C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3451), putative

Species:

Leishmania major

UniProt:

E9ADN9_LEIMA

TriTrypDb:

LmjF.29.0380 , LMJLV39_290009000 , LMJSD75_290009000

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005638	lamin filament	7	2
GO:0005815	microtubule organizing center	2	2
GO:0005882	intermediate filament	6	2
GO:0035869	ciliary transition zone	2	2
GO:0036064	ciliary basal body	3	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ADN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADN9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	2
GO:0030527	structural constituent of chromatin	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.572
CLV_NRD_NRD_1	296	298	PF00675	0.606
CLV_NRD_NRD_1	369	371	PF00675	0.456
CLV_NRD_NRD_1	422	424	PF00675	0.454
CLV_NRD_NRD_1	426	428	PF00675	0.453
CLV_NRD_NRD_1	441	443	PF00675	0.441
CLV_NRD_NRD_1	49	51	PF00675	0.551
CLV_NRD_NRD_1	56	58	PF00675	0.568
CLV_NRD_NRD_1	600	602	PF00675	0.607
CLV_PCSK_FUR_1	420	424	PF00082	0.568
CLV_PCSK_KEX2_1	341	343	PF00082	0.504
CLV_PCSK_KEX2_1	422	424	PF00082	0.456
CLV_PCSK_KEX2_1	440	442	PF00082	0.481
CLV_PCSK_KEX2_1	49	51	PF00082	0.513
CLV_PCSK_KEX2_1	504	506	PF00082	0.584
CLV_PCSK_KEX2_1	511	513	PF00082	0.631
CLV_PCSK_KEX2_1	56	58	PF00082	0.457
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.504
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.667
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.719
CLV_PCSK_SKI1_1	100	104	PF00082	0.713
CLV_PCSK_SKI1_1	124	128	PF00082	0.626
CLV_PCSK_SKI1_1	151	155	PF00082	0.469
CLV_PCSK_SKI1_1	272	276	PF00082	0.663
CLV_PCSK_SKI1_1	3	7	PF00082	0.520
CLV_PCSK_SKI1_1	341	345	PF00082	0.439
CLV_PCSK_SKI1_1	427	431	PF00082	0.509
CLV_PCSK_SKI1_1	548	552	PF00082	0.639
CLV_PCSK_SKI1_1	569	573	PF00082	0.434
CLV_PCSK_SKI1_1	597	601	PF00082	0.511
CLV_PCSK_SKI1_1	607	611	PF00082	0.389
CLV_PCSK_SKI1_1	787	791	PF00082	0.637
CLV_PCSK_SKI1_1	876	880	PF00082	0.413
CLV_PCSK_SKI1_1	932	936	PF00082	0.377
CLV_Separin_Metazoa	598	602	PF03568	0.491
DEG_APCC_DBOX_1	207	215	PF00400	0.565
DEG_APCC_DBOX_1	596	604	PF00400	0.461
DEG_APCC_DBOX_1	786	794	PF00400	0.591
DEG_APCC_DBOX_1	99	107	PF00400	0.716
DEG_Nend_UBRbox_3	1	3	PF02207	0.703
DOC_CYCLIN_RxL_1	337	348	PF00134	0.418
DOC_CYCLIN_RxL_1	929	937	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	102	105	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	788	794	PF00134	0.448
DOC_MAPK_gen_1	256	265	PF00069	0.463
DOC_MAPK_gen_1	545	553	PF00069	0.560
DOC_MAPK_HePTP_8	820	832	PF00069	0.363
DOC_MAPK_MEF2A_6	256	265	PF00069	0.446
DOC_MAPK_MEF2A_6	787	794	PF00069	0.465
DOC_MAPK_MEF2A_6	823	832	PF00069	0.343
DOC_MAPK_NFAT4_5	258	266	PF00069	0.454
DOC_PP1_RVXF_1	399	405	PF00149	0.575
