Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADP7_LEIMA

TriTrypDb:

LmjF.29.0460 , LMJLV39_290009900 , LMJSD75_290009900

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.546
CLV_C14_Caspase3-7	576	580	PF00656	0.528
CLV_C14_Caspase3-7	582	586	PF00656	0.507
CLV_C14_Caspase3-7	597	601	PF00656	0.479
CLV_C14_Caspase3-7	702	706	PF00656	0.620
CLV_NRD_NRD_1	128	130	PF00675	0.591
CLV_NRD_NRD_1	250	252	PF00675	0.436
CLV_NRD_NRD_1	302	304	PF00675	0.607
CLV_NRD_NRD_1	350	352	PF00675	0.466
CLV_NRD_NRD_1	420	422	PF00675	0.473
CLV_NRD_NRD_1	461	463	PF00675	0.614
CLV_NRD_NRD_1	521	523	PF00675	0.536
CLV_NRD_NRD_1	552	554	PF00675	0.528
CLV_NRD_NRD_1	569	571	PF00675	0.482
CLV_NRD_NRD_1	587	589	PF00675	0.591
CLV_NRD_NRD_1	605	607	PF00675	0.663
CLV_NRD_NRD_1	626	628	PF00675	0.792
CLV_NRD_NRD_1	644	646	PF00675	0.497
CLV_NRD_NRD_1	657	659	PF00675	0.514
CLV_NRD_NRD_1	675	677	PF00675	0.428
CLV_NRD_NRD_1	685	687	PF00675	0.509
CLV_NRD_NRD_1	84	86	PF00675	0.614
CLV_PCSK_FUR_1	655	659	PF00082	0.558
CLV_PCSK_KEX2_1	128	130	PF00082	0.525
CLV_PCSK_KEX2_1	302	304	PF00082	0.607
CLV_PCSK_KEX2_1	419	421	PF00082	0.489
CLV_PCSK_KEX2_1	460	462	PF00082	0.618
CLV_PCSK_KEX2_1	521	523	PF00082	0.536
CLV_PCSK_KEX2_1	569	571	PF00082	0.504
CLV_PCSK_KEX2_1	587	589	PF00082	0.591
CLV_PCSK_KEX2_1	605	607	PF00082	0.663
CLV_PCSK_KEX2_1	626	628	PF00082	0.792
CLV_PCSK_KEX2_1	657	659	PF00082	0.579
CLV_PCSK_KEX2_1	675	677	PF00082	0.423
CLV_PCSK_KEX2_1	685	687	PF00082	0.516
CLV_PCSK_KEX2_1	84	86	PF00082	0.614
CLV_PCSK_PC7_1	416	422	PF00082	0.479
CLV_PCSK_SKI1_1	131	135	PF00082	0.467
CLV_PCSK_SKI1_1	188	192	PF00082	0.454
CLV_PCSK_SKI1_1	247	251	PF00082	0.472
CLV_PCSK_SKI1_1	266	270	PF00082	0.467
CLV_PCSK_SKI1_1	347	351	PF00082	0.394
CLV_PCSK_SKI1_1	542	546	PF00082	0.455
CLV_PCSK_SKI1_1	558	562	PF00082	0.451
CLV_PCSK_SKI1_1	57	61	PF00082	0.438
CLV_PCSK_SKI1_1	588	592	PF00082	0.632
DEG_APCC_DBOX_1	130	138	PF00400	0.442
DEG_APCC_DBOX_1	187	195	PF00400	0.487
DEG_SPOP_SBC_1	46	50	PF00917	0.551
DEG_SPOP_SBC_1	699	703	PF00917	0.683
DOC_CKS1_1	332	337	PF01111	0.608
DOC_CKS1_1	476	481	PF01111	0.542
DOC_CYCLIN_RxL_1	275	284	PF00134	0.460
DOC_CYCLIN_RxL_1	347	359	PF00134	0.448
DOC_CYCLIN_RxL_1	536	546	PF00134	0.531
DOC_MAPK_gen_1	277	285	PF00069	0.483
DOC_MAPK_MEF2A_6	277	285	PF00069	0.503
DOC_USP7_MATH_1	14	18	PF00917	0.616
DOC_USP7_MATH_1	205	209	PF00917	0.451
