ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

E9ADQ9_LEIMA

TriTrypDb:

LmjF.29.0570 , LMJLV39_290011100 , LMJSD75_290011100

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.585
CLV_C14_Caspase3-7	519	523	PF00656	0.516
CLV_NRD_NRD_1	214	216	PF00675	0.538
CLV_NRD_NRD_1	396	398	PF00675	0.613
CLV_NRD_NRD_1	445	447	PF00675	0.525
CLV_NRD_NRD_1	489	491	PF00675	0.592
CLV_NRD_NRD_1	5	7	PF00675	0.674
CLV_PCSK_KEX2_1	396	398	PF00082	0.613
CLV_PCSK_KEX2_1	445	447	PF00082	0.525
CLV_PCSK_KEX2_1	468	470	PF00082	0.650
CLV_PCSK_KEX2_1	491	493	PF00082	0.527
CLV_PCSK_KEX2_1	5	7	PF00082	0.674
CLV_PCSK_KEX2_1	789	791	PF00082	0.667
CLV_PCSK_KEX2_1	833	835	PF00082	0.558
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.723
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.561
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.630
CLV_PCSK_PC1ET2_1	833	835	PF00082	0.597
CLV_PCSK_SKI1_1	132	136	PF00082	0.546
CLV_PCSK_SKI1_1	182	186	PF00082	0.671
CLV_PCSK_SKI1_1	252	256	PF00082	0.615
CLV_PCSK_SKI1_1	46	50	PF00082	0.581
CLV_PCSK_SKI1_1	492	496	PF00082	0.552
CLV_PCSK_SKI1_1	605	609	PF00082	0.350
CLV_PCSK_SKI1_1	61	65	PF00082	0.615
CLV_PCSK_SKI1_1	683	687	PF00082	0.347
DEG_APCC_DBOX_1	489	497	PF00400	0.676
DEG_APCC_DBOX_1	73	81	PF00400	0.539
DEG_APCC_DBOX_1	822	830	PF00400	0.539
DEG_SPOP_SBC_1	253	257	PF00917	0.579
DEG_SPOP_SBC_1	462	466	PF00917	0.607
DEG_SPOP_SBC_1	538	542	PF00917	0.551
DOC_CYCLIN_RxL_1	394	405	PF00134	0.479
DOC_CYCLIN_RxL_1	680	687	PF00134	0.399
DOC_CYCLIN_yClb5_NLxxxL_5	390	399	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.561
DOC_PP2B_LxvP_1	110	113	PF13499	0.502
DOC_PP4_FxxP_1	531	534	PF00568	0.591
DOC_USP7_MATH_1	153	157	PF00917	0.392
DOC_USP7_MATH_1	192	196	PF00917	0.733
DOC_USP7_MATH_1	232	236	PF00917	0.655
DOC_USP7_MATH_1	237	241	PF00917	0.670
DOC_USP7_MATH_1	494	498	PF00917	0.559
DOC_USP7_MATH_1	539	543	PF00917	0.665
DOC_USP7_MATH_1	623	627	PF00917	0.424
DOC_USP7_MATH_1	735	739	PF00917	0.503
DOC_USP7_MATH_1	744	748	PF00917	0.513
DOC_USP7_UBL2_3	753	757	PF12436	0.626
DOC_WW_Pin1_4	197	202	PF00397	0.588
DOC_WW_Pin1_4	228	233	PF00397	0.713
DOC_WW_Pin1_4	478	483	PF00397	0.646
DOC_WW_Pin1_4	629	634	PF00397	0.347
DOC_WW_Pin1_4	692	697	PF00397	0.555
DOC_WW_Pin1_4	86	91	PF00397	0.515
LIG_14-3-3_CanoR_1	152	158	PF00244	0.494
LIG_14-3-3_CanoR_1	233	242	PF00244	0.623
LIG_14-3-3_CanoR_1	338	348	PF00244	0.474
