LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ADQ0_LEIMA
TriTrypDb:
LmjF.29.0490 , LMJLV39_290010200 * , LMJSD75_290010200 *
Length:
364

Annotations

LeishMANIAdb annotations

Specific to Kinetoplastids, with fairly unique fold and uncertain topology

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 10
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9ADQ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADQ0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 241 243 PF00675 0.503
CLV_NRD_NRD_1 329 331 PF00675 0.539
CLV_NRD_NRD_1 70 72 PF00675 0.443
CLV_PCSK_KEX2_1 189 191 PF00082 0.666
CLV_PCSK_KEX2_1 241 243 PF00082 0.521
CLV_PCSK_KEX2_1 50 52 PF00082 0.534
CLV_PCSK_KEX2_1 70 72 PF00082 0.395
CLV_PCSK_PC1ET2_1 189 191 PF00082 0.666
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.534
CLV_PCSK_SKI1_1 20 24 PF00082 0.546
CLV_PCSK_SKI1_1 242 246 PF00082 0.510
DEG_Nend_Nbox_1 1 3 PF02207 0.676
DOC_AGCK_PIF_2 164 169 PF00069 0.444
DOC_MAPK_gen_1 47 56 PF00069 0.662
DOC_MAPK_MEF2A_6 107 115 PF00069 0.624
DOC_MAPK_MEF2A_6 47 56 PF00069 0.646
DOC_PP4_FxxP_1 41 44 PF00568 0.661
DOC_USP7_MATH_1 125 129 PF00917 0.644
DOC_USP7_MATH_1 203 207 PF00917 0.385
DOC_USP7_MATH_1 265 269 PF00917 0.740
DOC_WW_Pin1_4 181 186 PF00397 0.475
DOC_WW_Pin1_4 55 60 PF00397 0.734
LIG_14-3-3_CanoR_1 202 208 PF00244 0.437
LIG_14-3-3_CanoR_1 249 255 PF00244 0.646
LIG_14-3-3_CanoR_1 294 300 PF00244 0.647
LIG_BRCT_BRCA1_1 102 106 PF00533 0.697
LIG_BRCT_BRCA1_1 247 251 PF00533 0.721
LIG_BRCT_BRCA1_1 56 60 PF00533 0.708
LIG_FHA_1 100 106 PF00498 0.644
LIG_FHA_1 226 232 PF00498 0.581
LIG_FHA_1 310 316 PF00498 0.741
LIG_FHA_2 21 27 PF00498 0.736
LIG_FHA_2 297 303 PF00498 0.651
LIG_FHA_2 88 94 PF00498 0.699
LIG_IBAR_NPY_1 324 326 PF08397 0.666
LIG_LIR_Apic_2 346 351 PF02991 0.658
LIG_LIR_Gen_1 166 175 PF02991 0.396
LIG_LIR_Gen_1 57 65 PF02991 0.711
LIG_LIR_Nem_3 166 170 PF02991 0.392
LIG_LIR_Nem_3 206 211 PF02991 0.342
LIG_LIR_Nem_3 223 229 PF02991 0.536
LIG_LIR_Nem_3 248 254 PF02991 0.704
LIG_LIR_Nem_3 57 63 PF02991 0.663
LIG_Pex14_1 116 120 PF04695 0.597
LIG_Pex14_2 216 220 PF04695 0.481
LIG_Pex14_2 37 41 PF04695 0.715
LIG_PTB_Apo_2 321 328 PF02174 0.649
LIG_REV1ctd_RIR_1 213 223 PF16727 0.549
LIG_SH2_CRK 252 256 PF00017 0.717
LIG_SH2_GRB2like 117 120 PF00017 0.614
LIG_SH2_GRB2like 326 329 PF00017 0.676
LIG_SH2_SRC 237 240 PF00017 0.617
LIG_SH2_STAP1 165 169 PF00017 0.386
LIG_SH2_STAP1 213 217 PF00017 0.344
LIG_SH2_STAP1 252 256 PF00017 0.671
LIG_SH2_STAT3 72 75 PF00017 0.729
