Rad51 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

recA bacterial DNA recombination protein, putative

Species:

Leishmania major

UniProt:

E9ADP6_LEIMA

TriTrypDb:

LmjF.29.0450 , LMJLV39_290009800 , LMJSD75_290009800

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP6

Function

Biological processes
Term	Name	Level	Count
GO:0000730	DNA recombinase assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006310	DNA recombination	5	2
GO:0006312	mitotic recombination	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0042148	strand invasion	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0065003	protein-containing complex assembly	5	2
GO:0065004	protein-DNA complex assembly	6	2
GO:0071704	organic substance metabolic process	2	2
GO:0071824	protein-DNA complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090735	DNA repair complex assembly	6	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000150	DNA strand exchange activity	4	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0008094	ATP-dependent activity, acting on DNA	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.607
CLV_NRD_NRD_1	168	170	PF00675	0.628
CLV_NRD_NRD_1	223	225	PF00675	0.597
CLV_NRD_NRD_1	226	228	PF00675	0.594
CLV_NRD_NRD_1	614	616	PF00675	0.269
CLV_PCSK_FUR_1	165	169	PF00082	0.558
CLV_PCSK_KEX2_1	165	167	PF00082	0.615
CLV_PCSK_KEX2_1	168	170	PF00082	0.609
CLV_PCSK_KEX2_1	576	578	PF00082	0.269
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.269
CLV_PCSK_PC7_1	161	167	PF00082	0.562
CLV_PCSK_SKI1_1	107	111	PF00082	0.515
CLV_PCSK_SKI1_1	161	165	PF00082	0.704
CLV_PCSK_SKI1_1	169	173	PF00082	0.595
CLV_PCSK_SKI1_1	241	245	PF00082	0.487
CLV_PCSK_SKI1_1	611	615	PF00082	0.316
CLV_PCSK_SKI1_1	66	70	PF00082	0.560
CLV_Separin_Metazoa	454	458	PF03568	0.447
DEG_APCC_DBOX_1	106	114	PF00400	0.526
DEG_APCC_DBOX_1	167	175	PF00400	0.622
DEG_APCC_DBOX_1	240	248	PF00400	0.459
DEG_COP1_1	432	440	PF00400	0.308
DEG_MDM2_SWIB_1	297	305	PF02201	0.469
DEG_SPOP_SBC_1	581	585	PF00917	0.444
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.541
DOC_MAPK_DCC_7	594	602	PF00069	0.472
DOC_MAPK_MEF2A_6	594	602	PF00069	0.472
DOC_PP2B_LxvP_1	172	175	PF13499	0.663
DOC_USP7_MATH_1	264	268	PF00917	0.618
DOC_USP7_MATH_1	274	278	PF00917	0.449
DOC_USP7_MATH_1	337	341	PF00917	0.358
DOC_USP7_MATH_1	468	472	PF00917	0.628
DOC_USP7_MATH_1	487	491	PF00917	0.424
DOC_USP7_MATH_1	581	585	PF00917	0.466
DOC_USP7_MATH_1	636	640	PF00917	0.516
DOC_USP7_MATH_1	96	100	PF00917	0.719
DOC_WW_Pin1_4	358	363	PF00397	0.449
DOC_WW_Pin1_4	472	477	PF00397	0.555
DOC_WW_Pin1_4	577	582	PF00397	0.479
DOC_WW_Pin1_4	85	90	PF00397	0.642
LIG_14-3-3_CanoR_1	141	147	PF00244	0.598
LIG_14-3-3_CanoR_1	207	213	PF00244	0.518
LIG_14-3-3_CanoR_1	21	26	PF00244	0.519
LIG_14-3-3_CanoR_1	241	247	PF00244	0.517
LIG_14-3-3_CanoR_1	248	253	PF00244	0.541
LIG_14-3-3_CanoR_1	433	438	PF00244	0.366
LIG_14-3-3_CanoR_1	447	453	PF00244	0.438
LIG_14-3-3_CanoR_1	472	476	PF00244	0.607
LIG_14-3-3_CanoR_1	57	65	PF00244	0.588
LIG_14-3-3_CanoR_1	615	625	PF00244	0.469
LIG_Actin_WH2_2	146	163	PF00022	0.507
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_EH1_1	619	627	PF00400	0.516
LIG_EVH1_1	172	176	PF00568	0.665
LIG_FAT_LD_1	146	154	PF03623	0.564
LIG_FHA_1	247	253	PF00498	0.547
LIG_FHA_1	390	396	PF00498	0.398
LIG_FHA_1	432	438	PF00498	0.398
LIG_FHA_1	553	559	PF00498	0.484
LIG_FHA_1	591	597	PF00498	0.453
LIG_FHA_2	110	116	PF00498	0.525
LIG_FHA_2	180	186	PF00498	0.650
LIG_LIR_Gen_1	343	351	PF02991	0.342
LIG_LIR_Gen_1	547	558	PF02991	0.500
LIG_LIR_Gen_1	60	70	PF02991	0.533
LIG_LIR_Nem_3	343	347	PF02991	0.338
LIG_LIR_Nem_3	426	431	PF02991	0.424
LIG_LIR_Nem_3	547	553	PF02991	0.500
