Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADP4_LEIMA

TriTrypDb:

LmjF.29.0430 , LMJLV39_290009500 , LMJSD75_290009500

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP4

PDB structure(s): 7ane_ag

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.443
CLV_C14_Caspase3-7	420	424	PF00656	0.539
CLV_NRD_NRD_1	24	26	PF00675	0.430
CLV_NRD_NRD_1	296	298	PF00675	0.375
CLV_NRD_NRD_1	368	370	PF00675	0.372
CLV_NRD_NRD_1	395	397	PF00675	0.402
CLV_NRD_NRD_1	51	53	PF00675	0.412
CLV_NRD_NRD_1	520	522	PF00675	0.469
CLV_NRD_NRD_1	532	534	PF00675	0.436
CLV_NRD_NRD_1	537	539	PF00675	0.423
CLV_NRD_NRD_1	540	542	PF00675	0.341
CLV_PCSK_FUR_1	538	542	PF00082	0.541
CLV_PCSK_KEX2_1	296	298	PF00082	0.375
CLV_PCSK_KEX2_1	394	396	PF00082	0.385
CLV_PCSK_KEX2_1	42	44	PF00082	0.408
CLV_PCSK_KEX2_1	53	55	PF00082	0.412
CLV_PCSK_KEX2_1	537	539	PF00082	0.507
CLV_PCSK_KEX2_1	540	542	PF00082	0.498
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.408
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.412
CLV_PCSK_PC7_1	533	539	PF00082	0.547
CLV_PCSK_SKI1_1	383	387	PF00082	0.378
CLV_PCSK_SKI1_1	446	450	PF00082	0.546
CLV_PCSK_SKI1_1	88	92	PF00082	0.422
DEG_APCC_DBOX_1	445	453	PF00400	0.550
DEG_Nend_UBRbox_3	1	3	PF02207	0.612
DEG_SCF_FBW7_1	186	193	PF00400	0.522
DOC_CYCLIN_yClb1_LxF_4	86	91	PF00134	0.474
DOC_MAPK_gen_1	115	125	PF00069	0.460
DOC_MAPK_gen_1	258	267	PF00069	0.524
DOC_MAPK_gen_1	336	343	PF00069	0.360
DOC_MAPK_gen_1	383	393	PF00069	0.364
DOC_MAPK_gen_1	42	50	PF00069	0.416
DOC_MAPK_gen_1	52	60	PF00069	0.433
DOC_MAPK_gen_1	537	548	PF00069	0.581
DOC_MAPK_MEF2A_6	336	343	PF00069	0.360
DOC_PP1_RVXF_1	86	92	PF00149	0.466
DOC_PP2B_LxvP_1	349	352	PF13499	0.391
DOC_PP4_MxPP_1	412	415	PF00568	0.592
DOC_USP7_MATH_1	190	194	PF00917	0.522
DOC_USP7_MATH_1	229	233	PF00917	0.495
DOC_USP7_MATH_1	448	452	PF00917	0.600
DOC_USP7_MATH_1	503	507	PF00917	0.535
DOC_USP7_MATH_1	560	564	PF00917	0.552
DOC_USP7_MATH_1	81	85	PF00917	0.544
DOC_USP7_UBL2_3	407	411	PF12436	0.400
DOC_WW_Pin1_4	186	191	PF00397	0.546
DOC_WW_Pin1_4	225	230	PF00397	0.412
DOC_WW_Pin1_4	316	321	PF00397	0.369
LIG_14-3-3_CanoR_1	130	138	PF00244	0.513
LIG_14-3-3_CanoR_1	162	170	PF00244	0.402
LIG_14-3-3_CanoR_1	201	211	PF00244	0.364
LIG_14-3-3_CanoR_1	481	486	PF00244	0.547
LIG_14-3-3_CanoR_1	65	71	PF00244	0.388
LIG_14-3-3_CanoR_1	9	13	PF00244	0.556
LIG_Actin_WH2_2	104	120	PF00022	0.466
