Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADP9_LEIMA

TriTrypDb:

LmjF.29.0480 , LMJLV39_290010100 , LMJSD75_290010100

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.568
CLV_NRD_NRD_1	182	184	PF00675	0.519
CLV_NRD_NRD_1	206	208	PF00675	0.506
CLV_NRD_NRD_1	275	277	PF00675	0.604
CLV_NRD_NRD_1	290	292	PF00675	0.492
CLV_NRD_NRD_1	306	308	PF00675	0.566
CLV_PCSK_FUR_1	304	308	PF00082	0.515
CLV_PCSK_KEX2_1	205	207	PF00082	0.500
CLV_PCSK_KEX2_1	275	277	PF00082	0.583
CLV_PCSK_KEX2_1	290	292	PF00082	0.422
CLV_PCSK_KEX2_1	306	308	PF00082	0.507
CLV_PCSK_PC7_1	201	207	PF00082	0.488
CLV_PCSK_SKI1_1	242	246	PF00082	0.546
DEG_SPOP_SBC_1	64	68	PF00917	0.636
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.508
DOC_MAPK_gen_1	10	17	PF00069	0.509
DOC_MAPK_gen_1	288	295	PF00069	0.534
DOC_MAPK_HePTP_8	95	107	PF00069	0.497
DOC_MAPK_MEF2A_6	206	215	PF00069	0.596
DOC_MAPK_MEF2A_6	98	107	PF00069	0.503
DOC_PP2B_LxvP_1	101	104	PF13499	0.607
DOC_PP2B_LxvP_1	224	227	PF13499	0.592
DOC_USP7_MATH_1	150	154	PF00917	0.508
DOC_WW_Pin1_4	175	180	PF00397	0.675
DOC_WW_Pin1_4	306	311	PF00397	0.571
LIG_14-3-3_CanoR_1	10	16	PF00244	0.491
LIG_14-3-3_CanoR_1	28	35	PF00244	0.573
LIG_14-3-3_CanoR_1	63	73	PF00244	0.639
LIG_14-3-3_CanoR_1	98	102	PF00244	0.732
LIG_eIF4E_1	230	236	PF01652	0.511
LIG_FHA_1	115	121	PF00498	0.675
LIG_FHA_1	137	143	PF00498	0.614
LIG_FHA_2	176	182	PF00498	0.550
LIG_LIR_Gen_1	210	220	PF02991	0.587
LIG_LIR_Nem_3	210	215	PF02991	0.590
LIG_SH2_PTP2	212	215	PF00017	0.588
LIG_SH2_STAP1	199	203	PF00017	0.417
LIG_SH2_STAT3	190	193	PF00017	0.505
LIG_SH2_STAT5	212	215	PF00017	0.588
LIG_SH2_STAT5	230	233	PF00017	0.540
LIG_SH3_3	205	211	PF00018	0.663
MOD_CDC14_SPxK_1	309	312	PF00782	0.472
MOD_CDK_SPxK_1	306	312	PF00069	0.462
MOD_CK1_1	65	71	PF00069	0.797
MOD_CK1_1	97	103	PF00069	0.719
MOD_CK2_1	175	181	PF00069	0.561
MOD_GlcNHglycan	67	70	PF01048	0.669
MOD_GSK3_1	54	61	PF00069	0.729
MOD_NEK2_1	105	110	PF00069	0.644
MOD_NEK2_1	129	134	PF00069	0.541
MOD_NEK2_1	62	67	PF00069	0.753
MOD_NEK2_1	72	77	PF00069	0.561
MOD_NEK2_1	96	101	PF00069	0.681
MOD_NEK2_2	150	155	PF00069	0.486
MOD_NMyristoyl	1	7	PF02799	0.490
MOD_PKA_2	11	17	PF00069	0.500
MOD_PKA_2	62	68	PF00069	0.641
MOD_PKA_2	97	103	PF00069	0.717
MOD_Plk_1	168	174	PF00069	0.714
MOD_Plk_1	199	205	PF00069	0.504
MOD_ProDKin_1	175	181	PF00069	0.670
MOD_ProDKin_1	306	312	PF00069	0.577
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.671
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.574
TRG_ENDOCYTIC_2	212	215	PF00928	0.588
TRG_ER_diArg_1	204	207	PF00400	0.539
TRG_ER_diArg_1	304	307	PF00400	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y3	Leptomonas seymouri	54%	100%
A0A1X0NZJ3	Trypanosomatidae	36%	100%
A0A3S7X240	Leishmania donovani	90%	100%
A4HH49	Leishmania braziliensis	69%	100%
A4I4A0	Leishmania infantum	90%	100%
E9AM31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%