Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania major

UniProt:

E9ADN4_LEIMA

TriTrypDb:

LmjF.29.0330 , LMJLV39_290008500 , LMJSD75_290008500

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADN4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	11
GO:0008047	enzyme activator activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.345
CLV_NRD_NRD_1	25	27	PF00675	0.633
CLV_NRD_NRD_1	281	283	PF00675	0.598
CLV_NRD_NRD_1	71	73	PF00675	0.509
CLV_PCSK_KEX2_1	25	27	PF00082	0.632
CLV_PCSK_KEX2_1	259	261	PF00082	0.595
CLV_PCSK_KEX2_1	281	283	PF00082	0.539
CLV_PCSK_KEX2_1	70	72	PF00082	0.520
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.595
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.520
CLV_PCSK_PC7_1	277	283	PF00082	0.585
DEG_APCC_DBOX_1	145	153	PF00400	0.370
DEG_ODPH_VHL_1	292	303	PF01847	0.422
DEG_SPOP_SBC_1	237	241	PF00917	0.573
DEG_SPOP_SBC_1	58	62	PF00917	0.686
DOC_CKS1_1	353	358	PF01111	0.525
DOC_CYCLIN_yClb5_NLxxxL_5	202	211	PF00134	0.411
DOC_PP2B_LxvP_1	66	69	PF13499	0.525
DOC_USP7_MATH_1	188	192	PF00917	0.347
DOC_USP7_MATH_1	378	382	PF00917	0.659
DOC_USP7_MATH_1	56	60	PF00917	0.758
DOC_USP7_UBL2_3	224	228	PF12436	0.626
DOC_USP7_UBL2_3	47	51	PF12436	0.649
DOC_WW_Pin1_4	352	357	PF00397	0.697
DOC_WW_Pin1_4	373	378	PF00397	0.624
LIG_14-3-3_CanoR_1	111	116	PF00244	0.208
LIG_14-3-3_CanoR_1	146	150	PF00244	0.329
LIG_14-3-3_CanoR_1	242	250	PF00244	0.595
LIG_14-3-3_CanoR_1	287	294	PF00244	0.506
LIG_14-3-3_CanoR_1	314	320	PF00244	0.485
LIG_14-3-3_CanoR_1	8	18	PF00244	0.528
LIG_14-3-3_CanoR_1	92	101	PF00244	0.486
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_deltaCOP1_diTrp_1	312	322	PF00928	0.503
LIG_FHA_1	316	322	PF00498	0.503
LIG_FHA_1	349	355	PF00498	0.545
LIG_FHA_1	61	67	PF00498	0.683
LIG_FHA_2	140	146	PF00498	0.310
LIG_FHA_2	163	169	PF00498	0.307
LIG_FHA_2	361	367	PF00498	0.830
LIG_FHA_2	72	78	PF00498	0.609
LIG_Integrin_RGD_1	260	262	PF01839	0.589
LIG_LIR_Apic_2	217	223	PF02991	0.478
LIG_LIR_Gen_1	110	120	PF02991	0.278
LIG_LIR_Nem_3	110	115	PF02991	0.278
LIG_LIR_Nem_3	297	301	PF02991	0.529
LIG_PCNA_PIPBox_1	208	217	PF02747	0.318
LIG_PCNA_yPIPBox_3	205	215	PF02747	0.311
LIG_PDZ_Class_2	382	387	PF00595	0.594
LIG_SH2_CRK	220	224	PF00017	0.510
LIG_SH2_STAP1	167	171	PF00017	0.308
LIG_SH2_STAP1	311	315	PF00017	0.503
LIG_SH3_3	301	307	PF00018	0.529
LIG_SUMO_SIM_par_1	317	324	PF11976	0.510
LIG_TRAF2_1	307	310	PF00917	0.532
LIG_UBA3_1	154	162	PF00899	0.347
LIG_WRC_WIRS_1	189	194	PF05994	0.258
LIG_WRC_WIRS_1	298	303	PF05994	0.606
MOD_CK1_1	361	367	PF00069	0.675
MOD_CK1_1	381	387	PF00069	0.578
MOD_CK1_1	52	58	PF00069	0.783
MOD_CK1_1	59	65	PF00069	0.693
MOD_CK2_1	145	151	PF00069	0.304
MOD_CK2_1	162	168	PF00069	0.221
MOD_CK2_1	320	326	PF00069	0.529
MOD_CK2_1	338	344	PF00069	0.789
MOD_CK2_1	360	366	PF00069	0.811
MOD_Cter_Amidation	257	260	PF01082	0.620
MOD_Cter_Amidation	345	348	PF01082	0.525
MOD_GlcNHglycan	125	128	PF01048	0.278
MOD_GlcNHglycan	177	180	PF01048	0.410
MOD_GlcNHglycan	245	248	PF01048	0.528
MOD_GlcNHglycan	288	291	PF01048	0.558
MOD_GlcNHglycan	340	343	PF01048	0.745
MOD_GlcNHglycan	380	383	PF01048	0.608
MOD_GlcNHglycan	51	54	PF01048	0.736
MOD_GlcNHglycan	66	69	PF01048	0.664
MOD_GSK3_1	107	114	PF00069	0.278
MOD_GSK3_1	134	141	PF00069	0.327
MOD_GSK3_1	233	240	PF00069	0.641
MOD_GSK3_1	27	34	PF00069	0.680
MOD_GSK3_1	348	355	PF00069	0.656
MOD_GSK3_1	52	59	PF00069	0.695
MOD_GSK3_1	60	67	PF00069	0.674
MOD_N-GLC_2	100	102	PF02516	0.269
MOD_NEK2_1	64	69	PF00069	0.656
MOD_PIKK_1	3	9	PF00454	0.529
MOD_PIKK_1	92	98	PF00454	0.289
MOD_PK_1	111	117	PF00069	0.278
MOD_PKA_1	71	77	PF00069	0.502
MOD_PKA_2	123	129	PF00069	0.276
MOD_PKA_2	145	151	PF00069	0.370
MOD_PKA_2	175	181	PF00069	0.413
MOD_PKA_2	241	247	PF00069	0.596
MOD_PKA_2	27	33	PF00069	0.652
MOD_PKA_2	276	282	PF00069	0.530
MOD_PKA_2	286	292	PF00069	0.428
MOD_PKA_2	71	77	PF00069	0.599
MOD_Plk_2-3	145	151	PF00069	0.370
MOD_Plk_4	162	168	PF00069	0.300
MOD_Plk_4	349	355	PF00069	0.534
MOD_Plk_4	381	387	PF00069	0.607
MOD_ProDKin_1	352	358	PF00069	0.698
MOD_ProDKin_1	373	379	PF00069	0.624
TRG_ENDOCYTIC_2	117	120	PF00928	0.215
TRG_ENDOCYTIC_2	298	301	PF00928	0.612
TRG_ER_diArg_1	25	28	PF00400	0.587
TRG_NLS_MonoExtC_3	69	75	PF00514	0.508
TRG_NLS_MonoExtN_4	47	52	PF00514	0.653
TRG_NLS_MonoExtN_4	69	74	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F7	Leptomonas seymouri	60%	100%
A0A3Q8IE49	Leishmania donovani	90%	99%
A0A3S7X1K9	Leishmania donovani	28%	100%
A0A422N066	Trypanosoma rangeli	42%	100%
A4HH34	Leishmania braziliensis	66%	100%
A4I3Q4	Leishmania infantum	28%	100%
A4I485	Leishmania infantum	89%	99%
C9ZKP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AM46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%