LIG_14-3-3_CanoR_1	359	365	PF00244	0.406
LIG_14-3-3_CanoR_1	380	385	PF00244	0.508
LIG_14-3-3_CanoR_1	472	482	PF00244	0.672
LIG_14-3-3_CanoR_1	492	497	PF00244	0.608
LIG_14-3-3_CanoR_1	602	608	PF00244	0.339
LIG_14-3-3_CanoR_1	772	776	PF00244	0.691
LIG_Actin_WH2_2	105	122	PF00022	0.469
LIG_Actin_WH2_2	429	447	PF00022	0.519
LIG_Actin_WH2_2	716	733	PF00022	0.539
LIG_BIR_III_4	827	831	PF00653	0.650
LIG_BRCT_BRCA1_1	406	410	PF00533	0.521
LIG_BRCT_BRCA1_1	625	629	PF00533	0.399
LIG_CaM_NSCaTE_8	825	832	PF13499	0.462
LIG_CtBP_PxDLS_1	10	14	PF00389	0.709
LIG_CtBP_PxDLS_1	645	649	PF00389	0.466
LIG_eIF4E_1	376	382	PF01652	0.434
LIG_eIF4E_1	697	703	PF01652	0.501
LIG_FHA_1	122	128	PF00498	0.535
LIG_FHA_1	355	361	PF00498	0.447
LIG_FHA_1	431	437	PF00498	0.579
LIG_FHA_1	47	53	PF00498	0.595
LIG_FHA_1	630	636	PF00498	0.339
LIG_FHA_1	679	685	PF00498	0.340
LIG_FHA_1	696	702	PF00498	0.573
LIG_FHA_1	724	730	PF00498	0.623
LIG_FHA_1	783	789	PF00498	0.594
LIG_FHA_1	79	85	PF00498	0.552
LIG_FHA_2	116	122	PF00498	0.524
LIG_FHA_2	171	177	PF00498	0.616
LIG_FHA_2	261	267	PF00498	0.755
LIG_FHA_2	317	323	PF00498	0.542
LIG_FHA_2	340	346	PF00498	0.466
LIG_FHA_2	746	752	PF00498	0.616
LIG_FHA_2	779	785	PF00498	0.581
LIG_LIR_Apic_2	529	534	PF02991	0.582
LIG_LIR_Apic_2	694	700	PF02991	0.531
LIG_LIR_Gen_1	407	418	PF02991	0.503
LIG_LIR_Gen_1	515	525	PF02991	0.657
LIG_LIR_Nem_3	25	31	PF02991	0.670
LIG_LIR_Nem_3	343	349	PF02991	0.454
LIG_LIR_Nem_3	383	388	PF02991	0.607
LIG_LIR_Nem_3	407	413	PF02991	0.513
LIG_LIR_Nem_3	515	520	PF02991	0.614
LIG_LIR_Nem_3	60	66	PF02991	0.576
LIG_LIR_Nem_3	628	634	PF02991	0.479
LIG_LIR_Nem_3	668	674	PF02991	0.339
LIG_MYND_1	29	33	PF01753	0.621
LIG_NRBOX	377	383	PF00104	0.437
LIG_PCNA_yPIPBox_3	358	368	PF02747	0.408
LIG_Pex14_2	349	353	PF04695	0.425
LIG_Pex14_2	527	531	PF04695	0.560
LIG_SH2_CRK	697	701	PF00017	0.509
LIG_SH2_NCK_1	672	676	PF00017	0.339
LIG_SH2_NCK_1	780	784	PF00017	0.640
LIG_SH2_PTP2	304	307	PF00017	0.418
LIG_SH2_SRC	672	675	PF00017	0.408
LIG_SH2_STAP1	736	740	PF00017	0.511
LIG_SH2_STAP1	814	818	PF00017	0.557
LIG_SH2_STAT3	376	379	PF00017	0.604
LIG_SH2_STAT3	814	817	PF00017	0.686
LIG_SH2_STAT5	125	128	PF00017	0.451
LIG_SH2_STAT5	304	307	PF00017	0.487
LIG_SH2_STAT5	412	415	PF00017	0.501
LIG_SH2_STAT5	428	431	PF00017	0.511
LIG_SH2_STAT5	498	501	PF00017	0.501
LIG_SH2_STAT5	603	606	PF00017	0.339
LIG_SH2_STAT5	697	700	PF00017	0.517
