Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania major

UniProt:

E9ADQ6_LEIMA

TriTrypDb:

LmjF.29.0550 , LMJLV39_290010800 , LMJSD75_290010800

Length:

880

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.620
CLV_NRD_NRD_1	552	554	PF00675	0.535
CLV_PCSK_FUR_1	47	51	PF00082	0.546
CLV_PCSK_FUR_1	679	683	PF00082	0.313
CLV_PCSK_KEX2_1	49	51	PF00082	0.546
CLV_PCSK_KEX2_1	551	553	PF00082	0.504
CLV_PCSK_KEX2_1	681	683	PF00082	0.313
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.546
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.313
CLV_PCSK_PC7_1	677	683	PF00082	0.313
CLV_PCSK_SKI1_1	22	26	PF00082	0.490
CLV_PCSK_SKI1_1	434	438	PF00082	0.611
CLV_PCSK_SKI1_1	567	571	PF00082	0.663
CLV_PCSK_SKI1_1	689	693	PF00082	0.237
CLV_PCSK_SKI1_1	725	729	PF00082	0.268
CLV_PCSK_SKI1_1	778	782	PF00082	0.374
CLV_Separin_Metazoa	268	272	PF03568	0.471
CLV_Separin_Metazoa	548	552	PF03568	0.503
DEG_SCF_FBW7_1	356	362	PF00400	0.548
DEG_SCF_FBW7_1	384	391	PF00400	0.594
DEG_SCF_FBW7_2	506	512	PF00400	0.602
DEG_SPOP_SBC_1	373	377	PF00917	0.665
DEG_SPOP_SBC_1	378	382	PF00917	0.644
DEG_SPOP_SBC_1	388	392	PF00917	0.544
DEG_SPOP_SBC_1	457	461	PF00917	0.653
DOC_ANK_TNKS_1	87	94	PF00023	0.679
DOC_CKS1_1	29	34	PF01111	0.580
DOC_CKS1_1	295	300	PF01111	0.523
DOC_CKS1_1	345	350	PF01111	0.594
DOC_CKS1_1	356	361	PF01111	0.621
DOC_CKS1_1	417	422	PF01111	0.521
DOC_CKS1_1	506	511	PF01111	0.601
DOC_CKS1_1	92	97	PF01111	0.674
DOC_CYCLIN_RxL_1	149	160	PF00134	0.591
DOC_CYCLIN_yClb1_LxF_4	821	826	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	625	631	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	844	847	PF00134	0.612
DOC_MAPK_gen_1	776	783	PF00069	0.490
DOC_MAPK_MEF2A_6	800	809	PF00069	0.468
DOC_PP2B_LxvP_1	332	335	PF13499	0.569
DOC_PP2B_LxvP_1	843	846	PF13499	0.599
DOC_PP4_FxxP_1	675	678	PF00568	0.468
DOC_USP7_MATH_1	146	150	PF00917	0.726
DOC_USP7_MATH_1	188	192	PF00917	0.551
DOC_USP7_MATH_1	246	250	PF00917	0.616
DOC_USP7_MATH_1	316	320	PF00917	0.656
DOC_USP7_MATH_1	339	343	PF00917	0.648
DOC_USP7_MATH_1	357	361	PF00917	0.513
DOC_USP7_MATH_1	373	377	PF00917	0.561
DOC_USP7_MATH_1	378	382	PF00917	0.610
DOC_USP7_MATH_1	421	425	PF00917	0.583
DOC_USP7_MATH_1	457	461	PF00917	0.705
DOC_USP7_MATH_1	519	523	PF00917	0.685
DOC_USP7_MATH_1	533	537	PF00917	0.550
DOC_USP7_MATH_1	562	566	PF00917	0.709
DOC_USP7_MATH_1	614	618	PF00917	0.574