LIG_deltaCOP1_diTrp_1	380	388	PF00928	0.372
LIG_FHA_1	134	140	PF00498	0.431
LIG_FHA_1	194	200	PF00498	0.355
LIG_FHA_1	303	309	PF00498	0.347
LIG_FHA_1	408	414	PF00498	0.450
LIG_FHA_1	473	479	PF00498	0.413
LIG_FHA_2	104	110	PF00498	0.487
LIG_FHA_2	342	348	PF00498	0.429
LIG_FHA_2	490	496	PF00498	0.435
LIG_FHA_2	510	516	PF00498	0.291
LIG_FHA_2	557	563	PF00498	0.678
LIG_HCF-1_HBM_1	315	318	PF13415	0.386
LIG_LIR_Gen_1	121	129	PF02991	0.518
LIG_LIR_Gen_1	205	215	PF02991	0.367
LIG_LIR_Gen_1	216	227	PF02991	0.411
LIG_LIR_Gen_1	232	242	PF02991	0.469
LIG_LIR_Gen_1	287	294	PF02991	0.509
LIG_LIR_Gen_1	491	500	PF02991	0.434
LIG_LIR_Nem_3	121	125	PF02991	0.428
LIG_LIR_Nem_3	14	18	PF02991	0.435
LIG_LIR_Nem_3	150	154	PF02991	0.398
LIG_LIR_Nem_3	164	170	PF02991	0.301
LIG_LIR_Nem_3	205	211	PF02991	0.369
LIG_LIR_Nem_3	232	237	PF02991	0.343
LIG_LIR_Nem_3	251	257	PF02991	0.399
LIG_LIR_Nem_3	287	293	PF02991	0.509
LIG_LIR_Nem_3	389	393	PF02991	0.413
LIG_LIR_Nem_3	491	497	PF02991	0.429
LIG_NRBOX	448	454	PF00104	0.572
LIG_OCRL_FandH_1	392	404	PF00620	0.493
LIG_Pex14_1	31	35	PF04695	0.404
LIG_PTB_Apo_2	373	380	PF02174	0.510
LIG_PTB_Phospho_1	373	379	PF10480	0.512
LIG_REV1ctd_RIR_1	435	442	PF16727	0.407
LIG_SH2_CRK	270	274	PF00017	0.462
LIG_SH2_CRK	37	41	PF00017	0.468
LIG_SH2_CRK	494	498	PF00017	0.448
LIG_SH2_GRB2like	518	521	PF00017	0.426
LIG_SH2_PTP2	122	125	PF00017	0.474
LIG_SH2_SRC	208	211	PF00017	0.448
LIG_SH2_SRC	234	237	PF00017	0.378
LIG_SH2_STAP1	170	174	PF00017	0.461
LIG_SH2_STAP1	234	238	PF00017	0.337
LIG_SH2_STAP1	401	405	PF00017	0.385
LIG_SH2_STAP1	494	498	PF00017	0.429
LIG_SH2_STAT3	59	62	PF00017	0.526
LIG_SH2_STAT3	63	66	PF00017	0.461
LIG_SH2_STAT5	122	125	PF00017	0.426
LIG_SH2_STAT5	309	312	PF00017	0.333
LIG_SH2_STAT5	318	321	PF00017	0.389
LIG_SH2_STAT5	518	521	PF00017	0.426
LIG_SH2_STAT5	59	62	PF00017	0.526
LIG_SH3_3	416	422	PF00018	0.530
LIG_SH3_3	429	435	PF00018	0.392
LIG_SH3_4	26	33	PF00018	0.419
LIG_SUMO_SIM_par_1	339	344	PF11976	0.474
LIG_SUMO_SIM_par_1	450	456	PF11976	0.547
LIG_TYR_ITIM	120	125	PF00017	0.283
MOD_CK1_1	193	199	PF00069	0.408
MOD_CK1_1	38	44	PF00069	0.415
MOD_CK1_1	451	457	PF00069	0.588
MOD_CK2_1	474	480	PF00069	0.533
MOD_CK2_1	509	515	PF00069	0.342
MOD_CK2_1	556	562	PF00069	0.616
MOD_CK2_1	81	87	PF00069	0.558
MOD_Cter_Amidation	538	541	PF01082	0.486
MOD_GlcNHglycan	174	177	PF01048	0.533
MOD_GlcNHglycan	356	359	PF01048	0.552
MOD_GlcNHglycan	37	40	PF01048	0.412