LIG_LIR_Nem_3	60	65	PF02991	0.530
LIG_MYND_1	89	93	PF01753	0.646
LIG_NRBOX	317	323	PF00104	0.469
LIG_PCNA_yPIPBox_3	313	322	PF02747	0.469
LIG_PDZ_Class_3	645	650	PF00595	0.469
LIG_Pex14_2	297	301	PF04695	0.469
LIG_RPA_C_Fungi	138	150	PF08784	0.464
LIG_RPA_C_Fungi	374	386	PF08784	0.411
LIG_SH2_STAT5	384	387	PF00017	0.340
LIG_SH2_STAT5	640	643	PF00017	0.304
LIG_SH3_1	628	634	PF00018	0.272
LIG_SH3_2	52	57	PF14604	0.596
LIG_SH3_3	170	176	PF00018	0.682
LIG_SH3_3	250	256	PF00018	0.500
LIG_SH3_3	49	55	PF00018	0.602
LIG_SH3_3	628	634	PF00018	0.304
LIG_SH3_3	90	96	PF00018	0.816
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.537
LIG_SUMO_SIM_anti_2	211	216	PF11976	0.467
LIG_SUMO_SIM_anti_2	242	251	PF11976	0.534
LIG_SUMO_SIM_par_1	506	512	PF11976	0.304
LIG_TRAF2_1	133	136	PF00917	0.525
LIG_TRAF2_1	195	198	PF00917	0.521
LIG_WRC_WIRS_1	22	27	PF05994	0.510
LIG_WW_3	174	178	PF00397	0.629
MOD_CDK_SPxxK_3	358	365	PF00069	0.474
MOD_CK1_1	142	148	PF00069	0.571
MOD_CK1_1	471	477	PF00069	0.643
MOD_CK1_1	580	586	PF00069	0.308
MOD_CK1_1	588	594	PF00069	0.298
MOD_CK1_1	603	609	PF00069	0.242
MOD_CK1_1	79	85	PF00069	0.593
MOD_CK2_1	179	185	PF00069	0.761
MOD_CK2_1	448	454	PF00069	0.451
MOD_Cter_Amidation	225	228	PF01082	0.511
MOD_DYRK1A_RPxSP_1	577	581	PF00069	0.369
MOD_GlcNHglycan	1	4	PF01048	0.615
MOD_GlcNHglycan	124	127	PF01048	0.635
MOD_GlcNHglycan	221	224	PF01048	0.497
MOD_GlcNHglycan	268	271	PF01048	0.575
MOD_GlcNHglycan	275	279	PF01048	0.283
MOD_GlcNHglycan	298	301	PF01048	0.304
MOD_GlcNHglycan	339	342	PF01048	0.425
MOD_GlcNHglycan	41	44	PF01048	0.703
MOD_GlcNHglycan	420	423	PF01048	0.329
MOD_GlcNHglycan	587	590	PF01048	0.296
MOD_GlcNHglycan	59	62	PF01048	0.513
MOD_GlcNHglycan	605	608	PF01048	0.366
MOD_GlcNHglycan	98	101	PF01048	0.751
MOD_GSK3_1	242	249	PF00069	0.595
MOD_GSK3_1	296	303	PF00069	0.304
MOD_GSK3_1	468	475	PF00069	0.625
MOD_GSK3_1	577	584	PF00069	0.497
MOD_GSK3_1	588	595	PF00069	0.317
MOD_GSK3_1	636	643	PF00069	0.304
MOD_GSK3_1	96	103	PF00069	0.714
MOD_N-GLC_1	38	43	PF02516	0.583
MOD_N-GLC_2	549	551	PF02516	0.304
MOD_NEK2_1	219	224	PF00069	0.513
MOD_NEK2_1	246	251	PF00069	0.605
MOD_NEK2_1	350	355	PF00069	0.484
MOD_NEK2_1	356	361	PF00069	0.531
MOD_NEK2_1	499	504	PF00069	0.304
MOD_NEK2_1	600	605	PF00069	0.313
MOD_NEK2_1	614	619	PF00069	0.282
MOD_OFUCOSY	430	435	PF10250	0.431
MOD_PIKK_1	179	185	PF00454	0.521
MOD_PIKK_1	311	317	PF00454	0.304
MOD_PKA_2	142	148	PF00069	0.588
MOD_PKA_2	20	26	PF00069	0.523
MOD_PKA_2	247	253	PF00069	0.591
MOD_PKA_2	471	477	PF00069	0.595
MOD_PKA_2	487	493	PF00069	0.470
MOD_PKA_2	614	620	PF00069	0.304
MOD_PKA_2	79	85	PF00069	0.598
MOD_PKB_1	577	585	PF00069	0.304
MOD_Plk_1	274	280	PF00069	0.303
MOD_Plk_1	342	348	PF00069	0.433
MOD_Plk_1	530	536	PF00069	0.304
MOD_Plk_4	242	248	PF00069	0.528
MOD_Plk_4	423	429	PF00069	0.481
MOD_Plk_4	436	442	PF00069	0.312
MOD_Plk_4	636	642	PF00069	0.304
MOD_Plk_4	87	93	PF00069	0.680
MOD_ProDKin_1	358	364	PF00069	0.442
MOD_ProDKin_1	472	478	PF00069	0.557
MOD_ProDKin_1	577	583	PF00069	0.317
MOD_ProDKin_1	85	91	PF00069	0.644
TRG_DiLeu_BaEn_1	454	459	PF01217	0.445
TRG_DiLeu_BaEn_4	197	203	PF01217	0.491
TRG_DiLeu_LyEn_5	454	459	PF01217	0.445
TRG_ER_diArg_1	141	144	PF00400	0.585
TRG_ER_diArg_1	164	167	PF00400	0.564
TRG_ER_diArg_1	539	542	PF00400	0.313
TRG_NES_CRM1_1	54	67	PF08389	0.472
TRG_NLS_MonoExtC_3	223	228	PF00514	0.507
TRG_NLS_MonoExtN_4	574	580	PF00514	0.313
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U1	Leptomonas seymouri	46%	100%
A0A3Q8IE59	Leishmania donovani	87%	100%
A4HH46	Leishmania braziliensis	71%	100%
A4I499	Leishmania infantum	87%	100%
E9AM34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%