UBX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBX domain-containing protein

Species:

Leishmania major

UniProt:

E9ADN5_LEIMA

TriTrypDb:

LmjF.29.0340 , LMJLV39_290008600 , LMJSD75_290008600

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADN5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0050896	response to stimulus	1	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.368
CLV_C14_Caspase3-7	281	285	PF00656	0.679
CLV_C14_Caspase3-7	335	339	PF00656	0.546
CLV_PCSK_SKI1_1	163	167	PF00082	0.534
CLV_PCSK_SKI1_1	398	402	PF00082	0.493
DEG_SPOP_SBC_1	303	307	PF00917	0.571
DEG_SPOP_SBC_1	350	354	PF00917	0.470
DOC_CKS1_1	360	365	PF01111	0.373
DOC_CKS1_1	89	94	PF01111	0.615
DOC_MAPK_DCC_7	382	391	PF00069	0.547
DOC_MAPK_FxFP_2	80	83	PF00069	0.593
DOC_MAPK_MEF2A_6	134	142	PF00069	0.343
DOC_MAPK_MEF2A_6	273	280	PF00069	0.632
DOC_MAPK_MEF2A_6	382	391	PF00069	0.507
DOC_PP2B_PxIxI_1	386	392	PF00149	0.498
DOC_PP4_FxxP_1	110	113	PF00568	0.353
DOC_PP4_FxxP_1	80	83	PF00568	0.693
DOC_USP7_MATH_1	161	165	PF00917	0.483
DOC_USP7_MATH_1	245	249	PF00917	0.672
DOC_USP7_MATH_1	268	272	PF00917	0.566
DOC_USP7_MATH_1	302	306	PF00917	0.608
DOC_USP7_MATH_1	350	354	PF00917	0.547
DOC_USP7_MATH_1	97	101	PF00917	0.612
DOC_WW_Pin1_4	288	293	PF00397	0.614
DOC_WW_Pin1_4	319	324	PF00397	0.502
DOC_WW_Pin1_4	359	364	PF00397	0.390
DOC_WW_Pin1_4	44	49	PF00397	0.700
DOC_WW_Pin1_4	62	67	PF00397	0.620
DOC_WW_Pin1_4	68	73	PF00397	0.616
DOC_WW_Pin1_4	88	93	PF00397	0.724
LIG_14-3-3_CanoR_1	121	125	PF00244	0.358
LIG_14-3-3_CanoR_1	163	171	PF00244	0.498
LIG_14-3-3_CanoR_1	348	358	PF00244	0.494
LIG_14-3-3_CanoR_1	382	386	PF00244	0.509
LIG_14-3-3_CanoR_1	96	106	PF00244	0.542
LIG_AP2alpha_2	244	246	PF02296	0.678
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	339	343	PF00533	0.537
LIG_deltaCOP1_diTrp_1	219	223	PF00928	0.536
LIG_FHA_1	151	157	PF00498	0.452
LIG_FHA_1	305	311	PF00498	0.721
LIG_FHA_1	353	359	PF00498	0.390
LIG_FHA_2	235	241	PF00498	0.494
LIG_FHA_2	323	329	PF00498	0.542
LIG_FHA_2	333	339	PF00498	0.619
LIG_FHA_2	399	405	PF00498	0.547
LIG_FHA_2	49	55	PF00498	0.597
LIG_LIR_Apic_2	327	332	PF02991	0.566
LIG_LIR_Apic_2	380	386	PF02991	0.523
LIG_LIR_Apic_2	78	83	PF02991	0.690
LIG_LIR_Gen_1	55	66	PF02991	0.584
LIG_LIR_Nem_3	369	373	PF02991	0.387
LIG_LIR_Nem_3	390	395	PF02991	0.517
LIG_LIR_Nem_3	411	416	PF02991	0.390
LIG_LIR_Nem_3	55	61	PF02991	0.587
LIG_NRBOX	370	376	PF00104	0.353
LIG_Rb_LxCxE_1	166	187	PF01857	0.440
LIG_SH2_CRK	383	387	PF00017	0.428
LIG_SH2_NCK_1	329	333	PF00017	0.563
LIG_SH2_NCK_1	383	387	PF00017	0.428
LIG_SH2_NCK_1	58	62	PF00017	0.691
LIG_SH2_STAP1	173	177	PF00017	0.393
LIG_SH2_STAP1	28	32	PF00017	0.443
LIG_SH2_STAT5	115	118	PF00017	0.453
LIG_SH2_STAT5	24	27	PF00017	0.324
LIG_SH2_STAT5	329	332	PF00017	0.548
LIG_SH2_STAT5	370	373	PF00017	0.328
LIG_SH3_2	89	94	PF14604	0.601
LIG_SH3_3	239	245	PF00018	0.593
LIG_SH3_3	269	275	PF00018	0.690
LIG_SH3_3	287	293	PF00018	0.696
LIG_SH3_3	309	315	PF00018	0.588