DOC_USP7_MATH_1	289	293	PF00917	0.501
DOC_USP7_MATH_1	320	324	PF00917	0.511
DOC_USP7_MATH_1	390	394	PF00917	0.609
DOC_USP7_MATH_1	46	50	PF00917	0.572
DOC_USP7_MATH_1	482	486	PF00917	0.759
DOC_USP7_MATH_1	492	496	PF00917	0.661
DOC_USP7_MATH_1	501	505	PF00917	0.506
DOC_USP7_MATH_1	699	703	PF00917	0.685
DOC_USP7_MATH_1	714	718	PF00917	0.504
DOC_WW_Pin1_4	10	15	PF00397	0.642
DOC_WW_Pin1_4	144	149	PF00397	0.546
DOC_WW_Pin1_4	293	298	PF00397	0.612
DOC_WW_Pin1_4	331	336	PF00397	0.656
DOC_WW_Pin1_4	475	480	PF00397	0.662
DOC_WW_Pin1_4	692	697	PF00397	0.578
DOC_WW_Pin1_4	720	725	PF00397	0.640
DOC_WW_Pin1_4	88	93	PF00397	0.624
LIG_14-3-3_CanoR_1	173	177	PF00244	0.452
LIG_14-3-3_CanoR_1	24	29	PF00244	0.557
LIG_14-3-3_CanoR_1	251	260	PF00244	0.439
LIG_14-3-3_CanoR_1	266	271	PF00244	0.482
LIG_14-3-3_CanoR_1	375	380	PF00244	0.569
LIG_14-3-3_CanoR_1	536	544	PF00244	0.471
LIG_14-3-3_CanoR_1	587	591	PF00244	0.756
LIG_14-3-3_CanoR_1	605	615	PF00244	0.613
LIG_14-3-3_CanoR_1	675	681	PF00244	0.521
LIG_14-3-3_CanoR_1	685	694	PF00244	0.584
LIG_14-3-3_CanoR_1	7	14	PF00244	0.606
LIG_14-3-3_CanoR_1	720	724	PF00244	0.618
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BIR_III_1	1	5	PF00653	0.616
LIG_BIR_III_3	1	5	PF00653	0.616
LIG_BIR_III_4	633	637	PF00653	0.600
LIG_FHA_1	23	29	PF00498	0.572
LIG_FHA_1	308	314	PF00498	0.591
LIG_FHA_1	376	382	PF00498	0.430
LIG_FHA_1	448	454	PF00498	0.531
LIG_FHA_1	550	556	PF00498	0.418
LIG_FHA_1	620	626	PF00498	0.594
LIG_FHA_1	721	727	PF00498	0.638
LIG_FHA_1	96	102	PF00498	0.551
LIG_FHA_2	173	179	PF00498	0.412
LIG_FHA_2	307	313	PF00498	0.560
LIG_FHA_2	35	41	PF00498	0.551
LIG_FHA_2	409	415	PF00498	0.507
LIG_FHA_2	485	491	PF00498	0.635
LIG_FHA_2	574	580	PF00498	0.628
LIG_FHA_2	59	65	PF00498	0.460
LIG_GBD_Chelix_1	126	134	PF00786	0.499
LIG_LIR_Gen_1	659	668	PF02991	0.549
LIG_LIR_Nem_3	659	665	PF02991	0.549
LIG_LIR_Nem_3	692	697	PF02991	0.622
LIG_LIR_Nem_3	77	81	PF02991	0.774
LIG_MYND_1	724	728	PF01753	0.612
LIG_PTB_Apo_2	544	551	PF02174	0.421
LIG_PTB_Phospho_1	544	550	PF10480	0.421
LIG_RPA_C_Fungi	175	187	PF08784	0.367
LIG_RPA_C_Fungi	282	294	PF08784	0.423
LIG_RPA_C_Fungi	517	529	PF08784	0.530
LIG_RPA_C_Fungi	653	665	PF08784	0.514
LIG_SH2_STAT5	112	115	PF00017	0.644
LIG_SH2_STAT5	550	553	PF00017	0.416
LIG_SH3_3	332	338	PF00018	0.603
LIG_SH3_3	473	479	PF00018	0.544
LIG_SH3_3	486	492	PF00018	0.520