DOC_PP1_RVXF_1	899	906	PF00149	0.488
DOC_PP1_SILK_1	27	32	PF00149	0.463
DOC_PP2B_LxvP_1	102	105	PF13499	0.771
DOC_PP2B_LxvP_1	674	677	PF13499	0.531
DOC_PP2B_LxvP_1	788	791	PF13499	0.429
DOC_PP2B_LxvP_1	794	797	PF13499	0.491
DOC_PP2B_LxvP_1	810	813	PF13499	0.451
DOC_USP7_MATH_1	140	144	PF00917	0.595
DOC_USP7_MATH_1	180	184	PF00917	0.635
DOC_USP7_MATH_1	190	194	PF00917	0.586
DOC_USP7_MATH_1	230	234	PF00917	0.561
DOC_USP7_MATH_1	274	278	PF00917	0.658
DOC_USP7_MATH_1	529	533	PF00917	0.675
DOC_USP7_MATH_1	58	62	PF00917	0.704
DOC_USP7_MATH_1	640	644	PF00917	0.658
DOC_USP7_MATH_1	750	754	PF00917	0.526
DOC_USP7_MATH_1	95	99	PF00917	0.655
DOC_USP7_UBL2_3	124	128	PF12436	0.626
DOC_WW_Pin1_4	116	121	PF00397	0.741
DOC_WW_Pin1_4	129	134	PF00397	0.777
DOC_WW_Pin1_4	63	68	PF00397	0.619
DOC_WW_Pin1_4	69	74	PF00397	0.647
DOC_WW_Pin1_4	8	13	PF00397	0.649
DOC_WW_Pin1_4	855	860	PF00397	0.552
DOC_WW_Pin1_4	93	98	PF00397	0.697
DOC_WW_Pin1_4	934	939	PF00397	0.406
LIG_14-3-3_CanoR_1	297	305	PF00244	0.561
LIG_14-3-3_CanoR_1	3	12	PF00244	0.659
LIG_14-3-3_CanoR_1	342	348	PF00244	0.628
LIG_14-3-3_CanoR_1	370	378	PF00244	0.433
LIG_14-3-3_CanoR_1	407	414	PF00244	0.562
LIG_14-3-3_CanoR_1	601	610	PF00244	0.563
LIG_14-3-3_CanoR_1	618	628	PF00244	0.323
LIG_14-3-3_CanoR_1	656	665	PF00244	0.521
LIG_14-3-3_CanoR_1	81	90	PF00244	0.576
LIG_14-3-3_CanoR_1	876	882	PF00244	0.561
LIG_14-3-3_CanoR_1	91	99	PF00244	0.580
LIG_14-3-3_CanoR_1	943	950	PF00244	0.461
LIG_Actin_WH2_2	586	603	PF00022	0.480
LIG_APCC_ABBA_1	910	915	PF00400	0.365
LIG_BIR_III_2	885	889	PF00653	0.484
LIG_BRCT_BRCA1_1	131	135	PF00533	0.525
LIG_BRCT_BRCA1_1	678	682	PF00533	0.488
LIG_BRCT_BRCA1_1	874	878	PF00533	0.525
LIG_Clathr_ClatBox_1	344	348	PF01394	0.475
LIG_CtBP_PxDLS_1	285	289	PF00389	0.605
LIG_DLG_GKlike_1	357	364	PF00625	0.433
LIG_FHA_1	174	180	PF00498	0.636
LIG_FHA_1	194	200	PF00498	0.532
LIG_FHA_1	273	279	PF00498	0.744
LIG_FHA_1	5	11	PF00498	0.642
LIG_FHA_1	645	651	PF00498	0.508
LIG_FHA_1	738	744	PF00498	0.501
LIG_FHA_1	763	769	PF00498	0.463
LIG_FHA_1	855	861	PF00498	0.545
LIG_FHA_1	878	884	PF00498	0.435
LIG_FHA_1	939	945	PF00498	0.447
LIG_FHA_1	94	100	PF00498	0.610
LIG_FHA_1	951	957	PF00498	0.323
LIG_FHA_2	116	122	PF00498	0.754
LIG_FHA_2	374	380	PF00498	0.508
LIG_FHA_2	444	450	PF00498	0.464
LIG_FHA_2	487	493	PF00498	0.598
LIG_Integrin_RGD_1	533	535	PF01839	0.571
LIG_LIR_Gen_1	552	560	PF02991	0.498
LIG_LIR_Gen_1	689	698	PF02991	0.386
LIG_LIR_Gen_1	72	82	PF02991	0.494
LIG_LIR_Gen_1	881	889	PF02991	0.470
LIG_LIR_Gen_1	909	917	PF02991	0.423
LIG_LIR_Nem_3	46	51	PF02991	0.550
LIG_LIR_Nem_3	552	557	PF02991	0.500
LIG_LIR_Nem_3	679	684	PF02991	0.379
LIG_LIR_Nem_3	72	78	PF02991	0.753
LIG_LIR_Nem_3	909	913	PF02991	0.396