LIG_SH3_3	357	363	PF00018	0.369
LIG_SH3_3	38	44	PF00018	0.466
LIG_SH3_3	86	92	PF00018	0.635
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.435
LIG_SUMO_SIM_par_1	138	144	PF11976	0.432
LIG_SUMO_SIM_par_1	274	279	PF11976	0.596
LIG_SUMO_SIM_par_1	305	314	PF11976	0.619
LIG_SUMO_SIM_par_1	322	328	PF11976	0.346
LIG_WW_3	385	389	PF00397	0.432
LIG_WW_3	91	95	PF00397	0.576
MOD_CDK_SPxK_1	88	94	PF00069	0.572
MOD_CDK_SPxxK_3	359	366	PF00069	0.492
MOD_CK1_1	164	170	PF00069	0.437
MOD_CK1_1	262	268	PF00069	0.624
MOD_CK1_1	322	328	PF00069	0.516
MOD_CK1_1	352	358	PF00069	0.564
MOD_CK1_1	390	396	PF00069	0.458
MOD_CK1_1	60	66	PF00069	0.612
MOD_CK1_1	68	74	PF00069	0.617
MOD_CK2_1	282	288	PF00069	0.764
MOD_CK2_1	322	328	PF00069	0.483
MOD_CK2_1	398	404	PF00069	0.587
MOD_CK2_1	98	104	PF00069	0.645
MOD_DYRK1A_RPxSP_1	359	363	PF00069	0.501
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.689
MOD_GlcNHglycan	166	169	PF01048	0.514
MOD_GlcNHglycan	224	227	PF01048	0.495
MOD_GlcNHglycan	261	264	PF01048	0.764
MOD_GlcNHglycan	266	269	PF01048	0.701
MOD_GlcNHglycan	392	395	PF01048	0.538
MOD_GlcNHglycan	417	420	PF01048	0.392
MOD_GlcNHglycan	53	57	PF01048	0.704
MOD_GlcNHglycan	67	70	PF01048	0.669
MOD_GSK3_1	116	123	PF00069	0.421
MOD_GSK3_1	264	271	PF00069	0.691
MOD_GSK3_1	302	309	PF00069	0.714
MOD_GSK3_1	333	340	PF00069	0.530
MOD_GSK3_1	377	384	PF00069	0.486
MOD_GSK3_1	44	51	PF00069	0.677
MOD_GSK3_1	52	59	PF00069	0.655
MOD_N-GLC_1	175	180	PF02516	0.420
MOD_N-GLC_1	398	403	PF02516	0.494
MOD_NEK2_1	234	239	PF00069	0.515
MOD_NEK2_1	98	103	PF00069	0.654
MOD_NEK2_2	268	273	PF00069	0.577
MOD_NEK2_2	387	392	PF00069	0.367
MOD_PIKK_1	203	209	PF00454	0.555
MOD_PKA_2	120	126	PF00069	0.487
MOD_PKA_2	381	387	PF00069	0.414
MOD_Plk_1	143	149	PF00069	0.461
MOD_Plk_1	327	333	PF00069	0.508
MOD_Plk_1	337	343	PF00069	0.498
MOD_Plk_1	378	384	PF00069	0.483
MOD_Plk_2-3	120	126	PF00069	0.381
MOD_Plk_2-3	282	288	PF00069	0.575
MOD_Plk_2-3	327	333	PF00069	0.473
MOD_Plk_4	138	144	PF00069	0.346
MOD_Plk_4	166	172	PF00069	0.412
MOD_Plk_4	338	344	PF00069	0.566
MOD_ProDKin_1	288	294	PF00069	0.614
MOD_ProDKin_1	319	325	PF00069	0.498
MOD_ProDKin_1	359	365	PF00069	0.390
MOD_ProDKin_1	44	50	PF00069	0.704
MOD_ProDKin_1	62	68	PF00069	0.620
MOD_ProDKin_1	88	94	PF00069	0.728
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.420
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.366
TRG_ENDOCYTIC_2	58	61	PF00928	0.585
TRG_ER_diArg_1	343	346	PF00400	0.403
TRG_ER_diArg_1	93	96	PF00400	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T7	Leptomonas seymouri	59%	100%
A0A0S4JDU8	Bodo saltans	26%	83%
A0A1X0NZG7	Trypanosomatidae	29%	97%
A0A3Q8IH33	Leishmania donovani	95%	100%
A0A3R7M3Q4	Trypanosoma rangeli	29%	100%
A4HH35	Leishmania braziliensis	83%	100%
A4I486	Leishmania infantum	95%	100%
C9ZKP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AM45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B4U5	Trypanosoma cruzi	26%	100%