Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADR0_LEIMA

TriTrypDb:

LmjF.29.0580 , LMJLV39_290011200 , LMJSD75_290011200

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.462
CLV_NRD_NRD_1	127	129	PF00675	0.440
CLV_NRD_NRD_1	131	133	PF00675	0.563
CLV_NRD_NRD_1	146	148	PF00675	0.357
CLV_NRD_NRD_1	184	186	PF00675	0.636
CLV_NRD_NRD_1	206	208	PF00675	0.621
CLV_NRD_NRD_1	255	257	PF00675	0.565
CLV_NRD_NRD_1	368	370	PF00675	0.555
CLV_NRD_NRD_1	400	402	PF00675	0.696
CLV_NRD_NRD_1	433	435	PF00675	0.558
CLV_PCSK_FUR_1	125	129	PF00082	0.423
CLV_PCSK_FUR_1	204	208	PF00082	0.600
CLV_PCSK_KEX2_1	125	127	PF00082	0.448
CLV_PCSK_KEX2_1	130	132	PF00082	0.583
CLV_PCSK_KEX2_1	145	147	PF00082	0.360
CLV_PCSK_KEX2_1	184	186	PF00082	0.636
CLV_PCSK_KEX2_1	206	208	PF00082	0.621
CLV_PCSK_KEX2_1	368	370	PF00082	0.555
CLV_PCSK_KEX2_1	400	402	PF00082	0.693
CLV_PCSK_KEX2_1	433	435	PF00082	0.563
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.516
CLV_PCSK_PC7_1	126	132	PF00082	0.472
CLV_PCSK_SKI1_1	142	146	PF00082	0.429
CLV_PCSK_SKI1_1	328	332	PF00082	0.589
CLV_PCSK_SKI1_1	381	385	PF00082	0.578
CLV_PCSK_SKI1_1	390	394	PF00082	0.548
DEG_SPOP_SBC_1	279	283	PF00917	0.609
DEG_SPOP_SBC_1	294	298	PF00917	0.513
DEG_SPOP_SBC_1	392	396	PF00917	0.716
DEG_SPOP_SBC_1	455	459	PF00917	0.626
DEG_SPOP_SBC_1	80	84	PF00917	0.490
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.587
DOC_MAPK_DCC_7	185	195	PF00069	0.603
DOC_MAPK_gen_1	113	121	PF00069	0.429
DOC_MAPK_gen_1	446	455	PF00069	0.580
DOC_MAPK_GRA24_9	181	195	PF00069	0.596
DOC_MAPK_RevD_3	420	434	PF00069	0.517
DOC_USP7_MATH_1	271	275	PF00917	0.653
DOC_USP7_MATH_1	279	283	PF00917	0.582
DOC_USP7_MATH_1	370	374	PF00917	0.625
DOC_USP7_MATH_1	392	396	PF00917	0.721
DOC_USP7_MATH_1	454	458	PF00917	0.672
DOC_USP7_MATH_1	80	84	PF00917	0.563
DOC_USP7_MATH_1	87	91	PF00917	0.558
DOC_USP7_UBL2_3	475	479	PF12436	0.506
DOC_WW_Pin1_4	205	210	PF00397	0.636
DOC_WW_Pin1_4	267	272	PF00397	0.803
DOC_WW_Pin1_4	5	10	PF00397	0.646
LIG_14-3-3_CanoR_1	328	333	PF00244	0.575
LIG_14-3-3_CanoR_1	369	375	PF00244	0.617
LIG_14-3-3_CanoR_1	390	398	PF00244	0.656
LIG_Actin_WH2_2	370	387	PF00022	0.524
LIG_BIR_III_4	249	253	PF00653	0.481
LIG_eIF4E_1	171	177	PF01652	0.511
LIG_FHA_1	167	173	PF00498	0.601
LIG_FHA_1	457	463	PF00498	0.677
LIG_FHA_2	233	239	PF00498	0.635
LIG_FHA_2	244	250	PF00498	0.449
LIG_FHA_2	279	285	PF00498	0.610
LIG_FHA_2	329	335	PF00498	0.461
LIG_FHA_2	439	445	PF00498	0.525
LIG_Integrin_RGD_1	469	471	PF01839	0.630
LIG_LIR_Apic_2	323	329	PF02991	0.596
LIG_LIR_Gen_1	342	350	PF02991	0.456
LIG_LIR_Gen_1	418	426	PF02991	0.568
LIG_LIR_Gen_1	51	61	PF02991	0.515
LIG_LIR_Gen_1	62	71	PF02991	0.468
LIG_LIR_Nem_3	342	348	PF02991	0.478
LIG_LIR_Nem_3	418	422	PF02991	0.570
LIG_LIR_Nem_3	51	57	PF02991	0.556
LIG_LIR_Nem_3	62	67	PF02991	0.496
LIG_MYND_1	12	16	PF01753	0.607
LIG_SH2_CRK	345	349	PF00017	0.483
LIG_SH2_CRK	411	415	PF00017	0.488