LIG_SH2_STAT5 120 123 PF00017 0.605
LIG_SH2_STAT5 163 166 PF00017 0.390
LIG_SH2_STAT5 169 172 PF00017 0.379
LIG_SH2_STAT5 199 202 PF00017 0.443
LIG_SH2_STAT5 254 257 PF00017 0.673
LIG_SH2_STAT5 292 295 PF00017 0.661
LIG_SH2_STAT5 326 329 PF00017 0.690
LIG_SH2_STAT5 96 99 PF00017 0.654
LIG_SH3_3 15 21 PF00018 0.743
LIG_SH3_3 53 59 PF00018 0.643
LIG_SUMO_SIM_par_1 52 58 PF11976 0.640
LIG_TRAF2_1 90 93 PF00917 0.671
LIG_TYR_ITIM 250 255 PF00017 0.721
MOD_CK1_1 306 312 PF00069 0.704
MOD_CK1_1 99 105 PF00069 0.616
MOD_CK2_1 20 26 PF00069 0.742
MOD_CK2_1 80 86 PF00069 0.671
MOD_CK2_1 87 93 PF00069 0.657
MOD_GlcNHglycan 127 130 PF01048 0.474
MOD_GlcNHglycan 222 225 PF01048 0.456
MOD_GlcNHglycan 245 248 PF01048 0.477
MOD_GlcNHglycan 296 299 PF01048 0.453
MOD_GlcNHglycan 317 320 PF01048 0.460
MOD_GlcNHglycan 360 363 PF01048 0.505
MOD_GSK3_1 125 132 PF00069 0.724
MOD_GSK3_1 296 303 PF00069 0.638
MOD_GSK3_1 96 103 PF00069 0.679
MOD_N-GLC_1 129 134 PF02516 0.532
MOD_N-GLC_1 283 288 PF02516 0.449
MOD_N-GLC_1 306 311 PF02516 0.477
MOD_NEK2_1 139 144 PF00069 0.646
MOD_NEK2_1 225 230 PF00069 0.592
MOD_NEK2_1 245 250 PF00069 0.590
MOD_NEK2_1 293 298 PF00069 0.631
MOD_NEK2_1 300 305 PF00069 0.634
MOD_NEK2_1 315 320 PF00069 0.698
MOD_NEK2_1 358 363 PF00069 0.675
MOD_NEK2_1 63 68 PF00069 0.635
MOD_NEK2_2 203 208 PF00069 0.385
MOD_PIKK_1 257 263 PF00454 0.700
MOD_PIKK_1 309 315 PF00454 0.737
MOD_PK_1 283 289 PF00069 0.672
MOD_PKA_2 293 299 PF00069 0.632
MOD_PKA_2 358 364 PF00069 0.692
MOD_Plk_1 283 289 PF00069 0.680
MOD_Plk_4 203 209 PF00069 0.348
MOD_Plk_4 250 256 PF00069 0.734
MOD_Plk_4 300 306 PF00069 0.645
MOD_ProDKin_1 181 187 PF00069 0.470
MOD_ProDKin_1 55 61 PF00069 0.733
MOD_SUMO_for_1 11 14 PF00179 0.703
TRG_ENDOCYTIC_2 167 170 PF00928 0.383
TRG_ENDOCYTIC_2 213 216 PF00928 0.328
TRG_ENDOCYTIC_2 252 255 PF00928 0.718
TRG_ENDOCYTIC_2 292 295 PF00928 0.650
TRG_ENDOCYTIC_2 39 42 PF00928 0.670
TRG_ER_diArg_1 178 181 PF00400 0.444
TRG_ER_diArg_1 70 72 PF00400 0.702
TRG_Pf-PMV_PEXEL_1 51 55 PF00026 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I199 Leptomonas seymouri 77% 100%
A0A0S4JHX1 Bodo saltans 45% 100%
A0A1X0P043 Trypanosomatidae 65% 99%
A0A3Q8IE98 Leishmania donovani 99% 100%
A0A422NUJ6 Trypanosoma rangeli 62% 99%
A4HH50 Leishmania braziliensis 91% 100%
A4I4A1 Leishmania infantum 99% 100%
C9ZKM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AM30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
V5DLE6 Trypanosoma cruzi 65% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS