Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania major

UniProt:

E9ADQ8_LEIMA

TriTrypDb:

LmjF.29.0560 , LMJLV39_290011000 , LMJSD75_290011000

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ADQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADQ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.465
CLV_NRD_NRD_1	17	19	PF00675	0.506
CLV_NRD_NRD_1	227	229	PF00675	0.276
CLV_NRD_NRD_1	285	287	PF00675	0.353
CLV_NRD_NRD_1	342	344	PF00675	0.437
CLV_NRD_NRD_1	351	353	PF00675	0.363
CLV_PCSK_KEX2_1	285	287	PF00082	0.353
CLV_PCSK_KEX2_1	341	343	PF00082	0.448
CLV_PCSK_KEX2_1	353	355	PF00082	0.352
CLV_PCSK_KEX2_1	6	8	PF00082	0.452
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.448
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.420
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.452
CLV_PCSK_SKI1_1	167	171	PF00082	0.247
DEG_SCF_FBW7_1	127	134	PF00400	0.534
DOC_MAPK_gen_1	228	234	PF00069	0.473
DOC_MAPK_gen_1	350	360	PF00069	0.530
DOC_MAPK_MEF2A_6	214	223	PF00069	0.444
DOC_MAPK_MEF2A_6	353	362	PF00069	0.464
DOC_PP4_FxxP_1	120	123	PF00568	0.461
DOC_USP7_MATH_1	146	150	PF00917	0.563
DOC_USP7_MATH_1	388	392	PF00917	0.353
DOC_WW_Pin1_4	127	132	PF00397	0.498
LIG_14-3-3_CanoR_1	113	118	PF00244	0.444
LIG_14-3-3_CanoR_1	208	212	PF00244	0.442
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_2	145	149	PF00653	0.536
LIG_deltaCOP1_diTrp_1	158	162	PF00928	0.520
LIG_deltaCOP1_diTrp_1	176	184	PF00928	0.425
LIG_FHA_1	106	112	PF00498	0.536
LIG_FHA_1	138	144	PF00498	0.562
LIG_FHA_1	149	155	PF00498	0.460
LIG_FHA_1	32	38	PF00498	0.616
LIG_FHA_1	63	69	PF00498	0.619
LIG_FHA_2	59	65	PF00498	0.704
LIG_LIR_Apic_2	119	123	PF02991	0.442
LIG_LIR_Gen_1	116	123	PF02991	0.500
LIG_LIR_Gen_1	199	207	PF02991	0.455
LIG_LIR_Gen_1	74	83	PF02991	0.442
LIG_LIR_Nem_3	116	120	PF02991	0.473
LIG_LIR_Nem_3	180	184	PF02991	0.452
LIG_LIR_Nem_3	199	205	PF02991	0.380
LIG_LIR_Nem_3	309	313	PF02991	0.484
LIG_LIR_Nem_3	387	392	PF02991	0.344
LIG_LIR_Nem_3	74	78	PF02991	0.463
LIG_MYND_1	127	131	PF01753	0.471
LIG_Pex14_2	120	124	PF04695	0.461
LIG_Pex14_2	197	201	PF04695	0.442
LIG_RPA_C_Fungi	374	386	PF08784	0.383
LIG_SH2_PTP2	75	78	PF00017	0.347
LIG_SH2_SRC	204	207	PF00017	0.349
LIG_SH2_SRC	75	78	PF00017	0.375
LIG_SH2_STAP1	397	401	PF00017	0.404
LIG_SH2_STAT3	373	376	PF00017	0.444
LIG_SH2_STAT5	204	207	PF00017	0.279
LIG_SH2_STAT5	310	313	PF00017	0.387
LIG_SH2_STAT5	336	339	PF00017	0.348
LIG_SH2_STAT5	35	38	PF00017	0.757
LIG_SH2_STAT5	373	376	PF00017	0.477
LIG_SH2_STAT5	46	49	PF00017	0.649
LIG_SH2_STAT5	75	78	PF00017	0.323
LIG_SH3_3	192	198	PF00018	0.297
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.279
LIG_SUMO_SIM_par_1	74	80	PF11976	0.279
LIG_TYR_ITIM	200	205	PF00017	0.279
LIG_WRC_WIRS_1	117	122	PF05994	0.306
MOD_CK1_1	116	122	PF00069	0.286
MOD_CK1_1	393	399	PF00069	0.620
MOD_CK1_1	45	51	PF00069	0.757
MOD_CK2_1	146	152	PF00069	0.322
MOD_CK2_1	384	390	PF00069	0.332
MOD_GlcNHglycan	287	292	PF01048	0.476
MOD_GlcNHglycan	386	389	PF01048	0.535
MOD_GlcNHglycan	39	42	PF01048	0.680
MOD_GlcNHglycan	399	402	PF01048	0.520
MOD_GlcNHglycan	51	54	PF01048	0.740
MOD_GSK3_1	127	134	PF00069	0.410
MOD_GSK3_1	31	38	PF00069	0.696
MOD_GSK3_1	384	391	PF00069	0.572
MOD_GSK3_1	392	399	PF00069	0.656
MOD_GSK3_1	42	49	PF00069	0.588
MOD_GSK3_1	58	65	PF00069	0.629
MOD_LATS_1	23	29	PF00433	0.614
MOD_LATS_1	328	334	PF00433	0.520
MOD_NEK2_2	168	173	PF00069	0.355
MOD_PIKK_1	131	137	PF00454	0.319
MOD_PIKK_1	399	405	PF00454	0.523
MOD_PKA_2	207	213	PF00069	0.279
MOD_PKA_2	24	30	PF00069	0.640
MOD_Plk_4	116	122	PF00069	0.410
MOD_Plk_4	168	174	PF00069	0.432
MOD_Plk_4	196	202	PF00069	0.309
MOD_Plk_4	31	37	PF00069	0.763
MOD_Plk_4	42	48	PF00069	0.643
MOD_ProDKin_1	127	133	PF00069	0.357
MOD_SUMO_rev_2	176	184	PF00179	0.279
TRG_ENDOCYTIC_2	202	205	PF00928	0.291
TRG_ENDOCYTIC_2	310	313	PF00928	0.361
TRG_ENDOCYTIC_2	75	78	PF00928	0.366
TRG_ER_diArg_1	284	286	PF00400	0.377
TRG_NES_CRM1_1	70	82	PF08389	0.323
TRG_NLS_Bipartite_1	341	356	PF00514	0.343
TRG_NLS_MonoExtN_4	3	10	PF00514	0.699
TRG_NLS_MonoExtN_4	350	356	PF00514	0.331
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS5	Leptomonas seymouri	77%	99%
A0A1X0P115	Trypanosomatidae	58%	100%
A0A3R7MWK6	Trypanosoma rangeli	58%	100%
A0A3S7X264	Leishmania donovani	95%	100%
A4HH64	Leishmania braziliensis	86%	100%
A4I4A8	Leishmania infantum	95%	100%
C9ZKL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	90%
E9AM22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BUL7	Trypanosoma cruzi	57%	100%