DOC_USP7_MATH_1	851	855	PF00917	0.619
DOC_USP7_UBL2_3	139	143	PF12436	0.567
DOC_WW_Pin1_4	115	120	PF00397	0.651
DOC_WW_Pin1_4	128	133	PF00397	0.538
DOC_WW_Pin1_4	22	27	PF00397	0.536
DOC_WW_Pin1_4	28	33	PF00397	0.598
DOC_WW_Pin1_4	294	299	PF00397	0.562
DOC_WW_Pin1_4	312	317	PF00397	0.474
DOC_WW_Pin1_4	323	328	PF00397	0.593
DOC_WW_Pin1_4	344	349	PF00397	0.596
DOC_WW_Pin1_4	352	357	PF00397	0.614
DOC_WW_Pin1_4	382	387	PF00397	0.622
DOC_WW_Pin1_4	407	412	PF00397	0.709
DOC_WW_Pin1_4	416	421	PF00397	0.597
DOC_WW_Pin1_4	423	428	PF00397	0.565
DOC_WW_Pin1_4	446	451	PF00397	0.739
DOC_WW_Pin1_4	470	475	PF00397	0.614
DOC_WW_Pin1_4	484	489	PF00397	0.718
DOC_WW_Pin1_4	505	510	PF00397	0.602
DOC_WW_Pin1_4	524	529	PF00397	0.783
DOC_WW_Pin1_4	579	584	PF00397	0.590
DOC_WW_Pin1_4	610	615	PF00397	0.738
DOC_WW_Pin1_4	617	622	PF00397	0.542
DOC_WW_Pin1_4	838	843	PF00397	0.521
DOC_WW_Pin1_4	860	865	PF00397	0.588
DOC_WW_Pin1_4	91	96	PF00397	0.624
LIG_14-3-3_CanoR_1	293	298	PF00244	0.546
LIG_14-3-3_CanoR_1	551	560	PF00244	0.542
LIG_14-3-3_CanoR_1	714	722	PF00244	0.513
LIG_14-3-3_CanoR_1	771	777	PF00244	0.543
LIG_14-3-3_CanoR_1	83	92	PF00244	0.627
LIG_14-3-3_CanoR_1	858	864	PF00244	0.584
LIG_Actin_WH2_2	180	198	PF00022	0.544
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BIR_III_2	199	203	PF00653	0.605
LIG_BRCT_BRCA1_1	190	194	PF00533	0.598
LIG_BRCT_BRCA1_1	434	438	PF00533	0.671
LIG_BRCT_BRCA1_1	537	541	PF00533	0.623
LIG_Clathr_ClatBox_1	632	636	PF01394	0.365
LIG_CtBP_PxDLS_1	733	737	PF00389	0.468
LIG_deltaCOP1_diTrp_1	256	267	PF00928	0.486
LIG_FHA_1	159	165	PF00498	0.461
LIG_FHA_1	279	285	PF00498	0.488
LIG_FHA_1	398	404	PF00498	0.667
LIG_FHA_1	57	63	PF00498	0.653
LIG_FHA_1	839	845	PF00498	0.526
LIG_FHA_1	85	91	PF00498	0.676
LIG_FHA_2	253	259	PF00498	0.491
LIG_FHA_2	451	457	PF00498	0.594
LIG_FHA_2	492	498	PF00498	0.781
LIG_FHA_2	543	549	PF00498	0.593
LIG_FHA_2	638	644	PF00498	0.468
LIG_Integrin_isoDGR_2	81	83	PF01839	0.632
LIG_LIR_Apic_2	414	420	PF02991	0.522
LIG_LIR_Apic_2	617	621	PF02991	0.541
LIG_LIR_Gen_1	257	267	PF02991	0.419
LIG_LIR_Gen_1	630	639	PF02991	0.303
LIG_LIR_Gen_1	671	680	PF02991	0.468
LIG_LIR_Gen_1	754	762	PF02991	0.496
LIG_LIR_Gen_1	765	770	PF02991	0.458
LIG_LIR_Gen_1	815	824	PF02991	0.376
LIG_LIR_Nem_3	108	112	PF02991	0.501
LIG_LIR_Nem_3	257	263	PF02991	0.441
LIG_LIR_Nem_3	291	295	PF02991	0.485
LIG_LIR_Nem_3	342	346	PF02991	0.511
