C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADN7_LEIMA

TriTrypDb:

LmjF.29.0360 , LMJLV39_290008800 , LMJSD75_290008800

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADN7

PDB structure(s): 7aih_Ay , 7ane_Ay

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.449
CLV_NRD_NRD_1	29	31	PF00675	0.468
CLV_NRD_NRD_1	38	40	PF00675	0.500
CLV_PCSK_KEX2_1	133	135	PF00082	0.449
CLV_PCSK_KEX2_1	38	40	PF00082	0.500
CLV_PCSK_SKI1_1	6	10	PF00082	0.575
DEG_APCC_DBOX_1	5	13	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_CYCLIN_RxL_1	3	13	PF00134	0.532
DOC_PP1_RVXF_1	82	88	PF00149	0.443
DOC_USP7_MATH_1	20	24	PF00917	0.505
DOC_WW_Pin1_4	141	146	PF00397	0.395
DOC_WW_Pin1_4	168	173	PF00397	0.433
LIG_14-3-3_CanoR_1	3	9	PF00244	0.694
LIG_14-3-3_CanoR_1	38	44	PF00244	0.628
LIG_DCNL_PONY_1	1	4	PF03556	0.589
LIG_deltaCOP1_diTrp_1	108	113	PF00928	0.379
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.440
LIG_deltaCOP1_diTrp_1	49	53	PF00928	0.446
LIG_FHA_1	17	23	PF00498	0.618
LIG_FHA_2	126	132	PF00498	0.565
LIG_LIR_Apic_2	144	150	PF02991	0.523
LIG_LIR_Gen_1	108	118	PF02991	0.416
LIG_LIR_Nem_3	108	113	PF02991	0.378
LIG_SH2_STAT5	102	105	PF00017	0.507
LIG_SH2_STAT5	52	55	PF00017	0.590
LIG_SH3_3	157	163	PF00018	0.540
LIG_SH3_3	166	172	PF00018	0.434
LIG_UBA3_1	26	34	PF00899	0.464
LIG_ULM_U2AF65_1	30	36	PF00076	0.473
MOD_CDK_SPK_2	168	173	PF00069	0.433
MOD_CK2_1	125	131	PF00069	0.503
MOD_GlcNHglycan	22	25	PF01048	0.477
MOD_GSK3_1	10	17	PF00069	0.558
MOD_GSK3_1	139	146	PF00069	0.535
MOD_N-GLC_1	15	20	PF02516	0.507
MOD_PKA_1	30	36	PF00069	0.493
MOD_PKA_1	38	44	PF00069	0.515
MOD_PKA_2	37	43	PF00069	0.500
MOD_PKA_2	94	100	PF00069	0.430
MOD_PKB_1	28	36	PF00069	0.489
MOD_Plk_1	10	16	PF00069	0.556
MOD_ProDKin_1	141	147	PF00069	0.396
MOD_ProDKin_1	168	174	PF00069	0.439
MOD_SUMO_for_1	156	159	PF00179	0.504
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.501
TRG_ER_diArg_1	133	135	PF00400	0.491
TRG_ER_diArg_1	27	30	PF00400	0.484
TRG_ER_diArg_1	84	87	PF00400	0.377
TRG_NLS_MonoExtC_3	29	34	PF00514	0.466
TRG_NLS_MonoExtN_4	28	35	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F9	Leptomonas seymouri	85%	100%
A0A0S4KP62	Bodo saltans	60%	100%
A0A1X0P0Z3	Trypanosomatidae	64%	100%
A0A3Q8IR30	Leishmania donovani	98%	100%
A0A422NUJ5	Trypanosoma rangeli	74%	100%
A4HH37	Leishmania braziliensis	94%	100%
A4I488	Leishmania infantum	98%	100%
C9ZKP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AM43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%