C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADP3_LEIMA

TriTrypDb:

LmjF.29.0420 , LMJLV39_290009400 , LMJSD75_290009400

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.630
CLV_C14_Caspase3-7	275	279	PF00656	0.639
CLV_C14_Caspase3-7	364	368	PF00656	0.556
CLV_NRD_NRD_1	335	337	PF00675	0.580
CLV_NRD_NRD_1	57	59	PF00675	0.538
CLV_PCSK_FUR_1	333	337	PF00082	0.446
CLV_PCSK_KEX2_1	333	335	PF00082	0.597
CLV_PCSK_KEX2_1	57	59	PF00082	0.538
CLV_PCSK_SKI1_1	15	19	PF00082	0.636
CLV_PCSK_SKI1_1	219	223	PF00082	0.551
CLV_PCSK_SKI1_1	232	236	PF00082	0.450
CLV_PCSK_SKI1_1	300	304	PF00082	0.691
DEG_APCC_DBOX_1	218	226	PF00400	0.546
DEG_SPOP_SBC_1	137	141	PF00917	0.651
DOC_CKS1_1	102	107	PF01111	0.690
DOC_CYCLIN_RxL_1	297	305	PF00134	0.561
DOC_CYCLIN_RxL_1	9	22	PF00134	0.635
DOC_MAPK_gen_1	5	13	PF00069	0.642
DOC_MAPK_gen_1	57	68	PF00069	0.528
DOC_MAPK_MEF2A_6	61	70	PF00069	0.516
DOC_PP4_FxxP_1	253	256	PF00568	0.602
DOC_USP7_MATH_1	137	141	PF00917	0.656
DOC_USP7_MATH_1	169	173	PF00917	0.653
DOC_USP7_MATH_1	211	215	PF00917	0.645
DOC_USP7_MATH_1	298	302	PF00917	0.577
DOC_USP7_MATH_1	328	332	PF00917	0.535
DOC_USP7_MATH_1	338	342	PF00917	0.465
DOC_USP7_MATH_1	81	85	PF00917	0.494
DOC_USP7_UBL2_3	5	9	PF12436	0.645
DOC_WW_Pin1_4	146	151	PF00397	0.738
DOC_WW_Pin1_4	42	47	PF00397	0.559
DOC_WW_Pin1_4	98	103	PF00397	0.653
LIG_14-3-3_CanoR_1	273	283	PF00244	0.664
LIG_14-3-3_CanoR_1	357	363	PF00244	0.653
LIG_BIR_III_4	367	371	PF00653	0.603
LIG_FHA_1	12	18	PF00498	0.636
LIG_FHA_1	191	197	PF00498	0.711
LIG_FHA_1	22	28	PF00498	0.448
LIG_FHA_1	224	230	PF00498	0.616
LIG_FHA_2	243	249	PF00498	0.626
LIG_FHA_2	273	279	PF00498	0.656
LIG_FHA_2	362	368	PF00498	0.659
LIG_FHA_2	377	383	PF00498	0.532
LIG_LIR_Apic_2	250	256	PF02991	0.611
LIG_LIR_Apic_2	282	286	PF02991	0.650
LIG_LIR_Gen_1	293	302	PF02991	0.498
LIG_LIR_Gen_1	315	324	PF02991	0.507
LIG_LIR_Gen_1	84	92	PF02991	0.476
LIG_LIR_Nem_3	293	297	PF02991	0.545
LIG_LIR_Nem_3	315	320	PF02991	0.548
LIG_LIR_Nem_3	84	88	PF02991	0.458
LIG_NRBOX	379	385	PF00104	0.649
LIG_SH2_CRK	317	321	PF00017	0.609
LIG_SH2_NCK_1	121	125	PF00017	0.636
LIG_SH2_NCK_1	78	82	PF00017	0.378
LIG_SH2_STAP1	121	125	PF00017	0.636
LIG_SH2_STAT3	281	284	PF00017	0.664
LIG_SH2_STAT5	152	155	PF00017	0.624