LIG_LIR_Nem_3	630	634	PF02991	0.299
LIG_LIR_Nem_3	655	659	PF02991	0.503
LIG_LIR_Nem_3	671	675	PF02991	0.503
LIG_LIR_Nem_3	738	742	PF02991	0.511
LIG_LIR_Nem_3	754	760	PF02991	0.484
LIG_LIR_Nem_3	765	769	PF02991	0.482
LIG_LIR_Nem_3	815	819	PF02991	0.378
LIG_MYND_1	842	846	PF01753	0.613
LIG_PCNA_yPIPBox_3	771	781	PF02747	0.583
LIG_Pex14_2	71	75	PF04695	0.559
LIG_Pex14_2	752	756	PF04695	0.468
LIG_Pex14_2	766	770	PF04695	0.468
LIG_PTAP_UEV_1	147	152	PF05743	0.631
LIG_REV1ctd_RIR_1	767	775	PF16727	0.483
LIG_SH2_CRK	417	421	PF00017	0.516
LIG_SH2_CRK	561	565	PF00017	0.551
LIG_SH2_CRK	618	622	PF00017	0.541
LIG_SH2_CRK	742	746	PF00017	0.508
LIG_SH2_NCK_1	417	421	PF00017	0.516
LIG_SH2_NCK_1	561	565	PF00017	0.551
LIG_SH2_NCK_1	651	655	PF00017	0.454
LIG_SH2_SRC	300	303	PF00017	0.511
LIG_SH2_SRC	304	307	PF00017	0.592
LIG_SH2_SRC	517	520	PF00017	0.682
LIG_SH2_SRC	651	654	PF00017	0.454
LIG_SH2_STAP1	629	633	PF00017	0.327
LIG_SH2_STAT5	300	303	PF00017	0.433
LIG_SH2_STAT5	631	634	PF00017	0.297
LIG_SH2_STAT5	649	652	PF00017	0.468
LIG_SH3_1	608	614	PF00018	0.550
LIG_SH3_3	145	151	PF00018	0.631
LIG_SH3_3	292	298	PF00018	0.485
LIG_SH3_3	342	348	PF00018	0.602
LIG_SH3_3	353	359	PF00018	0.607
LIG_SH3_3	45	51	PF00018	0.682
LIG_SH3_3	500	506	PF00018	0.628
LIG_SH3_3	513	519	PF00018	0.606
LIG_SH3_3	590	596	PF00018	0.521
LIG_SH3_3	608	614	PF00018	0.550
LIG_SH3_3	89	95	PF00018	0.619
LIG_SH3_4	143	150	PF00018	0.525
LIG_Sin3_3	211	218	PF02671	0.488
LIG_SUMO_SIM_anti_2	630	636	PF11976	0.303
LIG_SUMO_SIM_par_1	25	31	PF11976	0.593
LIG_SUMO_SIM_par_1	630	636	PF11976	0.303
LIG_SUMO_SIM_par_1	655	662	PF11976	0.509
LIG_TRAF2_1	255	258	PF00917	0.525
LIG_TRAF2_1	303	306	PF00917	0.751
LIG_TRAF2_1	545	548	PF00917	0.538
LIG_TRAF2_1	640	643	PF00917	0.468
LIG_TRAF2_1	704	707	PF00917	0.468
LIG_TYR_ITIM	755	760	PF00017	0.503
LIG_WRC_WIRS_1	684	689	PF05994	0.433
LIG_WW_1	646	649	PF00397	0.454
MOD_CK1_1	177	183	PF00069	0.541
MOD_CK1_1	209	215	PF00069	0.562
MOD_CK1_1	362	368	PF00069	0.555
MOD_CK1_1	38	44	PF00069	0.694
MOD_CK1_1	382	388	PF00069	0.611
MOD_CK1_1	392	398	PF00069	0.584
MOD_CK1_1	407	413	PF00069	0.545
MOD_CK1_1	416	422	PF00069	0.598
MOD_CK1_1	466	472	PF00069	0.751
MOD_CK1_1	57	63	PF00069	0.646
MOD_CK1_1	578	584	PF00069	0.667
MOD_CK1_1	617	623	PF00069	0.534
MOD_CK1_1	838	844	PF00069	0.583
MOD_CK1_1	854	860	PF00069	0.762
MOD_CK1_1	863	869	PF00069	0.564
MOD_CK2_1	252	258	PF00069	0.507
