Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADP2_LEIMA

TriTrypDb:

LmjF.29.0410 , LMJLV39_290009300 , LMJSD75_290009300

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.654
CLV_C14_Caspase3-7	259	263	PF00656	0.595
CLV_C14_Caspase3-7	433	437	PF00656	0.556
CLV_NRD_NRD_1	324	326	PF00675	0.563
CLV_NRD_NRD_1	441	443	PF00675	0.636
CLV_PCSK_FUR_1	439	443	PF00082	0.615
CLV_PCSK_KEX2_1	324	326	PF00082	0.563
CLV_PCSK_KEX2_1	392	394	PF00082	0.523
CLV_PCSK_KEX2_1	441	443	PF00082	0.636
CLV_PCSK_KEX2_1	573	575	PF00082	0.587
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.585
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.587
CLV_PCSK_SKI1_1	329	333	PF00082	0.597
CLV_PCSK_SKI1_1	447	451	PF00082	0.660
CLV_PCSK_SKI1_1	482	486	PF00082	0.633
CLV_Separin_Metazoa	507	511	PF03568	0.692
DEG_APCC_DBOX_1	450	458	PF00400	0.617
DEG_APCC_DBOX_1	563	571	PF00400	0.640
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DEG_SCF_FBW7_1	336	343	PF00400	0.545
DEG_SCF_FBW7_2	402	408	PF00400	0.590
DEG_SPOP_SBC_1	340	344	PF00917	0.575
DOC_CKS1_1	402	407	PF01111	0.584
DOC_CKS1_1	489	494	PF01111	0.622
DOC_CKS1_1	74	79	PF01111	0.608
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.656
DOC_MAPK_gen_1	197	206	PF00069	0.545
DOC_MAPK_gen_1	392	398	PF00069	0.461
DOC_MAPK_MEF2A_6	197	206	PF00069	0.545
DOC_MAPK_MEF2A_6	290	298	PF00069	0.546
DOC_MAPK_RevD_3	558	574	PF00069	0.607
DOC_PP2B_LxvP_1	200	203	PF13499	0.663
DOC_PP2B_LxvP_1	450	453	PF13499	0.619
DOC_PP2B_LxvP_1	54	57	PF13499	0.664
DOC_PP4_FxxP_1	74	77	PF00568	0.543
DOC_USP7_MATH_1	11	15	PF00917	0.546
DOC_USP7_MATH_1	124	128	PF00917	0.672
DOC_USP7_MATH_1	227	231	PF00917	0.569
DOC_USP7_MATH_1	272	276	PF00917	0.643
DOC_USP7_MATH_1	340	344	PF00917	0.630
DOC_USP7_MATH_1	359	363	PF00917	0.556
DOC_USP7_MATH_1	430	434	PF00917	0.612
DOC_USP7_MATH_1	543	547	PF00917	0.703
DOC_USP7_MATH_1	77	81	PF00917	0.617
DOC_USP7_UBL2_3	157	161	PF12436	0.623
DOC_WW_Pin1_4	130	135	PF00397	0.682
DOC_WW_Pin1_4	183	188	PF00397	0.625
DOC_WW_Pin1_4	223	228	PF00397	0.633
DOC_WW_Pin1_4	265	270	PF00397	0.673
DOC_WW_Pin1_4	314	319	PF00397	0.631
DOC_WW_Pin1_4	329	334	PF00397	0.645
DOC_WW_Pin1_4	336	341	PF00397	0.591
DOC_WW_Pin1_4	377	382	PF00397	0.676
DOC_WW_Pin1_4	401	406	PF00397	0.585
DOC_WW_Pin1_4	409	414	PF00397	0.605
DOC_WW_Pin1_4	48	53	PF00397	0.611
DOC_WW_Pin1_4	488	493	PF00397	0.615
DOC_WW_Pin1_4	520	525	PF00397	0.646
DOC_WW_Pin1_4	73	78	PF00397	0.613
LIG_14-3-3_CanoR_1	265	269	PF00244	0.580
LIG_14-3-3_CanoR_1	360	368	PF00244	0.646
LIG_14-3-3_CanoR_1	375	383	PF00244	0.551
