Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania major

UniProt:

E9ADQ5_LEIMA

TriTrypDb:

LmjF.29.0540 , LMJLV39_290010700 , LMJSD75_290010700

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADQ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.699
CLV_C14_Caspase3-7	135	139	PF00656	0.672
CLV_C14_Caspase3-7	341	345	PF00656	0.635
CLV_NRD_NRD_1	142	144	PF00675	0.667
CLV_NRD_NRD_1	147	149	PF00675	0.517
CLV_NRD_NRD_1	174	176	PF00675	0.648
CLV_NRD_NRD_1	335	337	PF00675	0.323
CLV_NRD_NRD_1	367	369	PF00675	0.267
CLV_NRD_NRD_1	421	423	PF00675	0.299
CLV_NRD_NRD_1	45	47	PF00675	0.712
CLV_PCSK_KEX2_1	174	176	PF00082	0.648
CLV_PCSK_KEX2_1	213	215	PF00082	0.525
CLV_PCSK_KEX2_1	335	337	PF00082	0.314
CLV_PCSK_KEX2_1	367	369	PF00082	0.314
CLV_PCSK_KEX2_1	421	423	PF00082	0.309
CLV_PCSK_KEX2_1	500	502	PF00082	0.684
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.479
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.653
CLV_PCSK_PC7_1	209	215	PF00082	0.578
CLV_PCSK_SKI1_1	148	152	PF00082	0.665
CLV_PCSK_SKI1_1	213	217	PF00082	0.503
CLV_PCSK_SKI1_1	40	44	PF00082	0.650
CLV_PCSK_SKI1_1	403	407	PF00082	0.298
CLV_PCSK_SKI1_1	497	501	PF00082	0.650
DEG_APCC_DBOX_1	116	124	PF00400	0.603
DEG_SPOP_SBC_1	78	82	PF00917	0.691
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.406
DOC_MAPK_gen_1	412	418	PF00069	0.450
DOC_PP2B_LxvP_1	23	26	PF13499	0.515
DOC_SPAK_OSR1_1	127	131	PF12202	0.585
DOC_USP7_MATH_1	153	157	PF00917	0.680
DOC_USP7_MATH_1	178	182	PF00917	0.754
DOC_USP7_MATH_1	233	237	PF00917	0.493
DOC_USP7_MATH_1	28	32	PF00917	0.674
DOC_USP7_MATH_1	348	352	PF00917	0.484
DOC_USP7_MATH_1	38	42	PF00917	0.688
DOC_USP7_MATH_1	51	55	PF00917	0.730
DOC_USP7_MATH_1	67	71	PF00917	0.552
DOC_USP7_MATH_1	77	81	PF00917	0.669
DOC_WW_Pin1_4	105	110	PF00397	0.617
DOC_WW_Pin1_4	53	58	PF00397	0.693
DOC_WW_Pin1_4	79	84	PF00397	0.691
LIG_14-3-3_CanoR_1	115	121	PF00244	0.638
LIG_14-3-3_CanoR_1	27	35	PF00244	0.673
LIG_14-3-3_CanoR_1	3	8	PF00244	0.580
LIG_14-3-3_CanoR_1	393	397	PF00244	0.465
LIG_14-3-3_CanoR_1	40	48	PF00244	0.662
LIG_Actin_WH2_2	243	259	PF00022	0.508
LIG_Actin_WH2_2	363	379	PF00022	0.523
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.508
LIG_BRCT_BRCA1_1	396	400	PF00533	0.523
LIG_BRCT_BRCA1_1	414	418	PF00533	0.386
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.465
LIG_FHA_1	18	24	PF00498	0.487
LIG_FHA_1	251	257	PF00498	0.465
LIG_FHA_1	406	412	PF00498	0.465
LIG_FHA_1	427	433	PF00498	0.508
LIG_FHA_2	348	354	PF00498	0.512
LIG_FHA_2	69	75	PF00498	0.642
LIG_HP1_1	247	251	PF01393	0.508
LIG_Integrin_RGD_1	457	459	PF01839	0.572
LIG_LIR_Gen_1	126	132	PF02991	0.584
LIG_LIR_Nem_3	126	131	PF02991	0.584
LIG_LIR_Nem_3	245	249	PF02991	0.465
LIG_LIR_Nem_3	261	265	PF02991	0.465
LIG_LIR_Nem_3	381	385	PF02991	0.500
LIG_PCNA_yPIPBox_3	401	411	PF02747	0.508
LIG_Pex14_1	317	321	PF04695	0.508
LIG_SH2_CRK	387	391	PF00017	0.508
LIG_SH2_GRB2like	389	392	PF00017	0.508
LIG_SH2_PTP2	265	268	PF00017	0.465
LIG_SH2_PTP2	389	392	PF00017	0.508
LIG_SH2_SRC	339	342	PF00017	0.487