MOD_CK2_1	491	497	PF00069	0.771
MOD_CK2_1	542	548	PF00069	0.551
MOD_CK2_1	637	643	PF00069	0.468
MOD_CK2_1	701	707	PF00069	0.513
MOD_CK2_1	71	77	PF00069	0.572
MOD_CK2_1	812	818	PF00069	0.376
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.592
MOD_GlcNHglycan	1	4	PF01048	0.704
MOD_GlcNHglycan	102	105	PF01048	0.597
MOD_GlcNHglycan	109	112	PF01048	0.788
MOD_GlcNHglycan	128	131	PF01048	0.517
MOD_GlcNHglycan	144	147	PF01048	0.568
MOD_GlcNHglycan	148	151	PF01048	0.522
MOD_GlcNHglycan	190	193	PF01048	0.557
MOD_GlcNHglycan	208	211	PF01048	0.453
MOD_GlcNHglycan	231	234	PF01048	0.552
MOD_GlcNHglycan	235	238	PF01048	0.606
MOD_GlcNHglycan	312	315	PF01048	0.571
MOD_GlcNHglycan	318	321	PF01048	0.595
MOD_GlcNHglycan	361	364	PF01048	0.608
MOD_GlcNHglycan	381	384	PF01048	0.615
MOD_GlcNHglycan	406	409	PF01048	0.660
MOD_GlcNHglycan	434	437	PF01048	0.564
MOD_GlcNHglycan	439	442	PF01048	0.654
MOD_GlcNHglycan	519	522	PF01048	0.704
MOD_GlcNHglycan	537	540	PF01048	0.556
MOD_GlcNHglycan	553	556	PF01048	0.450
MOD_GlcNHglycan	577	580	PF01048	0.708
MOD_GlcNHglycan	793	796	PF01048	0.303
MOD_GlcNHglycan	835	838	PF01048	0.562
MOD_GlcNHglycan	867	870	PF01048	0.679
MOD_GSK3_1	107	114	PF00069	0.559
MOD_GSK3_1	138	145	PF00069	0.660
MOD_GSK3_1	202	209	PF00069	0.663
MOD_GSK3_1	229	236	PF00069	0.563
MOD_GSK3_1	242	249	PF00069	0.550
MOD_GSK3_1	312	319	PF00069	0.597
MOD_GSK3_1	323	330	PF00069	0.645
MOD_GSK3_1	355	362	PF00069	0.621
MOD_GSK3_1	373	380	PF00069	0.597
MOD_GSK3_1	38	45	PF00069	0.759
MOD_GSK3_1	382	389	PF00069	0.783
MOD_GSK3_1	390	397	PF00069	0.551
MOD_GSK3_1	407	414	PF00069	0.517
MOD_GSK3_1	446	453	PF00069	0.598
MOD_GSK3_1	463	470	PF00069	0.691
MOD_GSK3_1	504	511	PF00069	0.606
MOD_GSK3_1	519	526	PF00069	0.626
MOD_GSK3_1	531	538	PF00069	0.612
MOD_GSK3_1	575	582	PF00069	0.747
MOD_GSK3_1	606	613	PF00069	0.694
MOD_GSK3_1	67	74	PF00069	0.628
MOD_GSK3_1	829	836	PF00069	0.575
MOD_GSK3_1	846	853	PF00069	0.605
MOD_GSK3_1	856	863	PF00069	0.669
MOD_GSK3_1	96	103	PF00069	0.682
MOD_LATS_1	204	210	PF00433	0.484
MOD_N-GLC_1	397	402	PF02516	0.673
MOD_N-GLC_1	524	529	PF02516	0.662
MOD_N-GLC_1	531	536	PF02516	0.602
MOD_NEK2_1	27	32	PF00069	0.605
MOD_NEK2_1	437	442	PF00069	0.538
MOD_NEK2_1	465	470	PF00069	0.598
MOD_NEK2_1	523	528	PF00069	0.724
MOD_NEK2_1	560	565	PF00069	0.575
MOD_NEK2_1	586	591	PF00069	0.617
MOD_NEK2_1	616	621	PF00069	0.677
