2_1	317	320	PF00917	0.666
LIG_TRAF2_1	497	500	PF00917	0.568
LIG_TRAF2_1	520	523	PF00917	0.653
LIG_WW_3	1	5	PF00397	0.639
MOD_CDC14_SPxK_1	282	285	PF00782	0.553
MOD_CDK_SPK_2	387	392	PF00069	0.533
MOD_CDK_SPxK_1	279	285	PF00069	0.556
MOD_CDK_SPxxK_3	387	394	PF00069	0.527
MOD_CK1_1	254	260	PF00069	0.691
MOD_CK1_1	263	269	PF00069	0.681
MOD_CK1_1	270	276	PF00069	0.685
MOD_CK1_1	297	303	PF00069	0.657
MOD_CK1_1	314	320	PF00069	0.636
MOD_CK1_1	321	327	PF00069	0.649
MOD_CK1_1	331	337	PF00069	0.579
MOD_CK1_1	361	367	PF00069	0.689
MOD_CK2_1	270	276	PF00069	0.810
MOD_CK2_1	28	34	PF00069	0.588
MOD_CK2_1	297	303	PF00069	0.703
MOD_CK2_1	314	320	PF00069	0.726
MOD_CK2_1	39	45	PF00069	0.579
MOD_CK2_1	445	451	PF00069	0.658
MOD_CK2_1	453	459	PF00069	0.762
MOD_CK2_1	487	493	PF00069	0.625
MOD_CK2_1	595	601	PF00069	0.509
MOD_CK2_1	8	14	PF00069	0.617
MOD_GlcNHglycan	108	111	PF01048	0.667
MOD_GlcNHglycan	253	256	PF01048	0.620
MOD_GlcNHglycan	257	260	PF01048	0.655
MOD_GlcNHglycan	367	370	PF01048	0.812
MOD_GlcNHglycan	447	450	PF01048	0.728
MOD_GlcNHglycan	472	475	PF01048	0.661
MOD_GlcNHglycan	489	492	PF01048	0.657
MOD_GlcNHglycan	523	528	PF01048	0.837
MOD_GlcNHglycan	557	560	PF01048	0.627
MOD_GlcNHglycan	81	84	PF01048	0.686
MOD_GSK3_1	247	254	PF00069	0.623
MOD_GSK3_1	255	262	PF00069	0.660
MOD_GSK3_1	263	270	PF00069	0.657
MOD_GSK3_1	314	321	PF00069	0.630
MOD_GSK3_1	328	335	PF00069	0.600
MOD_GSK3_1	361	368	PF00069	0.708
MOD_GSK3_1	423	430	PF00069	0.380
MOD_GSK3_1	481	488	PF00069	0.639
MOD_GSK3_1	503	510	PF00069	0.577
MOD_GSK3_1	523	530	PF00069	0.748
MOD_GSK3_1	68	75	PF00069	0.697
MOD_N-GLC_1	331	336	PF02516	0.640
MOD_N-GLC_1	385	390	PF02516	0.485
MOD_N-GLC_1	465	470	PF02516	0.602
MOD_NEK2_1	143	148	PF00069	0.420
MOD_NEK2_1	178	183	PF00069	0.488
MOD_NEK2_2	150	155	PF00069	0.443
MOD_NEK2_2	39	44	PF00069	0.551
MOD_PIKK_1	128	134	PF00454	0.451
MOD_PIKK_1	191	197	PF00454	0.456
MOD_PKA_1	268	274	PF00069	0.597
MOD_PKA_2	150	156	PF00069	0.513
MOD_PKA_2	264	270	PF00069	0.706
MOD_PKA_2	271	277	PF00069	0.707
MOD_PKA_2	445	451	PF00069	0.513
MOD_PKA_2	601	607	PF00069	0.484
MOD_PKA_2	8	14	PF00069	0.496
MOD_PKB_1	231	239	PF00069	0.589
MOD_PKB_1	70	78	PF00069	0.560
MOD_Plk_1	236	242	PF00069	0.582
MOD_Plk_1	432	438	PF00069	0.565
MOD_Plk_1	567	573	PF00069	0.647
MOD_Plk_2-3	546	552	PF00069	0.622
MOD_Plk_2-3	601	607	PF00069	0.484
MOD_Plk_4	236	242	PF00069	0.522
MOD_Plk_4	595	601	PF00069	0.509
MOD_ProDKin_1	249	255	PF00069	0.667
MOD_ProDKin_1	279	285	PF00069	0.701
MOD_ProDKin_1	294	300	PF00069	0.678
MOD_ProDKin_1	335	341	PF00069	0.655
MOD_ProDKin_1	359	365	PF00069	0.662
MOD_ProDKin_1	387	393	PF00069	0.527
MOD_ProDKin_1	527	533	PF00069	0.697
MOD_ProDKin_1	54	60	PF00069	0.644
MOD_SUMO_for_1	200	203	PF00179	0.472
TRG_DiLeu_BaEn_1	164	169	PF01217	0.517
TRG_DiLeu_BaEn_1	611	616	PF01217	0.437
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.589
TRG_ENDOCYTIC_2	144	147	PF00928	0.450
TRG_ENDOCYTIC_2	22	25	PF00928	0.628
TRG_ENDOCYTIC_2	40	43	PF00928	0.543
TRG_ENDOCYTIC_2	600	603	PF00928	0.554
TRG_ER_diArg_1	188	191	PF00400	0.523
TRG_ER_diArg_1	219	221	PF00400	0.430
TRG_ER_diArg_1	230	233	PF00400	0.493
TRG_ER_diArg_1	278	281	PF00400	0.690
TRG_ER_diArg_1	3	6	PF00400	0.632
TRG_ER_diArg_1	391	394	PF00400	0.557
TRG_ER_diArg_1	591	593	PF00400	0.604
TRG_NLS_Bipartite_1	219	236	PF00514	0.461
TRG_NLS_MonoCore_2	187	192	PF00514	0.517
TRG_NLS_MonoCore_2	231	236	PF00514	0.566
TRG_NLS_MonoExtC_3	154	159	PF00514	0.485
TRG_NLS_MonoExtC_3	188	193	PF00514	0.523
TRG_NLS_MonoExtC_3	230	235	PF00514	0.564
TRG_NLS_MonoExtN_4	188	193	PF00514	0.523
TRG_NLS_MonoExtN_4	231	236	PF00514	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y7	Leptomonas seymouri	48%	100%
A0A3Q8IDJ2	Leishmania donovani	85%	100%
A4I4B3	Leishmania infantum	85%	100%
C9ZL55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AIT5	Leishmania braziliensis	72%	100%
E9AM17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%