Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADP8_LEIMA

TriTrypDb:

LmjF.29.0470 , LMJLV39_290010000 , LMJSD75_290010000

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ADP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.645
CLV_C14_Caspase3-7	289	293	PF00656	0.719
CLV_C14_Caspase3-7	294	298	PF00656	0.676
CLV_C14_Caspase3-7	401	405	PF00656	0.734
CLV_C14_Caspase3-7	91	95	PF00656	0.648
CLV_NRD_NRD_1	217	219	PF00675	0.465
CLV_NRD_NRD_1	225	227	PF00675	0.504
CLV_PCSK_KEX2_1	101	103	PF00082	0.406
CLV_PCSK_KEX2_1	216	218	PF00082	0.455
CLV_PCSK_KEX2_1	225	227	PF00082	0.505
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.406
CLV_PCSK_SKI1_1	102	106	PF00082	0.403
CLV_PCSK_SKI1_1	225	229	PF00082	0.478
CLV_PCSK_SKI1_1	23	27	PF00082	0.405
CLV_PCSK_SKI1_1	420	424	PF00082	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.700
DOC_CYCLIN_RxL_1	99	109	PF00134	0.605
DOC_MAPK_MEF2A_6	347	354	PF00069	0.724
DOC_MAPK_MEF2A_6	58	65	PF00069	0.591
DOC_USP7_MATH_1	100	104	PF00917	0.592
DOC_USP7_MATH_1	178	182	PF00917	0.509
DOC_USP7_MATH_1	190	194	PF00917	0.351
DOC_USP7_MATH_1	45	49	PF00917	0.613
DOC_USP7_MATH_1	95	99	PF00917	0.578
DOC_WW_Pin1_4	225	230	PF00397	0.640
DOC_WW_Pin1_4	232	237	PF00397	0.613
DOC_WW_Pin1_4	247	252	PF00397	0.692
DOC_WW_Pin1_4	311	316	PF00397	0.681
DOC_WW_Pin1_4	346	351	PF00397	0.719
DOC_WW_Pin1_4	35	40	PF00397	0.634
LIG_14-3-3_CanoR_1	149	153	PF00244	0.674
LIG_14-3-3_CanoR_1	218	227	PF00244	0.627
LIG_14-3-3_CanoR_1	67	71	PF00244	0.607
LIG_14-3-3_CanoR_1	7	16	PF00244	0.704
LIG_deltaCOP1_diTrp_1	302	309	PF00928	0.693
LIG_FHA_1	121	127	PF00498	0.613
LIG_FHA_1	130	136	PF00498	0.619
LIG_FHA_1	248	254	PF00498	0.712
LIG_FHA_1	315	321	PF00498	0.706
LIG_FHA_1	32	38	PF00498	0.626
LIG_FHA_1	8	14	PF00498	0.680
LIG_FHA_1	91	97	PF00498	0.589
LIG_FHA_2	266	272	PF00498	0.652
LIG_FHA_2	287	293	PF00498	0.827
LIG_FHA_2	408	414	PF00498	0.733
LIG_FHA_2	424	430	PF00498	0.541
LIG_LIR_Gen_1	161	171	PF02991	0.395
LIG_LIR_Gen_1	303	310	PF02991	0.693
LIG_LIR_Nem_3	103	108	PF02991	0.651
LIG_LIR_Nem_3	161	167	PF02991	0.315
LIG_LIR_Nem_3	189	194	PF02991	0.395
LIG_LIR_Nem_3	303	309	PF02991	0.694
LIG_NRBOX	75	81	PF00104	0.584
LIG_PDZ_Class_2	443	448	PF00595	0.651
LIG_SH2_CRK	164	168	PF00017	0.315
LIG_SH2_NCK_1	164	168	PF00017	0.395
LIG_SH2_SRC	202	205	PF00017	0.315
LIG_SH2_STAT5	164	167	PF00017	0.315
LIG_SH2_STAT5	19	22	PF00017	0.633
LIG_SH2_STAT5	202	205	PF00017	0.315
LIG_SH2_STAT5	206	209	PF00017	0.515
LIG_SH3_3	249	255	PF00018	0.733
LIG_Sin3_3	25	32	PF02671	0.646
LIG_SUMO_SIM_anti_2	10	18	PF11976	0.669
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.720
LIG_SUMO_SIM_par_1	316	324	PF11976	0.718