LIG_SH2_NCK_1	411	415	PF00017	0.578
LIG_SH2_SRC	171	174	PF00017	0.511
LIG_SH2_STAP1	50	54	PF00017	0.605
LIG_SH2_STAT5	171	174	PF00017	0.511
LIG_SH2_STAT5	411	414	PF00017	0.522
LIG_SH2_STAT5	63	66	PF00017	0.474
LIG_SH2_STAT5	94	97	PF00017	0.541
LIG_SH3_1	206	212	PF00018	0.607
LIG_SH3_3	191	197	PF00018	0.588
LIG_SH3_3	206	212	PF00018	0.631
LIG_SH3_3	6	12	PF00018	0.616
LIG_TRAF2_1	27	30	PF00917	0.567
LIG_UBA3_1	67	74	PF00899	0.499
MOD_CK1_1	232	238	PF00069	0.610
MOD_CK1_1	272	278	PF00069	0.700
MOD_CK1_1	396	402	PF00069	0.660
MOD_CK1_1	457	463	PF00069	0.679
MOD_CK1_1	477	483	PF00069	0.442
MOD_CK1_1	5	11	PF00069	0.647
MOD_CK1_1	59	65	PF00069	0.522
MOD_CK1_1	79	85	PF00069	0.436
MOD_CK1_1	90	96	PF00069	0.589
MOD_CK2_1	196	202	PF00069	0.609
MOD_CK2_1	232	238	PF00069	0.610
MOD_CK2_1	278	284	PF00069	0.616
MOD_CK2_1	328	334	PF00069	0.558
MOD_CK2_1	438	444	PF00069	0.527
MOD_GlcNHglycan	17	20	PF01048	0.664
MOD_GlcNHglycan	198	201	PF01048	0.767
MOD_GlcNHglycan	220	223	PF01048	0.637
MOD_GlcNHglycan	229	234	PF01048	0.561
MOD_GlcNHglycan	297	300	PF01048	0.700
MOD_GlcNHglycan	35	38	PF01048	0.610
MOD_GlcNHglycan	395	398	PF01048	0.643
MOD_GlcNHglycan	4	7	PF01048	0.642
MOD_GlcNHglycan	476	479	PF01048	0.583
MOD_GlcNHglycan	78	81	PF01048	0.686
MOD_GlcNHglycan	89	92	PF01048	0.564
MOD_GSK3_1	1	8	PF00069	0.776
MOD_GSK3_1	229	236	PF00069	0.738
MOD_GSK3_1	261	268	PF00069	0.695
MOD_GSK3_1	388	395	PF00069	0.616
MOD_GSK3_1	454	461	PF00069	0.620
MOD_GSK3_1	75	82	PF00069	0.595
MOD_GSK3_1	86	93	PF00069	0.520
MOD_NEK2_1	1	6	PF00069	0.521
MOD_PIKK_1	166	172	PF00454	0.613
MOD_PIKK_1	243	249	PF00454	0.482
MOD_PIKK_1	265	271	PF00454	0.647
MOD_PK_1	410	416	PF00069	0.584
MOD_PKA_1	126	132	PF00069	0.472
MOD_PKA_2	126	132	PF00069	0.508
MOD_PKA_2	294	300	PF00069	0.615
MOD_Plk_1	40	46	PF00069	0.623
MOD_Plk_1	438	444	PF00069	0.603
MOD_Plk_1	59	65	PF00069	0.389
MOD_Plk_2-3	438	444	PF00069	0.603
MOD_Plk_4	220	226	PF00069	0.692
MOD_ProDKin_1	205	211	PF00069	0.636
MOD_ProDKin_1	267	273	PF00069	0.804
MOD_ProDKin_1	5	11	PF00069	0.647
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.600
TRG_ENDOCYTIC_2	345	348	PF00928	0.444
TRG_ENDOCYTIC_2	411	414	PF00928	0.495
TRG_ER_diArg_1	112	115	PF00400	0.441
TRG_ER_diArg_1	125	128	PF00400	0.445
TRG_ER_diArg_1	130	132	PF00400	0.569
TRG_ER_diArg_1	146	148	PF00400	0.377
TRG_ER_diArg_1	184	187	PF00400	0.550
TRG_ER_diArg_1	204	207	PF00400	0.489
TRG_ER_diArg_1	337	340	PF00400	0.404
TRG_ER_diArg_1	367	369	PF00400	0.585
TRG_ER_diArg_1	433	435	PF00400	0.590
TRG_ER_diArg_1	463	466	PF00400	0.564
TRG_NLS_Bipartite_1	127	149	PF00514	0.463
TRG_NLS_MonoExtN_4	142	149	PF00514	0.434
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW8	Leptomonas seymouri	40%	97%
A0A3Q8IF08	Leishmania donovani	91%	100%
A4HH66	Leishmania braziliensis	64%	100%
A4I4B0	Leishmania infantum	91%	100%
E9AM20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%