LIG_SH2_STAT5	91	94	PF00017	0.518
LIG_SH3_2	102	107	PF14604	0.690
LIG_SH3_3	202	208	PF00018	0.689
LIG_SH3_3	396	402	PF00018	0.641
LIG_SH3_3	99	105	PF00018	0.785
LIG_SH3_4	5	12	PF00018	0.643
LIG_SUMO_SIM_anti_2	379	387	PF11976	0.648
LIG_SUMO_SIM_par_1	220	226	PF11976	0.527
LIG_SUMO_SIM_par_1	376	382	PF11976	0.595
LIG_TRAF2_1	268	271	PF00917	0.597
LIG_TRAF2_1	343	346	PF00917	0.551
LIG_TYR_ITIM	89	94	PF00017	0.512
MOD_CDK_SPxK_1	101	107	PF00069	0.686
MOD_CK1_1	139	145	PF00069	0.646
MOD_CK1_1	176	182	PF00069	0.667
MOD_CK1_1	190	196	PF00069	0.583
MOD_CK1_1	203	209	PF00069	0.602
MOD_CK2_1	287	293	PF00069	0.589
MOD_GlcNHglycan	122	125	PF01048	0.617
MOD_GlcNHglycan	167	170	PF01048	0.625
MOD_GlcNHglycan	171	174	PF01048	0.661
MOD_GlcNHglycan	175	178	PF01048	0.617
MOD_GlcNHglycan	205	208	PF01048	0.661
MOD_GlcNHglycan	213	216	PF01048	0.565
MOD_GlcNHglycan	310	314	PF01048	0.583
MOD_GlcNHglycan	394	399	PF01048	0.672
MOD_GSK3_1	146	153	PF00069	0.648
MOD_GSK3_1	165	172	PF00069	0.670
MOD_GSK3_1	187	194	PF00069	0.727
MOD_GSK3_1	195	202	PF00069	0.670
MOD_GSK3_1	217	224	PF00069	0.510
MOD_GSK3_1	357	364	PF00069	0.614
MOD_N-GLC_1	203	208	PF02516	0.657
MOD_NEK2_1	119	124	PF00069	0.635
MOD_NEK2_1	287	292	PF00069	0.593
MOD_NEK2_1	316	321	PF00069	0.611
MOD_NEK2_1	62	67	PF00069	0.530
MOD_NEK2_2	328	333	PF00069	0.527
MOD_PIKK_1	251	257	PF00454	0.650
MOD_PIKK_1	338	344	PF00454	0.545
MOD_PIKK_1	44	50	PF00454	0.535
MOD_PKA_2	272	278	PF00069	0.652
MOD_PKA_2	322	328	PF00069	0.630
MOD_Plk_1	163	169	PF00069	0.713
MOD_Plk_1	62	68	PF00069	0.581
MOD_Plk_2-3	272	278	PF00069	0.652
MOD_Plk_4	13	19	PF00069	0.668
MOD_Plk_4	298	304	PF00069	0.553
MOD_Plk_4	376	382	PF00069	0.652
MOD_ProDKin_1	146	152	PF00069	0.741
MOD_ProDKin_1	42	48	PF00069	0.563
MOD_ProDKin_1	98	104	PF00069	0.661
MOD_SUMO_for_1	183	186	PF00179	0.694
MOD_SUMO_rev_2	162	167	PF00179	0.754
TRG_DiLeu_BaEn_4	271	277	PF01217	0.624
TRG_ENDOCYTIC_2	317	320	PF00928	0.551
TRG_ENDOCYTIC_2	91	94	PF00928	0.518
TRG_ER_diArg_1	332	335	PF00400	0.594
TRG_ER_diArg_1	56	58	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X275	Leishmania donovani	94%	100%
A4HH43	Leishmania braziliensis	69%	98%
A4I496	Leishmania infantum	94%	100%
E9AM37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%