LIG_SH2_SRC	389	392	PF00017	0.508
LIG_SH2_STAP1	396	400	PF00017	0.508
LIG_SH2_STAT5	265	268	PF00017	0.467
LIG_SH2_STAT5	389	392	PF00017	0.508
LIG_SH3_3	190	196	PF00018	0.697
LIG_SH3_3	204	210	PF00018	0.588
LIG_SH3_3	234	240	PF00018	0.517
LIG_SH3_3	288	294	PF00018	0.522
LIG_SH3_3	377	383	PF00018	0.563
LIG_SH3_3	45	51	PF00018	0.732
LIG_SUMO_SIM_par_1	245	253	PF11976	0.508
LIG_SUMO_SIM_par_1	287	293	PF11976	0.529
LIG_SxIP_EBH_1	199	213	PF03271	0.605
LIG_TRAF2_1	467	470	PF00917	0.580
LIG_TYR_ITIM	385	390	PF00017	0.465
LIG_WW_3	24	28	PF00397	0.627
MOD_CDK_SPK_2	53	58	PF00069	0.696
MOD_CDK_SPxxK_3	79	86	PF00069	0.548
MOD_CK1_1	102	108	PF00069	0.632
MOD_CK1_1	116	122	PF00069	0.629
MOD_CK1_1	41	47	PF00069	0.684
MOD_CK1_1	450	456	PF00069	0.385
MOD_CK1_1	52	58	PF00069	0.662
MOD_CK1_1	82	88	PF00069	0.696
MOD_CK2_1	179	185	PF00069	0.685
MOD_CK2_1	347	353	PF00069	0.516
MOD_CK2_1	68	74	PF00069	0.767
MOD_Cter_Amidation	419	422	PF01082	0.308
MOD_GlcNHglycan	155	158	PF01048	0.686
MOD_GlcNHglycan	203	206	PF01048	0.676
MOD_GlcNHglycan	233	236	PF01048	0.270
MOD_GlcNHglycan	350	353	PF01048	0.471
MOD_GlcNHglycan	40	43	PF01048	0.678
MOD_GlcNHglycan	423	426	PF01048	0.265
MOD_GlcNHglycan	96	99	PF01048	0.716
MOD_GSK3_1	119	126	PF00069	0.703
MOD_GSK3_1	162	169	PF00069	0.748
MOD_GSK3_1	201	208	PF00069	0.616
MOD_GSK3_1	272	279	PF00069	0.465
MOD_GSK3_1	36	43	PF00069	0.657
MOD_GSK3_1	49	56	PF00069	0.733
MOD_GSK3_1	78	85	PF00069	0.669
MOD_N-GLC_1	113	118	PF02516	0.592
MOD_N-GLC_1	348	353	PF02516	0.479
MOD_NEK2_1	104	109	PF00069	0.621
MOD_NEK2_1	123	128	PF00069	0.650
MOD_NEK2_1	132	137	PF00069	0.595
MOD_NEK2_1	200	205	PF00069	0.627
MOD_NEK2_1	228	233	PF00069	0.508
MOD_NEK2_1	461	466	PF00069	0.509
MOD_NEK2_2	233	238	PF00069	0.508
MOD_OFUCOSY	226	232	PF10250	0.265
MOD_PIKK_1	142	148	PF00454	0.684
MOD_PIKK_1	166	172	PF00454	0.700
MOD_PIKK_1	282	288	PF00454	0.499
MOD_PIKK_1	99	105	PF00454	0.724
MOD_PKA_1	148	154	PF00069	0.679
MOD_PKA_1	412	418	PF00069	0.490
MOD_PKA_1	421	427	PF00069	0.470
MOD_PKA_2	116	122	PF00069	0.636
MOD_PKA_2	142	148	PF00069	0.676
MOD_PKA_2	324	330	PF00069	0.491
MOD_PKA_2	392	398	PF00069	0.465
MOD_PKA_2	421	427	PF00069	0.495
MOD_Plk_4	116	122	PF00069	0.608
MOD_Plk_4	179	185	PF00069	0.700
MOD_Plk_4	294	300	PF00069	0.487
MOD_Plk_4	371	377	PF00069	0.465
MOD_ProDKin_1	105	111	PF00069	0.617
MOD_ProDKin_1	53	59	PF00069	0.691
MOD_ProDKin_1	79	85	PF00069	0.694
MOD_SUMO_for_1	306	309	PF00179	0.487
MOD_SUMO_for_1	330	333	PF00179	0.508
TRG_DiLeu_BaEn_2	332	338	PF01217	0.508
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.543
TRG_ENDOCYTIC_2	387	390	PF00928	0.465
TRG_ER_diArg_1	2	5	PF00400	0.541
TRG_ER_diArg_1	335	337	PF00400	0.523
TRG_ER_diArg_1	366	368	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G3	Leptomonas seymouri	58%	95%
A0A3R7M512	Trypanosoma rangeli	50%	100%
A0A3S7X262	Leishmania donovani	94%	100%
A4HH55	Leishmania braziliensis	78%	99%
A4I4A6	Leishmania infantum	93%	100%
E9AM25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%