LIG_SH3_3	693	699	PF00018	0.554
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.355
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.407
LIG_SUMO_SIM_par_1	147	152	PF11976	0.482
LIG_SUMO_SIM_par_1	189	196	PF11976	0.420
MOD_CDK_SPxK_1	724	730	PF00069	0.615
MOD_CK1_1	27	33	PF00069	0.503
MOD_CK1_1	292	298	PF00069	0.522
MOD_CK1_1	331	337	PF00069	0.588
MOD_CK1_1	362	368	PF00069	0.493
MOD_CK1_1	393	399	PF00069	0.617
MOD_CK1_1	9	15	PF00069	0.667
MOD_CK2_1	113	119	PF00069	0.443
MOD_CK2_1	172	178	PF00069	0.452
MOD_CK2_1	306	312	PF00069	0.562
MOD_CK2_1	408	414	PF00069	0.494
MOD_CK2_1	460	466	PF00069	0.664
MOD_CK2_1	47	53	PF00069	0.557
MOD_CK2_1	484	490	PF00069	0.639
MOD_CK2_1	535	541	PF00069	0.543
MOD_CK2_1	58	64	PF00069	0.404
MOD_CK2_1	74	80	PF00069	0.685
MOD_CK2_1	96	102	PF00069	0.712
MOD_Cter_Amidation	458	461	PF01082	0.493
MOD_Cter_Amidation	585	588	PF01082	0.639
MOD_Cter_Amidation	82	85	PF01082	0.625
MOD_DYRK1A_RPxSP_1	720	724	PF00069	0.618
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.542
MOD_GlcNHglycan	287	290	PF01048	0.499
MOD_GlcNHglycan	291	294	PF01048	0.547
MOD_GlcNHglycan	314	317	PF01048	0.612
MOD_GlcNHglycan	392	395	PF01048	0.621
MOD_GlcNHglycan	456	459	PF01048	0.478
MOD_GlcNHglycan	462	465	PF01048	0.511
MOD_GlcNHglycan	482	485	PF01048	0.656
MOD_GlcNHglycan	494	497	PF01048	0.641
MOD_GlcNHglycan	537	540	PF01048	0.496
MOD_GlcNHglycan	600	603	PF01048	0.735
MOD_GlcNHglycan	622	625	PF01048	0.567
MOD_GlcNHglycan	710	713	PF01048	0.629
MOD_GlcNHglycan	716	719	PF01048	0.594
MOD_GlcNHglycan	92	95	PF01048	0.795
MOD_GlcNHglycan	97	101	PF01048	0.738
MOD_GSK3_1	140	147	PF00069	0.537
MOD_GSK3_1	251	258	PF00069	0.425
MOD_GSK3_1	27	34	PF00069	0.621
MOD_GSK3_1	281	288	PF00069	0.471
MOD_GSK3_1	289	296	PF00069	0.497
MOD_GSK3_1	330	337	PF00069	0.681
MOD_GSK3_1	356	363	PF00069	0.460
MOD_GSK3_1	47	54	PF00069	0.592
MOD_GSK3_1	480	487	PF00069	0.628
MOD_GSK3_1	531	538	PF00069	0.548
MOD_GSK3_1	594	601	PF00069	0.577
MOD_GSK3_1	6	13	PF00069	0.648
MOD_GSK3_1	675	682	PF00069	0.548
MOD_GSK3_1	685	692	PF00069	0.543
MOD_GSK3_1	716	723	PF00069	0.633
MOD_GSK3_1	84	91	PF00069	0.760
MOD_N-GLC_1	266	271	PF02516	0.452
MOD_N-GLC_1	328	333	PF02516	0.626
MOD_NEK2_1	133	138	PF00069	0.497
MOD_NEK2_1	230	235	PF00069	0.488
MOD_NEK2_1	281	286	PF00069	0.510
MOD_NEK2_1	32	37	PF00069	0.730
MOD_NEK2_1	360	365	PF00069	0.544