LIG_SH2_STAT5	767	770	PF00017	0.607
LIG_SH2_STAT5	780	783	PF00017	0.478
LIG_SH3_3	345	351	PF00018	0.580
LIG_SH3_3	381	387	PF00018	0.496
LIG_SH3_3	483	489	PF00018	0.731
LIG_SH3_3	542	548	PF00018	0.630
LIG_SH3_3	569	575	PF00018	0.616
LIG_SH3_3	635	641	PF00018	0.331
LIG_SH3_CIN85_PxpxPR_1	458	463	PF14604	0.677
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.692
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.338
LIG_SUMO_SIM_anti_2	737	744	PF11976	0.640
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.435
LIG_SUMO_SIM_par_1	124	131	PF11976	0.467
LIG_SUMO_SIM_par_1	371	377	PF11976	0.458
LIG_SUMO_SIM_par_1	741	748	PF11976	0.521
LIG_TRAF2_1	342	345	PF00917	0.589
LIG_TRAF2_1	513	516	PF00917	0.679
LIG_TRAF2_1	69	72	PF00917	0.575
LIG_UBA3_1	361	368	PF00899	0.502
MOD_CDK_SPK_2	197	202	PF00069	0.643
MOD_CDK_SPK_2	228	233	PF00069	0.700
MOD_CK1_1	241	247	PF00069	0.602
MOD_CK1_1	354	360	PF00069	0.416
MOD_CK1_1	374	380	PF00069	0.436
MOD_CK1_1	464	470	PF00069	0.797
MOD_CK1_1	477	483	PF00069	0.602
MOD_CK1_1	501	507	PF00069	0.576
MOD_CK1_1	695	701	PF00069	0.524
MOD_CK1_1	760	766	PF00069	0.628
MOD_CK1_1	782	788	PF00069	0.598
MOD_CK2_1	115	121	PF00069	0.482
MOD_CK2_1	153	159	PF00069	0.461
MOD_CK2_1	197	203	PF00069	0.740
MOD_CK2_1	218	224	PF00069	0.590
MOD_CK2_1	233	239	PF00069	0.685
MOD_CK2_1	316	322	PF00069	0.544
MOD_CK2_1	339	345	PF00069	0.588
MOD_CK2_1	56	62	PF00069	0.574
MOD_CK2_1	745	751	PF00069	0.514
MOD_CK2_1	778	784	PF00069	0.602
MOD_CK2_1	838	844	PF00069	0.625
MOD_CMANNOS	822	825	PF00535	0.546
MOD_GlcNHglycan	194	197	PF01048	0.765
MOD_GlcNHglycan	208	211	PF01048	0.546
MOD_GlcNHglycan	235	238	PF01048	0.779
MOD_GlcNHglycan	243	246	PF01048	0.689
MOD_GlcNHglycan	273	276	PF01048	0.613
MOD_GlcNHglycan	42	45	PF01048	0.717
MOD_GlcNHglycan	589	592	PF01048	0.489
MOD_GlcNHglycan	754	757	PF01048	0.671
MOD_GlcNHglycan	762	765	PF01048	0.606
MOD_GlcNHglycan	773	776	PF01048	0.489
MOD_GlcNHglycan	781	784	PF01048	0.527
MOD_GlcNHglycan	86	89	PF01048	0.530
MOD_GSK3_1	170	177	PF00069	0.660
MOD_GSK3_1	18	25	PF00069	0.656
MOD_GSK3_1	187	194	PF00069	0.552
MOD_GSK3_1	224	231	PF00069	0.663
MOD_GSK3_1	233	240	PF00069	0.656
MOD_GSK3_1	463	470	PF00069	0.714
MOD_GSK3_1	473	480	PF00069	0.601
MOD_GSK3_1	492	499	PF00069	0.453
MOD_GSK3_1	625	632	PF00069	0.499
MOD_GSK3_1	688	695	PF00069	0.524
MOD_GSK3_1	778	785	PF00069	0.613
MOD_GSK3_1	836	843	PF00069	0.563