LIG_MLH1_MIPbox_1	678	682	PF16413	0.468
LIG_MYND_1	104	108	PF01753	0.724
LIG_PDZ_Class_1	959	964	PF00595	0.453
LIG_SH2_STAP1	690	694	PF00017	0.391
LIG_SH2_STAT3	453	456	PF00017	0.420
LIG_SH2_STAT5	851	854	PF00017	0.349
LIG_SH3_3	102	108	PF00018	0.752
LIG_SH3_3	61	67	PF00018	0.717
LIG_SH3_3	76	82	PF00018	0.751
LIG_SH3_3	867	873	PF00018	0.446
LIG_SUMO_SIM_par_1	817	824	PF11976	0.440
LIG_SxIP_EBH_1	502	512	PF03271	0.559
LIG_TRAF2_1	200	203	PF00917	0.603
LIG_TRAF2_1	445	448	PF00917	0.448
LIG_UBA3_1	29	34	PF00899	0.467
LIG_UBA3_1	326	331	PF00899	0.557
LIG_WRC_WIRS_1	650	655	PF05994	0.411
LIG_WRC_WIRS_1	907	912	PF05994	0.486
MOD_CDK_SPxK_1	8	14	PF00069	0.568
MOD_CDK_SPxxK_3	93	100	PF00069	0.696
MOD_CK1_1	119	125	PF00069	0.752
MOD_CK1_1	131	137	PF00069	0.707
MOD_CK1_1	183	189	PF00069	0.610
MOD_CK1_1	193	199	PF00069	0.492
MOD_CK1_1	250	256	PF00069	0.542
MOD_CK1_1	300	306	PF00069	0.584
MOD_CK1_1	353	359	PF00069	0.606
MOD_CK1_1	406	412	PF00069	0.593
MOD_CK1_1	465	471	PF00069	0.504
MOD_CK1_1	66	72	PF00069	0.726
MOD_CK1_1	93	99	PF00069	0.697
MOD_CK2_1	140	146	PF00069	0.572
MOD_CK2_1	357	363	PF00069	0.515
MOD_CK2_1	373	379	PF00069	0.488
MOD_CK2_1	442	448	PF00069	0.452
MOD_CK2_1	808	814	PF00069	0.600
MOD_CK2_1	81	87	PF00069	0.751
MOD_GlcNHglycan	188	191	PF01048	0.594
MOD_GlcNHglycan	192	195	PF01048	0.573
MOD_GlcNHglycan	467	470	PF01048	0.501
MOD_GlcNHglycan	60	63	PF01048	0.655
MOD_GlcNHglycan	642	645	PF01048	0.637
MOD_GlcNHglycan	810	813	PF01048	0.588
MOD_GlcNHglycan	816	819	PF01048	0.501
MOD_GlcNHglycan	83	86	PF01048	0.594
MOD_GlcNHglycan	840	843	PF01048	0.643
MOD_GlcNHglycan	93	96	PF01048	0.543
MOD_GlcNHglycan	961	964	PF01048	0.559
MOD_GSK3_1	115	122	PF00069	0.734
MOD_GSK3_1	129	136	PF00069	0.707
MOD_GSK3_1	179	186	PF00069	0.602
MOD_GSK3_1	300	307	PF00069	0.465
MOD_GSK3_1	353	360	PF00069	0.589
MOD_GSK3_1	369	376	PF00069	0.586
MOD_GSK3_1	4	11	PF00069	0.728
MOD_GSK3_1	619	626	PF00069	0.423
MOD_GSK3_1	640	647	PF00069	0.493
MOD_GSK3_1	676	683	PF00069	0.394
MOD_GSK3_1	804	811	PF00069	0.646
MOD_GSK3_1	81	88	PF00069	0.642
MOD_GSK3_1	872	879	PF00069	0.450
MOD_GSK3_1	91	98	PF00069	0.675
MOD_GSK3_1	934	941	PF00069	0.537
MOD_GSK3_1	952	959	PF00069	0.395
MOD_N-GLC_1	183	188	PF02516	0.698
MOD_NEK2_1	179	184	PF00069	0.658
MOD_NEK2_1	304	309	PF00069	0.544
MOD_NEK2_1	385	390	PF00069	0.446
MOD_NEK2_1	581	586	PF00069	0.401
MOD_NEK2_1	611	616	PF00069	0.500
MOD_NEK2_1	665	670	PF00069	0.447
MOD_NEK2_1	808	813	PF00069	0.626
MOD_NEK2_2	938	943	PF00069	0.509
MOD_PIKK_1	206	212	PF00454	0.551
MOD_PIKK_1	230	236	PF00454	0.589
MOD_PIKK_1	43	49	PF00454	0.634
MOD_PIKK_1	443	449	PF00454	0.564
MOD_PIKK_1	657	663	PF00454	0.602
MOD_PKA_1	297	303	PF00069	0.583
MOD_PKA_1	504	510	PF00069	0.626