MOD_NEK2_1	71	76	PF00069	0.576
MOD_NEK2_1	716	721	PF00069	0.468
MOD_NEK2_1	770	775	PF00069	0.468
MOD_NEK2_1	829	834	PF00069	0.675
MOD_NEK2_2	42	47	PF00069	0.662
MOD_NEK2_2	458	463	PF00069	0.685
MOD_NEK2_2	851	856	PF00069	0.597
MOD_PIKK_1	35	41	PF00454	0.600
MOD_PIKK_1	472	478	PF00454	0.612
MOD_PIKK_1	491	497	PF00454	0.714
MOD_PIKK_1	57	63	PF00454	0.541
MOD_PIKK_1	770	776	PF00454	0.513
MOD_PKA_1	551	557	PF00069	0.536
MOD_PKA_1	689	695	PF00069	0.453
MOD_PKA_2	373	379	PF00069	0.671
MOD_PKA_2	483	489	PF00069	0.644
MOD_PKA_2	551	557	PF00069	0.531
MOD_PKA_2	770	776	PF00069	0.543
MOD_PKA_2	857	863	PF00069	0.594
MOD_Plk_1	54	60	PF00069	0.641
MOD_Plk_1	682	688	PF00069	0.433
MOD_Plk_4	166	172	PF00069	0.438
MOD_Plk_4	190	196	PF00069	0.603
MOD_Plk_4	327	333	PF00069	0.593
MOD_Plk_4	519	525	PF00069	0.803
MOD_Plk_4	582	588	PF00069	0.614
MOD_Plk_4	71	77	PF00069	0.596
MOD_Plk_4	751	757	PF00069	0.533
MOD_Plk_4	801	807	PF00069	0.468
MOD_ProDKin_1	115	121	PF00069	0.656
MOD_ProDKin_1	128	134	PF00069	0.538
MOD_ProDKin_1	22	28	PF00069	0.539
MOD_ProDKin_1	294	300	PF00069	0.565
MOD_ProDKin_1	312	318	PF00069	0.475
MOD_ProDKin_1	323	329	PF00069	0.592
MOD_ProDKin_1	344	350	PF00069	0.592
MOD_ProDKin_1	352	358	PF00069	0.616
MOD_ProDKin_1	382	388	PF00069	0.617
MOD_ProDKin_1	407	413	PF00069	0.711
MOD_ProDKin_1	416	422	PF00069	0.601
MOD_ProDKin_1	423	429	PF00069	0.565
MOD_ProDKin_1	446	452	PF00069	0.740
MOD_ProDKin_1	470	476	PF00069	0.614
MOD_ProDKin_1	484	490	PF00069	0.713
MOD_ProDKin_1	505	511	PF00069	0.603
MOD_ProDKin_1	524	530	PF00069	0.784
MOD_ProDKin_1	579	585	PF00069	0.590
MOD_ProDKin_1	610	616	PF00069	0.563
MOD_ProDKin_1	617	623	PF00069	0.537
MOD_ProDKin_1	838	844	PF00069	0.523
MOD_ProDKin_1	860	866	PF00069	0.590
MOD_ProDKin_1	91	97	PF00069	0.621
TRG_DiLeu_BaEn_2	670	676	PF01217	0.468
TRG_DiLeu_BaLyEn_6	839	844	PF01217	0.609
TRG_ENDOCYTIC_2	561	564	PF00928	0.574
TRG_ENDOCYTIC_2	629	632	PF00928	0.331
TRG_ENDOCYTIC_2	651	654	PF00928	0.454
TRG_ENDOCYTIC_2	742	745	PF00928	0.553
TRG_ENDOCYTIC_2	757	760	PF00928	0.478
TRG_ER_diArg_1	550	553	PF00400	0.508
TRG_ER_diArg_1	676	679	PF00400	0.468
TRG_NES_CRM1_1	279	291	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U4	Leptomonas seymouri	49%	77%
A0A3S7X257	Leishmania donovani	90%	100%
A4HH56	Leishmania braziliensis	73%	100%
A4I4A7	Leishmania infantum	90%	100%
E9AM24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%