Pep_M12B_propep domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADQ3_LEIMA

TriTrypDb:

LmjF.29.0520 , LMJLV39_290010500 , LMJSD75_290010500

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.552
CLV_C14_Caspase3-7	74	78	PF00656	0.601
CLV_NRD_NRD_1	62	64	PF00675	0.640
CLV_PCSK_KEX2_1	62	64	PF00082	0.640
CLV_PCSK_SKI1_1	218	222	PF00082	0.611
DEG_Nend_UBRbox_3	1	3	PF02207	0.700
DEG_SPOP_SBC_1	130	134	PF00917	0.594
DEG_SPOP_SBC_1	209	213	PF00917	0.627
DOC_CDC14_PxL_1	30	38	PF14671	0.659
DOC_CYCLIN_RxL_1	215	224	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.624
DOC_PP2B_LxvP_1	111	114	PF13499	0.632
DOC_USP7_MATH_1	167	171	PF00917	0.699
DOC_USP7_MATH_1	18	22	PF00917	0.619
DOC_USP7_MATH_1	204	208	PF00917	0.633
DOC_USP7_MATH_1	209	213	PF00917	0.593
DOC_USP7_MATH_1	58	62	PF00917	0.553
DOC_WW_Pin1_4	198	203	PF00397	0.691
LIG_14-3-3_CanoR_1	44	48	PF00244	0.667
LIG_BIR_III_2	24	28	PF00653	0.554
LIG_BRCT_BRCA1_1	212	216	PF00533	0.599
LIG_Clathr_ClatBox_1	116	120	PF01394	0.613
LIG_eIF4E_1	145	151	PF01652	0.619
LIG_EVH1_2	34	38	PF00568	0.662
LIG_FHA_1	135	141	PF00498	0.602
LIG_FHA_1	177	183	PF00498	0.661
LIG_FHA_1	212	218	PF00498	0.663
LIG_FHA_1	92	98	PF00498	0.725
LIG_FHA_2	96	102	PF00498	0.549
LIG_LIR_Nem_3	32	36	PF02991	0.533
LIG_LYPXL_yS_3	33	36	PF13949	0.664
LIG_SH2_STAT5	163	166	PF00017	0.506
LIG_SH3_3	161	167	PF00018	0.651
LIG_SH3_3	180	186	PF00018	0.693
LIG_SH3_3	188	194	PF00018	0.618
LIG_SUMO_SIM_par_1	90	98	PF11976	0.600
LIG_TRAF2_1	98	101	PF00917	0.546
LIG_TYR_ITIM	31	36	PF00017	0.661
MOD_CK1_1	211	217	PF00069	0.649
MOD_CK1_1	43	49	PF00069	0.659
MOD_CK2_1	171	177	PF00069	0.671
MOD_CK2_1	95	101	PF00069	0.544
MOD_GlcNHglycan	11	14	PF01048	0.483
MOD_GlcNHglycan	158	161	PF01048	0.620
MOD_GlcNHglycan	174	177	PF01048	0.499
MOD_GlcNHglycan	77	81	PF01048	0.535
MOD_GSK3_1	130	137	PF00069	0.640
MOD_GSK3_1	167	174	PF00069	0.789
MOD_GSK3_1	204	211	PF00069	0.712
MOD_GSK3_1	39	46	PF00069	0.772
MOD_GSK3_1	66	73	PF00069	0.737
MOD_GSK3_1	91	98	PF00069	0.597
MOD_NEK2_1	210	215	PF00069	0.615
MOD_PIKK_1	66	72	PF00454	0.682
MOD_PKA_2	167	173	PF00069	0.493
MOD_PKA_2	43	49	PF00069	0.645
MOD_PKA_2	70	76	PF00069	0.613
MOD_Plk_1	18	24	PF00069	0.678
MOD_Plk_1	40	46	PF00069	0.604
MOD_Plk_1	90	96	PF00069	0.644
MOD_ProDKin_1	198	204	PF00069	0.690
MOD_SUMO_for_1	88	91	PF00179	0.586
TRG_DiLeu_BaEn_4	90	96	PF01217	0.543
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.627
TRG_ENDOCYTIC_2	33	36	PF00928	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IR44	Leishmania donovani	85%	97%
A4HH53	Leishmania braziliensis	61%	100%
A4I4A4	Leishmania infantum	85%	97%
E9AM27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%