MOD_PKA_1	601	607	PF00069	0.573
MOD_PKA_2	174	180	PF00069	0.662
MOD_PKA_2	247	253	PF00069	0.546
MOD_PKA_2	369	375	PF00069	0.485
MOD_PKA_2	393	399	PF00069	0.423
MOD_PKA_2	406	412	PF00069	0.446
MOD_PKA_2	414	420	PF00069	0.442
MOD_PKA_2	504	510	PF00069	0.616
MOD_PKA_2	619	625	PF00069	0.421
MOD_PKA_2	866	872	PF00069	0.414
MOD_PKA_2	90	96	PF00069	0.609
MOD_PKA_2	915	921	PF00069	0.503
MOD_PKA_2	942	948	PF00069	0.444
MOD_PKB_1	355	363	PF00069	0.435
MOD_PKB_1	440	448	PF00069	0.353
MOD_Plk_1	25	31	PF00069	0.466
MOD_Plk_1	259	265	PF00069	0.641
MOD_Plk_1	300	306	PF00069	0.560
MOD_Plk_1	462	468	PF00069	0.584
MOD_Plk_1	611	617	PF00069	0.545
MOD_Plk_1	724	730	PF00069	0.403
MOD_Plk_1	738	744	PF00069	0.410
MOD_Plk_1	762	768	PF00069	0.417
MOD_Plk_1	804	810	PF00069	0.423
MOD_Plk_2-3	555	561	PF00069	0.509
MOD_Plk_4	25	31	PF00069	0.499
MOD_Plk_4	300	306	PF00069	0.560
MOD_Plk_4	623	629	PF00069	0.491
MOD_Plk_4	676	682	PF00069	0.417
MOD_Plk_4	750	756	PF00069	0.536
MOD_Plk_4	775	781	PF00069	0.508
MOD_Plk_4	866	872	PF00069	0.399
MOD_Plk_4	906	912	PF00069	0.410
MOD_Plk_4	956	962	PF00069	0.347
MOD_ProDKin_1	116	122	PF00069	0.740
MOD_ProDKin_1	129	135	PF00069	0.777
MOD_ProDKin_1	63	69	PF00069	0.621
MOD_ProDKin_1	8	14	PF00069	0.645
MOD_ProDKin_1	855	861	PF00069	0.564
MOD_ProDKin_1	93	99	PF00069	0.699
MOD_ProDKin_1	934	940	PF00069	0.404
MOD_SUMO_for_1	200	203	PF00179	0.488
MOD_SUMO_for_1	319	322	PF00179	0.407
MOD_SUMO_for_1	458	461	PF00179	0.551
MOD_SUMO_for_1	510	513	PF00179	0.591
MOD_SUMO_rev_2	328	333	PF00179	0.490
MOD_SUMO_rev_2	36	41	PF00179	0.510
MOD_SUMO_rev_2	421	430	PF00179	0.532
MOD_SUMO_rev_2	811	818	PF00179	0.494
TRG_DiLeu_BaEn_1	322	327	PF01217	0.408
TRG_DiLeu_BaEn_1	381	386	PF01217	0.539
TRG_DiLeu_BaEn_1	606	611	PF01217	0.389
TRG_DiLeu_BaEn_1	739	744	PF01217	0.476
TRG_DiLeu_BaEn_4	612	618	PF01217	0.477
TRG_DiLeu_BaLyEn_6	930	935	PF01217	0.396
TRG_DiLeu_LyEn_5	322	327	PF01217	0.551
TRG_ENDOCYTIC_2	690	693	PF00928	0.389
TRG_ENDOCYTIC_2	711	714	PF00928	0.432
TRG_ER_diArg_1	354	357	PF00400	0.475
TRG_ER_diArg_1	439	442	PF00400	0.445
TRG_ER_diArg_1	48	50	PF00400	0.595
TRG_ER_diArg_1	55	57	PF00400	0.619
TRG_ER_diArg_1	617	620	PF00400	0.399
TRG_NES_CRM1_1	380	395	PF08389	0.338
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	656	661	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE6	Leptomonas seymouri	62%	98%
A0A0S4IU72	Bodo saltans	29%	92%
A0A1X0NZR4	Trypanosomatidae	45%	100%
A0A3Q8IF75	Leishmania donovani	96%	99%
A0A3R7KK73	Trypanosoma rangeli	45%	100%
A4HH39	Leishmania braziliensis	81%	100%
A4I490	Leishmania infantum	96%	99%
C9ZKP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AM41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BPY2	Trypanosoma cruzi	44%	96%