LIG_14-3-3_CanoR_1	385	394	PF00244	0.649
LIG_14-3-3_CanoR_1	441	450	PF00244	0.657
LIG_14-3-3_CanoR_1	475	479	PF00244	0.615
LIG_14-3-3_CanoR_1	510	516	PF00244	0.584
LIG_14-3-3_CanoR_1	535	540	PF00244	0.614
LIG_DCNL_PONY_1	1	4	PF03556	0.518
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.624
LIG_FHA_1	179	185	PF00498	0.692
LIG_FHA_1	259	265	PF00498	0.572
LIG_FHA_1	293	299	PF00498	0.606
LIG_FHA_1	362	368	PF00498	0.589
LIG_FHA_1	378	384	PF00498	0.614
LIG_FHA_1	402	408	PF00498	0.631
LIG_FHA_1	547	553	PF00498	0.632
LIG_FHA_1	74	80	PF00498	0.662
LIG_FHA_2	311	317	PF00498	0.662
LIG_FHA_2	502	508	PF00498	0.700
LIG_FHA_2	63	69	PF00498	0.617
LIG_LIR_Apic_2	73	77	PF02991	0.546
LIG_LIR_Nem_3	129	135	PF02991	0.712
LIG_LRP6_Inhibitor_1	151	157	PF00058	0.550
LIG_MYND_1	140	144	PF01753	0.540
LIG_MYND_1	524	528	PF01753	0.550
LIG_NRBOX	110	116	PF00104	0.551
LIG_NRBOX	88	94	PF00104	0.474
LIG_Pex14_2	390	394	PF04695	0.508
LIG_Pex14_2	74	78	PF04695	0.544
LIG_RPA_C_Fungi	355	367	PF08784	0.647
LIG_SH2_STAT5	218	221	PF00017	0.650
LIG_SH3_1	399	405	PF00018	0.504
LIG_SH3_3	181	187	PF00018	0.615
LIG_SH3_3	192	198	PF00018	0.665
LIG_SH3_3	202	208	PF00018	0.541
LIG_SH3_3	266	272	PF00018	0.685
LIG_SH3_3	293	299	PF00018	0.663
LIG_SH3_3	330	336	PF00018	0.667
LIG_SH3_3	380	386	PF00018	0.546
LIG_SH3_3	399	405	PF00018	0.518
LIG_SH3_3	46	52	PF00018	0.591
LIG_SH3_3	481	487	PF00018	0.534
LIG_SH3_3	505	511	PF00018	0.666
LIG_SH3_3	513	519	PF00018	0.594
LIG_SH3_3	569	575	PF00018	0.643
LIG_SH3_3	76	82	PF00018	0.573
LIG_SH3_4	157	164	PF00018	0.631
LIG_SH3_CIN85_PxpxPR_1	194	199	PF14604	0.550
LIG_Sin3_3	148	155	PF02671	0.615
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.631
LIG_SUMO_SIM_par_1	294	300	PF11976	0.606
LIG_TRAF2_1	28	31	PF00917	0.552
LIG_TRAF2_1	471	474	PF00917	0.598
LIG_WW_3	194	198	PF00397	0.642
MOD_CDC14_SPxK_1	133	136	PF00782	0.683
MOD_CDK_SPxK_1	130	136	PF00069	0.684
MOD_CDK_SPxK_1	329	335	PF00069	0.632
MOD_CDK_SPxK_1	78	84	PF00069	0.573
MOD_CDK_SPxxK_3	409	416	PF00069	0.558
MOD_CK1_1	240	246	PF00069	0.641
MOD_CK1_1	258	264	PF00069	0.528
MOD_CK1_1	371	377	PF00069	0.572
MOD_CK1_1	445	451	PF00069	0.660
MOD_CK1_1	546	552	PF00069	0.643
MOD_CK2_1	310	316	PF00069	0.640
MOD_CK2_1	501	507	PF00069	0.641
MOD_CK2_1	62	68	PF00069	0.619
MOD_Cter_Amidation	322	325	PF01082	0.572
MOD_Cter_Amidation	439	442	PF01082	0.642
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.671
MOD_DYRK1A_RPxSP_1	401	405	PF00069	0.544
MOD_GlcNHglycan	125	129	PF01048	0.608
MOD_GlcNHglycan	229	232	PF01048	0.654
MOD_GlcNHglycan	239	242	PF01048	0.626