MOD_NEK2_1	708	713	PF00069	0.619
MOD_PIKK_1	261	267	PF00454	0.496
MOD_PIKK_1	398	404	PF00454	0.576
MOD_PIKK_1	47	53	PF00454	0.471
MOD_PIKK_1	531	537	PF00454	0.529
MOD_PIKK_1	648	654	PF00454	0.564
MOD_PK_1	24	30	PF00069	0.589
MOD_PK_1	657	663	PF00069	0.548
MOD_PKA_1	251	257	PF00069	0.426
MOD_PKA_1	460	466	PF00069	0.510
MOD_PKA_1	657	663	PF00069	0.548
MOD_PKA_1	675	681	PF00069	0.441
MOD_PKA_1	685	691	PF00069	0.508
MOD_PKA_1	84	90	PF00069	0.677
MOD_PKA_2	172	178	PF00069	0.457
MOD_PKA_2	32	38	PF00069	0.681
MOD_PKA_2	460	466	PF00069	0.545
MOD_PKA_2	535	541	PF00069	0.543
MOD_PKA_2	586	592	PF00069	0.758
MOD_PKA_2	594	600	PF00069	0.564
MOD_PKA_2	6	12	PF00069	0.611
MOD_PKA_2	657	663	PF00069	0.462
MOD_PKA_2	669	675	PF00069	0.493
MOD_PKA_2	684	690	PF00069	0.498
MOD_PKA_2	719	725	PF00069	0.639
MOD_PKA_2	84	90	PF00069	0.671
MOD_PKB_1	22	30	PF00069	0.657
MOD_PKB_1	655	663	PF00069	0.546
MOD_Plk_1	221	227	PF00069	0.441
MOD_Plk_1	266	272	PF00069	0.454
MOD_Plk_2-3	172	178	PF00069	0.486
MOD_Plk_2-3	196	202	PF00069	0.421
MOD_Plk_4	657	663	PF00069	0.548
MOD_ProDKin_1	10	16	PF00069	0.641
MOD_ProDKin_1	144	150	PF00069	0.547
MOD_ProDKin_1	293	299	PF00069	0.613
MOD_ProDKin_1	331	337	PF00069	0.647
MOD_ProDKin_1	475	481	PF00069	0.659
MOD_ProDKin_1	692	698	PF00069	0.579
MOD_ProDKin_1	720	726	PF00069	0.641
MOD_ProDKin_1	88	94	PF00069	0.622
MOD_SUMO_for_1	137	140	PF00179	0.496
MOD_SUMO_for_1	245	248	PF00179	0.449
MOD_SUMO_for_1	256	259	PF00179	0.424
MOD_SUMO_rev_2	254	258	PF00179	0.399
MOD_SUMO_rev_2	343	349	PF00179	0.393
MOD_SUMO_rev_2	538	545	PF00179	0.474
TRG_DiLeu_BaEn_3	222	228	PF01217	0.383
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.486
TRG_ENDOCYTIC_2	78	81	PF00928	0.780
TRG_ER_diArg_1	128	131	PF00400	0.612
TRG_ER_diArg_1	418	421	PF00400	0.520
TRG_ER_diArg_1	460	462	PF00400	0.512
TRG_ER_diArg_1	521	523	PF00400	0.536
TRG_ER_diArg_1	555	558	PF00400	0.447
TRG_ER_diArg_1	604	606	PF00400	0.643
TRG_ER_diArg_1	625	627	PF00400	0.798
TRG_ER_diArg_1	654	657	PF00400	0.572
TRG_ER_diArg_1	84	86	PF00400	0.590
TRG_NES_CRM1_1	345	358	PF08389	0.457
TRG_NLS_Bipartite_1	542	557	PF00514	0.376
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9M3	Leptomonas seymouri	35%	96%
A0A3Q8IH40	Leishmania donovani	88%	100%
A4HH47	Leishmania braziliensis	61%	100%
A4I491	Leishmania infantum	88%	100%
E9AM33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%