LIG_TRAF2_1	268	271	PF00917	0.707
LIG_TRAF2_1	375	378	PF00917	0.685
LIG_TRAF2_1	426	429	PF00917	0.628
LIG_WRC_WIRS_1	108	113	PF05994	0.659
MOD_CDK_SPxK_1	225	231	PF00069	0.636
MOD_CK1_1	11	17	PF00069	0.664
MOD_CK1_1	116	122	PF00069	0.611
MOD_CK1_1	162	168	PF00069	0.268
MOD_CK1_1	257	263	PF00069	0.711
MOD_CK1_1	31	37	PF00069	0.572
MOD_CK1_1	324	330	PF00069	0.723
MOD_CK1_1	371	377	PF00069	0.757
MOD_CK1_1	391	397	PF00069	0.671
MOD_CK1_1	48	54	PF00069	0.623
MOD_CK2_1	265	271	PF00069	0.696
MOD_CK2_1	316	322	PF00069	0.717
MOD_CK2_1	372	378	PF00069	0.767
MOD_CK2_1	407	413	PF00069	0.732
MOD_CK2_1	422	428	PF00069	0.552
MOD_GlcNHglycan	115	118	PF01048	0.423
MOD_GlcNHglycan	256	259	PF01048	0.622
MOD_GlcNHglycan	30	33	PF01048	0.406
MOD_GlcNHglycan	322	326	PF01048	0.503
MOD_GlcNHglycan	366	369	PF01048	0.528
MOD_GlcNHglycan	370	373	PF01048	0.515
MOD_GlcNHglycan	382	385	PF01048	0.500
MOD_GlcNHglycan	393	396	PF01048	0.459
MOD_GlcNHglycan	90	93	PF01048	0.474
MOD_GSK3_1	11	18	PF00069	0.629
MOD_GSK3_1	116	123	PF00069	0.599
MOD_GSK3_1	131	138	PF00069	0.630
MOD_GSK3_1	158	165	PF00069	0.477
MOD_GSK3_1	186	193	PF00069	0.315
MOD_GSK3_1	286	293	PF00069	0.704
MOD_GSK3_1	3	10	PF00069	0.639
MOD_GSK3_1	31	38	PF00069	0.667
MOD_GSK3_1	314	321	PF00069	0.707
MOD_GSK3_1	353	360	PF00069	0.705
MOD_GSK3_1	364	371	PF00069	0.682
MOD_GSK3_1	387	394	PF00069	0.679
MOD_GSK3_1	86	93	PF00069	0.623
MOD_NEK2_1	113	118	PF00069	0.733
MOD_NEK2_1	135	140	PF00069	0.626
MOD_NEK2_1	15	20	PF00069	0.610
MOD_NEK2_1	159	164	PF00069	0.315
MOD_NEK2_1	320	325	PF00069	0.738
MOD_NEK2_1	341	346	PF00069	0.737
MOD_NEK2_1	46	51	PF00069	0.633
MOD_NEK2_2	100	105	PF00069	0.655
MOD_PIKK_1	257	263	PF00454	0.637
MOD_PIKK_1	334	340	PF00454	0.687
MOD_PKA_1	357	363	PF00069	0.667
MOD_PKA_2	148	154	PF00069	0.651
MOD_PKA_2	66	72	PF00069	0.603
MOD_Plk_4	11	17	PF00069	0.664
MOD_Plk_4	131	137	PF00069	0.595
MOD_Plk_4	159	165	PF00069	0.315
MOD_Plk_4	178	184	PF00069	0.476
MOD_Plk_4	190	196	PF00069	0.244
MOD_ProDKin_1	225	231	PF00069	0.636
MOD_ProDKin_1	232	238	PF00069	0.613
MOD_ProDKin_1	247	253	PF00069	0.693
MOD_ProDKin_1	311	317	PF00069	0.683
MOD_ProDKin_1	346	352	PF00069	0.719
MOD_ProDKin_1	35	41	PF00069	0.635
MOD_SUMO_rev_2	322	330	PF00179	0.722
TRG_DiLeu_BaEn_1	59	64	PF01217	0.650
TRG_DiLeu_LyEn_5	59	64	PF01217	0.650
TRG_ENDOCYTIC_2	157	160	PF00928	0.575
TRG_ENDOCYTIC_2	164	167	PF00928	0.315
TRG_ER_diArg_1	216	218	PF00400	0.656
TRG_ER_diArg_1	224	226	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G2	Leptomonas seymouri	60%	100%
A0A3S7X253	Leishmania donovani	94%	100%
A4HH48	Leishmania braziliensis	74%	100%
A4I492	Leishmania infantum	94%	100%
E9AM32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%