MOD_GlcNHglycan	246	250	PF01048	0.651
MOD_GlcNHglycan	361	364	PF01048	0.580
MOD_GlcNHglycan	370	373	PF01048	0.615
MOD_GlcNHglycan	432	435	PF01048	0.606
MOD_GlcNHglycan	528	531	PF01048	0.650
MOD_GlcNHglycan	541	544	PF01048	0.574
MOD_GlcNHglycan	546	549	PF01048	0.539
MOD_GSK3_1	179	186	PF00069	0.643
MOD_GSK3_1	223	230	PF00069	0.761
MOD_GSK3_1	30	37	PF00069	0.607
MOD_GSK3_1	310	317	PF00069	0.630
MOD_GSK3_1	336	343	PF00069	0.551
MOD_GSK3_1	371	378	PF00069	0.671
MOD_GSK3_1	381	388	PF00069	0.600
MOD_GSK3_1	39	46	PF00069	0.592
MOD_GSK3_1	441	448	PF00069	0.641
MOD_GSK3_1	535	542	PF00069	0.665
MOD_GSK3_1	73	80	PF00069	0.613
MOD_N-GLC_1	130	135	PF02516	0.648
MOD_NEK2_1	264	269	PF00069	0.571
MOD_NEK2_1	368	373	PF00069	0.546
MOD_NEK2_1	43	48	PF00069	0.541
MOD_NEK2_1	457	462	PF00069	0.600
MOD_PIKK_1	419	425	PF00454	0.612
MOD_PIKK_1	43	49	PF00454	0.745
MOD_PKA_1	441	447	PF00069	0.631
MOD_PKA_2	198	204	PF00069	0.636
MOD_PKA_2	264	270	PF00069	0.572
MOD_PKA_2	359	365	PF00069	0.780
MOD_PKA_2	441	447	PF00069	0.631
MOD_PKA_2	474	480	PF00069	0.610
MOD_PKA_2	501	507	PF00069	0.615
MOD_PKA_2	534	540	PF00069	0.615
MOD_PKB_1	439	447	PF00069	0.610
MOD_Plk_1	445	451	PF00069	0.660
MOD_Plk_1	84	90	PF00069	0.492
MOD_Plk_4	214	220	PF00069	0.633
MOD_Plk_4	292	298	PF00069	0.632
MOD_Plk_4	34	40	PF00069	0.518
MOD_Plk_4	474	480	PF00069	0.586
MOD_ProDKin_1	130	136	PF00069	0.684
MOD_ProDKin_1	183	189	PF00069	0.627
MOD_ProDKin_1	223	229	PF00069	0.632
MOD_ProDKin_1	265	271	PF00069	0.673
MOD_ProDKin_1	314	320	PF00069	0.633
MOD_ProDKin_1	329	335	PF00069	0.646
MOD_ProDKin_1	336	342	PF00069	0.592
MOD_ProDKin_1	377	383	PF00069	0.676
MOD_ProDKin_1	401	407	PF00069	0.587
MOD_ProDKin_1	409	415	PF00069	0.605
MOD_ProDKin_1	48	54	PF00069	0.616
MOD_ProDKin_1	488	494	PF00069	0.616
MOD_ProDKin_1	520	526	PF00069	0.648
MOD_ProDKin_1	73	79	PF00069	0.610
MOD_SUMO_rev_2	268	278	PF00179	0.616
MOD_SUMO_rev_2	281	287	PF00179	0.603
MOD_SUMO_rev_2	322	331	PF00179	0.703
TRG_DiLeu_BaEn_1	474	479	PF01217	0.585
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.590
TRG_ER_diArg_1	196	199	PF00400	0.553
TRG_ER_diArg_1	334	337	PF00400	0.647
TRG_ER_diArg_1	439	442	PF00400	0.619
TRG_ER_diArg_1	563	566	PF00400	0.564
TRG_NLS_MonoCore_2	572	577	PF00514	0.637
TRG_NLS_MonoExtN_4	572	577	PF00514	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI2	Leptomonas seymouri	30%	100%
A0A3Q8IDI0	Leishmania donovani	88%	100%
A4HH42	Leishmania braziliensis	56%	100%
A4I495	Leishmania infantum	88%	100%
E9AM38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%