MOD_GlcNHglycan	427	430	PF01048	0.604
MOD_GSK3_1	125	132	PF00069	0.453
MOD_GSK3_1	186	193	PF00069	0.408
MOD_GSK3_1	225	232	PF00069	0.397
MOD_GSK3_1	417	424	PF00069	0.566
MOD_GSK3_1	556	563	PF00069	0.496
MOD_GSK3_1	7	14	PF00069	0.416
MOD_GSK3_1	90	97	PF00069	0.496
MOD_LATS_1	479	485	PF00433	0.437
MOD_N-GLC_1	407	412	PF02516	0.429
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	125	130	PF00069	0.413
MOD_NEK2_1	172	177	PF00069	0.418
MOD_NEK2_1	241	246	PF00069	0.367
MOD_NEK2_1	406	411	PF00069	0.391
MOD_NEK2_1	90	95	PF00069	0.388
MOD_NEK2_2	147	152	PF00069	0.474
MOD_PIKK_1	1	7	PF00454	0.572
MOD_PIKK_1	190	196	PF00454	0.499
MOD_PIKK_1	341	347	PF00454	0.494
MOD_PIKK_1	417	423	PF00454	0.526
MOD_PK_1	327	333	PF00069	0.535
MOD_PK_1	369	375	PF00069	0.507
MOD_PKA_1	369	375	PF00069	0.507
MOD_PKA_2	129	135	PF00069	0.507
MOD_PKA_2	161	167	PF00069	0.409
MOD_PKA_2	480	486	PF00069	0.561
MOD_PKA_2	532	538	PF00069	0.542
MOD_PKA_2	8	14	PF00069	0.554
MOD_Plk_1	422	428	PF00069	0.543
MOD_Plk_2-3	103	109	PF00069	0.426
MOD_Plk_2-3	474	480	PF00069	0.493
MOD_Plk_4	103	109	PF00069	0.484
MOD_Plk_4	11	17	PF00069	0.433
MOD_Plk_4	448	454	PF00069	0.490
MOD_Plk_4	481	487	PF00069	0.460
MOD_ProDKin_1	186	192	PF00069	0.538
MOD_ProDKin_1	225	231	PF00069	0.411
MOD_ProDKin_1	316	322	PF00069	0.376
MOD_SUMO_rev_2	330	339	PF00179	0.494
MOD_SUMO_rev_2	469	478	PF00179	0.536
TRG_DiLeu_BaEn_2	102	108	PF01217	0.428
TRG_ENDOCYTIC_2	122	125	PF00928	0.348
TRG_ENDOCYTIC_2	15	18	PF00928	0.439
TRG_ENDOCYTIC_2	208	211	PF00928	0.384
TRG_ENDOCYTIC_2	219	222	PF00928	0.403
TRG_ENDOCYTIC_2	234	237	PF00928	0.340
TRG_ENDOCYTIC_2	270	273	PF00928	0.465
TRG_ENDOCYTIC_2	37	40	PF00928	0.470
TRG_ENDOCYTIC_2	494	497	PF00928	0.423
TRG_ER_diArg_1	257	260	PF00400	0.486
TRG_ER_diArg_1	296	298	PF00400	0.375
TRG_ER_diArg_1	374	377	PF00400	0.493
TRG_ER_diArg_1	393	396	PF00400	0.387
TRG_ER_diArg_1	536	538	PF00400	0.491
TRG_ER_diArg_1	540	543	PF00400	0.480
TRG_NES_CRM1_1	323	335	PF08389	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G0	Leptomonas seymouri	81%	100%
A0A1X0NZI0	Trypanosomatidae	64%	98%
A0A3R7NNT1	Trypanosoma rangeli	64%	97%
A0A3S7X247	Leishmania donovani	98%	100%
A4HH44	Leishmania braziliensis	92%	100%
A4I497	Leishmania infantum	98%	100%
C9ZKN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	97%
E9AM36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DLE3	Trypanosoma cruzi	63%	97%