MOD_N-GLC_1	587	592	PF02516	0.489
MOD_N-GLC_2	212	214	PF02516	0.604
MOD_NEK2_1	108	113	PF00069	0.473
MOD_NEK2_1	191	196	PF00069	0.627
MOD_NEK2_1	352	357	PF00069	0.404
MOD_NEK2_1	413	418	PF00069	0.489
MOD_NEK2_1	745	750	PF00069	0.507
MOD_NEK2_2	371	376	PF00069	0.454
MOD_PIKK_1	170	176	PF00454	0.606
MOD_PIKK_1	354	360	PF00454	0.416
MOD_PIKK_1	793	799	PF00454	0.616
MOD_PK_1	380	386	PF00069	0.513
MOD_PK_1	757	763	PF00069	0.635
MOD_PKA_2	174	180	PF00069	0.720
MOD_PKA_2	232	238	PF00069	0.659
MOD_PKA_2	462	468	PF00069	0.592
MOD_PKA_2	771	777	PF00069	0.689
MOD_PKB_1	490	498	PF00069	0.566
MOD_Plk_1	187	193	PF00069	0.644
MOD_Plk_1	238	244	PF00069	0.701
MOD_Plk_1	587	593	PF00069	0.479
MOD_Plk_1	679	685	PF00069	0.385
MOD_Plk_1	736	742	PF00069	0.521
MOD_Plk_1	757	763	PF00069	0.745
MOD_Plk_2-3	167	173	PF00069	0.526
MOD_Plk_2-3	516	522	PF00069	0.523
MOD_Plk_4	121	127	PF00069	0.527
MOD_Plk_4	153	159	PF00069	0.490
MOD_Plk_4	360	366	PF00069	0.408
MOD_Plk_4	380	386	PF00069	0.429
MOD_Plk_4	474	480	PF00069	0.563
MOD_Plk_4	564	570	PF00069	0.629
MOD_Plk_4	611	617	PF00069	0.339
MOD_Plk_4	745	751	PF00069	0.652
MOD_Plk_4	757	763	PF00069	0.722
MOD_ProDKin_1	197	203	PF00069	0.587
MOD_ProDKin_1	228	234	PF00069	0.713
MOD_ProDKin_1	478	484	PF00069	0.647
MOD_ProDKin_1	629	635	PF00069	0.347
MOD_ProDKin_1	692	698	PF00069	0.552
MOD_ProDKin_1	86	92	PF00069	0.504
MOD_SUMO_for_1	185	188	PF00179	0.677
MOD_SUMO_rev_2	56	66	PF00179	0.565
MOD_SUMO_rev_2	747	755	PF00179	0.535
TRG_DiLeu_BaEn_3	344	350	PF01217	0.507
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.402
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.395
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.339
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.507
TRG_ENDOCYTIC_2	304	307	PF00928	0.418
TRG_ENDOCYTIC_2	412	415	PF00928	0.501
TRG_ENDOCYTIC_2	671	674	PF00928	0.353
TRG_ER_diArg_1	395	397	PF00400	0.607
TRG_ER_diArg_1	444	446	PF00400	0.509
TRG_ER_diArg_1	489	492	PF00400	0.552
TRG_ER_diArg_1	800	803	PF00400	0.606
TRG_ER_FFAT_2	774	786	PF00635	0.617
TRG_NES_CRM1_1	389	405	PF08389	0.575
TRG_NLS_MonoExtN_4	489	494	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G5	Leptomonas seymouri	56%	95%
A0A3Q8IF85	Leishmania donovani	91%	100%
A4HH65	Leishmania braziliensis	73%	100%
A4I4A9	Leishmania infantum	91%	100%
E9AM21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%